LOCUS       NM_198200                375 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus pyroglutamylated RFamide peptide (Qrfp), mRNA.
ACCESSION   NM_198200
VERSION     NM_198200.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 375)
  AUTHORS   Schreiber,A.L., Arceneaux,K.P. 3rd, Malbrue,R.A., Mouton,A.J.,
            Chen,C.S., Bench,E.M., Braymer,H.D. and Primeaux,S.D.
  TITLE     The effects of high fat diet and estradiol on hypothalamic
            prepro-QRFP mRNA expression in female rats
  JOURNAL   Neuropeptides 58, 103-109 (2016)
   PUBMED   26823127
  REMARK    GeneRIF: Studies support a role for estradiol (E2) in the
            regulation of prepro-QRFP mRNA in the ventral medial nucleus of the
            hypothalamus/arcuate nucleus and suggest that E2's effects on food
            intake may be via a direct effect on the orexigenic peptide, QRFP.
REFERENCE   2  (bases 1 to 375)
  AUTHORS   Primeaux,S.D., Barnes,M.J. and Braymer,H.D.
  TITLE     Hypothalamic QRFP: regulation of food intake and fat selection
  JOURNAL   Horm Metab Res 45 (13), 967-974 (2013)
   PUBMED   23979792
  REMARK    GeneRIF: The present review discusses the role of QRFP in the
            regulation of feeding behavior, with emphasis on the intake of
            dietary fat.
REFERENCE   3  (bases 1 to 375)
  AUTHORS   Primeaux,S.D.
  TITLE     QRFP in female rats: effects on high fat food intake and
            hypothalamic gene expression across the estrous cycle
  JOURNAL   Peptides 32 (6), 1270-1275 (2011)
   PUBMED   21473894
  REMARK    GeneRIF: QRFP may play a role in coordinating feeding behaviors
            with reproductive function in rats when energy demand is increased.
REFERENCE   4  (bases 1 to 375)
  AUTHORS   Yamamoto,T., Miyazaki,R. and Yamada,T.
  TITLE     Intracerebroventricular administration of 26RFa produces an
            analgesic effect in the rat formalin test
  JOURNAL   Peptides 30 (9), 1683-1688 (2009)
   PUBMED   19520126
  REMARK    GeneRIF: Data suggest that the GPR103-26RFa system modulates
            nociceptive transmission in both the spinal cord and the
            supraspinal brain in the formalin (paw) test.
REFERENCE   5  (bases 1 to 375)
  AUTHORS   Beck,B. and Richy,S.
  TITLE     Suppression of QRFP 43 in the hypothalamic ventromedial nucleus of
            Long-Evans rats fed a high-fat diet
  JOURNAL   Biochem Biophys Res Commun 383 (1), 78-82 (2009)
   PUBMED   19341706
  REMARK    GeneRIF: QRFP 43 might play a role downstream of leptin in the
            regulation of feeding behavior.
REFERENCE   6  (bases 1 to 375)
  AUTHORS   Navarro,V.M., Fernandez-Fernandez,R., Nogueiras,R., Vigo,E.,
            Tovar,S., Chartrel,N., Le Marec,O., Leprince,J., Aguilar,E.,
            Pinilla,L., Dieguez,C., Vaudry,H. and Tena-Sempere,M.
  TITLE     Novel role of 26RFa, a hypothalamic RFamide orexigenic peptide, as
            putative regulator of the gonadotropic axis
  JOURNAL   J Physiol 573 (Pt 1), 237-249 (2006)
   PUBMED   16543265
  REMARK    GeneRIF: potential role of the orexigenic peptide 26RFa in the
            control of the gonadotropic axis, thus suggesting its potential
            involvement in the joint control of energy balance and
            reproduction, especially in the female
REFERENCE   7  (bases 1 to 375)
  AUTHORS   Takayasu,S., Sakurai,T., Iwasaki,S., Teranishi,H., Yamanaka,A.,
            Williams,S.C., Iguchi,H., Kawasawa,Y.I., Ikeda,Y., Sakakibara,I.,
            Ohno,K., Ioka,R.X., Murakami,S., Dohmae,N., Xie,J., Suda,T.,
            Motoike,T., Ohuchi,T., Yanagisawa,M. and Sakai,J.
  TITLE     A neuropeptide ligand of the G protein-coupled receptor GPR103
            regulates feeding, behavioral arousal, and blood pressure in mice
  JOURNAL   Proc Natl Acad Sci U S A 103 (19), 7438-7443 (2006)
   PUBMED   16648250
REFERENCE   8  (bases 1 to 375)
  AUTHORS   Chartrel,N., Bruzzone,F., Dujardin,C., Leprince,J., Tollemer,H.,
            Anouar,Y., Vallarino,M., Costentin,J. and Vaudry,H.
  TITLE     Identification of 26RFa from frog brain: a novel hypothalamic
            neuropeptide with orexigenic activity in mammals
  JOURNAL   Ann N Y Acad Sci 1040, 80-83 (2005)
   PUBMED   15891009
  REMARK    GeneRIF: Prepro-26RFa mRNA is expressed exclusively in two
            hypothalamic nuclei involved in the control of feeding behavior.
REFERENCE   9  (bases 1 to 375)
  AUTHORS   Chartrel,N., Dujardin,C., Anouar,Y., Leprince,J., Decker,A.,
            Clerens,S., Do-Rego,J.C., Vandesande,F., Llorens-Cortes,C.,
            Costentin,J., Beauvillain,J.C. and Vaudry,H.
  TITLE     Identification of 26RFa, a hypothalamic neuropeptide of the RFamide
            peptide family with orexigenic activity
  JOURNAL   Proc Natl Acad Sci U S A 100 (25), 15247-15252 (2003)
   PUBMED   14657341
REFERENCE   10 (bases 1 to 375)
  AUTHORS   Fukusumi,S., Yoshida,H., Fujii,R., Maruyama,M., Komatsu,H.,
            Habata,Y., Shintani,Y., Hinuma,S. and Fujino,M.
  TITLE     A new peptidic ligand and its receptor regulating adrenal function
            in rats
  JOURNAL   J Biol Chem 278 (47), 46387-46395 (2003)
   PUBMED   12960173
  REMARK    GeneRIF: QRFP mRNA was highly expressed in the hypothalamus; QRFP
            receptor mRNA was highly expressed in the adrenal gland. Data
            suggests that QRFP and its receptor have a regulatory function in
            the rat adrenal gland.
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AB109627.1.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AB109627.1, AY438327.1 [ECO:0000345]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..375
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3p12"
     gene            1..375
                     /gene="Qrfp"
                     /gene_synonym="26RFa; NEWGENE_735020; P518"
                     /note="pyroglutamylated RFamide peptide"
                     /db_xref="GeneID:379044"
                     /db_xref="RGD:735020"
     CDS             1..375
                     /gene="Qrfp"
                     /gene_synonym="26RFa; NEWGENE_735020; P518"
                     /note="orexigenic neuropeptide QRFP; P518 precursor
                     protein"
                     /codon_start=1
                     /product="orexigenic neuropeptide QRFP precursor"
                     /protein_id="NP_937843.1"
                     /db_xref="GeneID:379044"
                     /db_xref="RGD:735020"
                     /translation="MRCLCSWLCLLLPLSACFPLLDRRGPTDIGDIGARMSWVQLTEG
                     HTPRSVQSPRPQALLVVAKEQQASRREHTGFRLGRQDSGSEATGFLPTDSEKASGPLG
                     TLAEELSSYSRRKGGFSFRFGR"
     exon            1..375
                     /gene="Qrfp"
                     /gene_synonym="26RFa; NEWGENE_735020; P518"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgaggtgcc tctgctcttg gctttgcctc ctcctgcctc tgagtgcctg ctttcctctg
       61 ctggacagaa ggggacccac agacatcggt gacatcggag ccagaatgag ctgggtccag
      121 ctgactgagg gacacacccc ccgctcagtt caaagtccac ggccacaggc cctgctcgtg
      181 gtggccaagg agcagcaggc ctctcgcagg gagcacactg gcttccgtct agggaggcag
      241 gacagtggca gtgaagccac ggggttcctg cccactgact cagagaaggc cagcggcccc
      301 ctggggactc tggcagagga gctcagcagc tacagccggc ggaagggagg cttcagcttc
      361 cgcttcggcc ggtga
//
