LOCUS       NM_031587                859 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus peroxisomal membrane protein 2 (Pxmp2), mRNA.
ACCESSION   NM_031587
VERSION     NM_031587.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 859)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   2  (bases 1 to 859)
  AUTHORS   Egawa,K., Shibata,H., Yamashita,S., Yurimoto,H., Sakai,Y. and
            Kato,H.
  TITLE     Overexpression and purification of rat peroxisomal membrane protein
            22, PMP22, in Pichia pastoris
  JOURNAL   Protein Expr Purif 64 (1), 47-54 (2009)
   PUBMED   18984054
  REMARK    GeneRIF: Overexcpression and puification of Pxmp2 in Pichia are
            reported.
REFERENCE   3  (bases 1 to 859)
  AUTHORS   Rokka,A., Antonenkov,V.D., Soininen,R., Immonen,H.L., Pirila,P.L.,
            Bergmann,U., Sormunen,R.T., Weckstrom,M., Benz,R. and Hiltunen,J.K.
  TITLE     Pxmp2 is a channel-forming protein in Mammalian peroxisomal
            membrane
  JOURNAL   PLoS One 4 (4), e5090 (2009)
   PUBMED   19352492
REFERENCE   4  (bases 1 to 859)
  AUTHORS   Sato,Y., Shibata,H., Nakano,H., Matsuzono,Y., Kashiwayama,Y.,
            Kobayashi,Y., Fujiki,Y., Imanaka,T. and Kato,H.
  TITLE     Characterization of the interaction between recombinant human
            peroxin Pex3p and Pex19p: identification of TRP-104 IN Pex3p as a
            critical residue for the interaction
  JOURNAL   J Biol Chem 283 (10), 6136-6144 (2008)
   PUBMED   18174172
REFERENCE   5  (bases 1 to 859)
  AUTHORS   Kikuchi,M., Hatano,N., Yokota,S., Shimozawa,N., Imanaka,T. and
            Taniguchi,H.
  TITLE     Proteomic analysis of rat liver peroxisome: presence of
            peroxisome-specific isozyme of Lon protease
  JOURNAL   J Biol Chem 279 (1), 421-428 (2004)
   PUBMED   14561759
REFERENCE   6  (bases 1 to 859)
  AUTHORS   Brosius,U., Dehmel,T. and Gartner,J.
  TITLE     Two different targeting signals direct human peroxisomal membrane
            protein 22 to peroxisomes
  JOURNAL   J Biol Chem 277 (1), 774-784 (2002)
   PUBMED   11590176
REFERENCE   7  (bases 1 to 859)
  AUTHORS   Reguenga,C., Oliveira,M.E., Gouveia,A.M., Eckerskorn,C.,
            Sa-Miranda,C. and Azevedo,J.E.
  TITLE     Identification of a 24 kDa intrinsic membrane protein from
            mammalian peroxisomes
  JOURNAL   Biochim Biophys Acta 1445 (3), 337-341 (1999)
   PUBMED   10366717
REFERENCE   8  (bases 1 to 859)
  AUTHORS   Miyawaki,T., Sohma,O., Suzuki,Y. and Takashima,S.
  TITLE     Developmental immunohistochemistry of the 22 kDa peroxisomal
            membrane protein in the human brain
  JOURNAL   Brain Res 700 (1-2), 285-288 (1995)
   PUBMED   8624723
REFERENCE   9  (bases 1 to 859)
  AUTHORS   Kaldi,K., Diestelkotter,P., Stenbeck,G., Auerbach,S., Jakle,U.,
            Magert,H.J., Wieland,F.T. and Just,W.W.
  TITLE     Membrane topology of the 22 kDa integral peroxisomal membrane
            protein
  JOURNAL   FEBS Lett 315 (3), 217-222 (1993)
   PUBMED   8422909
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000012.1.
            
            On Nov 20, 2020 this sequence version replaced NM_031587.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X70223.1, FM070575.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-152               JAXUCZ010000012.1  52053951-52054102
            153-263             JAXUCZ010000012.1  52056094-52056204
            264-426             JAXUCZ010000012.1  52058287-52058449
            427-546             JAXUCZ010000012.1  52060560-52060679
            547-859             JAXUCZ010000012.1  52063971-52064283
FEATURES             Location/Qualifiers
     source          1..859
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q16"
     gene            1..859
                     /gene="Pxmp2"
                     /gene_synonym="PMP 22; T44"
                     /note="peroxisomal membrane protein 2"
                     /db_xref="GeneID:29533"
                     /db_xref="RGD:61812"
     exon            1..152
                     /gene="Pxmp2"
                     /gene_synonym="PMP 22; T44"
                     /inference="alignment:Splign:2.1.0"
     CDS             31..615
                     /gene="Pxmp2"
                     /gene_synonym="PMP 22; T44"
                     /note="peroxisomal membrane protein 2, 22 kDa; liver
                     regeneration-related protein LRRG01; 22 kDa peroxisomal
                     membrane protein"
                     /codon_start=1
                     /product="peroxisomal membrane protein 2"
                     /protein_id="NP_113775.2"
                     /db_xref="GeneID:29533"
                     /db_xref="RGD:61812"
                     /translation="MAPAASRLRVESELGSLPKRALAQYLLFLKFYPVVTKAVSSGIL
                     SALGNLLAQMIEKKQKKDSRSLEVSGLLRYLVYGLFVTGPLSHYLYLFMEYWVPPEVP
                     WARVKRLLLDRLFFAPTFLLLFFFVMNLLEGKNISVFVAKMRSGFWPALQMNWRMWTP
                     LQFININYVPLQFRVLFANMAALFWYAYLASLGK"
     exon            153..263
                     /gene="Pxmp2"
                     /gene_synonym="PMP 22; T44"
                     /inference="alignment:Splign:2.1.0"
     exon            264..426
                     /gene="Pxmp2"
                     /gene_synonym="PMP 22; T44"
                     /inference="alignment:Splign:2.1.0"
     exon            427..546
                     /gene="Pxmp2"
                     /gene_synonym="PMP 22; T44"
                     /inference="alignment:Splign:2.1.0"
     exon            547..859
                     /gene="Pxmp2"
                     /gene_synonym="PMP 22; T44"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgcccgggac gactcagagc cgggatcgcg atggcacctg ccgcgtcaag gctgagggtg
       61 gaatccgagc tcgggtcgct tcccaagcga gcgctcgccc aatacttgct gtttctaaag
      121 ttctatccgg tggtcaccaa agctgtcagc agtggcattt tgtcagccct tggaaacctt
      181 ctggcccaga tgattgagaa gaagcagaaa aaagactctc gaagtctaga agtcagtggg
      241 cttctcagat atttagttta tgggttgttt gtcacaggtc ccctgagtca ctacctctac
      301 ctcttcatgg agtactgggt ccctcctgag gttccctggg ccagagtcaa gaggctcctg
      361 ctggatcgcc tgttctttgc cccaaccttt ctgctgctgt tcttcttcgt catgaacttg
      421 ctggagggaa aaaacatcag tgtctttgtt gccaagatga ggagtggctt ctggcctgct
      481 ctgcaaatga actggaggat gtggacaccc ttacagttca tcaacatcaa ctatgtgccc
      541 ttgcagttcc gggtgctctt tgccaacatg gcagctctgt tctggtatgc ctacctggcc
      601 tctctgggga agtgatgtct gatacaccgt ggatgaggtg tggggagatc caaccaccag
      661 caggagagag cagaatccat cattaaggac acctcatgac taaattatgt gattcaagat
      721 gccttaaaat tacagaggga ggaacgtgtc agtgtcggaa tcatgtgctt caaagagaca
      781 gcactagtct cggtggagtt aatcttagtt gtcactgcaa acaggtaaag gtcaataaac
      841 agtgatgcag ctgcttcca
//
