LOCUS       NM_001009646            1225 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus quinolinate phosphoribosyltransferase (Qprt),
            mRNA.
ACCESSION   NM_001009646 XM_215075
VERSION     NM_001009646.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1225)
  AUTHORS   Youn,H.S., Kim,T.G., Kim,M.K., Kang,G.B., Kang,J.Y., Lee,J.G.,
            An,J.Y., Park,K.R., Lee,Y., Im,Y.J., Lee,J.H. and Eom,S.H.
  TITLE     Structural Insights into the Quaternary Catalytic Mechanism of
            Hexameric Human Quinolinate Phosphoribosyltransferase, a Key Enzyme
            in de novo NAD Biosynthesis
  JOURNAL   Sci Rep 6, 19681 (2016)
   PUBMED   26805589
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1225)
  AUTHORS   Malik,S.S., Patterson,D.N., Ncube,Z. and Toth,E.A.
  TITLE     The crystal structure of human quinolinic acid
            phosphoribosyltransferase in complex with its inhibitor phthalic
            acid
  JOURNAL   Proteins 82 (3), 405-414 (2014)
   PUBMED   24038671
REFERENCE   3  (bases 1 to 1225)
  AUTHORS   Youn,H.S., Kim,M.K., Kang,G.B., Kim,T.G., Lee,J.G., An,J.Y.,
            Park,K.R., Lee,Y., Kang,J.Y., Song,H.E., Park,I., Cho,C.,
            Fukuoka,S. and Eom,S.H.
  TITLE     Crystal structure of Sus scrofa quinolinate
            phosphoribosyltransferase in complex with nicotinate mononucleotide
  JOURNAL   PLoS One 8 (4), e62027 (2013)
   PUBMED   23626766
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1225)
  AUTHORS   Houtkooper,R.H., Canto,C., Wanders,R.J. and Auwerx,J.
  TITLE     The secret life of NAD+: an old metabolite controlling new
            metabolic signaling pathways
  JOURNAL   Endocr Rev 31 (2), 194-223 (2010)
   PUBMED   20007326
  REMARK    Review article
REFERENCE   5  (bases 1 to 1225)
  AUTHORS   Liu,H., Woznica,K., Catton,G., Crawford,A., Botting,N. and
            Naismith,J.H.
  TITLE     Structural and kinetic characterization of quinolinate
            phosphoribosyltransferase (hQPRTase) from homo sapiens
  JOURNAL   J Mol Biol 373 (3), 755-763 (2007)
   PUBMED   17868694
REFERENCE   6  (bases 1 to 1225)
  AUTHORS   Fukuoka,S.I., Nyaruhucha,C.M. and Shibata,K.
  TITLE     Characterization and functional expression of the cDNA encoding
            human brain quinolinate phosphoribosyltransferase
  JOURNAL   Biochim Biophys Acta 1395 (2), 192-201 (1998)
   PUBMED   9473669
REFERENCE   7  (bases 1 to 1225)
  AUTHORS   Shin,M., Mori,Y., Kimura,A., Fujita,Y., Yoshida,K., Sano,K. and
            Umezawa,C.
  TITLE     NAD+ biosynthesis and metabolic fluxes of tryptophan in hepatocytes
            isolated from rats fed a clofibrate-containing diet
  JOURNAL   Biochem Pharmacol 52 (2), 247-252 (1996)
   PUBMED   8694849
REFERENCE   8  (bases 1 to 1225)
  AUTHORS   Schwarcz,R., Okuno,E. and White,R.J.
  TITLE     Basal ganglia lesions in the rat: effects on quinolinic acid
            metabolism
  JOURNAL   Brain Res 490 (1), 103-109 (1989)
   PUBMED   2527078
REFERENCE   9  (bases 1 to 1225)
  AUTHORS   Feldblum,S., Rougier,A., Loiseau,H., Loiseau,P., Cohadon,F.,
            Morselli,P.L. and Lloyd,K.G.
  TITLE     Quinolinic-phosphoribosyl transferase activity is decreased in
            epileptic human brain tissue
  JOURNAL   Epilepsia 29 (5), 523-529 (1988)
   PUBMED   3409840
REFERENCE   10 (bases 1 to 1225)
  AUTHORS   Kohler,C., Eriksson,L.G., Flood,P.R., Hardie,J.A., Okuno,E. and
            Schwarcz,R.
  TITLE     Quinolinic acid metabolism in the rat brain. Immunohistochemical
            identification of 3-hydroxyanthranilic acid oxygenase and
            quinolinic acid phosphoribosyltransferase in the hippocampal region
  JOURNAL   J Neurosci 8 (3), 975-987 (1988)
   PUBMED   3346732
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC088177.1.
            
            On Jan 13, 2005 this sequence version replaced XM_215075.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC088177.1, FQ209866.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1225
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q37"
     gene            1..1225
                     /gene="Qprt"
                     /note="quinolinate phosphoribosyltransferase"
                     /db_xref="GeneID:293504"
                     /db_xref="RGD:1310309"
     exon            1..61
                     /gene="Qprt"
                     /inference="alignment:Splign:2.1.0"
     CDS             49..948
                     /gene="Qprt"
                     /EC_number="2.4.2.19"
                     /note="nicotinate-nucleotide pyrophosphorylase; QPRTase;
                     QAPRTase"
                     /codon_start=1
                     /product="nicotinate-nucleotide pyrophosphorylase
                     [carboxylating]"
                     /protein_id="NP_001009646.1"
                     /db_xref="GeneID:293504"
                     /db_xref="RGD:1310309"
                     /translation="MDPEGLQFLLPPASLAALANSWLQEDCPGLNFASLVTGSAPAQA
                     VLWAKSPGVLAGRPFFDAIFTQLNCQVSWLLPEGSKLVPVVKVAEVRGPAHHLLLGER
                     VALNTLARCSGIASAAATAVEVATSTGWAGHVAGTRKTTPGFRLVEKYGLLVGGAECH
                     RYDLGGLVMVKDNHVVAAGSMEKAVLKARQAAGFPLKVEVECSSLKEALQAAEAGADL
                     VMLDNFKPEELHPTAATLKAKFPNVSVEASGGVTLDNLPQFCGTNIDVISLGMLTQAA
                     PALDFSLKLYAEGDIPVPHARRS"
     exon            62..597
                     /gene="Qprt"
                     /inference="alignment:Splign:2.1.0"
     exon            598..729
                     /gene="Qprt"
                     /inference="alignment:Splign:2.1.0"
     exon            730..1188
                     /gene="Qprt"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atctgaacag tagtggacac actgacccgc tggctactcc aagtcaccat ggaccctgaa
       61 ggtctgcagt tcctgttgcc ccctgcaagt ctggcagctc tggcaaacag ctggttgcaa
      121 gaggactgcc caggtctcaa ttttgcgtcc ttggttaccg ggtcggcccc tgcacaggct
      181 gtgctgtggg ccaaatcccc cggggttctg gcagggcgac ctttctttga tgccatcttc
      241 actcaactca actgccaagt gtcttggctc cttccagagg gatcgaagct ggtacctgtg
      301 gtcaaagtgg cagaggtcag gggacctgct caccacttgc tgctggggga acgagtggcc
      361 cttaacaccc tggcccgctg cagtgggatt gccagtgcgg cagcgacagc tgtggaggtg
      421 gccacaagca ctggctgggc tggacatgta gcaggcacga ggaagaccac gccagggttc
      481 cgactggtag agaagtatgg gctcctagta ggcggggctg aatgccaccg ctatgacctg
      541 ggagggctgg tgatggtgaa agacaaccat gtggtggcag ctggcagtat ggagaaggca
      601 gtgctgaagg cccggcaggc agctggcttt cccctgaagg tagaggtgga atgtagcagc
      661 ctgaaggagg ctttgcaggc agcagaggct ggggctgacc tggtcatgct ggacaacttc
      721 aagcctgagg agctgcaccc cacagcagct acacttaaag ccaaattccc caacgtgtct
      781 gtggaagcca gtgggggtgt cacactggac aacctccccc agttctgtgg gacaaatatt
      841 gatgtcatct cgttgggaat gctgacccag gctgctccag ccctggattt ttccctcaaa
      901 ctgtatgctg aaggagatat tccagtgcct catgctcgcc ggtcctaaag ctgaagaaga
      961 tgccaccaga atggattact gtggcttgtt gggccccttg ggtcacacat ctttaggttc
     1021 agaggccaac aggacataac tgaaatttac ctaggcttcc cactagctct gccatctcca
     1081 gcttgtgtga cttgctaggg ctgactttgg ttttgcttgc ctccgttttc tcatctgtga
     1141 agtgggtcta ataaatattc ggccttactg ggctgttgat gacaactaaa aaaaaaaaaa
     1201 aaaaaaaaaa aaaaaaaaaa aaaaa
//
