LOCUS       NM_001399516            1572 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus glutaminyl-peptide cyclotransferase (Qpct),
            transcript variant 1, mRNA.
ACCESSION   NM_001399516 XM_006239632
VERSION     NM_001399516.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1572)
  AUTHORS   Hellvard,A., Maresz,K., Schilling,S., Graubner,S., Heiser,U.,
            Jonsson,R., Cynis,H., Demuth,H.U., Potempa,J. and Mydel,P.
  TITLE     Glutaminyl cyclases as novel targets for the treatment of septic
            arthritis
  JOURNAL   J Infect Dis 207 (5), 768-777 (2013)
   PUBMED   23204180
REFERENCE   2  (bases 1 to 1572)
  AUTHORS   Huang,K.F., Liaw,S.S., Huang,W.L., Chia,C.Y., Lo,Y.C., Chen,Y.L.
            and Wang,A.H.
  TITLE     Structures of human Golgi-resident glutaminyl cyclase and its
            complexes with inhibitors reveal a large loop movement upon
            inhibitor binding
  JOURNAL   J Biol Chem 286 (14), 12439-12449 (2011)
   PUBMED   21288892
REFERENCE   3  (bases 1 to 1572)
  AUTHORS   Song,I., Chuang,C.Z. and Bateman,R.C. Jr.
  TITLE     Molecular cloning, sequence analysis and expression of human
            pituitary glutaminyl cyclase
  JOURNAL   J Mol Endocrinol 13 (1), 77-86 (1994)
   PUBMED   7999256
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000006.1.
            
            On Jan 10, 2022 this sequence version replaced XM_006239632.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ229106.1, FQ228724.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840132, SAMN16676810
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-154               JAXUCZ010000006.1  21748742-21748895   c
            155-301             JAXUCZ010000006.1  21737810-21737956   c
            302-580             JAXUCZ010000006.1  21731118-21731396   c
            581-757             JAXUCZ010000006.1  21724495-21724671   c
            758-857             JAXUCZ010000006.1  21722585-21722684   c
            858-974             JAXUCZ010000006.1  21720955-21721071   c
            975-1572            JAXUCZ010000006.1  21716824-21717421   c
FEATURES             Location/Qualifiers
     source          1..1572
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q12"
     gene            1..1572
                     /gene="Qpct"
                     /gene_synonym="Qpctl1; RGD1562284"
                     /note="glutaminyl-peptide cyclotransferase"
                     /db_xref="GeneID:313837"
                     /db_xref="RGD:1562284"
     exon            1..154
                     /gene="Qpct"
                     /gene_synonym="Qpctl1; RGD1562284"
                     /inference="alignment:Splign:2.1.0"
     CDS             32..1120
                     /gene="Qpct"
                     /gene_synonym="Qpctl1; RGD1562284"
                     /EC_number="2.3.2.5"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; glutaminyl cyclase; glutaminyl-peptide
                     cyclotransferase-like 1"
                     /codon_start=1
                     /product="glutaminyl-peptide cyclotransferase isoform 1
                     precursor"
                     /protein_id="NP_001386445.1"
                     /db_xref="GeneID:313837"
                     /db_xref="RGD:1562284"
                     /translation="MAGGEDRRVVGTRHLLLLATILSLTAGILSPVSAVAWTQEKNYH
                     QPAHLNSSSLRQVAEATSISEMWQNDLRPLLIERYPGSPGSYSARQHIMQRIQRLQAE
                     WVVEVDTFLSRTPYGYRSFSNIISTLNPEAKRHLVLACHYDSKYFPQWDSRVFVGATD
                     SAVPCAMMLELARALDKKLHSLKDVSGSRPDLSLRLIFFDGEEAFLHWSPQDSLYGSR
                     HLAQKMASSPHPPGSRGTNQLDGMDLLVLLDLIGAANPTFPNFFPKTTRWFTRLQAIE
                     QQLSELGLLKDHSLERKYFQNFGYGNIIQDDHIPFLRKGVPVLHLIASPFPEVWHTMD
                     DNEENLHSSTIDNLNKIIQVFVLEYLHL"
     exon            155..301
                     /gene="Qpct"
                     /gene_synonym="Qpctl1; RGD1562284"
                     /inference="alignment:Splign:2.1.0"
     exon            302..580
                     /gene="Qpct"
                     /gene_synonym="Qpctl1; RGD1562284"
                     /inference="alignment:Splign:2.1.0"
     exon            581..757
                     /gene="Qpct"
                     /gene_synonym="Qpctl1; RGD1562284"
                     /inference="alignment:Splign:2.1.0"
     exon            758..857
                     /gene="Qpct"
                     /gene_synonym="Qpctl1; RGD1562284"
                     /inference="alignment:Splign:2.1.0"
     exon            858..974
                     /gene="Qpct"
                     /gene_synonym="Qpctl1; RGD1562284"
                     /inference="alignment:Splign:2.1.0"
     exon            975..1572
                     /gene="Qpct"
                     /gene_synonym="Qpctl1; RGD1562284"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgggaatccg cgcccacaca ttcttgcaga gatggcaggc ggcgaagaca ggcgcgtcgt
       61 gggcacccgc cacctgctgc tgctggcgac catcctgtcc ctgacagccg ggattctgag
      121 tccggtctcc gctgttgcct ggacgcagga gaagaactac caccaaccag cacatctgaa
      181 ttcttcatct cttcgacaag tggcagaagc caccagcatt tctgagatgt ggcaaaatga
      241 cttgagacca ctgctgatag aacgatatcc tggatcgccc ggaagctatt ctgctcgtca
      301 gcacatcatg cagcgaattc agagacttca ggctgagtgg gtcgtggaag tcgacacctt
      361 cctcagtagg acgccctacg gatatcggtc cttctcaaat atcatcagca cccttaatcc
      421 ggaagcgaaa cgacacctgg tccttgcctg ccactatgac tccaaatact ttcctcaatg
      481 ggacagcaga gtgtttgtgg gagccactga ttcagccgtg ccgtgcgcaa tgatgttgga
      541 actcgctcgt gccttagaca agaaactcca ttccttgaag gatgtctccg gttccaggcc
      601 ggatctctcg ctccggctaa ttttctttga tggggaagag gcctttcttc actggtctcc
      661 tcaagattct ctgtatgggt ctcggcactt agctcagaag atggcatcaa gccctcaccc
      721 tcctggatca agaggcacca accaactgga tggcatggat ctgttggtct tactggattt
      781 aattggagca gcaaatccaa catttcctaa ttttttcccc aagactacca gatggtttac
      841 tagacttcaa gcaattgaac agcagctctc tgagttgggt ttactcaagg atcattcttt
      901 ggagaggaaa tattttcaga attttggtta tggaaatatt atccaggatg accacattcc
      961 atttttaaga aaaggtgtcc cagttcttca cctgatagct tctcctttcc ctgaagtctg
     1021 gcacaccatg gatgacaatg aagaaaatct gcactcgtca accattgaca atctcaacaa
     1081 aatcattcag gtctttgtgt tggaatatct tcacttgtaa tatgtgaatt tagtttctgg
     1141 taattgcttc tgcaacaact tcaagacatc gtttaaacca tctgacgcca gataaatgtt
     1201 gtgtgtccta tagattcatt ctgtaggtgt ctttgaatat gcggtcagca aattgtagaa
     1261 ttctatgacg ccctcactaa gtttcctcta gagacaagaa acatgtaaag aaataaaaaa
     1321 taatttttga aactcttttg gatgaaaact ttaaaatgac attagattca cttaccaatg
     1381 ccatagaatt gcaaacaatt cttaagtaca atgacgttgt actgtatagt ggtagtttta
     1441 tatgtgacgt tatatagtgt gttatataat atgtaatgaa acacagacat gtactttgac
     1501 agtcctaaag tttcttttag aaaagctttg tggagtttat ttcttgggaa ttaaagtcta
     1561 aattaaattg ta
//
