LOCUS       NM_001007624            2794 bp    mRNA    linear   ROD 02-APR-2024
DEFINITION  Rattus norvegicus glutaminyl-tRNA synthetase 1 (Qars1), mRNA.
ACCESSION   NM_001007624 XM_214381
VERSION     NM_001007624.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2794)
  AUTHORS   Ognjenovic,J., Wu,J., Matthies,D., Baxa,U., Subramaniam,S., Ling,J.
            and Simonovic,M.
  TITLE     The crystal structure of human GlnRS provides basis for the
            development of neurological disorders
  JOURNAL   Nucleic Acids Res 44 (7), 3420-3431 (2016)
   PUBMED   26869582
REFERENCE   2  (bases 1 to 2794)
  AUTHORS   Park,B.S., Jo,H.W. and Jung,J.
  TITLE     Expression profile of aminoacyl-tRNA synthetases in dorsal root
            ganglion neurons after peripheral nerve injury
  JOURNAL   J Mol Histol 46 (1), 115-122 (2015)
   PUBMED   25467976
REFERENCE   3  (bases 1 to 2794)
  AUTHORS   Zhang,X., Ling,J., Barcia,G., Jing,L., Wu,J., Barry,B.J.,
            Mochida,G.H., Hill,R.S., Weimer,J.M., Stein,Q., Poduri,A.,
            Partlow,J.N., Ville,D., Dulac,O., Yu,T.W., Lam,A.T.,
            Servattalab,S., Rodriguez,J., Boddaert,N., Munnich,A., Colleaux,L.,
            Zon,L.I., Soll,D., Walsh,C.A. and Nabbout,R.
  TITLE     Mutations in QARS, encoding glutaminyl-tRNA synthetase, cause
            progressive microcephaly, cerebral-cerebellar atrophy, and
            intractable seizures
  JOURNAL   Am J Hum Genet 94 (4), 547-558 (2014)
   PUBMED   24656866
REFERENCE   4  (bases 1 to 2794)
  AUTHORS   Kaminska,M., Havrylenko,S., Decottignies,P., Le Marechal,P.,
            Negrutskii,B. and Mirande,M.
  TITLE     Dynamic Organization of Aminoacyl-tRNA Synthetase Complexes in the
            Cytoplasm of Human Cells
  JOURNAL   J Biol Chem 284 (20), 13746-13754 (2009)
   PUBMED   19289464
REFERENCE   5  (bases 1 to 2794)
  AUTHORS   Kaminska,M., Havrylenko,S., Decottignies,P., Gillet,S., Le
            Marechal,P., Negrutskii,B. and Mirande,M.
  TITLE     Dissection of the structural organization of the aminoacyl-tRNA
            synthetase complex
  JOURNAL   J Biol Chem 284 (10), 6053-6060 (2009)
   PUBMED   19131329
REFERENCE   6  (bases 1 to 2794)
  AUTHORS   Kim,J.Y., Kang,Y.S., Lee,J.W., Kim,H.J., Ahn,Y.H., Park,H., Ko,Y.G.
            and Kim,S.
  TITLE     p38 is essential for the assembly and stability of macromolecular
            tRNA synthetase complex: implications for its physiological
            significance
  JOURNAL   Proc Natl Acad Sci U S A 99 (12), 7912-7916 (2002)
   PUBMED   12060739
REFERENCE   7  (bases 1 to 2794)
  AUTHORS   Ko,Y.G., Kim,E.Y., Kim,T., Park,H., Park,H.S., Choi,E.J. and Kim,S.
  TITLE     Glutamine-dependent antiapoptotic interaction of human
            glutaminyl-tRNA synthetase with apoptosis signal-regulating kinase
            1
  JOURNAL   J Biol Chem 276 (8), 6030-6036 (2001)
   PUBMED   11096076
REFERENCE   8  (bases 1 to 2794)
  AUTHORS   Ko,Y.G., Kang,Y.S., Kim,E.K., Park,S.G. and Kim,S.
  TITLE     Nucleolar localization of human methionyl-tRNA synthetase and its
            role in ribosomal RNA synthesis
  JOURNAL   J Cell Biol 149 (3), 567-574 (2000)
   PUBMED   10791971
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC082002.1.
            
            On Nov 29, 2004 this sequence version replaced XM_214381.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC082002.1, SRR8487230.48662.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2794
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q32"
     gene            1..2794
                     /gene="Qars1"
                     /gene_synonym="GlnRS; Qars; RGD1562301"
                     /note="glutaminyl-tRNA synthetase 1"
                     /db_xref="GeneID:290868"
                     /db_xref="RGD:1359448"
     exon            1..469
                     /gene="Qars1"
                     /gene_synonym="GlnRS; Qars; RGD1562301"
                     /inference="alignment:Splign:2.1.0"
     CDS             353..2680
                     /gene="Qars1"
                     /gene_synonym="GlnRS; Qars; RGD1562301"
                     /EC_number="6.1.1.18"
                     /codon_start=1
                     /product="glutamine--tRNA ligase"
                     /protein_id="NP_001007625.1"
                     /db_xref="GeneID:290868"
                     /db_xref="RGD:1359448"
                     /translation="MATPDSLALFTGLGLSENKARETLKNAALSTQLREAATQAQQTL
                     GSTIDKATGTLLYGLASRLRDTRRLSFLVGYIANKKIHTELQLSAALEYVRSHPLDPI
                     DTKDFEQECGVGVVVTPEQIEEAVEATINRHRPQLLVERYRFSMGLLMGEARAALRWA
                     DGKMIKNEVDMQVLHLLGPKMEADLEKKPKVAKARLEETDRKTAKDVVENGEVAGQTL
                     SLMEQLRGEALKFHKPGENYKTPGYVTTPHTMDLLKQHLEITGGQVRTRFPPEPNGIL
                     HIGHAKAINFNFGYAKANNGICFLRFDDTNPEKEEAKFFTAIYDMVTWLGYTPYKVTY
                     ASDYFDQLYAWAVELIRRGQAYVCHQRGEELKGHNPLPSPWRDRPIEESLLLFEAMRK
                     GKFAEGEATLRMKLVMEDGKMDPVAYRVKYTPHHRTGDKWCIYPTYDYTHCLCDSIEH
                     ITHSLCTKEFQARRSSYFWLCNALDVYCPVQWEYGRLNLHYAVVSKRKILQLVAAGAV
                     RDWDDPRLFTLTALRRRGFPPEAINNFCARVGVTVAQTTMEPHLLEACVRDVLNDTAP
                     RAMAVLEPLQVVITNFPAPKPLDIRVPNFPADETKGFHQVPFASTVFIERTDFKEESE
                     PGYKRLAWGQPVGLRHTGYVIELQHVVRGSSGCVECLEVTCRRADAGEKPKAFIHWVS
                     QPLVCEIRLYERLFQHKNPEDPVEVPGGFLSDLNPASLQVIKGALVDCSVALAKPFDK
                     FQFERLGYFSVDPDSHQGQVVFNRTVTLKEDPGKV"
     exon            470..617
                     /gene="Qars1"
                     /gene_synonym="GlnRS; Qars; RGD1562301"
                     /inference="alignment:Splign:2.1.0"
     exon            618..727
                     /gene="Qars1"
                     /gene_synonym="GlnRS; Qars; RGD1562301"
                     /inference="alignment:Splign:2.1.0"
     exon            728..803
                     /gene="Qars1"
                     /gene_synonym="GlnRS; Qars; RGD1562301"
                     /inference="alignment:Splign:2.1.0"
     exon            804..868
                     /gene="Qars1"
                     /gene_synonym="GlnRS; Qars; RGD1562301"
                     /inference="alignment:Splign:2.1.0"
     exon            869..922
                     /gene="Qars1"
                     /gene_synonym="GlnRS; Qars; RGD1562301"
                     /inference="alignment:Splign:2.1.0"
     exon            923..983
                     /gene="Qars1"
                     /gene_synonym="GlnRS; Qars; RGD1562301"
                     /inference="alignment:Splign:2.1.0"
     exon            984..1055
                     /gene="Qars1"
                     /gene_synonym="GlnRS; Qars; RGD1562301"
                     /inference="alignment:Splign:2.1.0"
     exon            1056..1141
                     /gene="Qars1"
                     /gene_synonym="GlnRS; Qars; RGD1562301"
                     /inference="alignment:Splign:2.1.0"
     exon            1142..1228
                     /gene="Qars1"
                     /gene_synonym="GlnRS; Qars; RGD1562301"
                     /inference="alignment:Splign:2.1.0"
     exon            1229..1328
                     /gene="Qars1"
                     /gene_synonym="GlnRS; Qars; RGD1562301"
                     /inference="alignment:Splign:2.1.0"
     exon            1329..1407
                     /gene="Qars1"
                     /gene_synonym="GlnRS; Qars; RGD1562301"
                     /inference="alignment:Splign:2.1.0"
     exon            1408..1516
                     /gene="Qars1"
                     /gene_synonym="GlnRS; Qars; RGD1562301"
                     /inference="alignment:Splign:2.1.0"
     exon            1517..1647
                     /gene="Qars1"
                     /gene_synonym="GlnRS; Qars; RGD1562301"
                     /inference="alignment:Splign:2.1.0"
     exon            1648..1740
                     /gene="Qars1"
                     /gene_synonym="GlnRS; Qars; RGD1562301"
                     /inference="alignment:Splign:2.1.0"
     exon            1741..1878
                     /gene="Qars1"
                     /gene_synonym="GlnRS; Qars; RGD1562301"
                     /inference="alignment:Splign:2.1.0"
     exon            1879..1966
                     /gene="Qars1"
                     /gene_synonym="GlnRS; Qars; RGD1562301"
                     /inference="alignment:Splign:2.1.0"
     exon            1967..2110
                     /gene="Qars1"
                     /gene_synonym="GlnRS; Qars; RGD1562301"
                     /inference="alignment:Splign:2.1.0"
     exon            2111..2215
                     /gene="Qars1"
                     /gene_synonym="GlnRS; Qars; RGD1562301"
                     /inference="alignment:Splign:2.1.0"
     exon            2216..2308
                     /gene="Qars1"
                     /gene_synonym="GlnRS; Qars; RGD1562301"
                     /inference="alignment:Splign:2.1.0"
     exon            2309..2436
                     /gene="Qars1"
                     /gene_synonym="GlnRS; Qars; RGD1562301"
                     /inference="alignment:Splign:2.1.0"
     exon            2437..2503
                     /gene="Qars1"
                     /gene_synonym="GlnRS; Qars; RGD1562301"
                     /inference="alignment:Splign:2.1.0"
     exon            2504..2629
                     /gene="Qars1"
                     /gene_synonym="GlnRS; Qars; RGD1562301"
                     /inference="alignment:Splign:2.1.0"
     exon            2630..2769
                     /gene="Qars1"
                     /gene_synonym="GlnRS; Qars; RGD1562301"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gatagagtcg gattcctagg gctgagagag aagaggccac gcctgagtct accagcagtt
       61 ttgttgctaa acagtttccc tttccttgcc caaggcaaat tttctaaagt ctcaaggacc
      121 caaccctgcc aaccgcttag aaccgggaag gcggaagcta actgcccgga aaagccagtc
      181 cggtcgctct ccggctcata aatggcgttg actagttggc gggccccgcc tcttttcact
      241 gaggaaggcc accattggtt cgcttcaaag cttcgtattc ttattggtca atgagcaaag
      301 gtcgctgtgc agatgggccc caaagtttct tttggtttcc ggtgtccctg ctatggctac
      361 tccggattcg ctggcgctgt tcaccggcct tggccttagc gaaaacaagg cccgcgagac
      421 tctcaagaac gcggctttga gcactcagct gcgcgaggcg gcgacccagg cacagcagac
      481 tctagggtct accatcgaca aggctactgg gaccctgcta tatggcttgg cctcccgact
      541 cagggatact cggcgtcttt ctttccttgt gggctatata gccaataaga agatccacac
      601 tgagctccag ctgagcgctg ctcttgaata tgttcggagt catcccctgg atcccattga
      661 taccaaggac ttcgagcagg aatgtggtgt tggtgtggtg gtgacaccag agcagattga
      721 ggaagctgtg gaggccacca taaataggca tcgtccacag ctcttagtgg aacggtaccg
      781 gttcagcatg gggctgttaa tgggagaggc tcgggctgcg ctcagatggg cagatggcaa
      841 aatgatcaag aacgaagtgg atatgcaggt cctccacctg ctggggccca aaatggaagc
      901 tgatctggag aagaagccca aggtggcaaa ggcacggctg gaagaaacag acaggaagac
      961 agcaaaagat gtggtggaga acggtgaagt ggctggccag accctgtctc taatggagca
     1021 gctccgggga gaggccctga agtttcataa accaggtgag aactataaga cgccaggcta
     1081 tgtgaccacg ccacatacca tggatctgct aaagcagcac ctggagatca ctgggggaca
     1141 ggtacgaacc cggtttcccc cagagcccaa tggaatcctg catattggac atgccaaagc
     1201 catcaatttc aactttggtt atgccaaggc caacaacggt atttgttttc tgcgttttga
     1261 tgacaccaac cctgagaagg aagaagcgaa attctttact gctatttatg acatggtgac
     1321 ctggctgggt tacacacctt acaaagtaac atacgcttct gactattttg accagttgta
     1381 tgcctgggct gtggaactga tccgtagggg tcaagcttat gtttgtcatc agagagggga
     1441 agagctcaaa ggccataacc ctttaccttc accatggaga gaccggccta ttgaggaatc
     1501 cttgctgctc tttgaggcaa tgcgaaaggg caaatttgca gagggtgagg ccacgcttcg
     1561 aatgaagttg gtgatggaag atggaaagat ggaccctgtg gcctatcgag tcaagtatac
     1621 gccacaccat cgcacagggg ataaatggtg catctacccc acctacgact acacacactg
     1681 tctctgtgat tccatcgagc acatcaccca ctcactgtgt accaaggaat tccaggctcg
     1741 acggtcttcc tacttttggt tgtgtaatgc actggatgtc tactgccctg tccagtggga
     1801 atatggccgc ctcaatctgc actatgctgt tgtctcaaag cggaagattc tccagcttgt
     1861 ggcagctggt gctgttcggg actgggatga cccacggctc ttcacactta ctgccctacg
     1921 acgacggggt tttccacctg aggccatcaa caacttctgt gctcgggtgg gggtcacagt
     1981 ggcacagacc acaatggaac ctcatcttct ggaagcctgt gtgcgtgacg tgctgaatga
     2041 cacagccccg cgtgccatgg ctgtgctaga gccactacaa gttgtcatca ctaactttcc
     2101 tgctcccaag cccttggaca tccgagtgcc aaacttccca gctgatgaga ccaagggctt
     2161 ccaccaggtt ccttttgctt ccactgtctt cattgagaga acggacttta aggaggagtc
     2221 agaaccaggc tataagcgcc tagcctgggg ccagcctgtg ggcctgagac acactggtta
     2281 cgtcattgaa ctgcagcatg ttgtcagggg ctccagtggc tgtgtggaat gcttggaggt
     2341 gacctgtaga cgagctgatg ctggagagaa gcccaaggcc tttattcact gggtgtcaca
     2401 gcctctggtg tgtgagattc gcctctatga gcgactattc cagcacaaga accctgaaga
     2461 ccctgtcgaa gtgcctggtg gattcctaag tgacttgaac ccggcatcac tacaagtgat
     2521 taaaggagcg ttggtggact gctctgtggc tttggcaaag ccctttgaca agttccagtt
     2581 tgagcgcctt gggtacttct ctgtggatcc ggatagccat caaggacagg ttgtcttcaa
     2641 ccgaacagtc acactcaaag aagacccagg caaagtatga actgaataca tgtggcccta
     2701 cctcattctg gaggctgggg gtgccctcac caccccacac tccatttcaa taaagagtaa
     2761 ttaaatccca aaaaaaaaaa aaaaaaaaaa aaaa
//
