LOCUS       NM_012638               2862 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus glycogen phosphorylase, muscle associated (Pygm),
            mRNA.
ACCESSION   NM_012638 XM_001076049 XM_342002
VERSION     NM_012638.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2862)
  AUTHORS   Pinacho,R., Vila,E., Prades,R., Tarrago,T., Castro,E., Ferrer,I.
            and Ramos,B.
  TITLE     The glial phosphorylase of glycogen isoform is reduced in the
            dorsolateral prefrontal cortex in chronic schizophrenia
  JOURNAL   Schizophr Res 177 (1-3), 37-43 (2016)
   PUBMED   27156240
  REMARK    GeneRIF: Results show that PYGM and RAC1 are altered in the
            dorsolateral prefrontal cortex in chronic schizophrenia and are
            controlled by NMDA signaling in the rodent cortex and cortical
            astrocytes suggesting an altered NMDA-dependent glycogenolysis in
            astrocytes in schizophrenia.
REFERENCE   2  (bases 1 to 2862)
  AUTHORS   Dairou,J., Pluvinage,B., Noiran,J., Petit,E., Vinh,J., Haddad,I.,
            Mary,J., Dupret,J.M. and Rodrigues-Lima,F.
  TITLE     Nitration of a critical tyrosine residue in the allosteric
            inhibitor site of muscle glycogen phosphorylase impairs its
            catalytic activity
  JOURNAL   J Mol Biol 372 (4), 1009-1021 (2007)
   PUBMED   17689562
REFERENCE   3  (bases 1 to 2862)
  AUTHORS   Birch,A.M., Kenny,P.W., Oikonomakos,N.G., Otterbein,L.,
            Schofield,P., Whittamore,P.R. and Whalley,D.P.
  TITLE     Development of potent, orally active
            1-substituted-3,4-dihydro-2-quinolone glycogen phosphorylase
            inhibitors
  JOURNAL   Bioorg Med Chem Lett 17 (2), 394-399 (2007)
   PUBMED   17095214
REFERENCE   4  (bases 1 to 2862)
  AUTHORS   Bouhamdan,M., Yan,H.D., Yan,X.H., Bannon,M.J. and Andrade,R.
  TITLE     Brain-specific regulator of G-protein signaling 9-2 selectively
            interacts with alpha-actinin-2 to regulate calcium-dependent
            inactivation of NMDA receptors
  JOURNAL   J Neurosci 26 (9), 2522-2530 (2006)
   PUBMED   16510730
REFERENCE   5  (bases 1 to 2862)
  AUTHORS   Kim,K.J., Moriyama,K., Han,K.R., Sharma,M., Han,X., Xie,G.X. and
            Palmer,P.P.
  TITLE     Differential expression of the regulator of G protein signaling
            RGS9 protein in nociceptive pathways of different age rats
  JOURNAL   Brain Res Dev Brain Res 160 (1), 28-39 (2005)
   PUBMED   16153714
REFERENCE   6  (bases 1 to 2862)
  AUTHORS   Johnson,L.N.
  TITLE     Glycogen phosphorylase: control by phosphorylation and allosteric
            effectors
  JOURNAL   FASEB J 6 (6), 2274-2282 (1992)
   PUBMED   1544539
  REMARK    Review article
REFERENCE   7  (bases 1 to 2862)
  AUTHORS   Crerar,M.M., Hudson,J.W., Matthews,K.E., David,E.S. and
            Golding,G.B.
  TITLE     Studies on the expression and evolution of the glycogen
            phosphorylase gene family in the rat
  JOURNAL   Genome 30 (4), 582-590 (1988)
   PUBMED   3209063
REFERENCE   8  (bases 1 to 2862)
  AUTHORS   Osawa,S., Chiu,R.H., McDonough,A., Miller,T.B. Jr. and Johnson,G.L.
  TITLE     Isolation of partial cDNAs for rat liver and muscle glycogen
            phosphorylase isozymes
  JOURNAL   FEBS Lett 202 (2), 282-288 (1986)
   PUBMED   2424788
REFERENCE   9  (bases 1 to 2862)
  AUTHORS   Hwang,P.K., See,Y.P., Vincentini,A.M., Powers,M.A., Fletterick,R.J.
            and Crerar,M.M.
  TITLE     Comparative sequence analysis of rat, rabbit, and human muscle
            glycogen phosphorylase cDNAs
  JOURNAL   Eur J Biochem 152 (2), 267-274 (1985)
   PUBMED   3840433
REFERENCE   10 (bases 1 to 2862)
  AUTHORS   Dietz,M.R., Chiasson,J.L., Soderling,T.R. and Exton,J.H.
  TITLE     Epinephrine regulation of skeletal muscle glycogen metabolism.
            Studies utilizing the perfused rat hindlimb preparation
  JOURNAL   J Biol Chem 255 (6), 2301-2307 (1980)
   PUBMED   6244274
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CR754132.1, CB803241.1, CR754647.1, CK357376.1, CB766603.1 and
            CK358095.1.
            
            On or before Oct 12, 2007 this sequence version replaced
            XM_342002.3, XM_001076049.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L10669.1, BC161897.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-711               CR754132.1         1-711
            712-1091            CB803241.1         31-410
            1092-1565           CR754647.1         155-628
            1566-2020           CK357376.1         272-726
            2021-2341           CB766603.1         97-417
            2342-2862           CK358095.1         1-521               c
FEATURES             Location/Qualifiers
     source          1..2862
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q43"
     gene            1..2862
                     /gene="Pygm"
                     /gene_synonym="Muscpho"
                     /note="glycogen phosphorylase, muscle associated"
                     /db_xref="GeneID:24701"
                     /db_xref="RGD:3461"
     exon            1..290
                     /gene="Pygm"
                     /gene_synonym="Muscpho"
                     /inference="alignment:Splign:2.1.0"
     CDS             48..2576
                     /gene="Pygm"
                     /gene_synonym="Muscpho"
                     /EC_number="2.4.1.1"
                     /note="myophosphorylase; Phosphorylase, glycogen; muscle
                     (McArdle syndrome); Phosphorylase glycogen; phosphorylase,
                     glycogen, muscle; muscle glycogen phosphorylase"
                     /codon_start=1
                     /product="glycogen phosphorylase, muscle form"
                     /protein_id="NP_036770.1"
                     /db_xref="GeneID:24701"
                     /db_xref="RGD:3461"
                     /translation="MSRPLSDQDKRKQISVRGLAGVENVSDLKKNFNRHLHFTLVKDR
                     NVATPRDYYFALAHTVRDHLVGRWIRTQQHYYEKDPKRIYYLSLEFYMGRTLQNTMVN
                     LALENACDEATYQLGLDMEELEEIEEDAGLGNGGLGRLAACFLDSMATLGLAAYGYGI
                     RYEFGIFNQKICGGWQMEEADDWLRYGNPWEKARPEFTLPVHFYGRVEHTSQGAKWVD
                     TQVVLAMPYDTPVPGYRNNVVNTMRLWSAKAPNDFNLKDFNVGGYIQAVLDRNLAENI
                     SRVLYPNDNFFEGKELRLKQEYFVVAATLQDIIRRFKSSKFGCRDPVRTNFDAFPDKV
                     AIQLNDTHPSLAIPELMRILVDLERLDWDKAWDVTVKTCAYTNHTVLPEALERWPVHL
                     METLLPRHLQIIYEINQRFLNRVAAAFPGDVDRLRRMSLVEEGAVKRINMAHLCIAGS
                     HAVNGVARIHSEILKKTIFKDFYELEPHKFQNKTNGITPRRWLVLCNPGLAEVIAERI
                     GEEYISDLDQLRKLLSYVDDEAFIRDVAKVKQENKLKFSAYLEREYKVHINPNSLFDV
                     QVKRIHEYKRQLLNCLHIITLYNRIKREPNRFMVPRTIMIGGKAAPGYHMAKMIIKLI
                     TAIGDVVNHDPAVGDRLRVIFLENYRVSLAEKVIPAADLSEQISTAGTEASGTGNMKF
                     MLNGALTIGTMDGANVEMAEEAGEDNFFIFGMRVEDVERLDQRGYNAQEYYDRIPELR
                     QIIEQLSSGFFSPKQPDLFKDIVNMLMHHDRFKVFADYEEYIKCQDKVSELYKNPREW
                     TRMVIRNIATSGKFSSDRTIAQYAREIWGVEPSRQRLPAPDEKI"
     exon            291..392
                     /gene="Pygm"
                     /gene_synonym="Muscpho"
                     /inference="alignment:Splign:2.1.0"
     exon            393..471
                     /gene="Pygm"
                     /gene_synonym="Muscpho"
                     /inference="alignment:Splign:2.1.0"
     exon            472..575
                     /gene="Pygm"
                     /gene_synonym="Muscpho"
                     /inference="alignment:Splign:2.1.0"
     exon            576..707
                     /gene="Pygm"
                     /gene_synonym="Muscpho"
                     /inference="alignment:Splign:2.1.0"
     exon            708..819
                     /gene="Pygm"
                     /gene_synonym="Muscpho"
                     /inference="alignment:Splign:2.1.0"
     exon            820..902
                     /gene="Pygm"
                     /gene_synonym="Muscpho"
                     /inference="alignment:Splign:2.1.0"
     exon            903..1046
                     /gene="Pygm"
                     /gene_synonym="Muscpho"
                     /inference="alignment:Splign:2.1.0"
     exon            1047..1139
                     /gene="Pygm"
                     /gene_synonym="Muscpho"
                     /inference="alignment:Splign:2.1.0"
     exon            1140..1286
                     /gene="Pygm"
                     /gene_synonym="Muscpho"
                     /inference="alignment:Splign:2.1.0"
     exon            1287..1450
                     /gene="Pygm"
                     /gene_synonym="Muscpho"
                     /inference="alignment:Splign:2.1.0"
     exon            1451..1565
                     /gene="Pygm"
                     /gene_synonym="Muscpho"
                     /inference="alignment:Splign:2.1.0"
     exon            1566..1667
                     /gene="Pygm"
                     /gene_synonym="Muscpho"
                     /inference="alignment:Splign:2.1.0"
     exon            1668..1815
                     /gene="Pygm"
                     /gene_synonym="Muscpho"
                     /inference="alignment:Splign:2.1.0"
     exon            1816..1874
                     /gene="Pygm"
                     /gene_synonym="Muscpho"
                     /inference="alignment:Splign:2.1.0"
     exon            1875..2016
                     /gene="Pygm"
                     /gene_synonym="Muscpho"
                     /inference="alignment:Splign:2.1.0"
     exon            2017..2224
                     /gene="Pygm"
                     /gene_synonym="Muscpho"
                     /inference="alignment:Splign:2.1.0"
     exon            2225..2359
                     /gene="Pygm"
                     /gene_synonym="Muscpho"
                     /inference="alignment:Splign:2.1.0"
     exon            2360..2426
                     /gene="Pygm"
                     /gene_synonym="Muscpho"
                     /inference="alignment:Splign:2.1.0"
     exon            2427..2841
                     /gene="Pygm"
                     /gene_synonym="Muscpho"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcaccgaag ccatcatctg ccctgttcgg cccaccctcc cgcagccatg tccaggcctc
       61 tttcagacca ggataagaga aagcaaatca gtgttcgtgg cctagctggc gtggaaaatg
      121 tgtctgacct gaaaaagaac ttcaaccgcc acctacattt caccctggtc aaggatcgca
      181 atgtggccac tccgagagat tactatttcg cactggctca caccgtgcgg gaccacctcg
      241 tgggacgctg gatccgcaca cagcagcatt actacgaaaa ggaccccaag aggatctact
      301 acctgtcttt ggagttctac atggggagga cactgcagaa caccatggtg aacctggcct
      361 tggagaatgc ctgcgatgag gccacctacc agctgggtct ggacatggag gagctggagg
      421 agatcgagga ggatgcaggg ttgggcaatg gaggcctggg acgcctggca gcttgcttcc
      481 tggactccat ggctacactg gggctagctg cctatggcta cgggatccgc tatgagtttg
      541 ggatttttaa tcagaagatc tgtgggggct ggcagatgga agaagctgat gactggcttc
      601 gctatggcaa cccctgggag aaggcccgcc cagagttcac gctgcctgtg cacttctacg
      661 gtcgagtgga gcacaccagt cagggtgcca agtgggtgga cacacaggta gtgttggcta
      721 tgccctatga cactcctgtg cctggctatc gaaacaacgt tgtcaacacc atgcgcctct
      781 ggtcggccaa ggcacctaat gacttcaacc tcaaggactt caacgttggc ggctacatcc
      841 aggccgtgct ggaccgaaac ctggctgaga acatctcacg tgttttgtac cccaatgata
      901 acttctttga agggaaggaa ttgcggctga agcaggagta ctttgtggtg gccgccaccc
      961 tccaggacat cattcgccgt ttcaagtcct ccaagtttgg ctgccgtgat cctgtgcgca
     1021 caaactttga tgctttccct gataaggtgg ccatccagct caacgacacc cacccttctt
     1081 tggccatccc tgaactgatg aggattctgg tggacctgga acgactggac tgggacaagg
     1141 cctgggatgt gacagtgaag acctgtgcct acaccaacca cacagtgctg cctgaagccc
     1201 tggagcgctg gccagtgcac ctcatggaga cactgcttcc ccgccatctg cagatcattt
     1261 atgagatcaa ccagcgtttc cttaatcggg tggcggccgc attccctggg gacgtagata
     1321 ggctgcggcg catgtcactc gtggaggaag gagcggtgaa acgcatcaac atggcacact
     1381 tgtgcattgc tggttcccac gcagtcaacg gtgtggctcg catccattcg gagatcctca
     1441 agaaaaccat cttcaaggac ttttatgagc tggagcctca caagttccag aacaagacca
     1501 atggcatcac ccctcggcgc tggttggttc tgtgtaaccc tgggctggca gaggtcattg
     1561 ctgagcgcat cggtgaggag tacatctcgg atctggacca gctacgcaag ctgctctcct
     1621 atgtggatga tgaagccttt atccgtgatg tggccaaagt gaaacaggaa aacaagttga
     1681 aattctctgc gtacctggag agggaataca aagtccacat caaccccaac tccctcttcg
     1741 acgtccaggt gaagaggatt catgagtata aacgccagct tctcaattgc cttcacatca
     1801 tcaccttgta taaccgcatc aaaagggagc ccaataggtt catggtgcca aggactatca
     1861 tgattggagg caaggctgca cccgggtacc acatggctaa gatgatcatc aagcttatca
     1921 ccgccattgg ggatgtggtc aaccacgacc ctgcggtggg agaccgcctc cgagtgatct
     1981 tcctggagaa ctaccgagtc tcactggctg agaaagttat tcccgctgct gacctctcag
     2041 agcagatctc caccgcgggc actgaggcct caggcactgg caacatgaag ttcatgctca
     2101 acggggctct gaccatcggc accatggatg gtgccaacgt ggagatggca gaggaggctg
     2161 gggaagataa cttcttcatc ttcggcatgc gggtggagga cgtggaaagg ctggaccaga
     2221 gagggtacaa tgcccaggaa tactacgacc ggattcctga gcttcggcag atcatcgaac
     2281 agttaagcag tggcttcttc tcccctaaac agcctgacct gttcaaggac atcgtcaaca
     2341 tgctcatgca ccatgaccgg tttaaagtct ttgcagatta tgaggaatac attaaatgcc
     2401 aggacaaagt cagtgagttg tacaagaacc caagagagtg gacacggatg gtgatcagga
     2461 acatagccac ctctggcaag ttttccagtg accgtaccat tgcccagtat gcccgggaga
     2521 tctggggtgt tgaaccttct cgtcagcgcc tgccagcccc agatgagaag atctgagctt
     2581 ccacaccaga ccccatacct gcctttgagt ctgtttgcaa ttcccggaat caggcccact
     2641 ccaggggttg ggcccctgga attacatctc taccctcccc cttttggaag cctcttttac
     2701 cagtctctag gtcctgatgc cagtgtgact aaagaccctg ccctcttctt ttccctcaac
     2761 tccctacccc ctttatttat gtatggggtc taaccaagtg cacccactcc ccaataaatc
     2821 gactctccat gaccttcctt aaaaaaaaaa aaaaaaaaaa aa
//
