LOCUS       NM_022390               1298 bp    mRNA    linear   ROD 22-SEP-2024
DEFINITION  Rattus norvegicus quinoid dihydropteridine reductase (Qdpr), mRNA.
ACCESSION   NM_022390
VERSION     NM_022390.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1298)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 1298)
  AUTHORS   Manjarrez-Gutierrez,G., Gonzalez-Ramirez,M., Boyzo-Montes de Oca,A.
            and Hernandez-Rodriguez,J.
  TITLE     Dihydropteridine reductase activity in the brainstem of
            intrauterine growth-restricted rats
  JOURNAL   Int J Dev Neurosci 28 (7), 621-624 (2010)
   PUBMED   20643204
  REMARK    GeneRIF: Data show that intrauterine growth restriction increases
            serotonin biosynthesis in the brainstem, which is accompanied by an
            increase in dihydropteridine reductase activity that may be a
            compensatory mechanism to maintain sufficient tetrahydrobiopterin.
REFERENCE   3  (bases 1 to 1298)
  AUTHORS   Lee,C.K., Han,J.S., Won,K.J., Jung,S.H., Park,H.J., Lee,H.M.,
            Kim,J., Park,Y.S., Kim,H.J., Park,P.J., Park,T.K. and Kim,B.
  TITLE     Diminished expression of dihydropteridine reductase is a potent
            biomarker for hypertensive vessels
  JOURNAL   Proteomics 9 (21), 4851-4858 (2009)
   PUBMED   19743417
  REMARK    GeneRIF: results suggest that the deficiency in tetrahydrobiopterin
            regeneration produced by diminished dihydrobiopterin reductase
            expression is involved in vascular disorders in hypertensive rats.
REFERENCE   4  (bases 1 to 1298)
  AUTHORS   Kvetnansky,R., Sabban,E.L. and Palkovits,M.
  TITLE     Catecholaminergic systems in stress: structural and molecular
            genetic approaches
  JOURNAL   Physiol Rev 89 (2), 535-606 (2009)
   PUBMED   19342614
  REMARK    Review article
REFERENCE   5  (bases 1 to 1298)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   6  (bases 1 to 1298)
  AUTHORS   Grimshaw,C.E., Matthews,D.A., Varughese,K.I., Skinner,M.,
            Xuong,N.H., Bray,T., Hoch,J. and Whiteley,J.M.
  TITLE     Characterization and nucleotide binding properties of a mutant
            dihydropteridine reductase containing an aspartate 37-isoleucine
            replacement
  JOURNAL   J Biol Chem 267 (22), 15334-15339 (1992)
   PUBMED   1639779
REFERENCE   7  (bases 1 to 1298)
  AUTHORS   Varughese,K.I., Skinner,M.M., Whiteley,J.M., Matthews,D.A. and
            Xuong,N.H.
  TITLE     Crystal structure of rat liver dihydropteridine reductase
  JOURNAL   Proc Natl Acad Sci U S A 89 (13), 6080-6084 (1992)
   PUBMED   1631094
REFERENCE   8  (bases 1 to 1298)
  AUTHORS   Matthews,D.A., Varughese,K.I., Skinner,M., Xuong,N.H., Hoch,J.,
            Trach,K., Schneider,M., Bray,T. and Whiteley,J.M.
  TITLE     Role of aspartate-37 in determining cofactor specificity and
            binding in rat liver dihydropteridine reductase
  JOURNAL   Arch Biochem Biophys 287 (2), 234-239 (1991)
   PUBMED   1898002
REFERENCE   9  (bases 1 to 1298)
  AUTHORS   Bullard,W.P., Guthrie,P.B., Russo,P.V. and Mandell,A.J.
  TITLE     Regional and subcellular distribution and some factors in the
            regulation of reduced pterins in rat brain
  JOURNAL   J Pharmacol Exp Ther 206 (1), 4-20 (1978)
   PUBMED   660556
REFERENCE   10 (bases 1 to 1298)
  AUTHORS   Sanchez-Urretia,L., Pierce,C.E. and Greengard,O.
  TITLE     Dihydropteridine reductase activity of adult, fetal and neoplastic
            tissues
  JOURNAL   Enzyme 23 (5), 346-352 (1978)
   PUBMED   710385
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000014.1.
            
            On Nov 26, 2020 this sequence version replaced NM_022390.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: J03481.1, BC072536.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-146               JAXUCZ010000014.1  69882776-69882921
            147-239             JAXUCZ010000014.1  69885277-69885369
            240-336             JAXUCZ010000014.1  69887293-69887389
            337-477             JAXUCZ010000014.1  69888259-69888399
            478-586             JAXUCZ010000014.1  69891078-69891186
            587-670             JAXUCZ010000014.1  69892559-69892642
            671-1298            JAXUCZ010000014.1  69895751-69896378
FEATURES             Location/Qualifiers
     source          1..1298
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14q11"
     gene            1..1298
                     /gene="Qdpr"
                     /note="quinoid dihydropteridine reductase"
                     /db_xref="GeneID:64192"
                     /db_xref="RGD:619915"
     exon            1..146
                     /gene="Qdpr"
                     /inference="alignment:Splign:2.1.0"
     CDS             51..776
                     /gene="Qdpr"
                     /EC_number="1.5.1.34"
                     /note="HDHPR"
                     /codon_start=1
                     /product="dihydropteridine reductase"
                     /protein_id="NP_071785.1"
                     /db_xref="GeneID:64192"
                     /db_xref="RGD:619915"
                     /translation="MAASGEARRVLVYGGRGALGSRCVQAFRARNWWVASIDVVENEE
                     ASASVIVKMTDSFTEQADQVTAEVGKLLGDQKVDAILCVAGGWAGGNAKSKSLFKNCD
                     LMWKQSIWTSTISSHLATKHLKEGGLLTLAGAKAALDGTPGMIGYGMAKGAVHQLCQS
                     LAGKNSGMPSGAAAIAVLPVTLDTPMNRKSMPEADFSSWTPLEFLVETFHDWITGNKR
                     PNSGSLIQVVTTDGKTELTPAYF"
     exon            147..239
                     /gene="Qdpr"
                     /inference="alignment:Splign:2.1.0"
     exon            240..336
                     /gene="Qdpr"
                     /inference="alignment:Splign:2.1.0"
     exon            337..477
                     /gene="Qdpr"
                     /inference="alignment:Splign:2.1.0"
     exon            478..586
                     /gene="Qdpr"
                     /inference="alignment:Splign:2.1.0"
     exon            587..670
                     /gene="Qdpr"
                     /inference="alignment:Splign:2.1.0"
     exon            671..1298
                     /gene="Qdpr"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtgcttttgg gtttggcgat cagttccgcg ggagtcttgt caggagcagg atggcggctt
       61 cgggcgaggc gcgccgagtg ctggtgtacg gcggcagggg tgctctgggc tcgcgctgcg
      121 tacaggcctt ccgggcccgc aactggtggg ttgccagcat tgatgtggtg gagaatgaag
      181 aggccagtgc cagcgtgatt gttaagatga cagattcatt cacggagcag gctgaccagg
      241 tcactgctga ggtcgggaag ctcctaggtg accagaaggt ggatgccatt ctctgtgtgg
      301 ctggaggatg ggccgggggc aatgccaaat ccaagtcact ctttaaaaac tgtgacctga
      361 tgtggaagca gagtatttgg acatccacca tctctagcca cttggccaca aagcacctga
      421 aggaaggagg cctcttgacc ctggccgggg ccaaagctgc gttggatggg actcctggga
      481 tgattggcta cggcatggcc aagggagccg tccatcagct ctgccagagc cttgcaggga
      541 agaacagtgg catgccgtct ggggctgccg ccattgctgt gcttcccgtc accctggata
      601 ctccgatgaa caggaaatca atgcccgagg cagacttcag ctcctggaca cccttagagt
      661 tcctggtgga gaccttccat gactggatca ctgggaacaa acggccaaac tcaggaagcc
      721 taatccaggt ggtaaccaca gacgggaaga cagagcttac tccagcctat ttctaagttg
      781 cacctcagtg cccaggagaa ccctcttgaa actctactaa cctgtgtctg tattgccgca
      841 cctggcccca tgttgtctgt attcctgttt gtggtacgag ataactagtc ccgtttgtct
      901 cttacgtagt gctccttttt tgtcctgggc tggtgaggta tgtttatggg gaatgagtgg
      961 gggcctgtaa gtagcaccat cagtgctgag gcccagggag gtatgtgtgc aggccgtcat
     1021 cccagcatcc cagactgctt tggagacccg tttgatagtt cattttttag catttggggc
     1081 actttgaaat ccaacttgtt tttaaattcc atgttagtgc catagatgta gtttttgctg
     1141 cctgaaaatt aactgccatg aaaattcatt ggtgatgtaa gtaagcaaaa cctaatggac
     1201 tctgttggat atcatttgtg ttccagccta ggctaagtgt ttatgagaac cattcgtgag
     1261 tgttcggagt gttcttccta ataaacacac ctcatgtc
//
