LOCUS       NM_001414465            4504 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus QKI, KH domain containing RNA binding (Qki),
            transcript variant 1, mRNA.
ACCESSION   NM_001414465 XM_039086925
VERSION     NM_001414465.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4504)
  AUTHORS   Montanes-Agudo,P., Aufiero,S., Schepers,E.N., van der Made,I.,
            Cocera-Ortega,L., Ernault,A.C., Richard,S., Kuster,D.W.D.,
            Christoffels,V.M., Pinto,Y.M. and Creemers,E.E.
  TITLE     The RNA-binding protein QKI governs a muscle-specific alternative
            splicing program that shapes the contractile function of
            cardiomyocytes
  JOURNAL   Cardiovasc Res 119 (5), 1161-1174 (2023)
   PUBMED   36627242
  REMARK    GeneRIF: The RNA-binding protein QKI governs a muscle-specific
            alternative splicing program that shapes the contractile function
            of cardiomyocytes.
REFERENCE   2  (bases 1 to 4504)
  AUTHORS   Liu,R., Li,H., Deng,J., Wu,Q., Liao,C., Xiao,Q. and Chang,Q.
  TITLE     QKI 6 ameliorates CIRI through promoting synthesis of triglyceride
            in neuron and inhibiting neuronal apoptosis associated with
            SIRT1-PPARgamma-PGC-1alpha axis
  JOURNAL   Brain Behav 11 (8), e2271 (2021)
   PUBMED   34227244
  REMARK    GeneRIF: QKI 6 ameliorates CIRI through promoting synthesis of
            triglyceride in neuron and inhibiting neuronal apoptosis associated
            with SIRT1-PPARgamma-PGC-1alpha axis.
REFERENCE   3  (bases 1 to 4504)
  AUTHORS   Wang,F., Yuan,Y., Yang,P. and Li,X.
  TITLE     Extracellular vesicles-mediated transfer of miR-208a/b exaggerate
            hypoxia/reoxygenation injury in cardiomyocytes by reducing QKI
            expression
  JOURNAL   Mol Cell Biochem 431 (1-2), 187-195 (2017)
   PUBMED   28283792
  REMARK    GeneRIF: extracellular vesicles-mediated transfer of miR-208a/b can
            exaggerate H/R injury in cardiomyocytes by reducing QKI expression.
            This represents a previously unrecognized pathway of H/R injury in
            cardiomyocytes.
REFERENCE   4  (bases 1 to 4504)
  AUTHORS   Ishizuka,A., Hasegawa,Y., Ishida,K., Yanaka,K. and Nakagawa,S.
  TITLE     Formation of nuclear bodies by the lncRNA Gomafu-associating
            proteins Celf3 and SF1
  JOURNAL   Genes Cells 19 (9), 704-721 (2014)
   PUBMED   25145264
REFERENCE   5  (bases 1 to 4504)
  AUTHORS   Kornblihtt,A.R., Schor,I.E., Allo,M., Dujardin,G., Petrillo,E. and
            Munoz,M.J.
  TITLE     Alternative splicing: a pivotal step between eukaryotic
            transcription and translation
  JOURNAL   Nat Rev Mol Cell Biol 14 (3), 153-165 (2013)
   PUBMED   23385723
  REMARK    Review article
            Erratum:[Nat Rev Mol Cell Biol. 2013 Mar;14(3).
            doi:10.1038/nrm3560]
REFERENCE   6  (bases 1 to 4504)
  AUTHORS   Noveroske,J.K., Lai,L., Gaussin,V., Northrop,J.L., Nakamura,H.,
            Hirschi,K.K. and Justice,M.J.
  TITLE     Quaking is essential for blood vessel development
  JOURNAL   Genesis 32 (3), 218-230 (2002)
   PUBMED   11892011
REFERENCE   7  (bases 1 to 4504)
  AUTHORS   Wu,H.Y., Dawson,M.R., Reynolds,R. and Hardy,R.J.
  TITLE     Expression of QKI proteins and MAP1B identifies actively
            myelinating oligodendrocytes in adult rat brain
  JOURNAL   Mol Cell Neurosci 17 (2), 292-302 (2001)
   PUBMED   11178867
REFERENCE   8  (bases 1 to 4504)
  AUTHORS   Wu,J., Zhou,L., Tonissen,K., Tee,R. and Artzt,K.
  TITLE     The quaking I-5 protein (QKI-5) has a novel nuclear localization
            signal and shuttles between the nucleus and the cytoplasm
  JOURNAL   J Biol Chem 274 (41), 29202-29210 (1999)
   PUBMED   10506177
REFERENCE   9  (bases 1 to 4504)
  AUTHORS   Amiguet,P., Gardinier,M.V., Zanetta,J.P. and Matthieu,J.M.
  TITLE     Purification and partial structural and functional characterization
            of mouse myelin/oligodendrocyte glycoprotein
  JOURNAL   J Neurochem 58 (5), 1676-1682 (1992)
   PUBMED   1373175
REFERENCE   10 (bases 1 to 4504)
  AUTHORS   Murad,S. and Kishimoto,Y.
  TITLE     Alpha hydroxylation of lignoceric acid to cerebronic acid during
            brain development. Diminished hydroxylase activity in
            myelin-deficient mouse mutants
  JOURNAL   J Biol Chem 250 (15), 5841-5846 (1975)
   PUBMED   1150661
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Nov 25, 2022 this sequence version replaced XM_039086925.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR22582419.764507.1,
                                           SRR26360181.1830756.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-567               JAXUCZ010000001.1  52935425-52935991
            568-710             JAXUCZ010000001.1  52971803-52971945
            711-827             JAXUCZ010000001.1  52985327-52985443
            828-971             JAXUCZ010000001.1  53015253-53015396
            972-1059            JAXUCZ010000001.1  53036230-53036317
            1060-1359           JAXUCZ010000001.1  53037381-53037680
            1360-1434           JAXUCZ010000001.1  53040419-53040493
            1435-4504           JAXUCZ010000001.1  53044269-53047338
FEATURES             Location/Qualifiers
     source          1..4504
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q11"
     gene            1..4504
                     /gene="Qki"
                     /gene_synonym="Qk"
                     /note="QKI, KH domain containing RNA binding"
                     /db_xref="GeneID:499022"
                     /db_xref="RGD:1584886"
     exon            1..567
                     /gene="Qki"
                     /gene_synonym="Qk"
                     /inference="alignment:Splign:2.1.0"
     CDS             426..1451
                     /gene="Qki"
                     /gene_synonym="Qk"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein quaking; rqkI; quaking, KH domain containing RNA
                     binding; KH domain-containing RNA-binding protein QKI;
                     homolog of mouse quaking QKI (KH domain RNA binding
                     protein); protein quaking-like"
                     /codon_start=1
                     /product="KH domain-containing RNA-binding protein QKI
                     isoform 1"
                     /protein_id="NP_001401394.1"
                     /db_xref="GeneID:499022"
                     /db_xref="RGD:1584886"
                     /translation="MVGEMETKEKPKPTPDYLMQLMNDKKLMSSLPNFCGIFNHLERL
                     LDEEISRVRKDMYNDTLNGSTEKRSAELPDAVGPIVQLQEKLYVPVKEYPDFNFVGRI
                     LGPRGLTAKQLEAETGCKIMVRGKGSMRDKKKEEQNRGKPNWEHLNEDLHVLITVEDA
                     QNRAEIKLKRAVEEVKKLLVPAAEGEDSLKKMQLMELAILNGTYRDANIKSPALAFSL
                     AATAQAAPRIITGPAPVLPPAALRTPTPAGPTIMPLIRQIQTAVMPNGTPHPTAAIVP
                     PGPEAGLIYTPYEYPYTLAPATSILEYPIEPSGVLGAVATKVRRHDMRVHPYQRIVTA
                     DRAATGN"
     exon            568..710
                     /gene="Qki"
                     /gene_synonym="Qk"
                     /inference="alignment:Splign:2.1.0"
     exon            711..827
                     /gene="Qki"
                     /gene_synonym="Qk"
                     /inference="alignment:Splign:2.1.0"
     exon            828..971
                     /gene="Qki"
                     /gene_synonym="Qk"
                     /inference="alignment:Splign:2.1.0"
     exon            972..1059
                     /gene="Qki"
                     /gene_synonym="Qk"
                     /inference="alignment:Splign:2.1.0"
     exon            1060..1359
                     /gene="Qki"
                     /gene_synonym="Qk"
                     /inference="alignment:Splign:2.1.0"
     exon            1360..1434
                     /gene="Qki"
                     /gene_synonym="Qk"
                     /inference="alignment:Splign:2.1.0"
     exon            1435..4504
                     /gene="Qki"
                     /gene_synonym="Qk"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcagtcggag cgcggcggcg gcggcggcaa cgcggagcgc cgcggcggac agcaccgcag
       61 actcgcgagc ttcggcgcag gcggcgcgac cggccgacga gcggcccccg gctcctcgcg
      121 gcgcagcggc cccgcgccgc gctcggcccg agacccgcct ccgccgccgg cctcgcgagg
      181 ggagccgcgc cgggcggccg aggagcggcg gccgcggcgc gtcgggccgg gcgaaagtgc
      241 ctgcgggggg cgggcgggcg cgcggagccg gccgccccgg ggctcggcgc gggagccgga
      301 gcgggagccg gcgcggagcg ggacgcggtg tcccgagcgg ccggcggccg gagctcgccc
      361 ccgcccctcc ctcctctcct ccggcggcgg cggcggcggg cggagtgagc tgcggagcct
      421 ggaatatggt cggggaaatg gaaacgaagg agaagccgaa gcccacccca gattacttga
      481 tgcagctgat gaacgacaag aagcttatga gcagcctgcc caacttctgc gggatcttca
      541 accacctcga gcggctgctg gacgaagaaa ttagcagagt acggaaagac atgtacaatg
      601 acacattaaa tggcagtaca gagaaaagga gtgcagaatt gcctgacgcg gtgggaccca
      661 ttgttcagtt acaagagaaa ctttatgtgc ctgtaaaaga ataccctgat tttaattttg
      721 ttgggagaat ccttggacct agaggactta cagctaaaca acttgaagca gaaacaggat
      781 gtaaaataat ggtccgaggc aaaggctcca tgagggataa aaagaaggag gagcaaaata
      841 gaggcaaacc caattgggag catctaaatg aagatttaca tgtactaatc actgtggaag
      901 atgctcaaaa cagagcagaa atcaagctga agagagcggt tgaagaagtg aagaagttac
      961 tggtacctgc agctgaagga gaagacagcc tgaagaagat gcagctgatg gagcttgcaa
     1021 ttctgaatgg cacctacaga gacgccaaca ttaaatcacc agcccttgcc ttttctcttg
     1081 cagcaactgc ccaggctgct ccaaggatca tcactgggcc cgcgcctgtc ctcccaccag
     1141 ctgctctgcg tacacccacg ccagctggcc ctaccataat gcctttgatc agacagattc
     1201 agaccgctgt catgccaaac ggaactcctc acccaactgc tgcaatagtc cctccagggc
     1261 ctgaagctgg gttaatctac acaccctatg agtaccccta cacgttggca ccagctacgt
     1321 caatccttga gtaccccatt gaacccagcg gtgtgttagg tgcggtggct actaaagttc
     1381 gaaggcacga tatgcgtgtc catccttacc aaaggattgt gaccgcagac cgagccgcca
     1441 ccggcaacta acctatgacc ttctgacctc tgaactcttc acccaatgat gacctgacca
     1501 tgcctgcctg ctgatcagtt aactggtaat cgcctttgct tgcctgtcgt cagtgcagcg
     1561 agctgaggca cttgtccgtt cgtcttacca tctaaccaaa caaaagacaa agaaattgtc
     1621 ctccaactca gcttttcccc ccctgtttgg gtgaaagtgg ttctagaacc tgcactgaat
     1681 agtagtaaag caataaggcc cgattcatcc cacagcactg atcatctttc aatgccccac
     1741 cccaagcgaa cggtaagaag gcctctctta agaaggggag acagatggcc ctaactactc
     1801 agtgacagag gcagttactg tgagagactt gtaggaatcc ttttctttcc tagcgaagtc
     1861 aaagctctct ctgaatgtac tgtgtgacaa tgcatcatgc atgaaccttc ggtcagggac
     1921 gtcattgggg aagtgacttc aaaagtattc aaaatttgac atgctgtttg tttagtcact
     1981 acagtgccct caaagggcag acattgcagc ctttttatat tgcctgccaa aatttgaagt
     2041 attagaacaa agtgtgccat gagagaaaaa cttaacaagg agttttgaaa agtaatgcaa
     2101 agaacaaaac tacaacacta tttttaaaaa gttgagtatc tgagttaaaa ttttcaaatc
     2161 tttattttac accacttaaa attatacgag aacaaggtac atgcattatg tgtcacatta
     2221 ctgggcaaac tgttcaaata ttttttttaa acctccctgt atagaaaata tcattaagga
     2281 tgtaaaagcc atgcttgcct atttgctgta tacatgtaat gaaattgtag ataaagtgta
     2341 gtgcattgaa acaaatgaac aaaaagtaga tacttttact atacaagggt gctggtgcag
     2401 aaaaaatata tatatttttg gaaatgtagc attttatact ttcaagtgtt ataaaaaaaa
     2461 gaaaaagaac aaagaaaccc tttatttcat taaatgattt tttctggtgg ttgtcaagaa
     2521 acaaaagacc aaaagagcct ttttgtcttt cttttttatt ttttaagtat tggaataagt
     2581 ctaaagaaaa agaaagtgcc ttattttcct tcatggtcat ttagtcaagt gtcctgtaag
     2641 atcagctcct ccctcagaat aaagttactg catgttcctc cctcgcccag tatgtgaaag
     2701 gagatatgag gagagacaaa tgagttgatg gtctaaatga taagatttgt gtcacgttat
     2761 cttgatgcca gtttgccaaa tctgatactg tgaaaaaaaa tttgatagct tttctaatgt
     2821 ctgactagta aattttaaaa tgccattctt ttacaaatca taattgagtt cttttagtta
     2881 ttaccgtctt cagtgttagc ccaaagaatt ctgaagttta gaaaaaaaat tatgtgagat
     2941 ctgaacatca gtttacagac aaaattaaat tagaacttta ttttatttgg agaagaggaa
     3001 tacaatggat tttttttctt accaattaga aataatcgta atgcctaaaa aactttttca
     3061 caaaaatgaa tctttgaaat tttttattgt tgaaaaagtg ttaagtaacc taaatttaat
     3121 cagctatctt atgtagtcca tctctgctgg cttcagtaac tgctcctaac cacaccattt
     3181 taactctgaa ggaatgtgga aagcctgcat cacagctaca ctggatgctc agctccattc
     3241 cttttcctct tgagtttctc tcttgaaagt cacacagttt tgtagttgaa gcagtttgtg
     3301 tgcatataag cctgcatata aacacttgag ttagtaagtc attgaactgc ccagtaccag
     3361 atgtggcaaa tctcaagtga ttgtgaactc ctggctcgtc aactcatgcc ctcttccata
     3421 ccctcatggc ttcacagtca aggtcagcag gaagctcatt ggccaccttc acggtgacct
     3481 ctccattatt ctgtctcact tggaaccatt ttcagtttat ttactatgca atagacagtc
     3541 cttgtttgta ctcagctttg gtttaatgta ccactgcttt gtctttctgt tacacatgtg
     3601 gtggttttga tttatttaca atatatgctg tgccattttg atttttattt tggttggttg
     3661 gttgaataaa tatgcgacac tcagaacact tgaggtgata gtttaaaaga aaaagaacag
     3721 taccagtatt tgatccagtc tcatctcagc tgtgttatac ctggacattt tagatgttta
     3781 tcaaaggtct tttatgggga agaaagtaaa tgtgtaaacc aatagacgtg tgacgtttat
     3841 gagtaatgct ggctctgaac aaacttctga aaacttagtt gacagtgttt tgagtcaact
     3901 gaaaaaagca tgacttttgg aatctctgaa tgccttggtt ctcagtatta tcactctatt
     3961 gaattttttt cttattaaag tatgtagttt tttagacttt tttcctgaca gtattatgta
     4021 attttttggc gtgggtagat gggagtgtcg cttgtatgtt accatacagc tgacatgtat
     4081 tttttgtcta ttctttatta tcttagtagt ttcatgctgt gtatgtacca taaccaacct
     4141 attgcctatg agaaacatgt aagataatgt atttacagcc attgttacaa gtttataatg
     4201 tatttttcta tcttgtttta tatgtatgtt atataacatt caaaagaatt tttttcttga
     4261 ttgagaaaag gatacaaaat gcaaaatcca caattttgat aactgaaaat cgccaattgt
     4321 tttgcagtac tttattatat tggtgtcttg tctttcttgg gcttttagtt agctaatgaa
     4381 tgaatacgtt agacacttct gggttttagt tgggatttta catagcttgc atttaattct
     4441 ttggttcttt gctgtttcta ttaacccata gcattatttt aataaatgtt ataataccaa
     4501 ccta
//
