LOCUS       NM_198199               1802 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus pyroglutamylated RFamide peptide receptor
            (Qrfpr), mRNA.
ACCESSION   NM_198199 XM_227067
VERSION     NM_198199.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1802)
  AUTHORS   Allerton,T.D. and Primeaux,S.D.
  TITLE     QRFP-26 enhances insulin's effects on glucose uptake in rat
            skeletal muscle cells
  JOURNAL   Peptides 69, 77-79 (2015)
   PUBMED   25895849
  REMARK    GeneRIF: prepro-QRFP mRNA and GPR103a mRNA are expressed in L6
            cells, though GPR103b mRNA was not detected. Using complementary
            assays, co-incubation with QRFP-26, increased insulin's ability to
            induce glycogen synthesis and 2-deoxyglucose uptake in L6 cells
REFERENCE   2  (bases 1 to 1802)
  AUTHORS   Santoro,M.L., Santos,C.M., Ota,V.K., Gadelha,A., Stilhano,R.S.,
            Diana,M.C., Silva,P.N., Spindola,L.M., Melaragno,M.I.,
            Bressan,R.A., Han,S.W., Abilio,V.C. and Belangero,S.I.
  TITLE     Expression profile of neurotransmitter receptor and regulatory
            genes in the prefrontal cortex of spontaneously hypertensive rats:
            relevance to neuropsychiatric disorders
  JOURNAL   Psychiatry Res 219 (3), 674-679 (2014)
   PUBMED   25041985
  REMARK    GeneRIF: Four genes were significantly downregulated in the PFC
            [prefrontal cortex ]of SHR[spontaneously hypertensive rat ]
            compared to Wistar rats (Gad2, Chrnb4, Slc5a7, and Qrfpr) and none
            in nucleus accumbens.
REFERENCE   3  (bases 1 to 1802)
  AUTHORS   Loktev,A.V. and Jackson,P.K.
  TITLE     Neuropeptide Y family receptors traffic via the Bardet-Biedl
            syndrome pathway to signal in neuronal primary cilia
  JOURNAL   Cell Rep 5 (5), 1316-1329 (2013)
   PUBMED   24316073
REFERENCE   4  (bases 1 to 1802)
  AUTHORS   Bruzzone,F., Lectez,B., Alexandre,D., Jegou,S., Mounien,L.,
            Tollemer,H., Chatenet,D., Leprince,J., Vallarino,M., Vaudry,H. and
            Chartrel,N.
  TITLE     Distribution of 26RFa binding sites and GPR103 mRNA in the central
            nervous system of the rat
  JOURNAL   J Comp Neurol 503 (4), 573-591 (2007)
   PUBMED   17534937
  REMARK    GeneRIF: the expression of GPR103 mRNA was more discrete, notably
            in the midbrain, the pons, and the medulla oblongata.
REFERENCE   5  (bases 1 to 1802)
  AUTHORS   Kampe,J., Wiedmer,P., Pfluger,P.T., Castaneda,T.R., Burget,L.,
            Mondala,H., Kerr,J., Liaw,C., Oldfield,B.J., Tschop,M.H. and
            Bagnol,D.
  TITLE     Effect of central administration of QRFP(26) peptide on energy
            balance and characterization of a second QRFP receptor in rat
  JOURNAL   Brain Res 1119 (1), 133-149 (2006)
   PUBMED   16996040
  REMARK    GeneRIF: We found an additional receptor with high homology for
            GPR103 in rat. This receptor increases inositol triphosphate
            production in transfected cells in presence of QRFP(26) and its
            mRNA was particularly enriched in the brain.(GPR103 protein, rat)
REFERENCE   6  (bases 1 to 1802)
  AUTHORS   Takayasu,S., Sakurai,T., Iwasaki,S., Teranishi,H., Yamanaka,A.,
            Williams,S.C., Iguchi,H., Kawasawa,Y.I., Ikeda,Y., Sakakibara,I.,
            Ohno,K., Ioka,R.X., Murakami,S., Dohmae,N., Xie,J., Suda,T.,
            Motoike,T., Ohuchi,T., Yanagisawa,M. and Sakai,J.
  TITLE     A neuropeptide ligand of the G protein-coupled receptor GPR103
            regulates feeding, behavioral arousal, and blood pressure in mice
  JOURNAL   Proc Natl Acad Sci U S A 103 (19), 7438-7443 (2006)
   PUBMED   16648250
  REMARK    GeneRIF: QRFP and GPR103A/B may regulate diverse neuroendocrine and
            behavioral functions and implicate this neuropeptide system in
            metabolic syndrome
REFERENCE   7  (bases 1 to 1802)
  AUTHORS   Fukusumi,S., Yoshida,H., Fujii,R., Maruyama,M., Komatsu,H.,
            Habata,Y., Shintani,Y., Hinuma,S. and Fujino,M.
  TITLE     A new peptidic ligand and its receptor regulating adrenal function
            in rats
  JOURNAL   J Biol Chem 278 (47), 46387-46395 (2003)
   PUBMED   12960173
  REMARK    GeneRIF: QRFP mRNA was highly expressed in the hypothalamus; QRFP
            receptor mRNA was highly expressed in the adrenal gland. Data
            suggests that QRFP and its receptor have a regulatory function in
            the rat adrenal gland.
REFERENCE   8  (bases 1 to 1802)
  AUTHORS   Jiang,Y., Luo,L., Gustafson,E.L., Yadav,D., Laverty,M., Murgolo,N.,
            Vassileva,G., Zeng,M., Laz,T.M., Behan,J., Qiu,P., Wang,L.,
            Wang,S., Bayne,M., Greene,J., Monsma,F. Jr. and Zhang,F.L.
  TITLE     Identification and characterization of a novel RF-amide peptide
            ligand for orphan G-protein-coupled receptor SP9155
  JOURNAL   J Biol Chem 278 (30), 27652-27657 (2003)
   PUBMED   12714592
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Oct 5, 2022 this sequence version replaced NM_198199.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB109630.1, SRR26360176.1784377.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06680430, SAMN06680445
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-412               JAXUCZ010000002.1  121024609-121025020 c
            413-571             JAXUCZ010000002.1  120990208-120990366 c
            572-633             JAXUCZ010000002.1  120988948-120989009 c
            634-869             JAXUCZ010000002.1  120984325-120984560 c
            870-967             JAXUCZ010000002.1  120982705-120982802 c
            968-1802            JAXUCZ010000002.1  120981235-120982069 c
FEATURES             Location/Qualifiers
     source          1..1802
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q25"
     gene            1..1802
                     /gene="Qrfpr"
                     /gene_synonym="AQ27; Gpr103"
                     /note="pyroglutamylated RFamide peptide receptor"
                     /db_xref="GeneID:310327"
                     /db_xref="RGD:728380"
     exon            1..412
                     /gene="Qrfpr"
                     /gene_synonym="AQ27; Gpr103"
                     /inference="alignment:Splign:2.1.0"
     CDS             73..1374
                     /gene="Qrfpr"
                     /gene_synonym="AQ27; Gpr103"
                     /note="QRFP receptor; SP9155; G-protein coupled receptor
                     103; orexigenic neuropeptide QRFP receptor"
                     /codon_start=1
                     /product="pyroglutamylated RF-amide peptide receptor"
                     /protein_id="NP_937842.1"
                     /db_xref="GeneID:310327"
                     /db_xref="RGD:728380"
                     /translation="MQALNITAEQFSRLLSAHNLTREQFIHRYGLRPLVYTPELPARA
                     KVAFALAGALIFALALFGNSLVIYVVTRSKAMRTVTNIFICSLALSDLLIAFFCIPVT
                     MLQNISDKWLGGAFICKMVPFVQSTAVVTEILTMTCIAVERHQGLVHPFKMKWQYTTR
                     RAFTILGVVWLAAIIVGSPMWHVQRLEIKYDFLYEKEHICCLEEWASPVHQRIYSTFI
                     LVILFLLPLVVMLVLYSKIGYELWIKKRVGDSSALQTIHGKEMSKIARKKKRAVIMMV
                     TVVALFAACWAPFHVVHMMVEYSNFEKEYDDVTIKMVFAVAQTIGFFNSICNPFVYAF
                     MNENFKKNFLSAVCYCIVKESSSPARKPGNSGISMMQKRAKLSRPQRPVEETKGDTFS
                     DASIDVKLCEQPREKRQLKRQLAFFSSELSENSTFGSGHEL"
     exon            413..571
                     /gene="Qrfpr"
                     /gene_synonym="AQ27; Gpr103"
                     /inference="alignment:Splign:2.1.0"
     exon            572..633
                     /gene="Qrfpr"
                     /gene_synonym="AQ27; Gpr103"
                     /inference="alignment:Splign:2.1.0"
     exon            634..869
                     /gene="Qrfpr"
                     /gene_synonym="AQ27; Gpr103"
                     /inference="alignment:Splign:2.1.0"
     exon            870..967
                     /gene="Qrfpr"
                     /gene_synonym="AQ27; Gpr103"
                     /inference="alignment:Splign:2.1.0"
     exon            968..1802
                     /gene="Qrfpr"
                     /gene_synonym="AQ27; Gpr103"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagctctgca ctgtcagcct agacttagat ttagaacagt agagcagagg ccagcaggac
       61 tctgcactca gcatgcaggc gctcaacatc accgcggagc agttctcccg gctgctgagc
      121 gcgcacaacc tgactcggga gcagttcatt catcgctatg ggctgagacc gctggtctac
      181 actccggagc tgcccgcgcg tgctaaagtg gcctttgcgc tggcaggagc actcattttt
      241 gccctggcgc tcttcggcaa ctctctggtc atctatgtgg tgacccgcag caaggccatg
      301 cgcaccgtca ccaacatctt catctgctct ctggcactca gtgatctgct cattgccttc
      361 ttctgcatcc ccgtcacgat gctccagaac atctccgaca agtggctggg tggtgccttc
      421 atctgcaaga tggtaccctt tgtccagtcc acggccgtcg tgacagaaat cctcaccatg
      481 acctgcatcg ctgttgagag gcaccaagga cttgtccatc cttttaaaat gaagtggcag
      541 tacaccaccc gaagggcctt cacgatcttg ggcgtggtct ggttggcggc catcatcgta
      601 ggatcaccca tgtggcacgt gcaacgcctt gagattaagt atgacttcct ctatgaaaaa
      661 gaacacatct gctgcttgga agaatgggcc agccccgtgc accagagaat ctacagcacc
      721 ttcattctcg tcatcctctt cctcctgcct cttgtggtaa tgctagtcct ctatagcaag
      781 attggctatg aactgtggat caagaagaga gtgggagaca gttcagcgct tcaaactatc
      841 cacgggaaag aaatgtccaa aatagccagg aagaagaagc gggctgtcat tatgatggtg
      901 actgtggtgg ctctctttgc tgcatgctgg gcacctttcc acgttgttca catgatggtt
      961 gagtacagta attttgaaaa agaatatgat gatgtcacaa tcaagatggt ctttgctgtc
     1021 gcgcagacaa ttggcttttt caactccatc tgtaatccct ttgtgtatgc gtttatgaat
     1081 gaaaacttca aaaagaattt tctgtctgct gtttgttatt gcatagtgaa agaatcctcc
     1141 tccccagcac ggaagcctgg gaattctgga atatcaatga tgcagaagag agcaaagtta
     1201 tctcgaccac agcgtccagt ggaagaaacc aaaggagaca cattcagtga tgccagcatt
     1261 gatgtcaaat tgtgcgagca gccgcgggag aaaagacaac tcaagagaca gctagccttc
     1321 ttcagttctg aactttctga aaactctact tttggtagtg gccatgaact gtaatgaaaa
     1381 cttcataatt aatagcattt gtatggaatg ttattttgag caaaggtcag gactattttt
     1441 ttaaatgaca agagaaacaa gacatgtttt tcatttaaat ggacataata cgtaacactg
     1501 taactttgaa aagttattat aacagctttg tagattatta aagtagattt atgaaagatg
     1561 tcgtgcataa taaagcaatg gttttggtag cagttttatc catgtagtta atgtaatgtg
     1621 acttatgtgt attgctaaat tattaaaatt gtatcatcat ccttgaatat taaacatctg
     1681 agcatcataa tgtaatttat agtgtgctgt tgaagttggg gaaacaattt tgtacaataa
     1741 ttttaaaaat caaaatgaat gatcaggcaa gtgacaacta ataaaacttg agacaaatgt
     1801 ca
//
