LOCUS       NM_001399677            2823 bp    mRNA    linear   ROD 29-OCT-2024
DEFINITION  Rattus norvegicus PX domain containing serine/threonine kinase like
            (Pxk), transcript variant 2, mRNA.
ACCESSION   NM_001399677 XM_006251775
VERSION     NM_001399677.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2823)
  AUTHORS   Harley,J.B., Alarcon-Riquelme,M.E., Criswell,L.A., Jacob,C.O.,
            Kimberly,R.P., Moser,K.L., Tsao,B.P., Vyse,T.J., Langefeld,C.D.,
            Nath,S.K., Guthridge,J.M., Cobb,B.L., Mirel,D.B., Marion,M.C.,
            Williams,A.H., Divers,J., Wang,W., Frank,S.G., Namjou,B.,
            Gabriel,S.B., Lee,A.T., Gregersen,P.K., Behrens,T.W., Taylor,K.E.,
            Fernando,M., Zidovetzki,R., Gaffney,P.M., Edberg,J.C., Rioux,J.D.,
            Ojwang,J.O., James,J.A., Merrill,J.T., Gilkeson,G.S., Seldin,M.F.,
            Yin,H., Baechler,E.C., Li,Q.Z., Wakeland,E.K., Bruner,G.R.,
            Kaufman,K.M. and Kelly,J.A.
  CONSRTM   International Consortium for Systemic Lupus Erythematosus Genetics
            (SLEGEN)
  TITLE     Genome-wide association scan in women with systemic lupus
            erythematosus identifies susceptibility variants in ITGAM, PXK,
            KIAA1542 and other loci
  JOURNAL   Nat Genet 40 (2), 204-210 (2008)
   PUBMED   18204446
REFERENCE   2  (bases 1 to 2823)
  AUTHORS   Gorokhova,S., Bibert,S., Geering,K. and Heintz,N.
  TITLE     A novel family of transmembrane proteins interacting with beta
            subunits of the Na,K-ATPase
  JOURNAL   Hum Mol Genet 16 (20), 2394-2410 (2007)
   PUBMED   17606467
REFERENCE   3  (bases 1 to 2823)
  AUTHORS   Zou,X., Qiu,G., Chen,C., Wu,M., Hu,Y., Zheng,H., Li,X., Gu,S.,
            Ji,C. and Mao,Y.
  TITLE     Expression pattern and subcellular localization of five splice
            isoforms of human PXK
  JOURNAL   Int J Mol Med 16 (4), 701-707 (2005)
   PUBMED   16142408
REFERENCE   4  (bases 1 to 2823)
  AUTHORS   Mao,H., Ferguson,T.S., Cibulsky,S.M., Holmqvist,M., Ding,C., Fei,H.
            and Levitan,I.B.
  TITLE     MONaKA, a novel modulator of the plasma membrane Na,K-ATPase
  JOURNAL   J Neurosci 25 (35), 7934-7943 (2005)
   PUBMED   16135750
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000015.1.
            
            On Jan 12, 2022 this sequence version replaced XM_006251775.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC098901.1, SRR26360172.1240092.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760389,
                                           SAMEA5760393 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-203               JAXUCZ010000015.1  19258469-19258671   c
            204-254             JAXUCZ010000015.1  19236473-19236523   c
            255-302             JAXUCZ010000015.1  19233863-19233910   c
            303-489             JAXUCZ010000015.1  19225988-19226174   c
            490-567             JAXUCZ010000015.1  19219283-19219360   c
            568-641             JAXUCZ010000015.1  19218656-19218729   c
            642-716             JAXUCZ010000015.1  19218083-19218157   c
            717-821             JAXUCZ010000015.1  19215430-19215534   c
            822-923             JAXUCZ010000015.1  19214930-19215031   c
            924-1085            JAXUCZ010000015.1  19211949-19212110   c
            1086-1203           JAXUCZ010000015.1  19211481-19211598   c
            1204-1282           JAXUCZ010000015.1  19210128-19210206   c
            1283-1331           JAXUCZ010000015.1  19208314-19208362   c
            1332-1409           JAXUCZ010000015.1  19205657-19205734   c
            1410-1496           JAXUCZ010000015.1  19205091-19205177   c
            1497-1566           JAXUCZ010000015.1  19204462-19204531   c
            1567-1629           JAXUCZ010000015.1  19200547-19200609   c
            1630-2823           JAXUCZ010000015.1  19190085-19191278   c
FEATURES             Location/Qualifiers
     source          1..2823
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15p14"
     gene            1..2823
                     /gene="Pxk"
                     /note="PX domain containing serine/threonine kinase like"
                     /db_xref="GeneID:306203"
                     /db_xref="RGD:727819"
     exon            1..203
                     /gene="Pxk"
                     /inference="alignment:Splign:2.1.0"
     CDS             102..1844
                     /gene="Pxk"
                     /note="isoform 2 is encoded by transcript variant 2; PX
                     domain-containing protein kinase-like protein; MONaKA;
                     modulator of Na,K-ATPase; PX serine/threonine kinase"
                     /codon_start=1
                     /product="PX domain-containing protein kinase-like protein
                     isoform 2"
                     /protein_id="NP_001386606.1"
                     /db_xref="GeneID:306203"
                     /db_xref="RGD:727819"
                     /translation="MAFMEKPPARKVLLDDTVPLTAAVEASQSLQSHTEYIIRVQRGI
                     SAENSWQIVRRYSDFDLLNNSLQITGLSLPLPPKKLIGNMDREFIAERQKGLQNYLNV
                     IMANHVLSNCELLKKFLDPNNYSANYTEIALQQVSMFFRSEPKWEVVEPLKDIGWRIR
                     KKYFLMKIKNQPKERLVLSWADLGPDKYLSDKDFQCLIKLLPSCVHPYIYRVTFATAS
                     ESSALLIRTFNDKGTLKDLIYKAKPKDPFLKKYCNPKKTQGLELQQIKTYGRQILEVL
                     KFLHDKGFPYGHLHAANVMLDGNTCRLLDLENSLLGLPSFYRSYFTQFRKINTLESVD
                     VHCFGHLLYEMTYGRPPDSVPVDSFPPASSMAVVAVLESTLSCEACKNGMPTVSRLLQ
                     MPLFSDVLLTTSEKPQFKIPTKLREALRIAKECIEKRLTEEQKQIHQHRRLTRAQSHH
                     GSEEERKRRKILARKKSKRSAVENSEEQPVKHSNANNSAGSGASSPLTSPSSPTPPST
                     AGLSSALPPPPPPPPPPPPPAGPSPGTEMPAPPLPQAVNGVNRGALLSSIQNFQKGTL
                     RKAKTCDHSAPKIG"
     exon            204..254
                     /gene="Pxk"
                     /inference="alignment:Splign:2.1.0"
     exon            255..302
                     /gene="Pxk"
                     /inference="alignment:Splign:2.1.0"
     exon            303..489
                     /gene="Pxk"
                     /inference="alignment:Splign:2.1.0"
     exon            490..567
                     /gene="Pxk"
                     /inference="alignment:Splign:2.1.0"
     exon            568..641
                     /gene="Pxk"
                     /inference="alignment:Splign:2.1.0"
     exon            642..716
                     /gene="Pxk"
                     /inference="alignment:Splign:2.1.0"
     exon            717..821
                     /gene="Pxk"
                     /inference="alignment:Splign:2.1.0"
     exon            822..923
                     /gene="Pxk"
                     /inference="alignment:Splign:2.1.0"
     exon            924..1085
                     /gene="Pxk"
                     /inference="alignment:Splign:2.1.0"
     exon            1086..1203
                     /gene="Pxk"
                     /inference="alignment:Splign:2.1.0"
     exon            1204..1282
                     /gene="Pxk"
                     /inference="alignment:Splign:2.1.0"
     exon            1283..1331
                     /gene="Pxk"
                     /inference="alignment:Splign:2.1.0"
     exon            1332..1409
                     /gene="Pxk"
                     /inference="alignment:Splign:2.1.0"
     exon            1410..1496
                     /gene="Pxk"
                     /inference="alignment:Splign:2.1.0"
     exon            1497..1566
                     /gene="Pxk"
                     /inference="alignment:Splign:2.1.0"
     exon            1567..1629
                     /gene="Pxk"
                     /inference="alignment:Splign:2.1.0"
     exon            1630..2823
                     /gene="Pxk"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gttgacagca gcggcgggac gcggcgggtg gcggggttcg gcgcctccgg ttcctgcccc
       61 ggcttcagag gcggcggcgg cggcggcggc gacggcccgg gatggccttc atggagaaac
      121 cgccagcccg caaggtgctg ctggacgaca cggtgccgct gacagcggcc gtcgaggcga
      181 gccagagtct gcagtcgcac acggaatata tcattcgggt acagagagga atttctgcag
      241 aaaatagctg gcagattgtc agaagataca gtgacttcga tttacttaac aacagcttgc
      301 agattacagg cctaagtctg cctcttcctc ccaagaaact gattggaaac atggaccgtg
      361 aattcatagc cgagaggcag aaaggcctgc agaactacct taatgttatc atggctaatc
      421 atgtcttgtc caattgtgag ctgcttaaga agtttctaga cccaaacaac tattctgcaa
      481 actatactga gatcgcctta cagcaggttt ccatgttctt ccgatcagaa ccaaagtggg
      541 aggttgtaga accactgaaa gacataggtt ggagaataag gaagaaatat ttcttgatga
      601 aaattaaaaa ccaaccaaag gagcgactgg tgctgagctg ggctgatctt ggcccagaca
      661 agtacttgtc agataaagat tttcaatgtc taatcaagct tctgccttcc tgtgtgcacc
      721 cttacatcta tcgggttacc tttgccacgg ctagcgaatc ttcagcgttg ctgattagaa
      781 cctttaatga taagggaact ctgaaggatc tgatctacaa ggcaaaacca aaagacccct
      841 tcctaaagaa atactgcaac cctaagaaaa cccagggcct tgaactccag caaataaaaa
      901 catatggacg gcagatatta gaggtactaa agttccttca tgacaaggga ttcccttatg
      961 gccatctcca tgcagctaac gtgatgctgg atggtaacac ttgccgtctg ctagatctcg
     1021 aaaactcttt attgggtctt ccttccttct accgatccta cttcacacag ttcaggaaga
     1081 tcaatacatt ggaaagtgta gatgtccact gtttcggcca cttactctat gaaatgactt
     1141 atggacgacc tccagactcc gtgcctgtgg actccttccc tccggcgtca tccatggctg
     1201 tggtggccgt actggagtct acgctgtctt gtgaagcctg taaaaacggc atgccgaccg
     1261 tctcccggct cttacagatg ccattattca gtgatgtttt actaacaact tcagaaaagc
     1321 cacagtttaa gattcccacg aaactaagag aggcactgag aatcgccaag gaatgtatag
     1381 agaagagact caccgaggaa cagaagcaga ttcaccagca tcgaagacta acgagagctc
     1441 agtcacacca tggatctgag gaggaaagga aaaggagaaa gatcttagct cgaaagaagt
     1501 caaaacgatc tgctgttgaa aacagtgaag agcagccagt gaagcacagc aacgccaata
     1561 actcagcagg atctggggcc agctcacctc tcacatcccc atcatctcca actccaccct
     1621 ccacggcagg actgtcttca gcgttacctc cacctcctcc gcctccgcca cctccaccgc
     1681 caccagcagg gccctcccca ggcaccgaga tgcctgctcc gcccctgccc caggccgtga
     1741 atggtgtgaa ccgtggggcc ttgctcagct ccatccagaa tttccaaaag ggaactttga
     1801 ggaaagccaa aacctgtgat cacagtgctc ctaagattgg ctgatacttc ttggttacac
     1861 tggagggcaa gctctttggt cccgtcccac cctttgagtc cctccttcct gggtgagttc
     1921 ttccacaact tccctcaagc cccttcctgg gtgaaccctt gcagagcccg tacagccagt
     1981 cctgcagaca ctccagtcag gaggcttttc aagagggaaa tgttctccag atagaataaa
     2041 gaggggccag cattgctgcc ttagtagttt gctcctttgt gactctaatg ggcttccttt
     2101 aggggcagca tcatatgggt tatcgttttc accagcgaaa ggaaaatgac agagaatcaa
     2161 aagcaatgac aatattctgt cacagcagcg aatggccttt gtcactctgt caaggtgttc
     2221 tcatagctca ttcctccgaa gcatcttttg gtgatttctt aggtagcacc cacgtgtact
     2281 cgctactctg ccccagatgc taacactaac caaggcagtt atgctgctga agcaaaggaa
     2341 cgggctcttc gttcttctgt ataccgtagg gatggggagc tcctcaggga atcccactgt
     2401 gctgagagca gcagctctgg gtgcatagtc agccacagtg taccagacac ggcactgacc
     2461 acagctaaag ctcttgccag ttgaaggact gtctcagtcc tcagcaatta aatccagtgg
     2521 gggtagaggg agggccaaca ttacaagtga atctggcatc tatagtgatc acttctgatc
     2581 tgatttatcc aacttcagca tctttttgat attactcagt tatcagaaat cttttatcct
     2641 atgatttgct taaacctttt aaataaattg cactttaaag gattataaaa aatccatttt
     2701 aaaattcaaa tacacacatc agtgttggtt actatgcaga aagaatgtta ttgtgtatag
     2761 tctcatgtaa tctgtgatac atgttcagct gtatttttta ttaaaagaaa tcatgtcaag
     2821 aaa
//
