LOCUS       NM_001108312            5837 bp    mRNA    linear   ROD 07-OCT-2023
DEFINITION  Rattus norvegicus similar to human chromosome 21 open reading frame
            91 (C11h21orf91), mRNA.
ACCESSION   NM_001108312 XM_001068357 XM_008768532 XM_340963
VERSION     NM_001108312.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5837)
  AUTHORS   Li SS, Qu Z, Haas M, Ngo L, Heo YJ, Kang HJ, Britto JM, Cullen HD,
            Vanyai HK, Tan SS, Chan-Ling T, Gunnersen JM and Heng JI.
  TITLE     The HSA21 gene EURL/C21ORF91 controls neurogenesis within the
            cerebral cortex and is implicated in the pathogenesis of Down
            Syndrome
  JOURNAL   Sci Rep 6, 29514 (2016)
   PUBMED   27404227
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000221.1.
            
            [WARNING] On Apr 3, 2024 this sequence was replaced by
            NM_001108312.4.
            
            On or before May 6, 2021 this sequence version replaced
            XM_008768532.3, NM_001108312.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ227934.1, FQ234045.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-251               JACYVU010000221.1  17261973-17262223   c
            252-385             JACYVU010000221.1  17261467-17261600   c
            386-901             JACYVU010000221.1  17236310-17236825   c
            902-964             JACYVU010000221.1  17235265-17235327   c
            965-5837            JACYVU010000221.1  17229129-17234001   c
FEATURES             Location/Qualifiers
     source          1..5837
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q11"
     gene            1..5837
                     /gene="C11h21orf91"
                     /gene_synonym="RGD1563888"
                     /note="similar to human chromosome 21 open reading frame
                     91"
                     /db_xref="GeneID:360692"
                     /db_xref="RGD:1563888"
     exon            1..251
                     /gene="C11h21orf91"
                     /gene_synonym="RGD1563888"
                     /inference="alignment:Splign:2.1.0"
     exon            252..385
                     /gene="C11h21orf91"
                     /gene_synonym="RGD1563888"
                     /inference="alignment:Splign:2.1.0"
     CDS             259..1131
                     /gene="C11h21orf91"
                     /gene_synonym="RGD1563888"
                     /codon_start=1
                     /product="protein EURL homolog"
                     /protein_id="NP_001101782.1"
                     /db_xref="GeneID:360692"
                     /db_xref="RGD:1563888"
                     /translation="MNEEEQFVNIDLNDDNICSVCKLGTDKDTLSFCHICFELNLEGV
                     PKSNLLHTKSLRGHKDCFEKYHLIANQDCSRSKLSKSTYEGVKTILSKKINWIVQYAQ
                     NKNLDLDSECSKTSQHHLFNFRHKPEKKLLPQFDSQVPKYSAKGLAGSAVGISSYTQR
                     ILDHREDTDFGLGILEDADALWTHSHNQAQKTEETSSVPERSVQTQSPRYSREELNSM
                     TLAEVVQLSTKLRQQIQEVFEELTHQVQEKDSLASELHVRHVAIEQLLKNCSKLPCLQ
                     VGRTGTRPHLSTNN"
     exon            386..901
                     /gene="C11h21orf91"
                     /gene_synonym="RGD1563888"
                     /inference="alignment:Splign:2.1.0"
     exon            902..964
                     /gene="C11h21orf91"
                     /gene_synonym="RGD1563888"
                     /inference="alignment:Splign:2.1.0"
     exon            965..5837
                     /gene="C11h21orf91"
                     /gene_synonym="RGD1563888"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aatagtgcgg atcgtggcgc gcgaacagcg tcccgcggag ccggacggta aaggtccttc
       61 tctgagccgc tctagtgcgt cggaccggtg ccgggacgga cggacggacg gacggacgga
      121 cggacagacg aggcggatcc cacgccgcgc cgacagccca cgatcctcga gtggagtcct
      181 cgggaccctc cggtccgtgg ctgcggagtc tccgacgtga gcggaccctt cccgggtgtc
      241 cccgtcccca cgggcactat gaacgaagag gagcagtttg taaacattga tttgaatgat
      301 gacaacattt gcagtgtttg taaactggga acagacaaag acacactctc cttctgccac
      361 atttgctttg agctaaatct cgagggagta ccaaagtcta atcttttaca caccaaatca
      421 ttgagaggcc acaaagactg ctttgaaaaa taccatttaa ttgccaacca ggattgttct
      481 cgatccaagc tctccaaaag tacttacgaa ggagttaaaa ccatcctgag taagaagata
      541 aactggattg tgcagtatgc ccaaaataag aatctggatt tggactcgga gtgttccaaa
      601 acttcccagc atcacctgtt taatttcagg cataagccag agaagaaatt actcccacag
      661 tttgactctc aggtgcccaa gtactcagcc aaggggttag caggaagcgc agtcggcatc
      721 tcaagctata cgcagagaat cctggaccac agggaggaca cggacttcgg gcttggtatc
      781 ctggaagacg cggatgcatt gtggactcac agtcacaacc aggcacagaa aacagaagag
      841 acgagctctg ttccggagcg gagtgtgcag acccagagtc ctcgctacag ccgagaagag
      901 ctgaattcga tgacgcttgc tgaagtagtt caactgagta caaagctccg acagcaaatc
      961 caggaagttt ttgaagagtt gacacaccag gtgcaagaaa aggactccct ggcatccgag
     1021 ctccacgtcc gtcacgtggc tatcgagcag ctcctcaaga actgttccaa gttgccctgc
     1081 ctccaagtgg gacggaccgg aacaaggcca cacctatcca ctaacaactg agctgagcac
     1141 agctcccgcg ctcttcatct ctgtcgctct gctaagcatc tggaccgaga aagcatttga
     1201 agaacgtcat ggtccatttt catggttgtt gtacttgcaa aacataagat aatattcatt
     1261 atctttatct aataaagcag atcactctag tccagggtta atcatttggc tacattcggg
     1321 gggctttttc ttataattac taaatgcccg tccctaactt ttacagtgtt tgactactta
     1381 aatccactgt tacagtgttt ctattgacca attttttatt gtaactcagc tgtcaagaca
     1441 acagaagcct aattaataag gtcttgcgtt agcctaaact actagagata attttaaaga
     1501 gggaaataga attcataata tcaccttatt tatgagcaat attttaatat aaaattttat
     1561 atataaaatt gctattttgg gtatttttca tcgtctttat aattttgtat ttgaatggcc
     1621 gtgtgtattt gcacttcgtt gtgtgaatat gttcacctct gtgaagatcg ctgcatcttg
     1681 gcgatacagt gtttttataa ctgttgtctt tctttccaaa gataaatgtg ttctggctag
     1741 tatttggaga agcaatctac atagctgagg tgtttgcact actaacagca taggaaaggg
     1801 gaatttactg ctctttaaag catatgtcca aatgagtaaa gcacattatt gttttctaag
     1861 gaaagcaatg ctcaattagc ttaggaggaa aatactagcc tattttttat gtgtcagtct
     1921 ccgtaacagt aaaagccccg cctcttaact ctcgtgactt cctgtgatgt gttagttttg
     1981 gacaaagtag gtcaactctc tgctcccagt ccactgtaaa tacgatcttc aaactgtacc
     2041 tgtccccctt ttgggggagg gggagataaa attattaggc gtgtcacttc acatggagtt
     2101 ccaataatct gttaactgtc caaattctgc catccacatc actgaagttg atccaagaaa
     2161 taaaaataaa agactaaaga aagaaagaaa gaagaaaaag cattttaaag gtactttcta
     2221 agttttaaaa tctaaaggga gagaagatta cagaaccaaa aaaaaaaaat caattcagta
     2281 aaaagcataa tataagctac tttgatttca gattcttaac taataagtta tttcaaaatg
     2341 ttagataagt tttaatgata aaataaaagc tataactagt ccaaagttaa aatggactct
     2401 ttagctggtg cttagaatgt atttgtgcgg tagatatttt ttggcttgca gaaatctaag
     2461 gaaagaaagc ctcatacgta aagatggttt ctgccttgaa gttggcagcc tgtatctggg
     2521 caagggtcag actttaatat ggagcataca tgatatttga ctaaacagat gactgcgtca
     2581 ctgtagaaaa agcacctttc ctaatgctaa gatgtattaa gccagcttgg ctagtcaata
     2641 tcccgttgtt tttgctttgt ccgaagaagc ttttgaagct ttttggaagg agcttttgaa
     2701 aaaagaaaaa tgctttttag cttctctcag ttcttggagc catccaagat gaatttgaaa
     2761 tccggagggc ggaggtgagt gcgttgcctt agttttgaga agctttaaat tgaacgtgtg
     2821 caatatggaa ggttccacgt gtagcagctg ggggcgtgtc ctgagggggc gtgtcctggt
     2881 tgtgccggta agcgtttcag tgctcagttg ttactgtcct gttttcaagt ttaactgcgc
     2941 tgtactcttg cctggcataa ctcattaaga ggagcagctg tctggatgat ggaaaggtcg
     3001 ttcttgggca gccataggag tgtgtgacat tcagttttgg gtacatgcag tgctcagtgt
     3061 atttctatca taggagacat acggtgcagt cctaaaaacc agtgataccc aaagaaaaac
     3121 gtgtgcttat ctcttaagga gttctctggc aaacatttag tttactaatg agtttggaat
     3181 aactggggtt tctcccgcgt actctaaggt cttaactggg acctccgact catttctttt
     3241 agatatttca ctgggaacac caaaggaatg gtgctaagtc gatctctggt gcggtggtaa
     3301 cactagtact cattcacatg gattttgctg gagtatacta ctttgtataa tttaactacc
     3361 cgttgtttgg attttttttg ttggtggtgg tttgcttgct tgcttgtttt gacacagggt
     3421 cttgctacat agctttggct agcctagcat tctctttgta gaccagacta gcctggaatt
     3481 tgtagcaatt ctcctgcctc aggaggagat ctagtactgt gattcaggtg taatctccta
     3541 ctcctagctt gctatgctct cttgattgaa tatgcaattg tcagatatgc aaaaataagg
     3601 atgggcttgg agttgaggtc caatttaggg aatatgaact tatacaagta ctggtttcta
     3661 tgtttagttc tgtgtgtttt gggcaagttc agaagaaact tcacacatga tttcatttct
     3721 taaaaacaat ttaagatgta ctgctagtga gctcgtacat ctgagggctt ctatgaggag
     3781 cgaagtgaaa ttttgtcaca ctagatgtca tagttaaaca agttgcgtat ttttttaaaa
     3841 tcagaagtca aatgtgattt taacacgatt tattttcttt aaagagtagt gttcttatgt
     3901 gcctagcgtc tatcaggccc tgggctatta attcctgtca ccatagtaaa tatacaaagg
     3961 ttttgctcct ggtattggtt ttatcatgtt gcccaggtct gaatggggtg ggggtggggg
     4021 gttgttgatg tatactgcca tggctggctt cagttttcgt attgtccatc cttgtagcat
     4081 ttctccggaa actaccgcct tactctcgta ttaatttctc agttaggcct ttggaacagg
     4141 cattcatttg acacaccatg ctggtggtct aaacggtcca ctttcttctc tgtgtgatta
     4201 ttgcatgtag tattggccta agggaagccc ttatgttcca ggtgcccacc atgtttgttt
     4261 cgccctagag tgcccattct cagaaacatt taatgattat atttcaaaat gtgtgcatgc
     4321 tggcaagtga tttcggaaac acagttgaaa catggttgcc ttcttgaaag gtagcttgtg
     4381 atttcttggt ctcttgccta cccttgagaa atggctttta cctttttgtt tgtctatata
     4441 gaaacctacc ctggtgttta ttctgttgag acctgtcagg tttttgttaa tttttgaagt
     4501 catcctttgg atcagtaggt gttaatgtgt accagtttgt gcttaacatg tttgttaaca
     4561 tcatgtggaa cgaaagtgct ccaaacttca gtaggaatct taaagatctt gccctttaaa
     4621 ggattttaaa gggttcagat gtgtgaccat gcaaaataat tacatggaca tgacctattt
     4681 taatggtaga atgttccttt cctcacgttt tgttttgact gtttggagga gttgttttac
     4741 tttttgcaag ttcattcact gacaactgtt accattgttc aagctacagc aagatgtgtg
     4801 gctcttttaa aacttcctgt gtatgaaaat tttatatacc ctctattaag atatgacctt
     4861 aaagtggaga tgtgatttga tttgggtctg attccagttt taccttgaac ggaatttttt
     4921 tctgagaaaa tttgtttttt tttaaaataa aaagccctga aggacagagc cctaaataaa
     4981 acacccttgc cgagttaagc tttgtggtgc cgggtataga agagtttgtc tgctggagta
     5041 ataggactct gtggggaaga gaagttcgtg ctggaccaga aagactgtga cctttgcctc
     5101 gcatttccct aatttcattc catgcccctg ctgatgtcat cggtcgcctg agcaacccca
     5161 agccacgccc acctagatag gaaccaatca cgtgggtgca gaaccttaag atttttaaca
     5221 tttagtttgt aaatgctttc actgatattt ttagcttgaa taaagctata attatttagt
     5281 agttctccct caatttcaag tttaccagcg tgaagcaaaa gtgtcctgga gatgtgcttg
     5341 tttaaagcta gccgcaccgg ctgcccgtgc tgccacgtgt agtggcttta gcattgatgt
     5401 ttggatcggt ttgatttcct tttttcttct ctctgtcctg ctgcctccag aagacgtggt
     5461 tttgaaaagt gtttagtagt ggtgcgtgcg tgcgtgcgtg cgtgcgtgcg tgcgtgcaag
     5521 agagagagag agagagagag agagagagag agagagagag agagagagag agagagagag
     5581 agagagaaat gttgctctaa acctggctgc ataagcaaca gtccatgaac tctgctgaca
     5641 tttagaaagc gaaaatgaag ctgccatggt caaagctaag tttgtctcaa aaaaaaaaaa
     5701 aaaaaaccat ttattgagtc atcgtctggg ttatatgcaa tttatatatt tgtattctgc
     5761 tttgaaactg taactagata agtctgtcta ctatttttaa ctttacaaga ataaaatatt
     5821 ttggtagcta tctccta
//
