LOCUS       NM_022250               1431 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus queuine tRNA-ribosyltransferase catalytic subunit
            1 (Qtrt1), mRNA.
ACCESSION   NM_022250
VERSION     NM_022250.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1431)
  AUTHORS   Chen,Y.C., Kelly,V.P., Stachura,S.V. and Garcia,G.A.
  TITLE     Characterization of the human tRNA-guanine transglycosylase:
            confirmation of the heterodimeric subunit structure
  JOURNAL   RNA 16 (5), 958-968 (2010)
   PUBMED   20354154
REFERENCE   2  (bases 1 to 1431)
  AUTHORS   Boland,C., Hayes,P., Santa-Maria,I., Nishimura,S. and Kelly,V.P.
  TITLE     Queuosine formation in eukaryotic tRNA occurs via a
            mitochondria-localized heteromeric transglycosylase
  JOURNAL   J Biol Chem 284 (27), 18218-18227 (2009)
   PUBMED   19414587
REFERENCE   3  (bases 1 to 1431)
  AUTHORS   Shindo-Okada,N., Okada,N., Ohgi,T., Goto,T. and Nishimura,S.
  TITLE     Transfer ribonucleic acid guanine transglycosylase isolated from
            rat liver
  JOURNAL   Biochemistry 19 (2), 395-400 (1980)
   PUBMED   6986171
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC097321.1.
            
            On Oct 12, 2007 this sequence version replaced NM_022250.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC097321.1, SRR8487230.58597.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
FEATURES             Location/Qualifiers
     source          1..1431
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q13"
     gene            1..1431
                     /gene="Qtrt1"
                     /gene_synonym="Tgt; Tgut"
                     /note="queuine tRNA-ribosyltransferase catalytic subunit
                     1"
                     /db_xref="GeneID:64016"
                     /db_xref="RGD:620996"
     exon            1..255
                     /gene="Qtrt1"
                     /gene_synonym="Tgt; Tgut"
                     /inference="alignment:Splign:2.1.0"
     CDS             13..1224
                     /gene="Qtrt1"
                     /gene_synonym="Tgt; Tgut"
                     /EC_number="2.4.2.64"
                     /note="guanine insertion enzyme; tRNA-guanine
                     transglycosylase; queuine tRNA-ribosyltransferase 1"
                     /codon_start=1
                     /product="queuine tRNA-ribosyltransferase catalytic
                     subunit 1"
                     /protein_id="NP_071586.2"
                     /db_xref="GeneID:64016"
                     /db_xref="RGD:620996"
                     /translation="MAAVGSPGSLESAPRIMRLVAECSRSRARAGELRLPHGTVATPV
                     FMPVGTQATMKGITAEQLDSLGCRICLGNTYHLGLRPGPELIQKAHGLHGFMNWPHNL
                     LTDSGGFQMVSLISLSEVTEEGVRFRSPYDGEETLLSPERSVEIQNALGSDIIMQLDD
                     VVSSTVTGPRVEEAMHRSVRWLDRCIAAHKRQDKQNLFAIIQGGLNADLRTTCLKEMT
                     KRDVPGFAIGGLSGGESKEQFWKMVALSTSMLPKDKPRYLMGVGYATDLVVCVALGCD
                     MFDCVYPTRTARFGSALVPTGNLQLKKQQYAKDFSPINPECPCATCQTHSRAFLHTLL
                     HSDNTAALHHLTVHNIAYQLQLLSAARSSILEQRFPDFVRNFMRTMYGDHSLCPAWAI
                     EALASVGITLT"
     exon            256..324
                     /gene="Qtrt1"
                     /gene_synonym="Tgt; Tgut"
                     /inference="alignment:Splign:2.1.0"
     exon            325..463
                     /gene="Qtrt1"
                     /gene_synonym="Tgt; Tgut"
                     /inference="alignment:Splign:2.1.0"
     exon            464..542
                     /gene="Qtrt1"
                     /gene_synonym="Tgt; Tgut"
                     /inference="alignment:Splign:2.1.0"
     exon            543..658
                     /gene="Qtrt1"
                     /gene_synonym="Tgt; Tgut"
                     /inference="alignment:Splign:2.1.0"
     exon            659..797
                     /gene="Qtrt1"
                     /gene_synonym="Tgt; Tgut"
                     /inference="alignment:Splign:2.1.0"
     exon            798..873
                     /gene="Qtrt1"
                     /gene_synonym="Tgt; Tgut"
                     /inference="alignment:Splign:2.1.0"
     exon            874..983
                     /gene="Qtrt1"
                     /gene_synonym="Tgt; Tgut"
                     /inference="alignment:Splign:2.1.0"
     exon            984..1071
                     /gene="Qtrt1"
                     /gene_synonym="Tgt; Tgut"
                     /inference="alignment:Splign:2.1.0"
     exon            1072..1408
                     /gene="Qtrt1"
                     /gene_synonym="Tgt; Tgut"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccggaactga aaatggcggc ggtaggcagc ccaggttcgc ttgagtccgc tccacgaatc
       61 atgcggctag tcgctgagtg cagtcgctcc agagctcggg ccggtgagct gcggctgccg
      121 catggaacgg tagccacccc tgtgttcatg cctgtgggta cacaggccac catgaagggt
      181 atcaccgcgg agcagctgga ctccctgggc tgccgcatct gcttgggcaa cacctaccat
      241 ctggggttga ggccgggtcc ggagctgatc cagaaagctc acggtcttca cggtttcatg
      301 aattggcccc acaatctgct gacggatagc ggcggcttcc agatggtgtc tctcatctcc
      361 ttgtccgagg tgacggagga gggcgtccgc ttccgctcgc cctatgatgg agaagagaca
      421 cttttgagcc cagagaggtc ggtggagatc cagaacgctc tgggctcgga catcatcatg
      481 cagttggacg atgtggtgag cagcacggtg acaggccctc gagtggagga ggccatgcac
      541 aggtcagtcc gctggctgga cagatgcatc gcagcccata agcgtcagga caagcagaac
      601 ctctttgcca tcatccaggg cggactgaat gctgatcttc ggaccacttg cctgaaagag
      661 atgaccaaga gggatgtgcc gggctttgcc atcggaggtc tgagcggagg agagagcaag
      721 gagcagttct ggaagatggt ggcattgagc acctccatgc tgcctaagga caagccacgc
      781 tacctgatgg gggttggcta tgccaccgat ttggtggtct gcgtggccct tggatgtgac
      841 atgttcgact gtgtataccc cacacggaca gcgcgttttg gatccgccct tgtgcccact
      901 gggaacctgc agttgaagaa gcagcagtac gccaaggact tcagccccat aaaccccgag
      961 tgtccctgtg ccacctgcca gacgcacagc cgcgccttct tgcacaccct gctgcacagt
     1021 gacaacaccg cagcgctgca ccacctcacc gtgcacaaca ttgcctatca gctgcagctc
     1081 ctgagcgccg cgcgcagcag tatcttggaa cagcgctttc ccgacttcgt gcggaacttc
     1141 atgcggacca tgtatgggga ccacagcctc tgtcctgcct gggccattga agcactggcc
     1201 tctgtgggaa tcacactcac atgacctggt tgctggggaa ggacgctggg gtacagggaa
     1261 tattgaagga ctctttttta caaaagattt tgttactact ttttgttttc atttaagatc
     1321 ttgtatcttt taagatctcc ctgtcttctt tcttcctcat tgtagttgga tttctcgatt
     1381 ctcggtaaga agtaaaccag agagtggaaa aaaaaaaaaa aaaaaaaaaa a
//
