LOCUS       NM_172322                844 bp    mRNA    linear   ROD 07-JAN-2025
DEFINITION  Rattus norvegicus PYD and CARD domain containing (Pycard), mRNA.
ACCESSION   NM_172322
VERSION     NM_172322.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 844)
  AUTHORS   Li,X. and Yang,N.
  TITLE     Exosome miR-223-3p in the bone marrow-derived mesenchymal stem
            cells alleviates the inflammation and airway remodeling through
            NLRP3-induced ASC/Caspase-1/GSDMD signaling pathway
  JOURNAL   Int Immunopharmacol 123, 110746 (2023)
   PUBMED   37549514
  REMARK    GeneRIF: Exosome miR-223-3p in the bone marrow-derived mesenchymal
            stem cells alleviates the inflammation and airway remodeling
            through NLRP3-induced ASC/Caspase-1/GSDMD signaling pathway.
REFERENCE   2  (bases 1 to 844)
  AUTHORS   Choudhury,A., Bullock,D., Lim,A., Argemi,J., Orning,P., Lien,E.,
            Bataller,R. and Mandrekar,P.
  TITLE     Inhibition of HSP90 and Activation of HSF1 Diminish Macrophage
            NLRP3 Inflammasome Activity in Alcohol-Associated Liver Injury
  JOURNAL   Alcohol Clin Exp Res 44 (6), 1300-1311 (2020)
   PUBMED   32282939
REFERENCE   3  (bases 1 to 844)
  AUTHORS   Hou,L., Yang,Z., Wang,Z., Zhang,X., Zhao,Y., Yang,H., Zheng,B.,
            Tian,W., Wang,S., He,Z. and Wang,X.
  TITLE     NLRP3/ASC-mediated alveolar macrophage pyroptosis enhances HMGB1
            secretion in acute lung injury induced by cardiopulmonary bypass
  JOURNAL   Lab Invest 98 (8), 1052-1064 (2018)
   PUBMED   29884910
  REMARK    GeneRIF: Data indicate that the NLR family, pyrin domain containing
            3 protein (Nlrp3)/PYD and CARD domain containing protein
            (ASC)-mediated alveolar macrophage (AM) pyroptosis increased
            high-mobility group box 1(HMGB1) secretion in cardiopulmonary
            bypass (CPB)-induced acute lung injury (ALI).
REFERENCE   4  (bases 1 to 844)
  AUTHORS   Vajjhala,P.R., Kaiser,S., Smith,S.J., Ong,Q.R., Soh,S.L.,
            Stacey,K.J. and Hill,J.M.
  TITLE     Identification of multifaceted binding modes for pyrin and ASC
            pyrin domains gives insights into pyrin inflammasome assembly
  JOURNAL   J Biol Chem 289 (34), 23504-23519 (2014)
   PUBMED   25006247
REFERENCE   5  (bases 1 to 844)
  AUTHORS   Lu,A., Magupalli,V.G., Ruan,J., Yin,Q., Atianand,M.K., Vos,M.R.,
            Schroder,G.F., Fitzgerald,K.A., Wu,H. and Egelman,E.H.
  TITLE     Unified polymerization mechanism for the assembly of ASC-dependent
            inflammasomes
  JOURNAL   Cell 156 (6), 1193-1206 (2014)
   PUBMED   24630722
REFERENCE   6  (bases 1 to 844)
  AUTHORS   Masumoto,J., Dowds,T.A., Schaner,P., Chen,F.F., Ogura,Y., Li,M.,
            Zhu,L., Katsuyama,T., Sagara,J., Taniguchi,S., Gumucio,D.L.,
            Nunez,G. and Inohara,N.
  TITLE     ASC is an activating adaptor for NF-kappa B and caspase-8-dependent
            apoptosis
  JOURNAL   Biochem Biophys Res Commun 303 (1), 69-73 (2003)
   PUBMED   12646168
REFERENCE   7  (bases 1 to 844)
  AUTHORS   Masumoto,J., Zhou,W., Chen,F.F., Su,F., Kuwada,J.Y., Hidaka,E.,
            Katsuyama,T., Sagara,J., Taniguchi,S., Ngo-Hazelett,P.,
            Postlethwait,J.H., Nunez,G. and Inohara,N.
  TITLE     Caspy, a zebrafish caspase, activated by ASC oligomerization is
            required for pharyngeal arch development
  JOURNAL   J Biol Chem 278 (6), 4268-4276 (2003)
   PUBMED   12464617
REFERENCE   8  (bases 1 to 844)
  AUTHORS   Stehlik,C., Fiorentino,L., Dorfleutner,A., Bruey,J.M., Ariza,E.M.,
            Sagara,J. and Reed,J.C.
  TITLE     The PAAD/PYRIN-family protein ASC is a dual regulator of a
            conserved step in nuclear factor kappaB activation pathways
  JOURNAL   J Exp Med 196 (12), 1605-1615 (2002)
   PUBMED   12486103
REFERENCE   9  (bases 1 to 844)
  AUTHORS   Martinon,F., Burns,K. and Tschopp,J.
  TITLE     The inflammasome: a molecular platform triggering activation of
            inflammatory caspases and processing of proIL-beta
  JOURNAL   Mol Cell 10 (2), 417-426 (2002)
   PUBMED   12191486
REFERENCE   10 (bases 1 to 844)
  AUTHORS   Masumoto,J., Taniguchi,S., Nakayama,K., Ayukawa,K. and Sagara,J.
  TITLE     Murine ortholog of ASC, a CARD-containing protein, self-associates
            and exhibits restricted distribution in developing mouse embryos
  JOURNAL   Exp Cell Res 262 (2), 128-133 (2001)
   PUBMED   11139337
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Oct 11, 2022 this sequence version replaced NM_172322.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ227544.1, CV795154.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676809 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-450               JAXUCZ010000001.1  192032970-192033419 c
            451-507             JAXUCZ010000001.1  192032683-192032739 c
            508-844             JAXUCZ010000001.1  192032124-192032460 c
FEATURES             Location/Qualifiers
     source          1..844
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q37"
     gene            1..844
                     /gene="Pycard"
                     /gene_synonym="Asc"
                     /note="PYD and CARD domain containing"
                     /db_xref="GeneID:282817"
                     /db_xref="RGD:628637"
     exon            1..450
                     /gene="Pycard"
                     /gene_synonym="Asc"
                     /inference="alignment:Splign:2.1.0"
     CDS             180..761
                     /gene="Pycard"
                     /gene_synonym="Asc"
                     /function="involved in apoptosis, inflammation and
                     differentiation"
                     /codon_start=1
                     /product="apoptosis-associated speck-like protein
                     containing a CARD"
                     /protein_id="NP_758825.2"
                     /db_xref="GeneID:282817"
                     /db_xref="RGD:628637"
                     /translation="MGRARDAILDALENLTADEFKKFKMKLLTAPVREGYGRIPRGAL
                     LQMDPIDLTDKLVSYYLEGYGLELTMTVLRDMGIQELAEQLQKIMEESGAVATATSVP
                     AQGTARTEHFVDQHRQALIARVTEVDGLLDALYGNVLTEGQYQAVRAETTNQNKMRKL
                     FSFAPAWNLTCKNLFLEALRQTQPYLVTDLEQS"
     exon            451..507
                     /gene="Pycard"
                     /gene_synonym="Asc"
                     /inference="alignment:Splign:2.1.0"
     exon            508..844
                     /gene="Pycard"
                     /gene_synonym="Asc"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cttgaagggc tggcagcagg caggctgcag caggcgagct gcagcaggcg agctgcagca
       61 ggcgagctgc agcaggcgag ctgcagcagg cgagctgcag caggcgagct gcagcaggcg
      121 agctgcagca ggctagcagc ggcaagagta aaaggtgacc gcggctgccc acctgagcca
      181 tggggcgggc acgagatgcc atcctggacg ctcttgaaaa cttgacagcg gatgagttta
      241 aaaagttcaa gatgaagctg ctgacagcgc cagtgcggga aggctatggg cgcatcccac
      301 ggggggccct gctgcagatg gaccccatag acctcactga taaactcgtc agctactatc
      361 tggaggggta tggcttggag ctcacaatga ctgtgcttag agacatgggc atacaggagc
      421 tggctgagca gctgcaaaag attatggaag agtctggagc tgtggctact gcaaccagtg
      481 tccctgctca gggcacagcc agaacagaac attttgtgga ccaacacagg caagcactca
      541 ttgccagggt cacagaagtt gatggtttgc tggatgctct gtatggcaat gtgctgactg
      601 aaggacagta ccaggcagtt cgtgcagaga ccaccaacca aaacaagatg aggaagctct
      661 ttagctttgc tccagcctgg aacctgacct gcaagaactt gttccttgag gccttgaggc
      721 aaacacagcc ctacttggtg acagacctgg aacagagctg aggtatcttt tccagctaca
      781 catctagctc ctggttttgt atacaaaatt ttctaaaaac aagtttgtat ttgtgttttc
      841 tcga
//
