LOCUS       NP_001178806             500 aa            linear   ROD 01-APR-2024
DEFINITION  periodic tryptophan protein 1 homolog [Rattus norvegicus].
ACCESSION   NP_001178806 XP_343187
VERSION     NP_001178806.1
DBSOURCE    REFSEQ: accession NM_001191877.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 500)
  AUTHORS   Liu,Y., Mattila,J., Ventela,S., Yadav,L., Zhang,W., Lamichane,N.,
            Sundstrom,J., Kauko,O., Grenman,R., Varjosalo,M., Westermarck,J.
            and Hietakangas,V.
  TITLE     PWP1 Mediates Nutrient-Dependent Growth Control through Nucleolar
            Regulation of Ribosomal Gene Expression
  JOURNAL   Dev Cell 43 (2), 240-252 (2017)
   PUBMED   29065309
REFERENCE   2  (residues 1 to 500)
  AUTHORS   Shen,J., Jia,W., Yu,Y., Chen,J., Cao,X., Du,Y., Zhang,X., Zhu,S.,
            Chen,W., Xi,J., Wei,T., Wang,G., Yuan,D., Duan,T., Jiang,C. and
            Kang,J.
  TITLE     Pwp1 is required for the differentiation potential of mouse
            embryonic stem cells through regulating Stat3 signaling
  JOURNAL   Stem Cells 33 (3), 661-673 (2015)
   PUBMED   25335925
COMMENT     INFERRED REFSEQ: This record is predicted by genome sequence
            analysis and is not yet supported by experimental evidence. The
            reference sequence was derived from JAXUCZ010000007.1.
            
            On Jul 17, 2010 this sequence version replaced XP_343187.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643297.24580.1,
                                           SRR26643292.28789.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q13"
     Protein         1..500
                     /product="periodic tryptophan protein 1 homolog"
                     /calculated_mol_wt=55679
     Region          <198..286
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          <252..413
                     /region_name="WD40"
                     /note="WD40 domain, found in a number of eukaryotic
                     proteins that cover a wide variety of functions including
                     adaptor/regulatory modules in signal transduction,
                     pre-mRNA processing and cytoskeleton assembly; typically
                     contains a GH dipeptide 11-24 residues from...; cl29593"
                     /db_xref="CDD:475233"
     Region          258..295
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          302..341
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          344..381
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          389..423
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          432..457
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     CDS             1..500
                     /gene="Pwp1"
                     /gene_synonym="RGD1310705"
                     /coded_by="NM_001191877.1:60..1562"
                     /db_xref="GeneID:362856"
                     /db_xref="RGD:1310705"
ORIGIN      
        1 mnrsrqvtcv awvrrgvake tpdkvelske evkrliaeak eklqeeggse eeevgspsed
       61 gmqrarvqar ptepledgdp qddrtlddde laeydldnyd qednpdaeti gesllgltvy
      121 gsndqdpyvt lkdteqyehe dflikptdnl ivcgraeqeq cnlevhvynq eeesfyvhhd
      181 illsayplsv ewlnfdpspd aatgnyiavg nmtpvievwd ldivdslepv ftlgsklskk
      241 kkkkgkksss aeghtdavld lswnktvrnv lasasadstv ilwdlsvgkp aarltahtdk
      301 vqtlqfhpfe aqtlisgsyd ksvalydcrd psqnhrlwrf sgqiervtwn hfspchflas
      361 tddgfvynld arsdkpiftl nahndeisgl dlssqikgcl vtasadkfvk iwdilgerps
      421 lihsrdmkmg vlfcssccpd lpfvyafggq keglrvwdis tvssvneafg rrerlaigst
      481 kglsvsdpcr sgspqtpmes
//
