LOCUS       NM_001011993            1489 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus pyrroline-5-carboxylate reductase 3 (Pycr3),
            mRNA.
ACCESSION   NM_001011993 XM_216961
VERSION     NM_001011993.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1489)
  AUTHORS   De Ingeniis,J., Ratnikov,B., Richardson,A.D., Scott,D.A.,
            Aza-Blanc,P., De,S.K., Kazanov,M., Pellecchia,M., Ronai,Z.,
            Osterman,A.L. and Smith,J.W.
  TITLE     Functional specialization in proline biosynthesis of melanoma
  JOURNAL   PLoS One 7 (9), e45190 (2012)
   PUBMED   23024808
REFERENCE   2  (bases 1 to 1489)
  AUTHORS   Suzuki,H., Fukunishi,Y., Kagawa,I., Saito,R., Oda,H., Endo,T.,
            Kondo,S., Bono,H., Okazaki,Y. and Hayashizaki,Y.
  TITLE     Protein-protein interaction panel using mouse full-length cDNAs
  JOURNAL   Genome Res 11 (10), 1758-1765 (2001)
   PUBMED   11591653
REFERENCE   3  (bases 1 to 1489)
  AUTHORS   Merrill,M.J., Yeh,G.C. and Phang,J.M.
  TITLE     Purified human erythrocyte pyrroline-5-carboxylate reductase.
            Preferential oxidation of NADPH
  JOURNAL   J Biol Chem 264 (16), 9352-9358 (1989)
   PUBMED   2722838
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC087166.1.
            
            On Feb 11, 2005 this sequence version replaced XM_216961.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC087166.1, FQ220816.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132267
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1489
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q34"
     gene            1..1489
                     /gene="Pycr3"
                     /gene_synonym="Pycrl"
                     /note="pyrroline-5-carboxylate reductase 3"
                     /db_xref="GeneID:300035"
                     /db_xref="RGD:1309115"
     exon            1..154
                     /gene="Pycr3"
                     /gene_synonym="Pycrl"
                     /inference="alignment:Splign:2.1.0"
     CDS             64..888
                     /gene="Pycr3"
                     /gene_synonym="Pycrl"
                     /EC_number="1.5.1.2"
                     /note="P5CR 3; P5C reductase 3; pyrroline-5-carboxylate
                     reductase-like protein"
                     /codon_start=1
                     /product="pyrroline-5-carboxylate reductase 3"
                     /protein_id="NP_001011993.1"
                     /db_xref="GeneID:300035"
                     /db_xref="RGD:1309115"
                     /translation="MADEMSEPRRVGFVGAGRMAEAIAQGLIRAGKVEAKQVLASAPT
                     DKNLCHFRALGCQTTHSNHEVLQNCPLVIFATKPQVLPAVLAEVAPVVTTEHIIVSVA
                     AGISLSSMEELLPPKTRVLRVSPNLPCVVQEGAMVMTRGHHAGNEDAKLLQNLLEACG
                     QCIEVPESYVDIHTGLSGSGVAFVCTFSEALAEGAIKMGMPSDLAHRIAAQTLLGTAK
                     MLQQEGKHPAQLRTDVLTPAGTTIHGLHALEQGGFRAAAMSAVEAATCRAKELSKK"
     exon            155..219
                     /gene="Pycr3"
                     /gene_synonym="Pycrl"
                     /inference="alignment:Splign:2.1.0"
     exon            220..399
                     /gene="Pycr3"
                     /gene_synonym="Pycrl"
                     /inference="alignment:Splign:2.1.0"
     exon            400..612
                     /gene="Pycr3"
                     /gene_synonym="Pycrl"
                     /inference="alignment:Splign:2.1.0"
     exon            613..705
                     /gene="Pycr3"
                     /gene_synonym="Pycrl"
                     /inference="alignment:Splign:2.1.0"
     exon            706..1466
                     /gene="Pycr3"
                     /gene_synonym="Pycrl"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aatgcagctc tagtgggcgg ggcccgctgc agcaaggacg agagaaggcc agctcggaac
       61 cggatggcgg atgagatgtc tgaacctcgg cgtgtgggct tcgtaggtgc tggtcgcatg
      121 gcggaagcca ttgcccaagg cctcatccga gcaggcaaag tagaagcaaa gcaagtgctg
      181 gccagtgcac caacagacaa gaacctctgc cacttcaggg ctctgggttg ccagactact
      241 cactccaacc acgaggtgct gcaaaactgc ccactcgtca tctttgccac caaaccccaa
      301 gtcctgccag ctgttctggc agaagtggcc cctgtagtca ccactgagca catcattgta
      361 tccgtggctg ctgggatctc tctgagctct atggaggagc tgttaccccc gaaaacacga
      421 gtactgcgag tctctcccaa tctaccctgc gtagttcagg agggagctat ggttatgaca
      481 cggggccacc atgctgggaa tgaagacgcc aagctcctac agaacttgct ggaagcctgt
      541 gggcagtgca tagaggttcc tgagtcctac gtcgatatcc acactggcct cagcggcagt
      601 ggtgtggcct ttgtgtgtac attttcggag gccctggctg aaggcgccat caagatgggc
      661 atgcccagtg acctggccca ccgcattgcc gctcagaccc tgctggggac agccaaaatg
      721 ctgcagcagg aagggaagca cccagcccag ctgcggacgg atgtgctcac accagctgga
      781 accaccatcc acgggcttca tgccctagag cagggcggtt ttcgagcagc tgccatgagt
      841 gctgtggaag cagctacctg ccgggctaaa gagctcagca agaagtaagg caaggcctca
      901 gacgagacta caggctcctt gcccatctgc aggctctgtg gtgaggatag ccctgcgtgg
      961 gtgttgtatt gggcggtcct ctgagcttaa cggccatagt cttcatccga gaagctgtga
     1021 ctacccgtaa gataccatca agaggggttg gggatttagc tcagcggtag agcgcttgcc
     1081 tagcgagcac aaggccctgg gttcggtccc caactccgaa aaaaattaaa aaaaaaaaag
     1141 ataccatcaa gagtcaagat ggggtgtgtt gactgtgacg ttcagtcaag gattcaagga
     1201 aggaaaaggg agggtcactc aatccttctc tgagatttca gatcctcctt ctgcacctcc
     1261 cagccagtta cagttgtgtc ctcattgtgc agggcctcat ggtctcagga gggggtagaa
     1321 tgtgtagcct gtgaaggtgg tagacatcat cccccatgct ggcgtgagac gttttgatgg
     1381 ttgtggctgc tttgtgatca cccacactcc cgtaagcaac accccgttca tattctctaa
     1441 gcccaataaa ctcatttgtt ccctaaaaaa aaaaaaaaaa aaaaaaaaa
//
