LOCUS       NM_001414339            3261 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus PWWP domain containing 2A (Pwwp2a), transcript
            variant 1, mRNA.
ACCESSION   NM_001414339 XM_006246135
VERSION     NM_001414339.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3261)
  AUTHORS   Su,L., Nian,Y. and Zhu,T.
  TITLE     Circ_PWWP2A promotes lung fibroblast proliferation and fibrosis via
            the miR-27b-3p/GATA3 axis, thereby aggravating idiopathic pulmonary
            fibrosis
  JOURNAL   Acta Biochim Pol 70 (3), 525-532 (2023)
   PUBMED   37672715
  REMARK    GeneRIF: Circ_PWWP2A promotes lung fibroblast proliferation and
            fibrosis via the miR-27b-3p/GATA3 axis, thereby aggravating
            idiopathic pulmonary fibrosis.
REFERENCE   2  (bases 1 to 3261)
  AUTHORS   Punzeler,S., Link,S., Wagner,G., Keilhauer,E.C., Kronbeck,N.,
            Spitzer,R.M., Leidescher,S., Markaki,Y., Mentele,E., Regnard,C.,
            Schneider,K., Takahashi,D., Kusakabe,M., Vardabasso,C., Zink,L.M.,
            Straub,T., Bernstein,E., Harata,M., Leonhardt,H., Mann,M.,
            Rupp,R.A. and Hake,S.B.
  TITLE     Multivalent binding of PWWP2A to H2A.Z regulates mitosis and neural
            crest differentiation
  JOURNAL   EMBO J 36 (15), 2263-2279 (2017)
   PUBMED   28645917
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Nov 18, 2022 this sequence version replaced XM_006246135.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643297.33527.1,
                                           SRR26360190.1554027.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-587               JAXUCZ010000010.1  28656994-28657580
            588-3261            JAXUCZ010000010.1  28680066-28682739
FEATURES             Location/Qualifiers
     source          1..3261
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q21"
     gene            1..3261
                     /gene="Pwwp2a"
                     /gene_synonym="RGD1305891"
                     /note="PWWP domain containing 2A"
                     /db_xref="GeneID:303060"
                     /db_xref="RGD:1305891"
     exon            1..587
                     /gene="Pwwp2a"
                     /gene_synonym="RGD1305891"
                     /inference="alignment:Splign:2.1.0"
     CDS             64..2256
                     /gene="Pwwp2a"
                     /gene_synonym="RGD1305891"
                     /note="isoform 1 is encoded by transcript variant 1; PWWP
                     domain-containing protein 2A"
                     /codon_start=1
                     /product="PWWP domain-containing protein 2A isoform 1"
                     /protein_id="NP_001401268.1"
                     /db_xref="GeneID:303060"
                     /db_xref="RGD:1305891"
                     /translation="MAAVAAEAAATAASPGDGGAGEAEPELEPIPGSEAGTPLPVTAT
                     EAAVPDGEADGRQSAPQADEQPLPPPPPPPPPGELAGSSEAEEAKPPEPAAVPVPPPE
                     QPPAAPEQPEDAPRPPPAPALVPPAGGDSAVSHLIPGSEVRVTLDHIIEDALVVSFRL
                     GEKLFSGVLMDLSKRFGPHGIPVTVFPKRECKDKPDAMQLQSNTFQEGIEVKREVNGA
                     IPDALSPVPPPDCLWTSKPPPLFHEGAPYPPPLFIRDTYNQSIPQPPPRKIKRPKRKM
                     YREEPTSIMNAIKLRPRQVLCDKCKNSVVAEKKEIRKGSSDSSRYEDKKRRNDSVATV
                     NKKLKTDHKVDGKNQNESQRRNAVVRVSSIPHSRGRVVKVSAQANTSKAQLNTKKVLQ
                     SKNMDHAKAREVLKIAKEKAQKKQSETSTSKNAHSKVHFTRRYQNPSSGSLPPRVRLK
                     PQRYRNEENDSSLKTGLEKIRSGKLAPKPQSRCTSTRSAGEAPSETQSPSEGPEESPS
                     EVQDTSKVHVPGEQEELRTLGKKGSKSSISVYLTINQEKSDSSSASVCSIDSMDDLKS
                     SNSECSSSESCVFPPGCMHAPSASSTSTSSSSKEEEGLSNSLKMKIFSKNVSKCITPD
                     GRTICVGDIVWAKIYGFPWWPARILTITVSRRDNGLLARQEARISWFASPTTSFLALS
                     QLSPFLENFQLRFNKKRKGLYRRAITEAAKAAKQLTPEVRALLTQFET"
     exon            588..3261
                     /gene="Pwwp2a"
                     /gene_synonym="RGD1305891"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atcccagccg cgctgccgcc gccgccgcag cccgagtcgg aggagggaga aaccagcgag
       61 aaaatggcgg ccgtggctgc tgaggcggcg gcgaccgcgg cgtcccccgg ggacgggggc
      121 gccggtgagg ccgagccgga gctagagccc attccgggca gtgaggccgg cacccccctc
      181 ccggtcacgg ccacggaggc ggcggtgccg gacggcgagg ccgatgggcg ccagtccgcc
      241 cctcaggccg acgagcagcc gctgccgccg ccgccgccgc cgccaccgcc gggggagctg
      301 gctggtagct ccgaggctga ggaggcgaag ccgcctgagc ccgcggctgt cccggtcccg
      361 ccgcccgagc agcctccggc cgccccggag cagccggagg acgcgccacg gccgccgcca
      421 gctccggcgc tcgtgccgcc ggcgggcggg gactcagcgg tatcgcacct catcccgggc
      481 tcggaggtgc gggtcacgct ggaccacatc atcgaggacg cgctcgtggt gtcgttccgc
      541 ctcggggaga agctcttctc cggggtcctc atggacctgt ctaaaaggtt tgggccccat
      601 gggatccctg tgacagtatt tcccaaaagg gaatgtaagg acaaaccgga cgccatgcag
      661 cttcaaagta acacattcca agaagggata gaagtcaagc gggaagtgaa tggtgctatt
      721 cccgatgccc tttctccagt ccctcctcct gattgcctgt ggacttccaa accacctcct
      781 ctcttccatg aaggagcacc ttatcctccc cccttgttta tcagggacac atataaccaa
      841 tcaatacctc agcctcctcc ccggaaaatt aagcgaccca aacgaaaaat gtacagggaa
      901 gaacccactt caataatgaa tgcgataaag ctacgtccca ggcaagtcct gtgtgataag
      961 tgtaaaaaca gtgttgttgc agaaaagaag gaaattagga aaggtagcag tgactcttct
     1021 aggtatgaag ataaaaaacg gagaaacgat agtgtagcta ctgtgaacaa aaaactgaaa
     1081 actgaccata aagtggatgg gaaaaaccaa aacgaaagcc agagaaggaa tgctgtggtg
     1141 agggtttcca gtatccctca tagcaggggc agagtagtca aggtttctgc tcaggcaaat
     1201 acatcaaaag ctcagttaaa taccaagaaa gtgcttcaga gcaagaacat ggatcacgca
     1261 aaagctcggg aagtattgaa aattgccaaa gaaaaggcac agaagaagca aagtgaaacc
     1321 tccacttcca aaaatgcgca ctcgaaagtc catttcacac gccggtatca gaatcctagc
     1381 tcaggttctc tcccacctcg agtgcgctta aaaccacaac ggtacaggaa tgaagaaaac
     1441 gactcttctc tgaagacggg actggagaaa attcggagtg gcaagctggc ccctaagccg
     1501 cagtctcgat gtacctccac ccgctcagca ggtgaggccc cttcagaaac acagagcccc
     1561 tcagaaggcc cagaagagtc ccccagtgag gttcaggaca caagcaaagt gcatgtgcct
     1621 ggggagcagg aggagctgcg gacgttgggc aaaaagggca gcaaaagcag tatatctgtt
     1681 tacctgacca taaaccaaga gaaatctgac tcttccagtg cttcagtgtg tagcattgat
     1741 agcatggatg atttgaaatc ctccaactct gagtgtagct cctctgagag ctgcgttttt
     1801 cctcccggct gtatgcacgc accctctgcc tcttccactt ctacttcctc ctcttcaaag
     1861 gaagaggagg gcctcagtaa ttccttgaaa atgaaaatct tttccaaaaa cgtctctaaa
     1921 tgtatcacac cagatggcag gaccatatgc gtaggggaca ttgtttgggc caagatatat
     1981 ggcttcccat ggtggccagc ccgtattctt actataactg tgagccggag agataacggc
     2041 cttttagccc ggcaggaggc ccgtatttca tggtttgcat ctccaacaac atctttcctt
     2101 gctctgtcac aactctcccc ctttctagaa aacttccagt tacggtttaa taagaagaga
     2161 aagggtctgt atcgcagggc tatcacagag gcggctaagg ctgctaagca gctgacccct
     2221 gaagtgcggg ctttgttgac acaatttgaa acatgaacat ggacagtaag gtaggcaaga
     2281 accactggag ctgctgcaga tccctggcta gttaggagtc gtttccacta gctagcttag
     2341 ccaaactgga gagaaattgc actcacttgg ctttttatat gtaatatata gccattttta
     2401 gactaagaag cttaaaactg aaacatgctt caaatttcct cttcaagaag taggatttta
     2461 agaatatttt ccagttttga aattgaaaac catcctaagg catagaagcc atagcttcaa
     2521 atgaaacagt tgttgcaggg actgttaatt gccatttgta gctagtgtat gtgtgtgtgt
     2581 gcatataaat acatgtacat acacacaaca acacacctac atacatacac atgtataaac
     2641 tattgtctgt caccatgtga cacaggttgc aatatttggg gttttagtaa gggctggagc
     2701 ttggggaacg gtggctactc aatgattact tgttttataa cagtgaacac ttagactctc
     2761 tatgcacata atggtgtaaa agcttggtcc tgggtatttg acagataggt gcttgctgtg
     2821 acacattggg atgcttgctg tttagtaata gctgaccagg ctgtacacat cgcccagtat
     2881 gggattaaaa ctattaagac tagacaagtt cgagtcagca ctctcttgtc cggttaggtt
     2941 gtaaaacaaa cagatactta gttgggacat ttcgataggt tttatttggc gtatataaat
     3001 agttgagtga aaatttagtc agatttctcc tgactggctg ttcctaaatt cttaggacag
     3061 gtcctagtaa ttaacacttt gtgaattaat gtcatgtgta attgttgcat tttggatgta
     3121 cctaatttga tagtttttaa gaagcatttt ccagttaagg taatctgttt gcaggtcaga
     3181 aaatgagaaa tgtaattgta taatgcattg aaatgtaaaa aaaaacaaaa aaagctgtaa
     3241 ataaaatcaa ctaaatccaa a
//
