LOCUS       NM_013188               3873 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Rattus norvegicus glycogen phosphorylase B (Pygb), mRNA.
ACCESSION   NM_013188 XM_001057365 XM_342542
VERSION     NM_013188.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3873)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   2  (bases 1 to 3873)
  AUTHORS   Dienel,G.A., Ball,K.K. and Cruz,N.F.
  TITLE     A glycogen phosphorylase inhibitor selectively enhances local rates
            of glucose utilization in brain during sensory stimulation of
            conscious rats: implications for glycogen turnover
  JOURNAL   J Neurochem 102 (2), 466-478 (2007)
   PUBMED   17442042
  REMARK    GeneRIF: Thus, glycogen is an active fuel for specific structures
            in normal activated brain, not simply an emergency fuel depot and
            flux-generated pyruvate greatly exceeded net accumulation of
            lactate or net consumption of glycogen during activation. T
REFERENCE   3  (bases 1 to 3873)
  AUTHORS   Pfeiffer-Guglielmi,B., Francke,M., Reichenbach,A. and Hamprecht,B.
  TITLE     Glycogen phosphorylase isozymes and energy metabolism in the rat
            peripheral nervous system--an immunocytochemical study
  JOURNAL   Brain Res 1136 (1), 20-27 (2007)
   PUBMED   17239832
REFERENCE   4  (bases 1 to 3873)
  AUTHORS   Birch,A.M., Kenny,P.W., Oikonomakos,N.G., Otterbein,L.,
            Schofield,P., Whittamore,P.R. and Whalley,D.P.
  TITLE     Development of potent, orally active
            1-substituted-3,4-dihydro-2-quinolone glycogen phosphorylase
            inhibitors
  JOURNAL   Bioorg Med Chem Lett 17 (2), 394-399 (2007)
   PUBMED   17095214
REFERENCE   5  (bases 1 to 3873)
  AUTHORS   Pfeiffer-Guglielmi,B., Coles,J.A., Francke,M., Reichenbach,A.,
            Fleckenstein,B., Jung,G., Nicaise,G. and Hamprecht,B.
  TITLE     Immunocytochemical analysis of rat vagus nerve by antibodies
            against glycogen phosphorylase isozymes
  JOURNAL   Brain Res 1110 (1), 23-29 (2006)
   PUBMED   16879805
  REMARK    GeneRIF: We have demonstrated immunocytochemically the presence of
            glycogen phosphorylase, brain form in large and small axons of the
            rat vagus nerve, but not in Schwann cells.
REFERENCE   6  (bases 1 to 3873)
  AUTHORS   Lomako,J., Lomako,W.M., Whelan,W.J., Dombro,R.S., Neary,J.T. and
            Norenberg,M.D.
  TITLE     Glycogen synthesis in the astrocyte: from glycogenin to proglycogen
            to glycogen
  JOURNAL   FASEB J 7 (14), 1386-1393 (1993)
   PUBMED   8224611
REFERENCE   7  (bases 1 to 3873)
  AUTHORS   Hudson,J.W., Hefferon,K.L. and Crerar,M.M.
  TITLE     Comparative analysis of species-independent, isozyme-specific
            amino-acid substitutions in mammalian muscle, brain and liver
            glycogen phosphorylases
  JOURNAL   Biochim Biophys Acta 1164 (2), 197-208 (1993)
   PUBMED   7916624
REFERENCE   8  (bases 1 to 3873)
  AUTHORS   Mayer,D., Seelmann-Eggebert,G. and Letsch,I.
  TITLE     Glycogen phosphorylase isoenzymes from hepatoma 3924A and from a
            non-tumorigenic liver cell line. Comparison with the liver and
            brain enzymes
  JOURNAL   Biochem J 282 (Pt 3) (Pt 3), 665-673 (1992)
   PUBMED   1554349
REFERENCE   9  (bases 1 to 3873)
  AUTHORS   Johnson,L.N.
  TITLE     Glycogen phosphorylase: control by phosphorylation and allosteric
            effectors
  JOURNAL   FASEB J 6 (6), 2274-2282 (1992)
   PUBMED   1544539
  REMARK    Review article
REFERENCE   10 (bases 1 to 3873)
  AUTHORS   Crerar,M.M., Hudson,J.W., Matthews,K.E., David,E.S. and
            Golding,G.B.
  TITLE     Studies on the expression and evolution of the glycogen
            phosphorylase gene family in the rat
  JOURNAL   Genome 30 (4), 582-590 (1988)
   PUBMED   3209063
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB720204.1, L10668.1, CK357665.1, CO400919.1, CA504871.1 and
            AW535913.1.
            
            On or before Oct 13, 2007 this sequence version replaced
            XM_342542.3, XM_001057365.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L10668.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-525               CB720204.1         1-525
            526-1647            L10668.1           426-1547
            1648-2197           CK357665.1         140-689
            2198-2689           CO400919.1         323-814
            2690-3211           L10668.1           2590-3111
            3212-3849           CA504871.1         19-656              c
            3850-3873           AW535913.1         1-24                c
FEATURES             Location/Qualifiers
     source          1..3873
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q41"
     gene            1..3873
                     /gene="Pygb"
                     /gene_synonym="GLYPHOA"
                     /note="glycogen phosphorylase B"
                     /db_xref="GeneID:25739"
                     /db_xref="RGD:3460"
     exon            1..352
                     /gene="Pygb"
                     /gene_synonym="GLYPHOA"
                     /inference="alignment:Splign:2.1.0"
     CDS             110..2641
                     /gene="Pygb"
                     /gene_synonym="GLYPHOA"
                     /EC_number="2.4.1.1"
                     /note="brain glycogen phosphorylase; phosphorylase,
                     glycogen; brain"
                     /codon_start=1
                     /product="glycogen phosphorylase, brain form"
                     /protein_id="NP_037320.1"
                     /db_xref="GeneID:25739"
                     /db_xref="RGD:3460"
                     /translation="MAKPLTDSERQKQISVRGIAGLGDVAEVRKSFNRHLHFTLVKDR
                     NVATPRDYFFALAHTVRDHLVGRWIRTQQHYYERDPKRIYYLSLEFYMGRTLQNTMVN
                     LGLQTACDEATYQLGLDLEELEEIEEDAGLGNGGLGRLAACFLDSMATLGLAAYGYGI
                     RYEFGIFNQKIVNGWQVEEADDWLRYGNPWEKARPEYMLPVHFYGRVEHTPNGVLWLD
                     TQVVLAMPYDTPVPGYKNNTVNTMRLWSAKAPNDFKLKDFNVGDYIEAVLDRNLAENI
                     SRVLYPNDNFFEGKELRLKQEYFVVAATLQDIIRRFKSSKFGCRDPVRTCFETFPDKV
                     AIQLNDTHPALSIPELMRILVDVEKVDWDKAWEITKKTCAYTNHTVLPEALERWPVSM
                     FEKLLPRHLEIIYAINQRHLDHVAALFPGDVDRLRRMSVIEEGDCKRINMAHLCVIGS
                     HAVNGVARIHSEIVKQSVFKDFYELEPEKFQNKTNGITPRRWLLLCNPGLAEIIVERI
                     GEGFLTDLSQLKKLLSLVDDEAFIRDVAKVKQENKLKFSAQLEKEYKVKINPASMFDV
                     HVKRIHEYKRQLLNCLHIITLYNRIKKDPTKTFVPRTVMIGGKAAPGYHMAKMIIKLV
                     TSIGDVVNHDPVVGDRLRVIFLENYRVSLAEKVIPAADLSQQISTAGTEASGTGNMKF
                     MLNGALTIGTMDGANVEMAEEAGEENLFIFGMRVEDVEALDQKGYNAREFYERLPELR
                     QAVDQISSGFFSPKDPDCFKDVVNMLMYHDRFKVFADYEAYIQCQAQVDHLYRNPKDW
                     TKKVIRNIACSGKFSSDRTITEYAREIWGVEPSDLQIPPPNLPKD"
     exon            353..454
                     /gene="Pygb"
                     /gene_synonym="GLYPHOA"
                     /inference="alignment:Splign:2.1.0"
     exon            455..533
                     /gene="Pygb"
                     /gene_synonym="GLYPHOA"
                     /inference="alignment:Splign:2.1.0"
     exon            534..637
                     /gene="Pygb"
                     /gene_synonym="GLYPHOA"
                     /inference="alignment:Splign:2.1.0"
     exon            638..769
                     /gene="Pygb"
                     /gene_synonym="GLYPHOA"
                     /inference="alignment:Splign:2.1.0"
     exon            770..881
                     /gene="Pygb"
                     /gene_synonym="GLYPHOA"
                     /inference="alignment:Splign:2.1.0"
     exon            882..964
                     /gene="Pygb"
                     /gene_synonym="GLYPHOA"
                     /inference="alignment:Splign:2.1.0"
     exon            965..1108
                     /gene="Pygb"
                     /gene_synonym="GLYPHOA"
                     /inference="alignment:Splign:2.1.0"
     exon            1109..1201
                     /gene="Pygb"
                     /gene_synonym="GLYPHOA"
                     /inference="alignment:Splign:2.1.0"
     exon            1202..1348
                     /gene="Pygb"
                     /gene_synonym="GLYPHOA"
                     /inference="alignment:Splign:2.1.0"
     exon            1349..1512
                     /gene="Pygb"
                     /gene_synonym="GLYPHOA"
                     /inference="alignment:Splign:2.1.0"
     exon            1513..1627
                     /gene="Pygb"
                     /gene_synonym="GLYPHOA"
                     /inference="alignment:Splign:2.1.0"
     exon            1628..1729
                     /gene="Pygb"
                     /gene_synonym="GLYPHOA"
                     /inference="alignment:Splign:2.1.0"
     exon            1730..1877
                     /gene="Pygb"
                     /gene_synonym="GLYPHOA"
                     /inference="alignment:Splign:2.1.0"
     exon            1878..1936
                     /gene="Pygb"
                     /gene_synonym="GLYPHOA"
                     /inference="alignment:Splign:2.1.0"
     exon            1937..2078
                     /gene="Pygb"
                     /gene_synonym="GLYPHOA"
                     /inference="alignment:Splign:2.1.0"
     exon            2079..2286
                     /gene="Pygb"
                     /gene_synonym="GLYPHOA"
                     /inference="alignment:Splign:2.1.0"
     exon            2287..2421
                     /gene="Pygb"
                     /gene_synonym="GLYPHOA"
                     /inference="alignment:Splign:2.1.0"
     exon            2422..2488
                     /gene="Pygb"
                     /gene_synonym="GLYPHOA"
                     /inference="alignment:Splign:2.1.0"
     exon            2489..3858
                     /gene="Pygb"
                     /gene_synonym="GLYPHOA"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccggcctct gccgcagtcc ttggcgccag agacgctgca gcatctcagc actagaggct
       61 tctctgctcg ctcctggtcc atccttcgtc ctctacctca tctggcgcca tggcgaagcc
      121 attgacggac agtgagaggc agaagcagat cagtgtgcgt ggcatcgccg ggctaggcga
      181 cgtggccgag gtgcggaaga gcttcaacag gcacctgcac ttcacgctgg tcaaggaccg
      241 caatgtggcc actccccgcg actacttctt cgctctggca cacacggttc gcgaccacct
      301 agtgggccgc tggatccgca cgcaacagca ttactacgaa cgggacccca agcgtatcta
      361 ctacctttcc ctggaattct acatgggccg cacactgcag aacaccatgg tgaacctggg
      421 ccttcagact gcatgtgatg aagccactta tcagttgggg ttggacttgg aagaactaga
      481 ggaaatagag gaggatgctg gccttgggaa tggtggcctg gggcggctgg cagcttgctt
      541 ccttgattcg atggccacgc tgggtctagc tgcatatggc tatggaatcc gctatgaatt
      601 tgggattttc aaccaaaaga ttgtcaatgg ctggcaggtt gaagaagctg acgactggct
      661 gcgctacgga aacccatggg agaaggcgcg gccggagtac atgctgcctg tgcacttcta
      721 cgggagggtg gagcacaccc ctaacggtgt cctctggctg gacacacagg tggtactcgc
      781 catgccctat gacaccccag tgcctgggta taagaacaac accgtcaaca ccatgaggct
      841 ctggtctgcc aaggcaccca atgacttcaa gctgaaggac ttcaacgttg gggactacat
      901 cgaagctgtc ctggacagga acttggccga gaacatctcc agggtcctgt atcccaatga
      961 caatttcttc gagggaaagg agctgcggct gaagcaggag tactttgtgg tggccgccac
     1021 cctccaggac atcattagaa ggttcaagtc gtccaagttt ggctgccggg atccagtgag
     1081 aacctgtttc gagacattcc cagacaaggt agccatccag ctgaatgaca cccatcccgc
     1141 gctgtccatc cccgagctca tgcggatcct ggtggacgtg gagaaggtag actgggataa
     1201 ggcctgggag atcaccaaga agacctgtgc ctacaccaac cacactgtgc tgcccgaggc
     1261 cttggagcgc tggcccgtgt ctatgtttga gaagctgctg ccgcgacacc tggaaatcat
     1321 ctatgccatc aaccagaggc acctggatca cgtggctgcc ctgtttcccg gggatgtgga
     1381 ccgcttgagg aggatgtctg tgattgagga aggggactgc aagagaatca acatggcaca
     1441 cctgtgtgtg attgggtccc acgccgtgaa cggggtggca aggattcact ccgagatcgt
     1501 gaagcagtct gtcttcaagg acttttatga gctggagcca gagaagttcc agaacaagac
     1561 caatggtatc acgccccgac ggtggctgct cttgtgcaat ccggggctgg cagaaatcat
     1621 tgtggagaga atcggggaag gtttcctgac tgatctgagc caactgaaga agctgctgtc
     1681 actggttgat gatgaggcct tcatcaggga tgtagccaag gtcaagcagg aaaacaagct
     1741 gaagttctct gcccagctag agaaggaata caaggtgaag atcaaccctg cgtccatgtt
     1801 tgatgtgcac gtcaagagga tccacgagta caagcggcag ctgctcaact gcttacacat
     1861 catcaccctg tacaaccgaa taaagaagga tccaaccaag acctttgtgc ccaggactgt
     1921 tatgatcgga ggcaaggcag ctcctggtta ccacatggct aagatgatca tcaagctggt
     1981 cacatccatt ggagatgttg tcaatcatga tccagttgtg ggcgacaggc tcagagtgat
     2041 cttcctggag aactaccgtg tgtctttagc tgagaaagtg atcccagccg ccgacctgtc
     2101 acagcagatc tccactgcgg gcaccgaggc ctcgggcacc ggcaacatga agttcatgct
     2161 caacggagct ctcaccatcg gcaccatgga tggtgccaac gtggagatgg ccgaggaggc
     2221 cggggaggag aacctcttca tctttggtat gcgggtggaa gatgttgagg ccttggacca
     2281 gaaagggtac aatgccagag aattctacga gcgcctgcct gagctgaggc aggctgtgga
     2341 tcagatcagc agtggcttct tttctcccaa agatccagac tgcttcaagg atgtggttaa
     2401 catgctgatg taccatgaca gattcaaggt atttgcagac tatgaagcct acatccaatg
     2461 ccaggcccag gtggaccatc tataccggaa tcccaaggat tggactaaaa aggtgatcag
     2521 aaatatagcc tgctctggca aattctccag tgaccggacc atcactgagt atgcccggga
     2581 gatctggggt gtagagccct ctgacctgca gatcccaccc cctaatctcc ccaaggacta
     2641 attcttccac acagtgagac cagtggcttg tgtggctgac tgtgccccat acaaggcact
     2701 gcaagcagct ggtcccagct atcccaagtg ctatgtttcc gggaaggacc atgggaatgg
     2761 ttttgaggac ctggataagg aagaagtatg tggcatcctc ttggtttctt acagaagaac
     2821 tctttcagag ttcatagcac agatgggcag agatggtccc cacagcttca acccatcatc
     2881 atccccagag gatgaggagg gaggaggtgg agctgagccc ccagaatcct ccacataact
     2941 gagtgaactt aagcctttag ttttgggggt ctgaataggg atctgtgatg gagccagtat
     3001 tcctatgtgt tctgctaata cccgggtcac tagctgtagg ttagagccaa ccccagtgtg
     3061 tggtcttgtt ggcctgctgg gtagagcctt ttcttcaggt ttcatgctca cagtttttcc
     3121 tttacccttg gctgaattga gtatctgggt ggttgatcca tatggggcca tgcctctgta
     3181 gccacctgta gaaccctgtg ggtgtcatgc agaacccaga accctgaaga ggagaataaa
     3241 gagagacctc tatcccatat ttgaggcctt ggttaaggac tggcaatttt atagacggtt
     3301 ggcttagtcc tttgcttttt caacaggaaa taacacttca tgaggaattg aaactagcta
     3361 aagccttcct tttttgcaag taaaccttgt acttggtcag tctggatatt tctgccctgg
     3421 ctgactcagc tgctagtcct gcagtagggc ctggttccca ctctgctaca gcagcatagt
     3481 gagaaagagc ggttaagccc acccactaca ggagccatgc tcctccctga gggcagagta
     3541 gggttgtcag agaactacat aaaactcctt ccagagattc accaccttgc attgctgtat
     3601 ctggttcggg atgggcagga aaacgcctca ctttcctcaa ccctggcagt gtttactggg
     3661 aagtgtctgt tttcagcact caattcaccg gaaccactgt ggtagctttg ggggtgggtg
     3721 ggcaggttct ggggctggtc atctgctgcc ctgtgcatga ggtcccttga agccataata
     3781 catgatcacc cctctactat ttactgttac ctccttgtaa gagaaatgga ttaaacttct
     3841 atacccatgg ttggccaaaa aaaaaaaaaa aaa
//
