LOCUS       NP_001099700             383 aa            linear   ROD 22-MAR-2023
DEFINITION  glutaminyl-peptide cyclotransferase-like protein [Rattus
            norvegicus].
ACCESSION   NP_001099700 XP_001066591 XP_214869
VERSION     NP_001099700.1
DBSOURCE    REFSEQ: accession NM_001106230.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 383)
  AUTHORS   Huang KF, Liaw SS, Huang WL, Chia CY, Lo YC, Chen YL and Wang AH.
  TITLE     Structures of human Golgi-resident glutaminyl cyclase and its
            complexes with inhibitors reveal a large loop movement upon
            inhibitor binding
  JOURNAL   J Biol Chem 286 (14), 12439-12449 (2011)
   PUBMED   21288892
REFERENCE   2  (residues 1 to 383)
  AUTHORS   Ghosh D, Lippert D, Krokhin O, Cortens JP and Wilkins JA.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   3  (residues 1 to 383)
  AUTHORS   Cynis H, Rahfeld JU, Stephan A, Kehlen A, Koch B, Wermann M, Demuth
            HU and Schilling S.
  TITLE     Isolation of an isoenzyme of human glutaminyl cyclase: retention in
            the Golgi complex suggests involvement in the protein maturation
            machinery
  JOURNAL   J Mol Biol 379 (5), 966-980 (2008)
   PUBMED   18486145
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473979.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XP_001066591.1, XP_214869.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC169076.1, SRR8487226.32931.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760476, SAMN16093050
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..383
                     /organism="Rattus norvegicus"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     Protein         1..383
                     /product="glutaminyl-peptide cyclotransferase-like
                     protein"
                     /EC_number="2.3.2.5"
                     /calculated_mol_wt=42487
     Region          82..380
                     /region_name="M28_QC_like"
                     /note="M28 Zn-peptidase glutaminyl cyclase; cd03880"
                     /db_xref="CDD:349876"
     Site            order(187,226..228,232,237..238,270..271,325..326,343,347,
                     351..352)
                     /site_type="active"
                     /db_xref="CDD:349876"
     CDS             1..383
                     /gene="Qpctl"
                     /gene_synonym="RGD1308128"
                     /coded_by="NM_001106230.1:60..1211"
                     /db_xref="GeneID:292687"
                     /db_xref="RGD:1308128"
ORIGIN      
        1 mspasrgrsr qrlgdrglmk ppslskrrll prvqllplll lalalglafy ivwnswhpgv
       61 eevsrsrdlr vpligslsea klrlvvgqld pqrlwgtflr pllivrppgs pgnlqvrkfl
      121 eatlqslsag whveldpfta stplgpldfg nvvatldpga arhltlachy dskffppglp
      181 pfvgatdsav pcalllelvq aldvmlsrik qqaapvtlql lfldgeealk ewgpkdslyg
      241 srhlaqimes iphspgptri qaielfvlld llgapspiff shfprtarwf qrlrsiekrl
      301 hrlnllqshp qevmyfqpge ppgpveddhi pflrrgvpvl hliampfpav whtpadtean
      361 lhpptvhnls rilavflaey lgl
//
