LOCUS       NM_001008829            1586 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus RT1 class Ia, locus A2 (RT1-A2), mRNA.
ACCESSION   NM_001008829 XM_579224
VERSION     NM_001008829.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1586)
  AUTHORS   Rolle,A., Meyer,M., Calderazzo,S., Jager,D. and Momburg,F.
  TITLE     Distinct HLA-E Peptide Complexes Modify Antibody-Driven Effector
            Functions of Adaptive NK Cells
  JOURNAL   Cell Rep 24 (8), 1967-1976 (2018)
   PUBMED   30134159
REFERENCE   2  (bases 1 to 1586)
  AUTHORS   Walters,L.C., Harlos,K., Brackenridge,S., Rozbesky,D.,
            Barrett,J.R., Jain,V., Walter,T.S., O'Callaghan,C.A., Borrow,P.,
            Toebes,M., Hansen,S.G., Sacha,J.B., Abdulhaqq,S., Greene,J.M.,
            Fruh,K., Marshall,E., Picker,L.J., Jones,E.Y., McMichael,A.J. and
            Gillespie,G.M.
  TITLE     Pathogen-derived HLA-E bound epitopes reveal broad primary anchor
            pocket tolerability and conformationally malleable peptide binding
  JOURNAL   Nat Commun 9 (1), 3137 (2018)
   PUBMED   30087334
  REMARK    Erratum:[Nat Commun. 2018 Nov 13;9(1):4833. PMID: 30420666]
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1586)
  AUTHORS   Dai,K.Z., Ryan,J.C., Naper,C. and Vaage,J.T.
  TITLE     Identification of MHC Class Ib Ligands for Stimulatory and
            Inhibitory Ly49 Receptors and Induction of Potent NK Cell
            Alloresponses in Rats
  JOURNAL   J Immunol 200 (8), 2847-2859 (2018)
   PUBMED   29531166
REFERENCE   4  (bases 1 to 1586)
  AUTHORS   Harriff,M.J., Wolfe,L.M., Swarbrick,G., Null,M., Cansler,M.E.,
            Canfield,E.T., Vogt,T., Toren,K.G., Li,W., Jackson,M.,
            Lewinsohn,D.A., Dobos,K.M. and Lewinsohn,D.M.
  TITLE     HLA-E Presents Glycopeptides from the Mycobacterium tuberculosis
            Protein MPT32 to Human CD8+ T cells
  JOURNAL   Sci Rep 7 (1), 4622 (2017)
   PUBMED   28676677
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1586)
  AUTHORS   Caccamo,N., Pietra,G., Sullivan,L.C., Brooks,A.G., Prezzemolo,T.,
            La Manna,M.P., Di Liberto,D., Joosten,S.A., van Meijgaarden,K.E.,
            Di Carlo,P., Titone,L., Moretta,L., Mingari,M.C., Ottenhoff,T.H.
            and Dieli,F.
  TITLE     Human CD8 T lymphocytes recognize Mycobacterium tuberculosis
            antigens presented by HLA-E during active tuberculosis and express
            type 2 cytokines
  JOURNAL   Eur J Immunol 45 (4), 1069-1081 (2015)
   PUBMED   25631937
  REMARK    Erratum:[Eur J Immunol. 2019 Jun;49(6):971. PMID: 31161602]
REFERENCE   6  (bases 1 to 1586)
  AUTHORS   Llano,M., Lee,N., Navarro,F., Garcia,P., Albar,J.P., Geraghty,D.E.
            and Lopez-Botet,M.
  TITLE     HLA-E-bound peptides influence recognition by inhibitory and
            triggering CD94/NKG2 receptors: preferential response to an
            HLA-G-derived nonamer
  JOURNAL   Eur J Immunol 28 (9), 2854-2863 (1998)
   PUBMED   9754572
REFERENCE   7  (bases 1 to 1586)
  AUTHORS   Braud,V.M., Allan,D.S., O'Callaghan,C.A., Soderstrom,K.,
            D'Andrea,A., Ogg,G.S., Lazetic,S., Young,N.T., Bell,J.I.,
            Phillips,J.H., Lanier,L.L. and McMichael,A.J.
  TITLE     HLA-E binds to natural killer cell receptors CD94/NKG2A, B and C
  JOURNAL   Nature 391 (6669), 795-799 (1998)
   PUBMED   9486650
REFERENCE   8  (bases 1 to 1586)
  AUTHORS   Joly,E., Le Rolle,A.F., Gonzalez,A.L., Mehling,B., Stevens,J.,
            Coadwell,W.J., Hunig,T., Howard,J.C. and Butcher,G.W.
  TITLE     Co-evolution of rat TAP transporters and MHC class I RT1-A
            molecules
  JOURNAL   Curr Biol 8 (3), 169-172 (1998)
   PUBMED   9443915
REFERENCE   9  (bases 1 to 1586)
  AUTHORS   Braud,V.M., Allan,D.S., Wilson,D. and McMichael,A.J.
  TITLE     TAP- and tapasin-dependent HLA-E surface expression correlates with
            the binding of an MHC class I leader peptide
  JOURNAL   Curr Biol 8 (1), 1-10 (1998)
   PUBMED   9427624
REFERENCE   10 (bases 1 to 1586)
  AUTHORS   Attaya,M., Jameson,S., Martinez,C.K., Hermel,E., Aldrich,C.,
            Forman,J., Lindahl,K.F., Bevan,M.J. and Monaco,J.J.
  TITLE     Ham-2 corrects the class I antigen-processing defect in RMA-S cells
  JOURNAL   Nature 355 (6361), 647-649 (1992)
   PUBMED   1538753
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000020.1.
            
            On Mar 5, 2021 this sequence version replaced NM_001008829.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ231785.1, FQ231678.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-93                JAXUCZ010000020.1  4872871-4872963
            94-363              JAXUCZ010000020.1  4873167-4873436
            364-639             JAXUCZ010000020.1  4873618-4873893
            640-915             JAXUCZ010000020.1  4874876-4875151
            916-1044            JAXUCZ010000020.1  4875246-4875374
            1045-1074           JAXUCZ010000020.1  4875551-4875580
            1075-1122           JAXUCZ010000020.1  4875778-4875825
            1123-1586           JAXUCZ010000020.1  4875959-4876422
FEATURES             Location/Qualifiers
     source          1..1586
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20p12"
     gene            1..1586
                     /gene="RT1-A2"
                     /gene_synonym="RT1-A2n; RT1.A2(N); RT1A-2"
                     /note="RT1 class Ia, locus A2"
                     /db_xref="GeneID:24974"
                     /db_xref="RGD:1595923"
     exon            1..93
                     /gene="RT1-A2"
                     /gene_synonym="RT1-A2n; RT1.A2(N); RT1A-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             27..1127
                     /gene="RT1-A2"
                     /gene_synonym="RT1-A2n; RT1.A2(N); RT1A-2"
                     /note="RT1 class I gene (A-2); RT1 class Ia, A2n"
                     /codon_start=1
                     /product="RT1 class Ia, locus A2 precursor"
                     /protein_id="NP_001008829.1"
                     /db_xref="GeneID:24974"
                     /db_xref="RGD:1595923"
                     /translation="MMEPCTLLLLLAVALTPTQTRAGSHSLRYFVTAVSRPGLGEPRY
                     MEVGYVDDTQFVRYDSDAENPRYEPRAPWMEREGPEYWERETQNAKRNEQVYRVDLRT
                     ALRYYNQSEGGSHTIQRMYGCDMGSDGSLLRGYYQDAYDGRDYIALNEDLKTWTAADF
                     AAQITRSKWDQAGVAERLRAYLEGTCVEWLRRYLELGKETLLRSDPPEAHVTLHPRPE
                     GDVTLRCWALGFYPADITLTWQLNGEDLTQDMELVETRPAGDGTFQKWASVVVPLGKE
                     QNYTCRVEHEGLPEPLSQRWEPSPSTNSNMETTVIYVVLGAIIGTLAIIGIVVAVVRK
                     RRRNTGGKGDYTPAPGRDSSQSSDVSLPDCKA"
     exon            94..363
                     /gene="RT1-A2"
                     /gene_synonym="RT1-A2n; RT1.A2(N); RT1A-2"
                     /inference="alignment:Splign:2.1.0"
     exon            364..639
                     /gene="RT1-A2"
                     /gene_synonym="RT1-A2n; RT1.A2(N); RT1A-2"
                     /inference="alignment:Splign:2.1.0"
     exon            640..915
                     /gene="RT1-A2"
                     /gene_synonym="RT1-A2n; RT1.A2(N); RT1A-2"
                     /inference="alignment:Splign:2.1.0"
     exon            916..1044
                     /gene="RT1-A2"
                     /gene_synonym="RT1-A2n; RT1.A2(N); RT1A-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1045..1074
                     /gene="RT1-A2"
                     /gene_synonym="RT1-A2n; RT1.A2(N); RT1A-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1075..1122
                     /gene="RT1-A2"
                     /gene_synonym="RT1-A2n; RT1.A2(N); RT1A-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1123..1586
                     /gene="RT1-A2"
                     /gene_synonym="RT1-A2n; RT1.A2(N); RT1A-2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agatccgtcc cggatctcac agggggatga tggagccctg cactctgctc ctgctgctgg
       61 cggtcgccct gaccccgacc cagacccgcg ccggctctca ctcgctgcgg tatttcgtca
      121 ccgccgtgtc ccggcccggc ctcggggagc cccggtacat ggaagtgggc tacgtggacg
      181 acacgcagtt cgtgcgctac gacagcgatg cagagaatcc gagatacgag ccgcgggcgc
      241 cgtggatgga gcgggagggg ccggagtatt gggagaggga gacccagaac gccaagagaa
      301 acgagcaggt ttaccgagtg gacctgagga ccgcgctccg ctactacaac cagagcgagg
      361 gcggctctca caccatccag aggatgtatg gctgtgacat ggggtcggac gggagcctcc
      421 tccgcgggta ttatcaggac gcttacgacg gccgcgatta catcgccctg aacgaagacc
      481 tgaaaacgtg gacggcggcg gactttgcgg cacagatcac ccggagcaag tgggatcagg
      541 ctggtgttgc agagagactc agggcctacc tggagggcac gtgcgtggag tggctccgca
      601 gatacctgga actcgggaag gagacgctgc tgcgctcaga tcccccagag gcacatgtga
      661 cccttcaccc cagacctgaa ggtgatgtca ccctgaggtg ctgggccctg ggcttctacc
      721 ctgctgacat caccctgacc tggcagttga atggggagga cctgacccag gacatggagc
      781 ttgtggagac caggcctgca ggggatggaa cctttcagaa gtgggcatct gtggtggtgc
      841 ctcttgggaa ggagcagaat tacacatgcc gtgtggagca tgaggggctg cctgagccac
      901 tttcccagag atgggagcct tctccatcga ccaactccaa catggaaacc actgtcattt
      961 atgtcgtcct tggagccatc attggaactc tggccatcat tggaattgta gtggctgttg
     1021 tgaggaagag gaggagaaac acaggtggga aaggtgacta cacccctgct ccaggcaggg
     1081 acagctccca gagctctgat gtgtctctcc cagattgtaa agcatgaaga cagctgcctg
     1141 gagtggactg agtgacagac gatgtgttca ggtctctcct gtgacaccca gagccctcag
     1201 ttctctttag acaccagtgt ctgaagttcc ctgtgattct atggcttctg tgtgaagaac
     1261 tgtggagccc agcccgccct gcacacctgg accctgtccc tgcactgcct gtgttcccta
     1321 ccaaggccaa ccttgctggt ccagcctagg gttcaggggt ggggacatct gcatcctgtc
     1381 cctccctgct accctgagct tgagctcctc acttccacac tgagaataag aatctgagtg
     1441 tgaacttgat tgttcacatc cttgacccaa gtgtggatgg ctttttaatt actggattga
     1501 gaatacttag aggttttttg ttttggggtt ttgctttgtt tgattttgtt tttgaataaa
     1561 ataaatggca gatggagaag cttcca
//
