LOCUS       NM_022268               2715 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Rattus norvegicus glycogen phosphorylase L (Pygl), mRNA.
ACCESSION   NM_022268
VERSION     NM_022268.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2715)
  AUTHORS   Wei,J., Zhang,F., Zhang,Y., Cao,C., Li,X., Li,D., Liu,X., Yang,H.
            and Huang,L.
  TITLE     Proteomic investigation of signatures for geniposide-induced
            hepatotoxicity
  JOURNAL   J Proteome Res 13 (12), 5724-5733 (2014)
   PUBMED   25336395
  REMARK    GeneRIF: Data show that two biomarkers, glycine N-methyltransferase
            (GNMT) and glycogen phosphorylase (PYGL), were found to indicate
            early hepatic injuries.
REFERENCE   2  (bases 1 to 2715)
  AUTHORS   Archambaud,C., Nahori,M.A., Soubigou,G., Becavin,C., Laval,L.,
            Lechat,P., Smokvina,T., Langella,P., Lecuit,M. and Cossart,P.
  TITLE     Impact of lactobacilli on orally acquired listeriosis
  JOURNAL   Proc Natl Acad Sci U S A 109 (41), 16684-16689 (2012)
   PUBMED   23012479
REFERENCE   3  (bases 1 to 2715)
  AUTHORS   Zhang,T., Wang,S., Lin,Y., Xu,W., Ye,D., Xiong,Y., Zhao,S. and
            Guan,K.L.
  TITLE     Acetylation negatively regulates glycogen phosphorylase by
            recruiting protein phosphatase 1
  JOURNAL   Cell Metab 15 (1), 75-87 (2012)
   PUBMED   22225877
REFERENCE   4  (bases 1 to 2715)
  AUTHORS   Davit-Spraul,A., Piraud,M., Dobbelaere,D., Valayannopoulos,V.,
            Labrune,P., Habes,D., Bernard,O., Jacquemin,E. and Baussan,C.
  TITLE     Liver glycogen storage diseases due to phosphorylase system
            deficiencies: diagnosis thanks to non invasive blood enzymatic and
            molecular studies
  JOURNAL   Mol Genet Metab 104 (1-2), 137-143 (2011)
   PUBMED   21646031
REFERENCE   5  (bases 1 to 2715)
  AUTHORS   Zhang,D.W., Shao,J., Lin,J., Zhang,N., Lu,B.J., Lin,S.C., Dong,M.Q.
            and Han,J.
  TITLE     RIP3, an energy metabolism regulator that switches TNF-induced cell
            death from apoptosis to necrosis
  JOURNAL   Science 325 (5938), 332-336 (2009)
   PUBMED   19498109
REFERENCE   6  (bases 1 to 2715)
  AUTHORS   Schiebel,K., Pekel,E. and Mayer,D.
  TITLE     The nucleotide sequence of rat liver glycogen phosphorylase cDNA
  JOURNAL   Biochim Biophys Acta 1130 (3), 349-351 (1992)
   PUBMED   1339293
REFERENCE   7  (bases 1 to 2715)
  AUTHORS   Mayer,D., Seelmann-Eggebert,G. and Letsch,I.
  TITLE     Glycogen phosphorylase isoenzymes from hepatoma 3924A and from a
            non-tumorigenic liver cell line. Comparison with the liver and
            brain enzymes
  JOURNAL   Biochem J 282 (Pt 3) (Pt 3), 665-673 (1992)
   PUBMED   1554349
REFERENCE   8  (bases 1 to 2715)
  AUTHORS   Johnson,L.N.
  TITLE     Glycogen phosphorylase: control by phosphorylation and allosteric
            effectors
  JOURNAL   FASEB J 6 (6), 2274-2282 (1992)
   PUBMED   1544539
  REMARK    Review article
REFERENCE   9  (bases 1 to 2715)
  AUTHORS   Carabaza,A., Ciudad,C.J., Baque,S. and Guinovart,J.J.
  TITLE     Glucose has to be phosphorylated to activate glycogen synthase, but
            not to inactivate glycogen phosphorylase in hepatocytes
  JOURNAL   FEBS Lett 296 (2), 211-214 (1992)
   PUBMED   1733780
REFERENCE   10 (bases 1 to 2715)
  AUTHORS   Katz,J., Golden,S. and Wals,P.A.
  TITLE     Glycogen synthesis by rat hepatocytes
  JOURNAL   Biochem J 180 (2), 389-402 (1979)
   PUBMED   114169
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from X63515.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X63515.1, BC070901.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760494 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2715
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q24"
     gene            1..2715
                     /gene="Pygl"
                     /note="glycogen phosphorylase L"
                     /db_xref="GeneID:64035"
                     /db_xref="RGD:620687"
     exon            1..258
                     /gene="Pygl"
                     /inference="alignment:Splign:2.1.0"
     CDS             16..2568
                     /gene="Pygl"
                     /EC_number="2.4.1.1"
                     /note="liver glycogen phosphorylase; phosphorylase,
                     glycogen, liver"
                     /codon_start=1
                     /product="glycogen phosphorylase, liver form"
                     /protein_id="NP_071604.1"
                     /db_xref="GeneID:64035"
                     /db_xref="RGD:620687"
                     /translation="MAKPLTDQEKRRQISIRGIVGVENVAELKKGFNRHLHFTLVKDR
                     NVATPRDYYFALAHTVRDHLVGRWIRTQQHYYDKCPKRVYYLSLEFYMGRTLQNTMIN
                     LGLQNACDEAIYQLGLDMEELEEIEEDAGLGNGGLGRLAACFLDSMATLGLAAYGYGI
                     RYEYGIFNQKIREGWQVEEADDWLRHGNPWEKARPEFMLPVHFYGRVEHTQAGTKWVD
                     TQVVLALPYDTPVPGYMNNTVNTMRLWSARAPNDFNLQDFNVGDYIQAVLDRNLAENI
                     SRVLYPNDNFFEGKELRLKQEYFVVAATLQDVIRRFKASKFGSKDGVGTVFDAFPDQV
                     AIQLNDTHPALAIPELMRIFVDIEKLPWSKAWEITKKTFAYTNHTVLPEALERWPVDL
                     VEKLLPRHLQIIYEINQKHLDRIVALFPKDIDRMRRMSLIEEEGGKRINMAHLCIVGC
                     HAVNGVAKIHSDIVKTQVFKDFSELEPDKFQNKTNGITPRRWLLLCNPGLADLIAEKI
                     GEDYVKDLSQLTKLHSFVGDDIFLREIAKVKQENKLKFSQFLEKEYKVKINPSSMFDV
                     HVKRIHEYKRQLLNCLHVITMYNRIKKDPKKFFVPRTVIIGGKAAPGYHMAKMIIKLV
                     TSVAEVVNNDPMVGSKLKVIFLENYRVSLAEKVIPATDLSEQISTAGTEASGTGNMKF
                     MLNGALTIGTMDGANVEMAEEAGEENLFIFGMRVDDVAALDKKGYEAKEYYEALPELK
                     LVIDQIDNGFFSPNQPDLFKDIINMLFYHDRFKVFADYEAYVKCQEKVSQLYMNQKAW
                     NTMVLRNIAASGKFSSDRTIREYAKDIWNMEPSDLKISLSKESSNGVNANGK"
     exon            259..360
                     /gene="Pygl"
                     /inference="alignment:Splign:2.1.0"
     exon            361..439
                     /gene="Pygl"
                     /inference="alignment:Splign:2.1.0"
     exon            440..543
                     /gene="Pygl"
                     /inference="alignment:Splign:2.1.0"
     exon            544..675
                     /gene="Pygl"
                     /inference="alignment:Splign:2.1.0"
     exon            676..787
                     /gene="Pygl"
                     /inference="alignment:Splign:2.1.0"
     exon            788..870
                     /gene="Pygl"
                     /inference="alignment:Splign:2.1.0"
     exon            871..1014
                     /gene="Pygl"
                     /inference="alignment:Splign:2.1.0"
     exon            1015..1107
                     /gene="Pygl"
                     /inference="alignment:Splign:2.1.0"
     exon            1108..1254
                     /gene="Pygl"
                     /inference="alignment:Splign:2.1.0"
     exon            1255..1418
                     /gene="Pygl"
                     /inference="alignment:Splign:2.1.0"
     exon            1419..1533
                     /gene="Pygl"
                     /inference="alignment:Splign:2.1.0"
     exon            1534..1635
                     /gene="Pygl"
                     /inference="alignment:Splign:2.1.0"
     exon            1636..1783
                     /gene="Pygl"
                     /inference="alignment:Splign:2.1.0"
     exon            1784..1842
                     /gene="Pygl"
                     /inference="alignment:Splign:2.1.0"
     exon            1843..1984
                     /gene="Pygl"
                     /inference="alignment:Splign:2.1.0"
     exon            1985..2192
                     /gene="Pygl"
                     /inference="alignment:Splign:2.1.0"
     exon            2193..2327
                     /gene="Pygl"
                     /inference="alignment:Splign:2.1.0"
     exon            2328..2394
                     /gene="Pygl"
                     /inference="alignment:Splign:2.1.0"
     exon            2395..2712
                     /gene="Pygl"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccgccacccg caaccatggc gaagcccttg accgaccagg aaaagcgacg gcagatcagc
       61 atccgcggca tcgtgggcgt ggagaacgta gcggagctga aaaagggctt caatcgtcac
      121 ctgcacttca ctctggtcaa ggaccgcaat gtggccaccc cccgcgacta ctacttcgcc
      181 cttgcgcaca cagtgcgcga ccacctggtg gggcgctgga tccgcacaca gcagcactac
      241 tatgacaagt gccccaagag ggtgtattac ctctctctgg aattttacat gggccgaaca
      301 ttacagaaca ccatgatcaa ccttggctta cagaatgcct gcgacgaagc tatttaccag
      361 ctcgggctgg acatggagga gttggaagaa attgaagaag atgctgggct tggcaatggt
      421 ggtcttggga ggcttgctgc ctgcttcttg gactccatgg caacgctggg gcttgcagcc
      481 tatggatacg gcatccgtta tgaatatgga atcttcaatc agaagatccg agaagggtgg
      541 caggtagagg aggcagatga ctggctcagg catggaaacc cttgggagaa ggctcgtcct
      601 gaattcatgc tgcctgtgca tttctacgga agagtagagc acacccaggc aggaacaaag
      661 tgggtcgaca cccaggtggt gctggctttg ccgtacgaca cccccgtacc tgggtatatg
      721 aacaacacgg tgaacactat gcgcctctgg tcggcccgag cacccaatga ctttaacctt
      781 caagacttta atgtcggaga ctacattcag gctgtgctgg accggaacct ggctgagaat
      841 atctccagag tgctgtaccc caacgataac ttttttgaag ggaaggagct gaggctgaag
      901 caggagtact ttgtggtggc tgcgaccctg caggatgtca tccgacgttt caaggcctcc
      961 aagttcggct ccaaggatgg tgtaggaacc gtgtttgatg cttttccaga tcaggtagcc
     1021 atccagctga atgacacaca tcccgcactc gccatcccgg agctgatgag gatctttgtg
     1081 gacattgaaa aattgccctg gtccaaggcc tgggagatca ccaagaagac ctttgcctac
     1141 accaaccaca cggtgctccc ggaggccctg gagcgctggc cagtggacct ggtggagaag
     1201 ctgctgcctc gacacttgca gatcatttat gagatcaatc agaagcattt agatagaatc
     1261 gtggccctgt ttcctaaaga catcgaccgc atgcggcgga tgtctctcat cgaagaggaa
     1321 ggaggcaaaa ggatcaacat ggcccacctc tgcatcgtgg gctgccacgc ggtgaacggg
     1381 gtagcgaaga tccactcgga catcgtgaag acccaagtat tcaaggactt cagtgagcta
     1441 gaaccagaca agttccagaa taaaaccaac gggatcaccc cgaggcgctg gctcttactc
     1501 tgcaacccag ggctggctga cttgatagca gagaaaattg gagaagacta tgtgaaagac
     1561 ctgagccagc tgacgaagct ccacagcttc gtgggcgacg acatcttcct ccgggaaata
     1621 gccaaagtga agcaggaaaa taaactgaaa ttctcccagt tcctggaaaa ggagtacaag
     1681 gtgaagatca acccatcttc catgtttgac gtgcacgtga agcggatcca cgagtacaaa
     1741 cgacagcttc tgaactgcct gcatgtgatc accatgtaca atcgcatcaa gaaagaccct
     1801 aagaagttct tcgtgccaag gacagtcata attggtggga aagctgcccc aggatatcac
     1861 atggccaaaa tgatcataaa gctggtcacc tccgtggcag aagtggtgaa caacgaccct
     1921 atggttggca gcaagttgaa agtcatcttc ttggagaact acagagtgtc tcttgctgaa
     1981 aaagtcattc cagccacgga cctgtcagaa cagatctcca ctgctggcac ggaagcctcg
     2041 gggacgggca acatgaagtt catgctgaac ggggccctga ccatcgggac tatggatggg
     2101 gccaatgtgg agatggcgga ggaggccggg gaggaaaacc tgttcatctt tggcatgagg
     2161 gtagatgatg tggccgctct ggacaagaaa gggtatgagg ccaaagaata ttatgaggcc
     2221 cttccagaac tgaagctggt cattgaccaa attgacaatg gcttcttttc tcccaatcag
     2281 ccagacctct tcaaagacat catcaacatg ttattttatc atgacagatt taaagtcttt
     2341 gcagactacg aagcctatgt caagtgtcaa gaaaaagtca gtcagctgta tatgaatcaa
     2401 aaagcctgga acacaatggt tctcagaaac atagctgcct cggggaagtt ctccagtgac
     2461 cgaacaatca gggagtatgc caaggacatc tggaacatgg agccttccga tctgaagatc
     2521 tccctatcta aggagtccag caatggggtc aacgccaatg ggaagtaaat gctaaaatat
     2581 attcttattc aataacttct tactggactt gagtactctt agagcttccc tgagtctgtt
     2641 ttgttattga atggttagta aatgtatttc tgtattagag ctaaaaataa aatgtcaact
     2701 tcgagttgtc aaaaa
//
