LOCUS       NM_001197023            6670 bp    mRNA    linear   ROD 10-APR-2024
DEFINITION  Rattus norvegicus KIAA0319 homolog (Kiaa0319), mRNA.
ACCESSION   NM_001197023 XM_001070349 XM_341527
VERSION     NM_001197023.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6670)
  AUTHORS   Guidi,L.G., Mattley,J., Martinez-Garay,I., Monaco,A.P.,
            Linden,J.F., Velayos-Baeza,A. and Molnar,Z.
  TITLE     Knockout Mice for Dyslexia Susceptibility Gene Homologs KIAA0319
            and KIAA0319L have Unaffected Neuronal Migration but Display
            Abnormal Auditory Processing
  JOURNAL   Cereb Cortex 27 (12), 5831-5845 (2017)
   PUBMED   29045729
REFERENCE   2  (bases 1 to 6670)
  AUTHORS   Martinez-Garay,I., Guidi,L.G., Holloway,Z.G., Bailey,M.A.,
            Lyngholm,D., Schneider,T., Donnison,T., Butt,S.J., Monaco,A.P.,
            Molnar,Z. and Velayos-Baeza,A.
  TITLE     Normal radial migration and lamination are maintained in
            dyslexia-susceptibility candidate gene homolog Kiaa0319 knockout
            mice
  JOURNAL   Brain Struct Funct 222 (3), 1367-1384 (2017)
   PUBMED   27510895
REFERENCE   3  (bases 1 to 6670)
  AUTHORS   Franquinho,F., Nogueira-Rodrigues,J., Duarte,J.M., Esteves,S.S.,
            Carter-Su,C., Monaco,A.P., Molnar,Z., Velayos-Baeza,A., Brites,P.
            and Sousa,M.M.
  TITLE     The Dyslexia-susceptibility Protein KIAA0319 Inhibits Axon Growth
            Through Smad2 Signaling
  JOURNAL   Cereb Cortex 27 (3), 1732-1747 (2017)
   PUBMED   28334068
  REMARK    GeneRIF: Study establishes KIAA0319 as a novel player in axon
            growth and regeneration with the ability to repress the intrinsic
            growth potential of axons; describes a novel regulatory mechanism
            operating during peripheral nervous system and central nervous
            system axon growth, and offers novel targets for the development of
            effective therapies to promote axon regeneration
REFERENCE   4  (bases 1 to 6670)
  AUTHORS   Centanni,T.M., Booker,A.B., Sloan,A.M., Chen,F., Maher,B.J.,
            Carraway,R.S., Khodaparast,N., Rennaker,R., LoTurco,J.J. and
            Kilgard,M.P.
  TITLE     Knockdown of the dyslexia-associated gene Kiaa0319 impairs temporal
            responses to speech stimuli in rat primary auditory cortex
  JOURNAL   Cereb Cortex 24 (7), 1753-1766 (2014)
   PUBMED   23395846
  REMARK    GeneRIF: These results provide the first evidence that decreased
            expression of the dyslexia-associated gene Kiaa0319 can alter
            cortical responses and impair phoneme processing in auditory
            cortex.
REFERENCE   5  (bases 1 to 6670)
  AUTHORS   Centanni,T.M., Chen,F., Booker,A.M., Engineer,C.T., Sloan,A.M.,
            Rennaker,R.L., LoTurco,J.J. and Kilgard,M.P.
  TITLE     Speech sound processing deficits and training-induced neural
            plasticity in rats with dyslexia gene knockdown
  JOURNAL   PLoS One 9 (5), e98439 (2014)
   PUBMED   24871331
  REMARK    GeneRIF: Reduced expression of the dyslexia-associated gene
            KIAA0319 can cause phoneme processing impairments similar to those
            seen in dyslexia.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6670)
  AUTHORS   Szalkowski,C.E., Fiondella,C.F., Truong,D.T., Rosen,G.D.,
            LoTurco,J.J. and Fitch,R.H.
  TITLE     The effects of Kiaa0319 knockdown on cortical and subcortical
            anatomy in male rats
  JOURNAL   Int J Dev Neurosci 31 (2), 116-122 (2013)
   PUBMED   23220223
  REMARK    GeneRIF: These results suggest that Kiaa0319 has a specific
            involvement in neural systems important for temporal processing.
REFERENCE   7  (bases 1 to 6670)
  AUTHORS   Peschansky,V.J., Burbridge,T.J., Volz,A.J., Fiondella,C.,
            Wissner-Gross,Z., Galaburda,A.M., Lo Turco,J.J. and Rosen,G.D.
  TITLE     The effect of variation in expression of the candidate dyslexia
            susceptibility gene homolog Kiaa0319 on neuronal migration and
            dendritic morphology in the rat
  JOURNAL   Cereb Cortex 20 (4), 884-897 (2010)
   PUBMED   19679544
REFERENCE   8  (bases 1 to 6670)
  AUTHORS   Levecque,C., Velayos-Baeza,A., Holloway,Z.G. and Monaco,A.P.
  TITLE     The dyslexia-associated protein KIAA0319 interacts with adaptor
            protein 2 and follows the classical clathrin-mediated endocytosis
            pathway
  JOURNAL   Am J Physiol Cell Physiol 297 (1), C160-C168 (2009)
   PUBMED   19419997
REFERENCE   9  (bases 1 to 6670)
  AUTHORS   Wang,Y., Paramasivam,M., Thomas,A., Bai,J., Kaminen-Ahola,N.,
            Kere,J., Voskuil,J., Rosen,G.D., Galaburda,A.M. and Loturco,J.J.
  TITLE     DYX1C1 functions in neuronal migration in developing neocortex
  JOURNAL   Neuroscience 143 (2), 515-522 (2006)
   PUBMED   16989952
REFERENCE   10 (bases 1 to 6670)
  AUTHORS   Paracchini,S., Thomas,A., Castro,S., Lai,C., Paramasivam,M.,
            Wang,Y., Keating,B.J., Taylor,J.M., Hacking,D.F., Scerri,T.,
            Francks,C., Richardson,A.J., Wade-Martins,R., Stein,J.F.,
            Knight,J.C., Copp,A.J., Loturco,J. and Monaco,A.P.
  TITLE     The chromosome 6p22 haplotype associated with dyslexia reduces the
            expression of KIAA0319, a novel gene involved in neuronal migration
  JOURNAL   Hum Mol Genet 15 (10), 1659-1666 (2006)
   PUBMED   16600991
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000017.1.
            
            On Apr 7, 2023 this sequence version replaced NM_001197023.1.
            
            Sequence Note:.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360176.1189348.1,
                                           SRR26360194.2069063.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-152               JAXUCZ010000017.1  40653528-40653679   c
            153-299             JAXUCZ010000017.1  40642935-40643081   c
            300-1075            JAXUCZ010000017.1  40639973-40640748   c
            1076-1265           JAXUCZ010000017.1  40639251-40639440   c
            1266-1364           JAXUCZ010000017.1  40634883-40634981   c
            1365-1462           JAXUCZ010000017.1  40633262-40633359   c
            1463-1550           JAXUCZ010000017.1  40632142-40632229   c
            1551-1643           JAXUCZ010000017.1  40629834-40629926   c
            1644-1776           JAXUCZ010000017.1  40627729-40627861   c
            1777-2005           JAXUCZ010000017.1  40626886-40627114   c
            2006-2129           JAXUCZ010000017.1  40624712-40624835   c
            2130-2262           JAXUCZ010000017.1  40622906-40623038   c
            2263-2411           JAXUCZ010000017.1  40620968-40621116   c
            2412-2563           JAXUCZ010000017.1  40619813-40619964   c
            2564-2702           JAXUCZ010000017.1  40618070-40618208   c
            2703-2862           JAXUCZ010000017.1  40616242-40616401   c
            2863-3005           JAXUCZ010000017.1  40611718-40611860   c
            3006-3128           JAXUCZ010000017.1  40609649-40609771   c
            3129-3219           JAXUCZ010000017.1  40607843-40607933   c
            3220-3311           JAXUCZ010000017.1  40605961-40606052   c
            3312-6670           JAXUCZ010000017.1  40590546-40593904   c
FEATURES             Location/Qualifiers
     source          1..6670
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17p11"
     gene            1..6670
                     /gene="Kiaa0319"
                     /gene_synonym="RGD1307443"
                     /note="KIAA0319 homolog"
                     /db_xref="GeneID:361244"
                     /db_xref="RGD:1307443"
     exon            1..152
                     /gene="Kiaa0319"
                     /gene_synonym="RGD1307443"
                     /inference="alignment:Splign:2.1.0"
     exon            153..299
                     /gene="Kiaa0319"
                     /gene_synonym="RGD1307443"
                     /inference="alignment:Splign:2.1.0"
     CDS             245..3490
                     /gene="Kiaa0319"
                     /gene_synonym="RGD1307443"
                     /note="dyslexia susceptibility 2"
                     /codon_start=1
                     /product="dyslexia-associated protein KIAA0319 homolog
                     precursor"
                     /protein_id="NP_001183952.1"
                     /db_xref="GeneID:361244"
                     /db_xref="RGD:1307443"
                     /translation="MVSPPGVLSSLLLLAAMAGGSSQQCSEGRTYSDAIISPNLESIR
                     IMRVSHTFSVGDCTAACCDLPSCDLAWWFEGSCYLVNCMRPENCEPRTTGPIRSYLTF
                     VRRPVQRSGQLLDYGDMMLGRGSPSGAWGDSLEDLRKDLPFLGKDGGPEETAEYSDDY
                     KELERGLLQPSNQQDPRGSAEYPDWSLLPSSDGDFNASATGDNSAASTEKLQDLTPYP
                     LDQEQLQSLNESTWSPTPRHSEMSSMWPSSVTASPTEEGLEGEETLQLQEQPNNSSGK
                     KVPMPSHNPSPASLESSPTTVEKSSIFTVTPWSRDPGTPTFPASTVLPGLISPSWPLS
                     PTTSRTVKALAVSAGDNLVLTLPNGEAELKASVEPAPPADTAYTYEWSLMSHPVDFQG
                     KIKQENKPTLHLSQLSVGLYAFRVAVSGENAFGEGYVNVTVMPAARINQPPVAIVSPQ
                     IQELSLPLTSALIDGSQSTDDAEIVSYHWEEVDGPFLGEAFLDDSPLLRLSNLDPGNY
                     TFRLTITDSDGATNSTTAALIIRGSLDYPPVANAGPNQTITLPQNTIILNGNQSSDDH
                     QIVLYEWFPDPGGESKEMVMQGAQTPYLHLSELQEGEYTFQLMVTDSSGQQSTALVTL
                     TVQAENNQAPVAVAGPDKELVFPVQSAMLDGSRSSDDHGIVCYRWEHIRGPSAVEMEN
                     VDKAIATVTGLQVGTYHFRLTVRDQQGLSSTSTLTVAVKKENNSPPRAQAGGRHVLML
                     PNNSITLDGSRSTDDRGIVSYLWIRDGQSPAAGDIIGSSDNGAALQLTNLVEGVYTFH
                     LLVTDSQGASDSDTAIVEVLPDPKKDGMVELILQVGVEQLTEQQKETLVRQLAVLLNV
                     LDSDVKVLKIQAHTDVSTVIVFYVQSGSPFKVLRAADVARNLHKRLSKEKGAFLLFKV
                     LRIDTAGCLLKCSGHGHCDPITKRCICSQLWMENLLQRYMWDGESNCEWSVFYVAALA
                     LTLTVLTGAVTWVCICCCRRRKRTKIRKKTKYTILDNMDEQERMELRPKYGIKHRSTE
                     HNSSLMVSESEFESDQDTLFSQERMERGVLKGSLNGSARSGVSFGYYSKDR"
     exon            300..1075
                     /gene="Kiaa0319"
                     /gene_synonym="RGD1307443"
                     /inference="alignment:Splign:2.1.0"
     exon            1076..1265
                     /gene="Kiaa0319"
                     /gene_synonym="RGD1307443"
                     /inference="alignment:Splign:2.1.0"
     exon            1266..1364
                     /gene="Kiaa0319"
                     /gene_synonym="RGD1307443"
                     /inference="alignment:Splign:2.1.0"
     exon            1365..1462
                     /gene="Kiaa0319"
                     /gene_synonym="RGD1307443"
                     /inference="alignment:Splign:2.1.0"
     exon            1463..1550
                     /gene="Kiaa0319"
                     /gene_synonym="RGD1307443"
                     /inference="alignment:Splign:2.1.0"
     exon            1551..1643
                     /gene="Kiaa0319"
                     /gene_synonym="RGD1307443"
                     /inference="alignment:Splign:2.1.0"
     exon            1644..1776
                     /gene="Kiaa0319"
                     /gene_synonym="RGD1307443"
                     /inference="alignment:Splign:2.1.0"
     exon            1777..2005
                     /gene="Kiaa0319"
                     /gene_synonym="RGD1307443"
                     /inference="alignment:Splign:2.1.0"
     exon            2006..2129
                     /gene="Kiaa0319"
                     /gene_synonym="RGD1307443"
                     /inference="alignment:Splign:2.1.0"
     exon            2130..2262
                     /gene="Kiaa0319"
                     /gene_synonym="RGD1307443"
                     /inference="alignment:Splign:2.1.0"
     exon            2263..2411
                     /gene="Kiaa0319"
                     /gene_synonym="RGD1307443"
                     /inference="alignment:Splign:2.1.0"
     exon            2412..2563
                     /gene="Kiaa0319"
                     /gene_synonym="RGD1307443"
                     /inference="alignment:Splign:2.1.0"
     exon            2564..2702
                     /gene="Kiaa0319"
                     /gene_synonym="RGD1307443"
                     /inference="alignment:Splign:2.1.0"
     exon            2703..2862
                     /gene="Kiaa0319"
                     /gene_synonym="RGD1307443"
                     /inference="alignment:Splign:2.1.0"
     exon            2863..3005
                     /gene="Kiaa0319"
                     /gene_synonym="RGD1307443"
                     /inference="alignment:Splign:2.1.0"
     exon            3006..3128
                     /gene="Kiaa0319"
                     /gene_synonym="RGD1307443"
                     /inference="alignment:Splign:2.1.0"
     exon            3129..3219
                     /gene="Kiaa0319"
                     /gene_synonym="RGD1307443"
                     /inference="alignment:Splign:2.1.0"
     exon            3220..3311
                     /gene="Kiaa0319"
                     /gene_synonym="RGD1307443"
                     /inference="alignment:Splign:2.1.0"
     exon            3312..6670
                     /gene="Kiaa0319"
                     /gene_synonym="RGD1307443"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcgctgaatc accagcaccc gctggcagca tctgtgcagc ctcaggggtg ggcaggtgtc
       61 gcctgcaggt gtgcctcgca ggtggcccga ccggacctca gctactgggc agtctggagc
      121 agcacggagc ctggagatcg ctgggaatgg agttctagaa ggctacatct gactggctca
      181 tcaaccatca aagagagtct ttctaaatcc actgccttgg aagcctcatc ctgtgtgagg
      241 cagaatggtg tccccaccag gagtactgtc ttccttgctg ctgctggcag ccatggcagg
      301 tggcagctct cagcagtgct ctgagggcag gacttactcc gacgccatca tttcacctaa
      361 cctggaaagc attagaatca tgcgggtgtc tcacaccttc tctgtgggag actgtacagc
      421 agcttgctgt gacttgccca gctgtgacct ggcctggtgg tttgagggca gctgctatct
      481 ggtgaactgc atgcgcccgg agaactgcga gcccaggacc acaggcccca tccgatctta
      541 cctcactttc gtgcgcagac ctgtccagag gtctgggcag ctgctggact atggagacat
      601 gatgctaggc aggggctccc cttcaggagc ttggggagac tcccttgagg acctcaggaa
      661 ggacttgccc tttctaggca aagatggggg gccagaggag actgctgagt actcggatga
      721 ttacaaggaa ctggagcggg gcctcctgca accctccaac caacaagacc ccagaggcag
      781 cgcagagtac cccgactgga gcctgctgcc cagcagtgat ggagatttca atgcttcagc
      841 tacgggagac aactcagctg cttccacaga gaagctgcag gacctcacgc cctacccact
      901 ggaccaggag cagctgcagt ccctgaatga gtcaacttgg tcccctacac ccagacactc
      961 tgaaatgagc agtatgtggc cttcctctgt gactgcatca cctacagaag agggactgga
     1021 gggagaagag actttacagc tccaagagca accaaacaat agttctggaa aaaaggttcc
     1081 aatgccttcc cataatcctt cccctgccag cctggagtct agcccaacca cggtggaaaa
     1141 gagctccatt tttacagtca ctccatggag cagagatcct ggcaccccaa catttcctgc
     1201 cagtacagtc ctccctgggc tgatctcacc ttcgtggccc ttgtcaccta ccacttccag
     1261 gacagtaaag gctcttgctg tgtctgctgg agataactta gtactaacct tacccaatgg
     1321 agaagcagaa ctgaaggcct ctgttgagcc agcgccccct gcagacacag cttacaccta
     1381 tgaatggagt ttaatgagcc atcctgtaga cttccaaggt aaaatcaaac aagaaaacaa
     1441 gccgactctt cacctttctc agttgtctgt gggtctctat gccttcagag tggctgtttc
     1501 tggtgagaat gcatttggag aaggatatgt caatgtcaca gttatgccag ctgcaagaat
     1561 caatcagcca cctgtagcta ttgtttctcc ccagatacaa gagctcagtt tgcctttgac
     1621 ctcagccctg attgacggca gccaaagtac agatgatgct gaaattgtga gttaccactg
     1681 ggaagaagtc gacgggccct tcctaggaga ggcctttctg gacgattccc cactcttacg
     1741 attgtcgaat ctagatcctg gtaactacac ttttaggttg accatcacag actcagatgg
     1801 cgctactaac tccaccactg cagccctcat catccgtggt tctttggact acccacctgt
     1861 tgccaatgca ggaccaaatc agaccatcac tttgccccaa aacaccatca tactgaacgg
     1921 gaaccagagc agtgatgatc accagattgt cctctatgag tggttcccag accctggtgg
     1981 tgagagcaag gagatggtca tgcagggagc acagacccca tacctccact tgtctgagct
     2041 gcaggaagga gagtacacgt tccaactgat ggtgacggat tcctcaggac agcaatccac
     2101 tgctttggtc actctgactg tccaggctga aaacaaccag gctccggtgg ctgtggcagg
     2161 ccctgataag gagctggttt tcccagtgca gagtgctatg ctggatggga gcaggagcag
     2221 tgatgatcac ggcattgtct gctaccgctg ggagcacatc agaggcccca gtgcagtgga
     2281 gatggagaat gtggacaaag ccatagccac tgtcaccggg cttcaggtgg gtacctacca
     2341 cttccggcta actgtgagag accagcaggg tctgagcagc acatccaccc tcactgtggc
     2401 tgtgaagaag gaaaataata gtcctcccag agcccaggct ggtggcagac atgttcttat
     2461 gcttcccaat aattccatta ctttggacgg ttcaaggtct actgatgacc gaggaattgt
     2521 gtcctatcta tggatccggg atggccagag tccagctgct ggagatatca ttggaagctc
     2581 tgacaacggg gcggctctgc agctcaccaa tctggtggaa ggagtctaca cttttcactt
     2641 gctggtcact gacagtcagg gggcctccga ctcagacact gccattgtgg aggtgctgcc
     2701 agaccccaag aaggatggca tggtggagtt gatcctgcag gttggtgttg agcagctgac
     2761 agagcagcag aaggaaactc tagtgaggca actggctgtg cttctgaatg tgctagactc
     2821 agacgtgaaa gtgttgaaga tccaggctca cacggatgtc agcactgtga ttgtatttta
     2881 tgtacagagt gggtcacctt tcaaggttct cagagctgct gacgtggcca ggaatctgca
     2941 caagcggctt tccaaggaga agggggcttt cctgcttttc aaggtcttga ggatagacac
     3001 agcaggatgc cttctcaagt gttcaggcca tggtcactgt gaccccatca caaagcgttg
     3061 catttgctcc cagctgtgga tggagaacct cctacagcgg tacatgtggg atggcgagag
     3121 caactgtgag tggagtgtat tctacgtggc agctctggcg ttgaccctaa cagtgctaac
     3181 tggagctgtg acttgggtgt gcatctgctg ttgcaggaga cgaaaaagga ctaagataag
     3241 gaagaaaaca aagtacacca tcctagacaa catggatgaa caggaaagaa tggaactgag
     3301 gcccaaatac ggtatcaagc acaggagcac cgagcacaac tccagtctga tggtgtcgga
     3361 gtctgagttt gaaagcgacc aggacacact attcagccaa gaaaggatgg agagaggagt
     3421 tctgaagggt tccctgaatg gctctgctag aagtggagtt tcctttggtt attactcaaa
     3481 ggacagataa caggatgttg tggaaggacc tcacgagctt gtgactcagt accggatgct
     3541 gggagttatc acaaagctga ctcctgcttg gcacagtgca ttggcacctc tctccagggg
     3601 ccttgctctg tgctccacag agtgattcaa agacccaggt ttttggaact ttcaagacac
     3661 aaaacaaaat cctgcttatt caactgatgc tcatcaatag agaaaagggg tgcataaaac
     3721 ctctgcggag tcgactgaaa agttttgtgt ctccgtagcg aacactttat tatagttatt
     3781 gtccatgatg aaattaggct aacacccgtt tctatttcta gcccacagga aagacaagtt
     3841 aagaagggtt gattctctat agaagctgtg actgccttta agaaccttcc agaagcagct
     3901 tctcagaggc cctgcaggat caatgtgtag ttcatctgcg agggaggaac catctgtgtg
     3961 tagcttcctg tctgtgatgc agctaggtgt ggctagctag aaggtcagga actaaggaag
     4021 cagcagaatc taaggacagc aggcaataga gatggggagg ggcgaatgac ctgcaggtta
     4081 agtgttgaag gtagccttta acatttttct cattcacttt ctctaagaaa aagaaaccac
     4141 gactgcttat tattgtaact tttattgaga acactgtgta gcacttccat ggaaagcagg
     4201 gaggactggg tgatcacaga catattccca aactttaaaa tatactccta atgaggggac
     4261 tgtggtcacc atgttctgag cccctacaaa gacttcctag tgaaataact ggacagaaca
     4321 ttcaccattt atgcttaaaa acttatttaa gggactggag aaatggctat atataagacc
     4381 tcatggctct tgcagaagac cttggttcag tcacccttac aattgtccag aactccactt
     4441 tctggtctct ggcagcagca gcagcatgag gaatgtgcag agttcatgca tgtagttcat
     4501 acatgagcat taaaaaaatc ttaaaaacat gtttaaaaat caaagaacta aattttatat
     4561 tagttcttta cacaaaaaag atttatacaa tgtcccccga aaaagctccc gctctccccc
     4621 ctcagccatg aactggagat gattacagcc tgagatgttg atcaggttat agtagttgcc
     4681 catggccccg agactgctgg ccttggcaat gcccttggcg tttagagagt ggaagagcag
     4741 tacgtacggt agtctgagct tagagaaaga gagtagagtg tagcaggaat tcagtgctag
     4801 ccttggccat acaacaggtt tgagggcaac ctggactata tgagatccta tgttaaaaaa
     4861 tgaaaaaagg aaaaggtaaa agaattagaa tcacaattta aattttagta atagaatttt
     4921 ctatttctga gctgaaaact caaaaaacca aaaattcaga ggccccagtg tattatactt
     4981 tactggcgaa ttgatcaaat aaaaacgtgt aggaatatac ttttatttta aaagtaatat
     5041 ctttatgtct atatatcata gttcaatatt atctataatg ttagaggaac agtgattttt
     5101 tttttatttt agcactagta tttagcttca taagcagaat cttccctatc caatgaccag
     5161 actgaggcta gtttagtggg taaccggacg tttctggcac agagaatcca ataaagcatc
     5221 aagctgaagc ctgtgaaccc tgctgcttta tgtgcacgag tgtgcatcac tcatagttga
     5281 ccttcccaag taatcctgaa agaaaacatt cctctgtgtt aggcacccac cgcaggtcca
     5341 gggagcataa gtgatttcca cagggatgga gtcagtagat ctgggaatcg agtgctaagg
     5401 cctactttac agtgcatgaa gaagtccaga catgttggag ggcaagtctt ggagaacctt
     5461 ctagacccct gaaagttctg ttgctgggat gaagaggaaa gctttgagtg tgcctgagag
     5521 caaaagacaa gtaggggacc atggacctgg tgtctcccac aggatccagc acactctaag
     5581 ccacccatcc tctaggtttg tagtgggctt gctggttctg tccctggctg tctcagcctg
     5641 gtctctctga tctattcatc acaaaagaac cttgagtcta tagtgaatca gaaataaaca
     5701 tcacagtggt tactggaaaa tggatcctgt cttgtgaccc acttgttctc ggggactgaa
     5761 aagggggtaa gccctcagca tccatctggt gctatcttga gacctgaaga ctctaagctg
     5821 ttgacaaaga gagaaaaaca tgtctctaga gcagcgattc tgcgaccctt taatacagct
     5881 cctcatgttg tgatccacac tgcaaattat tgcttcctca taactgtaat tttgctactg
     5941 ttttgaatcg tattgcaaat acctgctctc tgactcctct ggaggttgca gcccatgggc
     6001 tgagaaactg ccgtggaggg tgggagaaca tttatagggt tcagaggctg agagcacagc
     6061 tactttctga tttagacaaa gatcaaatgc cagcattccc caaccgagta tgtttaaaac
     6121 accttaaaga cacacattga ggaaagccgt cacttgtgat tctagcactt gaaaggtggc
     6181 aggaggaaga tcaggggttt aagagcaccg tgcacagcta catactgtat tcaaggccag
     6241 cccaggatac agtctcaagc aagcaaacaa ccatctagtg aaataagaaa atggtgacat
     6301 aaatcagcag ggaaagaccc ctgctgccaa acttgggttt gattcctagg acccacatgg
     6361 tagagggaaa gaaccaatgc ccaaaagttg ccttctggcc ttcacacaaa atatttggca
     6421 gtgtatgctt acacatgcaa gtgtgtacac acacatacaa tcataattta aaaatatgta
     6481 ttcctccata cttccttcac atggcgagga ggacctttgt tgttgttttt tttttttttc
     6541 cttaatgtga ccaagatatc ttggattttg agtcttgatt ttattctttt aagtgtatta
     6601 ttttccacat gttttgaata acaaggtatt gattcttgta taagattatt aaatacatat
     6661 gctgacctaa
//
