LOCUS       NM_001007702            3131 bp    mRNA    linear   ROD 14-FEB-2025
DEFINITION  Rattus norvegicus similar to RIKEN cDNA 3110043O21 (RGD1359108),
            mRNA.
ACCESSION   NM_001007702 XM_232875
VERSION     NM_001007702.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3131)
  AUTHORS   Zheng,W., Wang,K., Wu,Y., Yan,G., Zhang,C., Li,Z., Wang,L. and
            Chen,S.
  TITLE     C9orf72 regulates the unfolded protein response and stress granule
            formation by interacting with eIF2alpha
  JOURNAL   Theranostics 12 (17), 7289-7306 (2022)
   PUBMED   36438488
  REMARK    GeneRIF: C9orf72 regulates the unfolded protein response and stress
            granule formation by interacting with eIF2alpha.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3131)
  AUTHORS   Chen,J., Zhang,M., Bai,H., Shi,P., Du,M., Zhang,S. and Lou,J.
  TITLE     Overexpression of C9orf72 exacerbates Abeta25-35-induced oxidative
            stress and apoptosis in PC12 cells
  JOURNAL   Acta Neurobiol Exp (Wars) 82 (1), 77-87 (2022)
   PUBMED   35451425
  REMARK    GeneRIF: Overexpression of C9orf72 exacerbates Abeta2535induced
            oxidative stress and apoptosis in PC12 cells.
REFERENCE   3  (bases 1 to 3131)
  AUTHORS   Dong,W., Ma,Y., Guan,F., Zhang,X., Chen,W., Zhang,L. and Zhang,L.
  TITLE     Ablation of C9orf72 together with excitotoxicity induces ALS in
            rats
  JOURNAL   FEBS J 288 (5), 1712-1723 (2021)
   PUBMED   32745320
  REMARK    GeneRIF: Ablation of C9orf72 together with excitotoxicity induces
            ALS in rats.
REFERENCE   4  (bases 1 to 3131)
  AUTHORS   Guo,Q., Lehmer,C., Martinez-Sanchez,A., Rudack,T., Beck,F.,
            Hartmann,H., Perez-Berlanga,M., Frottin,F., Hipp,M.S., Hartl,F.U.,
            Edbauer,D., Baumeister,W. and Fernandez-Busnadiego,R.
  TITLE     In Situ Structure of Neuronal C9orf72 Poly-GA Aggregates Reveals
            Proteasome Recruitment
  JOURNAL   Cell 172 (4), 696-705 (2018)
   PUBMED   29398115
  REMARK    GeneRIF: In Situ Structure of Neuronal C9orf72 Poly-GA Aggregates
            Reveals Proteasome Recruitment.
REFERENCE   5  (bases 1 to 3131)
  AUTHORS   Maharjan,N., Kunzli,C., Buthey,K. and Saxena,S.
  TITLE     C9ORF72 Regulates Stress Granule Formation and Its Deficiency
            Impairs Stress Granule Assembly, Hypersensitizing Cells to Stress
  JOURNAL   Mol Neurobiol 54 (4), 3062-3077 (2017)
   PUBMED   27037575
REFERENCE   6  (bases 1 to 3131)
  AUTHORS   Ugolino,J., Ji,Y.J., Conchina,K., Chu,J., Nirujogi,R.S., Pandey,A.,
            Brady,N.R., Hamacher-Brady,A. and Wang,J.
  TITLE     Loss of C9orf72 Enhances Autophagic Activity via Deregulated mTOR
            and TFEB Signaling
  JOURNAL   PLoS Genet 12 (11), e1006443 (2016)
   PUBMED   27875531
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 3131)
  AUTHORS   O'Rourke,J.G., Bogdanik,L., Yanez,A., Lall,D., Wolf,A.J.,
            Muhammad,A.K., Ho,R., Carmona,S., Vit,J.P., Zarrow,J., Kim,K.J.,
            Bell,S., Harms,M.B., Miller,T.M., Dangler,C.A., Underhill,D.M.,
            Goodridge,H.S., Lutz,C.M. and Baloh,R.H.
  TITLE     C9orf72 is required for proper macrophage and microglial function
            in mice
  JOURNAL   Science 351 (6279), 1324-1329 (2016)
   PUBMED   26989253
REFERENCE   8  (bases 1 to 3131)
  AUTHORS   Xiao,S., MacNair,L., McGoldrick,P., McKeever,P.M., McLean,J.R.,
            Zhang,M., Keith,J., Zinman,L., Rogaeva,E. and Robertson,J.
  TITLE     Isoform-specific antibodies reveal distinct subcellular
            localizations of C9orf72 in amyotrophic lateral sclerosis
  JOURNAL   Ann Neurol 78 (4), 568-583 (2015)
   PUBMED   26174152
REFERENCE   9  (bases 1 to 3131)
  AUTHORS   Atkinson,R.A., Fernandez-Martos,C.M., Atkin,J.D., Vickers,J.C. and
            King,A.E.
  TITLE     C9ORF72 expression and cellular localization over mouse development
  JOURNAL   Acta Neuropathol Commun 3, 59 (2015)
   PUBMED   26408000
  REMARK    Erratum:[Acta Neuropathol Commun. 2016 Jan 04;4:2. doi:
            10.1186/s40478-015-0253-8.. PMID: 26727886]
            Publication Status: Online-Only
REFERENCE   10 (bases 1 to 3131)
  AUTHORS   Farg,M.A., Sundaramoorthy,V., Sultana,J.M., Yang,S., Atkinson,R.A.,
            Levina,V., Halloran,M.A., Gleeson,P.A., Blair,I.P., Soo,K.Y.,
            King,A.E. and Atkin,J.D.
  TITLE     C9ORF72, implicated in amytrophic lateral sclerosis and
            frontotemporal dementia, regulates endosomal trafficking
  JOURNAL   Hum Mol Genet 23 (13), 3579-3595 (2014)
   PUBMED   24549040
  REMARK    Erratum:[Hum Mol Genet. 2017 Oct 15;26(20):4093-4094. doi:
            10.1093/hmg/ddx309.. PMID: 28973528]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Apr 3, 2023 this sequence version replaced NM_001007702.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC081927.1, SRR26643299.22273.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-47                JAXUCZ010000005.1  54587311-54587357   c
            48-533              JAXUCZ010000005.1  54579794-54580279   c
            534-593             JAXUCZ010000005.1  54578603-54578662   c
            594-689             JAXUCZ010000005.1  54577209-54577304   c
            690-754             JAXUCZ010000005.1  54576649-54576713   c
            755-827             JAXUCZ010000005.1  54575152-54575224   c
            828-944             JAXUCZ010000005.1  54573290-54573406   c
            945-1180            JAXUCZ010000005.1  54568052-54568287   c
            1181-1238           JAXUCZ010000005.1  54565799-54565856   c
            1239-1348           JAXUCZ010000005.1  54564469-54564578   c
            1349-3131           JAXUCZ010000005.1  54562570-54564352   c
FEATURES             Location/Qualifiers
     source          1..3131
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q21"
     gene            1..3131
                     /gene="RGD1359108"
                     /gene_synonym="C9orf72"
                     /note="similar to RIKEN cDNA 3110043O21"
                     /db_xref="GeneID:313155"
                     /db_xref="RGD:1359108"
     exon            1..47
                     /gene="RGD1359108"
                     /gene_synonym="C9orf72"
                     /inference="alignment:Splign:2.1.0"
     exon            48..533
                     /gene="RGD1359108"
                     /gene_synonym="C9orf72"
                     /inference="alignment:Splign:2.1.0"
     CDS             90..1535
                     /gene="RGD1359108"
                     /gene_synonym="C9orf72"
                     /note="protein C9orf72 homolog; guanine nucleotide
                     exchange C9orf72 homolog; uncharacterized protein C9orf72
                     homolog"
                     /codon_start=1
                     /product="guanine nucleotide exchange factor C9orf72
                     homolog"
                     /protein_id="NP_001007703.1"
                     /db_xref="GeneID:313155"
                     /db_xref="RGD:1359108"
                     /translation="MSTICPPPSPAVAKTEIALSGESPLLAATFAYWDNILGPRVRHI
                     WAPKTDQVLLSDGEITFLANHTLNGEILRNAESGAIDVKFFVLSEKGVIIVSLIFDGN
                     WNGDRSTYGLSIILPQTELSFYLPLHRVCVDRLTHIIRKGRIWMHKERQENVQKIVLE
                     GTERMEDQGQSIIPMLTGEVIPVMELLASMRSHSVPEDLDIADTVLNDDDIGDSCHEG
                     FLLNAISSHLQTCGCSVVVGSSAEKVNKIVRTLCLFLTPAERKCSRLCEAESSFKYES
                     GLFVQGLLKDATGSFVLPFRQVMYAPYPTTHIDVDVNTVKQMPPCHEHIYNQRRYMRS
                     ELTAFWRATSEEDMAQDTIIYTDESFTPDLNIFQDVLHRDTLVKAFLDQVFHLKPGLS
                     LRSTFLAQFLLILHRKALTLIKYIEDDTQKGKKPFKSLRNLKIDLDLTAEGDLNIIMA
                     LAEKIKPGLHSFIFGRPFYTSVQERDVLMTF"
     exon            534..593
                     /gene="RGD1359108"
                     /gene_synonym="C9orf72"
                     /inference="alignment:Splign:2.1.0"
     exon            594..689
                     /gene="RGD1359108"
                     /gene_synonym="C9orf72"
                     /inference="alignment:Splign:2.1.0"
     exon            690..754
                     /gene="RGD1359108"
                     /gene_synonym="C9orf72"
                     /inference="alignment:Splign:2.1.0"
     exon            755..827
                     /gene="RGD1359108"
                     /gene_synonym="C9orf72"
                     /inference="alignment:Splign:2.1.0"
     exon            828..944
                     /gene="RGD1359108"
                     /gene_synonym="C9orf72"
                     /inference="alignment:Splign:2.1.0"
     exon            945..1180
                     /gene="RGD1359108"
                     /gene_synonym="C9orf72"
                     /inference="alignment:Splign:2.1.0"
     exon            1181..1238
                     /gene="RGD1359108"
                     /gene_synonym="C9orf72"
                     /inference="alignment:Splign:2.1.0"
     exon            1239..1348
                     /gene="RGD1359108"
                     /gene_synonym="C9orf72"
                     /inference="alignment:Splign:2.1.0"
     exon            1349..3131
                     /gene="RGD1359108"
                     /gene_synonym="C9orf72"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggttgcggtc cctgcgccgg cggtgaaggc gcagcggcgg cgagtggcta ttgcaagcgt
       61 ttggataatg tgagacctgg gatgcaggga tgtcgactat ctgcccccca ccatctcctg
      121 ctgttgccaa gacagagatt gctttaagtg gtgaatcacc cttgttggcg gctacctttg
      181 cttactggga taatattctt ggtcctagag taaggcacat ttgggctcca aagacagacc
      241 aagtactcct cagtgatgga gaaatcactt ttcttgccaa ccacactctg aatggagaaa
      301 ttcttcggaa tgcggagagt ggggcaatag atgtaaagtt ttttgtctta tctgaaaagg
      361 gcgtcattat tgtttcatta atcttcgacg ggaactggaa cggagatcgg agcacttacg
      421 gactatcaat tatactgccg cagacggagc tgagtttcta cctcccactg cacagagtgt
      481 gtgttgacag gctaacgcac atcattcgaa aaggaaggat atggatgcac aaggaaagac
      541 aagaaaatgt ccagaaaatt gtcttggaag gcaccgagag gatggaagat cagggtcaga
      601 gtatcatccc tatgcttact ggggaggtca tccctgtgat ggagctgctt gcgtctatga
      661 gatcacacag tgttcctgaa gacctcgata tagctgatac agtactcaat gatgatgaca
      721 ttggtgacag ctgtcatgaa ggctttcttc tcaatgccat cagctcacat ctgcagacct
      781 gcggctgttc tgtggtggta ggcagcagtg cagagaaagt aaataagata gtaagaacac
      841 tgtgcctttt tctgacacca gcagagagga agtgctccag gctgtgtgaa gccgaatcgt
      901 cctttaaata cgaatctgga ctctttgtac aaggcttgct aaaggatgcg actggcagtt
      961 ttgtactacc tttccggcaa gttatgtatg ccccttatcc caccacacac atcgatgtgg
     1021 atgtcaacac tgtcaagcag atgccaccgt gtcatgaaca tatttataat caacgcagat
     1081 acatgaggtc agagctgaca gccttctgga gggcaacttc agaagaggac atggctcagg
     1141 acaccatcat ctacacagat gagagcttca ctcctgattt gaatattttc caagatgtct
     1201 tacacagaga cactctagtg aaagcctttc tggatcaggt cttccatttg aagcctggcc
     1261 tgtctctcag gagtactttc cttgcacagt tcctcctcat tcttcacaga aaagccttga
     1321 cactaatcaa gtacatagag gatgacacgc agaaggggaa aaagcccttt aagtctcttc
     1381 ggaacctgaa gatagatctt gatttaacag cagagggcga ccttaacata ataatggctc
     1441 tagctgagaa aattaagcca ggcctacact ctttcatctt cgggagacct ttctacacta
     1501 gtgtccaaga acgtgatgtt ctaatgactt tttaaacatg tggtttgctc cgtgtgtctc
     1561 atgacagtca cacttgctgt tacagtgtct cagcgctttg gacacatcct tcctccaggg
     1621 tcctgccgca ggacacgtta cactacactt gtcagtagag gtctgtacca gatgtcaggt
     1681 acatcgttgt agtgaatgtc tcttttccta gactagatgt accctcgtag ggacttatgt
     1741 ttacaaccct cctaagtact agtgctgtct tgtaaggata cgaatgaagg gatgtaaact
     1801 tcaccacaac tgctggttgg ttttgttgtt tttgtttttt gaaacttata attcatggtt
     1861 tacatgcatc acactgaaac cctagttagc tttttacagg taagctgtga gttgactgcc
     1921 tgtccctgtg ttctctggcc tgtacgatct gtggcgtgta ggatcacttt tgcaacaact
     1981 aaaaactaaa gcactttgtt tgcagttcta cagaaagcaa cttagtctgt ctgcagattc
     2041 gtttttgaaa gaagacatga gaaagcggag ttttaggtga agtcagttgt tggatcttcc
     2101 tttatagact tagtccttta gatgtggtct gtatagacat gcccaaccat catgcatggg
     2161 cactgaatat cgtgaactgt ggtatgcttt ttgttggttt attgtacttc tgtcaaagaa
     2221 agtggcattg gtttttataa ttgttgccaa gttttaaggt taattttcat tatttttgag
     2281 ccaaattaaa atgtgcacct cctgtgcctt tcccaatctt ggaaaatata atttcttggc
     2341 agaaggtcag atttcagggc ccagtcactt tcgtctgact tccctttgca cagtccgcca
     2401 tgggcctggc ttagaagttc ttgtaaacta tgccagagag tacattcgct gataaaatct
     2461 tctttgcaga gcaggagagc ttcttgcctc tttcctttca tttctgcctg gactttggtg
     2521 ttctccacgt tccctgcatc ctaaggacag caggagaact ctgaccccag tgctatttct
     2581 ctaggtgcta ttgtggcaaa ctcaagcggt ccgtctctgt ccctgtaacg ttcgtacctt
     2641 gctggctgtg aagtactgac tggtaaagct ccgtgctaca gcagtgtagg gtatacacaa
     2701 acacaagtaa gtgttttatt taaaactgtg gacttagcat aaaaagggag actatattta
     2761 ttttttacaa aagggataaa aatggaaccc tttcctcacc caccagattt agtcagaaaa
     2821 aaacattcta ttctgaaagg tcacagtggt tttgacatga cacatcagaa caacgcacac
     2881 tgtccatgat ggcttatgaa ctccaagtca ctccatcatg gtaaatgggt agatccctcc
     2941 ttctagtgtg ccacaccatt gcttcccaca gtagaatctt atttaagtgc taagtgttgt
     3001 ctctgctggt ttactctgtt gttttagaga atgtaagttg tatagtgaat aagttattga
     3061 agcatgtgta aacactgtta tacatctttt ctcctagatg gggaatttgg aataaaatac
     3121 ctttaaaatt c
//
