LOCUS       NM_001012208            1582 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus pyrroline-5-carboxylate reductase 2 (Pycr2),
            mRNA.
ACCESSION   NM_001012208 XM_344180
VERSION     NM_001012208.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1582)
  AUTHORS   Nakayama,T., Al-Maawali,A., El-Quessny,M., Rajab,A., Khalil,S.,
            Stoler,J.M., Tan,W.H., Nasir,R., Schmitz-Abe,K., Hill,R.S.,
            Partlow,J.N., Al-Saffar,M., Servattalab,S., LaCoursiere,C.M.,
            Tambunan,D.E., Coulter,M.E., Elhosary,P.C., Gorski,G.,
            Barkovich,A.J., Markianos,K., Poduri,A. and Mochida,G.H.
  TITLE     Mutations in PYCR2, Encoding Pyrroline-5-Carboxylate Reductase 2,
            Cause Microcephaly and Hypomyelination
  JOURNAL   Am J Hum Genet 96 (5), 709-719 (2015)
   PUBMED   25865492
REFERENCE   2  (bases 1 to 1582)
  AUTHORS   De Ingeniis,J., Ratnikov,B., Richardson,A.D., Scott,D.A.,
            Aza-Blanc,P., De,S.K., Kazanov,M., Pellecchia,M., Ronai,Z.,
            Osterman,A.L. and Smith,J.W.
  TITLE     Functional specialization in proline biosynthesis of melanoma
  JOURNAL   PLoS One 7 (9), e45190 (2012)
   PUBMED   23024808
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC079222.1.
            
            On Feb 11, 2005 this sequence version replaced XM_344180.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC079222.1, SRR8487227.205113.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1582
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q26"
     gene            1..1582
                     /gene="Pycr2"
                     /note="pyrroline-5-carboxylate reductase 2"
                     /db_xref="GeneID:364064"
                     /db_xref="RGD:1310074"
     exon            1..182
                     /gene="Pycr2"
                     /inference="alignment:Splign:2.1.0"
     CDS             116..1078
                     /gene="Pycr2"
                     /EC_number="1.5.1.2"
                     /note="P5CR 2; P5C reductase 2; pyrroline-5-carboxylate
                     reductase family, member 2"
                     /codon_start=1
                     /product="pyrroline-5-carboxylate reductase 2"
                     /protein_id="NP_001012208.1"
                     /db_xref="GeneID:364064"
                     /db_xref="RGD:1310074"
                     /translation="MSVGFIGAGQLACALARGFTAAGVLSAHKIIASSPEMDLPTVSA
                     LRKMGVNLTRSNKDTVRHSDVLFLAVKPHIIPFILDEIGADVQERHIVVSCAAGVTIS
                     SVEKKLMAFQPAPKVIRCMTNTPVVVREGATVYATGTHALVEDGKLLEQLMSSVGFCT
                     EVEEDLIDAITGLSGSGPAYAFMALDALADGGVKMGVPRRLAVRLGAQALLGAAKMLL
                     DSEDHPGQLKDNVCSPGGATIHALHFLESGGFRSLLINAVEASCIRTRELQSMADQEK
                     VSPAALKKTLLDRVKLESPTVSTLAPPSSGKLLTRNPAQGSKRE"
     exon            183..253
                     /gene="Pycr2"
                     /inference="alignment:Splign:2.1.0"
     exon            254..433
                     /gene="Pycr2"
                     /inference="alignment:Splign:2.1.0"
     exon            434..655
                     /gene="Pycr2"
                     /inference="alignment:Splign:2.1.0"
     exon            656..748
                     /gene="Pycr2"
                     /inference="alignment:Splign:2.1.0"
     exon            749..912
                     /gene="Pycr2"
                     /inference="alignment:Splign:2.1.0"
     exon            913..1540
                     /gene="Pycr2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcatcccggt ttgaaagctg ttgcgagcaa ttcggatccg tctttttcca cgcgcagaca
       61 ctgagccccg gattcccaga gtctccgggt cggcgctcgc cgggatcctg cagccatgag
      121 cgtgggtttc atcggcgcgg gccagctggc ctgtgctctg gcgcggggct tcacggccgc
      181 gggcgtcctg tcggctcaca agataatagc cagctccccg gaaatggacc tgcccacggt
      241 gtctgcgctc aggaagatgg gtgtgaatct gacccgaagc aataaggaca cggtgcggca
      301 cagtgacgtc ctgttcctgg ctgtgaagcc ccacatcatc cccttcatcc tggatgagat
      361 cggggctgac gtgcaggaga ggcacatcgt ggtctcctgt gcggctggcg tcaccatcag
      421 ttctgtggag aagaagctga tggctttcca gccagccccc aaagtgatcc gctgcatgac
      481 caacacgcct gtggtggtcc gagagggggc cactgtgtac gccacaggca cccatgctct
      541 ggtggaagat gggaagcttc tggagcagct gatgagcagt gtgggcttct gcacagaggt
      601 ggaggaagac ctcattgatg ctatcacagg gctcagcggc agcgggcccg cctacgcgtt
      661 tatggccctg gatgcgctgg cagacggcgg ggtgaagatg ggcgtgccgc ggcgcctggc
      721 agtccgactg ggagctcagg cgttgctggg agcagctaag atgctgctgg attcagagga
      781 ccacccgggc cagctcaagg acaacgtctg ctcccctggg ggggccacca tccatgccct
      841 gcacttcctg gagagtgggg gcttccgctc tctgctcatc aatgcagttg aggcctcctg
      901 tattcgaaca agagagctgc agtccatggc tgaccaagaa aaggtgtccc ctgccgccct
      961 taagaagacc ctcctggaca gagtgaagct ggagtcaccc acggtgtcca cgctggcccc
     1021 acccagctca gggaaactcc ttacaagaaa ccctgcccag ggaagcaaga gggagtgagg
     1081 aggagtctgt ggggtgtccc tgtcccctgt agtacaggga gggcaggctc aggtctgggg
     1141 gtgaaagctg cttactctgt tcacctggtg ccaccaagtc cttctcttgt cctgtggcag
     1201 aaggcactct gaagaggcag ctgatgccag aagccagaga gcccagcgtg cctctccaag
     1261 agaggtggag gccctggagt ctgcatcccc ctcagcagaa gtctgtggag aactttagtt
     1321 agatccaagg gtggttcagt ttgacctcca ggtgaggtga gtggaaacag gaatcctctg
     1381 aattaaaaac gtgcaaaaga agcatgtggc tgggtgttgc aggtggatgt gtggggaatc
     1441 ccaagacctt ttcgcttaac tcttctgtac aggtgtcacc tagaaggtga tgttctgggc
     1501 tagttttagc tgctttaata aagagcttat ttatttttga aaaaaaaaaa aaaaaaaaaa
     1561 aaaaaaaaaa aaaaaaaaaa aa
//
