LOCUS       NM_001034080             535 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Rattus norvegicus peptide YY (Pyy), mRNA.
ACCESSION   NM_001034080 XM_213468
VERSION     NM_001034080.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 535)
  AUTHORS   Sridhar,A., Khan,D., Elliott,J.A., Naughton,V., Flatt,P.R.,
            Irwin,N. and Moffett,C.R.
  TITLE     RYGB surgery has modest effects on intestinal morphology and gut
            hormone populations in the bypassed biliopancreatic limb but causes
            reciprocal changes in GLP-2 and PYY in the alimentary limb
  JOURNAL   PLoS One 18 (5), e0286062 (2023)
   PUBMED   37228045
  REMARK    GeneRIF: RYGB surgery has modest effects on intestinal morphology
            and gut hormone populations in the bypassed biliopancreatic limb
            but causes reciprocal changes in GLP-2 and PYY in the alimentary
            limb.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 535)
  AUTHORS   Acar,I., Cetinkaya,A., Lay,I. and Ileri-Gurel,E.
  TITLE     The role of calcium sensing receptors in GLP-1 and PYY secretion
            after acute intraduodenal administration of L-Tryptophan in rats
  JOURNAL   Nutr Neurosci 23 (6), 481-489 (2020)
   PUBMED   30222528
  REMARK    GeneRIF: The role of calcium sensing receptors in GLP-1 and PYY
            secretion after acute intraduodenal administration of L-Tryptophan
            in rats.
REFERENCE   3  (bases 1 to 535)
  AUTHORS   Zapata,R.C., Singh,A. and Chelikani,P.K.
  TITLE     Peptide YY mediates the satiety effects of diets enriched with whey
            protein fractions in male rats
  JOURNAL   FASEB J 32 (2), 850-861 (2018)
   PUBMED   29042449
  REMARK    GeneRIF: Peptide YY mediates the satiety effects of diets enriched
            with whey protein fractions in male rats
REFERENCE   4  (bases 1 to 535)
  AUTHORS   Johnson,M.L., Saffrey,M.J. and Taylor,V.J.
  TITLE     Glucagon-like peptide-1 (GLP-1) increases in plasma and colon
            tissue prior to estrus and circulating levels change with
            increasing age in reproductively competent Wistar rats
  JOURNAL   Peptides 90, 55-62 (2017)
   PUBMED   28237410
  REMARK    GeneRIF: Additional analysis of the findings demonstrated
            significant interactions of ovarian cycle stage and fed/fasted
            status with age on GLP-1, but not PYY plasma concentrations
REFERENCE   5  (bases 1 to 535)
  AUTHORS   Ramracheya,R.D., McCulloch,L.J., Clark,A., Wiggins,D.,
            Johannessen,H., Olsen,M.K., Cai,X., Zhao,C.M., Chen,D. and
            Rorsman,P.
  TITLE     PYY-Dependent Restoration of Impaired Insulin and Glucagon
            Secretion in Type 2 Diabetes following Roux-En-Y Gastric Bypass
            Surgery
  JOURNAL   Cell Rep 15 (5), 944-950 (2016)
   PUBMED   27117413
  REMARK    GeneRIF: These findings indicate that the mechanism underlying type
            2 diabetes remission may be mediated by PYY.
REFERENCE   6  (bases 1 to 535)
  AUTHORS   Lundell,I., Blomqvist,A.G., Berglund,M.M., Schober,D.A.,
            Johnson,D., Statnick,M.A., Gadski,R.A., Gehlert,D.R. and
            Larhammar,D.
  TITLE     Cloning of a human receptor of the NPY receptor family with high
            affinity for pancreatic polypeptide and peptide YY
  JOURNAL   J Biol Chem 270 (49), 29123-29128 (1995)
   PUBMED   7493937
REFERENCE   7  (bases 1 to 535)
  AUTHORS   Rosenblum,W.M., O'Leary,D.K. and Blaker,W.J.
  TITLE     Computerized Moire analysis of progressive addition lenses
  JOURNAL   Optom Vis Sci 69 (12), 936-940 (1992)
   PUBMED   1300516
REFERENCE   8  (bases 1 to 535)
  AUTHORS   Krasinski,S.D., Wheeler,M.B. and Leiter,A.B.
  TITLE     Isolation, characterization, and developmental expression of the
            rat peptide-YY gene
  JOURNAL   Mol Endocrinol 5 (3), 433-440 (1991)
   PUBMED   1890992
REFERENCE   9  (bases 1 to 535)
  AUTHORS   Corder,R., Gaillard,R.C. and Bohlen,P.
  TITLE     Isolation and sequence of rat peptide YY and neuropeptide Y
  JOURNAL   Regul Pept 21 (3-4), 253-261 (1988)
   PUBMED   3413293
REFERENCE   10 (bases 1 to 535)
  AUTHORS   Leiter,A.B., Toder,A., Wolfe,H.J., Taylor,I.L., Cooperman,S.,
            Mandel,G. and Goodman,R.H.
  TITLE     Peptide YY. Structure of the precursor and expression in exocrine
            pancreas
  JOURNAL   J Biol Chem 262 (27), 12984-12988 (1987)
   PUBMED   3654598
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BF551062.1 and AA998735.1.
            
            On Oct 13, 2005 this sequence version replaced XM_213468.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB238226.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06680427, SAMN06680435
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-276               BF551062.1         8-283
            277-320             AA998735.1         216-259             c
            321-323             BF551062.1         328-330
            324-535             AA998735.1         1-212               c
FEATURES             Location/Qualifiers
     source          1..535
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q32.1"
     gene            1..535
                     /gene="Pyy"
                     /gene_synonym="GHYY; peptide-YY; RATGHYY; Yy"
                     /note="peptide YY"
                     /db_xref="GeneID:287730"
                     /db_xref="RGD:1593289"
     exon            1..69
                     /gene="Pyy"
                     /gene_synonym="GHYY; peptide-YY; RATGHYY; Yy"
                     /inference="alignment:Splign:2.1.0"
     CDS             70..366
                     /gene="Pyy"
                     /gene_synonym="GHYY; peptide-YY; RATGHYY; Yy"
                     /note="peptide tyrosine-tyrosine (YY); peptide tyrosine
                     tyrosine"
                     /codon_start=1
                     /product="peptide YY precursor"
                     /protein_id="NP_001029252.1"
                     /db_xref="GeneID:287730"
                     /db_xref="RGD:1593289"
                     /translation="MVAVRRPWPVMVAMLLVLLACLGALVDAYPAKPEAPGEDASPEE
                     LSRYYASLRHYLNLVTRQRYGKREVPAALFSKLLFTDDSENLPFRSRPEGVDQW"
     exon            70..257
                     /gene="Pyy"
                     /gene_synonym="GHYY; peptide-YY; RATGHYY; Yy"
                     /inference="alignment:Splign:2.1.0"
     exon            258..341
                     /gene="Pyy"
                     /gene_synonym="GHYY; peptide-YY; RATGHYY; Yy"
                     /inference="alignment:Splign:2.1.0"
     exon            342..522
                     /gene="Pyy"
                     /gene_synonym="GHYY; peptide-YY; RATGHYY; Yy"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtccagccct cgagcttctc ctgccttcca tctcctcctg ctcatctcgc ttcaggagct
       61 gtagctgcta tggtggcggt acgcaggcct tggcccgtta tggtcgcaat gctgcttgtc
      121 ctgctcgcct gcctgggagc gctggtggac gcctaccccg ctaaaccaga ggctccgggc
      181 gaagatgcct ccccggagga gctgagccgc tactatgctt ccctgcgcca ctacctcaac
      241 ctggtcaccc ggcagcggta tgggaaaaga gaagtccccg cagctctgtt ctccaaactg
      301 ctcttcacag acgacagcga gaatctcccc ttcaggtctc ggccagaagg tgtggaccag
      361 tggtgaagac ccccaaggcc tcccgtgaga tgtgctaact acaccgactt cacttgcatg
      421 tttggtttaa gaagagggga cttcgtgtct cagacaccca ggctggaggg ctgtgtgtgt
      481 tcatgtcccc gtcctcaaat aaaaagcaaa tttcgcacaa aaaaaaaaaa aaaaa
//
