LOCUS       NM_001014034            1967 bp    mRNA    linear   ROD 08-APR-2024
DEFINITION  Rattus norvegicus glutaminyl-tRNA amidotransferase subunit QRSL1
            (Qrsl1), mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_001014034 XM_228391
VERSION     NM_001014034.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1967)
  AUTHORS   Echevarria,L., Clemente,P., Hernandez-Sierra,R., Gallardo,M.E.,
            Fernandez-Moreno,M.A. and Garesse,R.
  TITLE     Glutamyl-tRNAGln amidotransferase is essential for mammalian
            mitochondrial translation in vivo
  JOURNAL   Biochem J 460 (1), 91-101 (2014)
   PUBMED   24579914
REFERENCE   2  (bases 1 to 1967)
  AUTHORS   Nagao,A., Suzuki,T., Katoh,T., Sakaguchi,Y. and Suzuki,T.
  TITLE     Biogenesis of glutaminyl-mt tRNAGln in human mitochondria
  JOURNAL   Proc Natl Acad Sci U S A 106 (38), 16209-16214 (2009)
   PUBMED   19805282
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000020.1 and BC089213.1.
            
            On Mar 18, 2021 this sequence version replaced NM_001014034.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC089213.1, SRR26643290.55302.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-25                JAXUCZ010000020.1  48964788-48964812   c
            26-1862             BC089213.1         1-1837
            1863-1967           JAXUCZ010000020.1  48939858-48939962   c
FEATURES             Location/Qualifiers
     source          1..1967
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20q13"
     gene            1..1967
                     /gene="Qrsl1"
                     /note="glutaminyl-tRNA amidotransferase subunit QRSL1"
                     /db_xref="GeneID:309911"
                     /db_xref="RGD:1359490"
     exon            1..122
                     /gene="Qrsl1"
                     /inference="alignment:Splign:2.1.0"
     CDS             99..1676
                     /gene="Qrsl1"
                     /EC_number="6.3.5.7"
                     /note="glutamyl-tRNA(Gln) amidotransferase subunit A
                     homolog; QRSL1, glutaminyl-tRNA amidotransferase subunit
                     A; glutaminyl-tRNA synthase (glutamine-hydrolyzing)-like
                     1; glu-AdT subunit A; glutaminyl-tRNA synthase-like
                     protein 1"
                     /codon_start=1
                     /product="glutamyl-tRNA(Gln) amidotransferase subunit A,
                     mitochondrial"
                     /protein_id="NP_001014056.1"
                     /db_xref="GeneID:309911"
                     /db_xref="RGD:1359490"
                     /translation="MLGRTLREVSSALKQGHITPTELCKKCLSLIKKTKYLNAYITVS
                     EEVALKQAEESEKRYKQGQSLGDLDGIPVAVKDNFSTSGIETTCASNMLKGYLPPYNA
                     TVVQRLLDQGALLMGKTNLDEFAMGSGSTDGVFGPVKNPWTYSKQYRERSRQDAQEDS
                     HWLITGGSSGGSAAAVAAFTCFAALGSDTGGSTRNPAAHCGTVGFKPSYGLVSRHGLI
                     PLVNSMDVPGIFTRCVDDTAIVLGVLAGHDPKDSTTVNDPVKPTTLPSVPDVSGLCIG
                     IPKEYLVPELSSEIRSLWSQAADLFEAEGARVIEVCLPHTCYSIVCYHVLCTSEVASN
                     MARFDGLQYGHRSAVDMSSTEALYAATRQEGFNDVVKGRILSGNFFLLKENYENYFVK
                     AQKVRRLIVNDFVNVFGSGVDVLLTPTTLTQAVPYLEFIKEDNRTRSAQDDIFTQAVN
                     MAGLPAVNVPVALSSQGLPIGLQLIGRAFCDQQLLTVAKWFEKQVQFPVIQLQDLMDD
                     GSLVPENGKLTSGSLTQ"
     exon            123..282
                     /gene="Qrsl1"
                     /inference="alignment:Splign:2.1.0"
     exon            283..381
                     /gene="Qrsl1"
                     /inference="alignment:Splign:2.1.0"
     exon            382..478
                     /gene="Qrsl1"
                     /inference="alignment:Splign:2.1.0"
     exon            479..646
                     /gene="Qrsl1"
                     /inference="alignment:Splign:2.1.0"
     exon            647..822
                     /gene="Qrsl1"
                     /inference="alignment:Splign:2.1.0"
     exon            823..935
                     /gene="Qrsl1"
                     /inference="alignment:Splign:2.1.0"
     exon            936..1128
                     /gene="Qrsl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1129..1249
                     /gene="Qrsl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1250..1455
                     /gene="Qrsl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1456..1967
                     /gene="Qrsl1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaggatccaa gatgtctgcg cccatgtaac gccggtgacc gacgttgact tcttcctctg
       61 ctctgggatc ctgtggtact gggctgactc agaggactat gctgggccgg actctccgag
      121 aagtttcttc agccctgaag cagggccaca ttacaccaac agagctctgc aagaaatgtc
      181 tctccctcat caagaaaacc aagtacctaa atgcttacat taccgtttca gaagaggtgg
      241 ctttaaagca agctgaagaa tcggagaaaa ggtacaagca aggtcagtct cttggagatt
      301 tggatggaat ccctgttgct gtaaaagaca acttcagcac gtccggcatt gagacaacat
      361 gtgcatcaaa tatgttaaaa ggttatttac cgccttacaa tgccacagtc gttcagaggc
      421 tgttggatca gggagcgctg ctcatgggga aaacaaatct ggatgagttt gccatgggat
      481 ctggaagcac agatggcgtg tttggaccag ttaaaaaccc ctggacgtat tcaaagcagt
      541 acagagaaag aagccggcag gatgcacagg aggattcaca ctggctgata actggaggaa
      601 gctcgggcgg cagcgcagcg gctgtggctg cgttcacgtg ctttgcggct ctggggtcag
      661 acactggcgg atccaccagg aaccctgctg cccattgcgg gaccgttggt ttcaaaccaa
      721 gctatggctt agtttcccga cacggcctta ttcccctggt gaattcaatg gacgtgccag
      781 gaatctttac cagatgtgtg gacgatacgg cgattgtgct aggtgtgctg gctggacatg
      841 accccaaaga ttccaccaca gtaaacgacc ctgttaagcc aaccacgctt cccagcgtgc
      901 cggatgtgag cggactgtgt attggaattc cgaaggaata tctagtacca gaattgtcaa
      961 gtgagatacg gtctctctgg tcccaagctg ctgacctctt tgaggctgaa ggagccagag
     1021 tgattgaggt gtgtctgcca cacacctgct actccatcgt ctgctaccac gtactgtgca
     1081 catcagaagt agcatcaaat atggcgagat ttgacgggct acagtacggt cacaggtctg
     1141 ctgttgatat gtcgtctact gaagccctgt atgcggctac cagacaggaa gggttcaatg
     1201 acgtggtgaa aggaagaatt ctctcgggaa actttttctt attaaaagaa aattatgaga
     1261 attattttgt caaggcacag aaagtgaggc gtctcattgt gaatgatttc gtgaatgttt
     1321 ttggctctgg ggtggatgtc ctgctgacac ccaccaccct gactcaggca gtgccgtact
     1381 tggagttcat caaagaagac aacaggacac gcagtgccca ggatgacatt ttcacgcagg
     1441 ctgtgaacat ggcaggcctg ccagcagtga atgtccctgt ggccctctca agccaagggc
     1501 tgccaatagg actgcagcta attggacggg cattctgtga ccagcagctt ctgacagttg
     1561 ccaagtggtt tgaaaaacaa gtacagtttc ctgttattca actgcaggac ctcatggacg
     1621 atggctcctt ggttcctgag aatggaaagt taacttctgg ttctctaacc cagtagtgat
     1681 cagaataacg tgcaagtggt cggtgggagg aggctggggt cctgcctggg cctcaggctt
     1741 gctaggcaag ccccctgcca tgggacagaa tccccacctc cccaccgtgc agttagatag
     1801 actccaagaa gtgctgttct ctagagtgtc agtgaccaag ttcaccgcca accccgtctg
     1861 tcctggggat cacgttctca aatccctgag atgctgttaa ctgtaatatt ctttacattg
     1921 tatattgtga ttgtaaaatt ctatattaaa atgttctata aatgcaa
//
