LOCUS       NP_001009646             299 aa            linear   ROD 24-JUN-2024
DEFINITION  nicotinate-nucleotide pyrophosphorylase [carboxylating] [Rattus
            norvegicus].
ACCESSION   NP_001009646 XP_215075
VERSION     NP_001009646.1
DBSOURCE    REFSEQ: accession NM_001009646.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 299)
  AUTHORS   Youn,H.S., Kim,T.G., Kim,M.K., Kang,G.B., Kang,J.Y., Lee,J.G.,
            An,J.Y., Park,K.R., Lee,Y., Im,Y.J., Lee,J.H. and Eom,S.H.
  TITLE     Structural Insights into the Quaternary Catalytic Mechanism of
            Hexameric Human Quinolinate Phosphoribosyltransferase, a Key Enzyme
            in de novo NAD Biosynthesis
  JOURNAL   Sci Rep 6, 19681 (2016)
   PUBMED   26805589
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 299)
  AUTHORS   Malik,S.S., Patterson,D.N., Ncube,Z. and Toth,E.A.
  TITLE     The crystal structure of human quinolinic acid
            phosphoribosyltransferase in complex with its inhibitor phthalic
            acid
  JOURNAL   Proteins 82 (3), 405-414 (2014)
   PUBMED   24038671
REFERENCE   3  (residues 1 to 299)
  AUTHORS   Youn,H.S., Kim,M.K., Kang,G.B., Kim,T.G., Lee,J.G., An,J.Y.,
            Park,K.R., Lee,Y., Kang,J.Y., Song,H.E., Park,I., Cho,C.,
            Fukuoka,S. and Eom,S.H.
  TITLE     Crystal structure of Sus scrofa quinolinate
            phosphoribosyltransferase in complex with nicotinate mononucleotide
  JOURNAL   PLoS One 8 (4), e62027 (2013)
   PUBMED   23626766
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 299)
  AUTHORS   Houtkooper,R.H., Canto,C., Wanders,R.J. and Auwerx,J.
  TITLE     The secret life of NAD+: an old metabolite controlling new
            metabolic signaling pathways
  JOURNAL   Endocr Rev 31 (2), 194-223 (2010)
   PUBMED   20007326
  REMARK    Review article
REFERENCE   5  (residues 1 to 299)
  AUTHORS   Liu,H., Woznica,K., Catton,G., Crawford,A., Botting,N. and
            Naismith,J.H.
  TITLE     Structural and kinetic characterization of quinolinate
            phosphoribosyltransferase (hQPRTase) from homo sapiens
  JOURNAL   J Mol Biol 373 (3), 755-763 (2007)
   PUBMED   17868694
REFERENCE   6  (residues 1 to 299)
  AUTHORS   Fukuoka,S.I., Nyaruhucha,C.M. and Shibata,K.
  TITLE     Characterization and functional expression of the cDNA encoding
            human brain quinolinate phosphoribosyltransferase
  JOURNAL   Biochim Biophys Acta 1395 (2), 192-201 (1998)
   PUBMED   9473669
REFERENCE   7  (residues 1 to 299)
  AUTHORS   Shin,M., Mori,Y., Kimura,A., Fujita,Y., Yoshida,K., Sano,K. and
            Umezawa,C.
  TITLE     NAD+ biosynthesis and metabolic fluxes of tryptophan in hepatocytes
            isolated from rats fed a clofibrate-containing diet
  JOURNAL   Biochem Pharmacol 52 (2), 247-252 (1996)
   PUBMED   8694849
REFERENCE   8  (residues 1 to 299)
  AUTHORS   Schwarcz,R., Okuno,E. and White,R.J.
  TITLE     Basal ganglia lesions in the rat: effects on quinolinic acid
            metabolism
  JOURNAL   Brain Res 490 (1), 103-109 (1989)
   PUBMED   2527078
REFERENCE   9  (residues 1 to 299)
  AUTHORS   Feldblum,S., Rougier,A., Loiseau,H., Loiseau,P., Cohadon,F.,
            Morselli,P.L. and Lloyd,K.G.
  TITLE     Quinolinic-phosphoribosyl transferase activity is decreased in
            epileptic human brain tissue
  JOURNAL   Epilepsia 29 (5), 523-529 (1988)
   PUBMED   3409840
REFERENCE   10 (residues 1 to 299)
  AUTHORS   Kohler,C., Eriksson,L.G., Flood,P.R., Hardie,J.A., Okuno,E. and
            Schwarcz,R.
  TITLE     Quinolinic acid metabolism in the rat brain. Immunohistochemical
            identification of 3-hydroxyanthranilic acid oxygenase and
            quinolinic acid phosphoribosyltransferase in the hippocampal region
  JOURNAL   J Neurosci 8 (3), 975-987 (1988)
   PUBMED   3346732
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC088177.1.
            
            On Jan 13, 2005 this sequence version replaced XP_215075.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC088177.1, FQ209866.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..299
                     /organism="Rattus norvegicus"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q37"
     Protein         1..299
                     /product="nicotinate-nucleotide pyrophosphorylase
                     [carboxylating]"
                     /EC_number="2.4.2.19"
                     /note="nicotinate-nucleotide pyrophosphorylase; QPRTase;
                     QAPRTase"
                     /calculated_mol_wt=31166
     Region          8..12
                     /region_name="Important for hexamer formation.
                     /evidence=ECO:0000250|UniProtKB:Q15274"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5I0M2.1)"
     Region          21..285
                     /region_name="nadC"
                     /note="nicotinate-nucleotide pyrophosphorylase; TIGR00078"
                     /db_xref="CDD:272894"
     CDS             1..299
                     /gene="Qprt"
                     /coded_by="NM_001009646.1:49..948"
                     /db_xref="GeneID:293504"
                     /db_xref="RGD:1310309"
ORIGIN      
        1 mdpeglqfll ppaslaalan swlqedcpgl nfaslvtgsa paqavlwaks pgvlagrpff
       61 daiftqlncq vswllpegsk lvpvvkvaev rgpahhlllg ervalntlar csgiasaaat
      121 avevatstgw aghvagtrkt tpgfrlveky gllvggaech rydlgglvmv kdnhvvaags
      181 mekavlkarq aagfplkvev ecsslkealq aaeagadlvm ldnfkpeelh ptaatlkakf
      241 pnvsveasgg vtldnlpqfc gtnidvislg mltqaapald fslklyaegd ipvpharrs
//
