LOCUS       NM_017076               1938 bp    mRNA    linear   ROD 17-AUG-2024
DEFINITION  Rattus norvegicus PVR cell adhesion molecule (Pvr), mRNA.
ACCESSION   NM_017076
VERSION     NM_017076.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1938)
  AUTHORS   Mutoji,K., Singh,A., Nguyen,T., Gildersleeve,H., Kaucher,A.V.,
            Oatley,M.J., Oatley,J.M., Velte,E.K., Geyer,C.B., Cheng,K.,
            McCarrey,J.R. and Hermann,B.P.
  TITLE     TSPAN8 Expression Distinguishes Spermatogonial Stem Cells in the
            Prepubertal Mouse Testis
  JOURNAL   Biol Reprod 95 (6), 117 (2016)
   PUBMED   27733379
REFERENCE   2  (bases 1 to 1938)
  AUTHORS   Fukumoto,Y., Kurita,S., Takai,Y. and Ogita,H.
  TITLE     Role of scaffold protein afadin dilute domain-interacting protein
            (ADIP) in platelet-derived growth factor-induced cell movement by
            activating Rac protein through Vav2 protein
  JOURNAL   J Biol Chem 286 (50), 43537-43548 (2011)
   PUBMED   22027834
REFERENCE   3  (bases 1 to 1938)
  AUTHORS   Kuo,J.C., Han,X., Hsiao,C.T., Yates,J.R. 3rd and Waterman,C.M.
  TITLE     Analysis of the myosin-II-responsive focal adhesion proteome
            reveals a role for beta-Pix in negative regulation of focal
            adhesion maturation
  JOURNAL   Nat Cell Biol 13 (4), 383-393 (2011)
   PUBMED   21423176
REFERENCE   4  (bases 1 to 1938)
  AUTHORS   Enloe,B.M. and Jay,D.G.
  TITLE     Inhibition of Necl-5 (CD155/PVR) reduces glioblastoma dispersal and
            decreases MMP-2 expression and activity
  JOURNAL   J Neurooncol 102 (2), 225-235 (2011)
   PUBMED   20680398
  REMARK    GeneRIF: High Necl-5 is associated with glioblastoma.
REFERENCE   5  (bases 1 to 1938)
  AUTHORS   Bachelet,I., Munitz,A., Mankutad,D. and Levi-Schaffer,F.
  TITLE     Mast cell costimulation by CD226/CD112 (DNAM-1/Nectin-2): a novel
            interface in the allergic process
  JOURNAL   J Biol Chem 281 (37), 27190-27196 (2006)
   PUBMED   16831868
REFERENCE   6  (bases 1 to 1938)
  AUTHORS   Bottino,C., Castriconi,R., Pende,D., Rivera,P., Nanni,M.,
            Carnemolla,B., Cantoni,C., Grassi,J., Marcenaro,S., Reymond,N.,
            Vitale,M., Moretta,L., Lopez,M. and Moretta,A.
  TITLE     Identification of PVR (CD155) and Nectin-2 (CD112) as cell surface
            ligands for the human DNAM-1 (CD226) activating molecule
  JOURNAL   J Exp Med 198 (4), 557-567 (2003)
   PUBMED   12913096
REFERENCE   7  (bases 1 to 1938)
  AUTHORS   Ikeda,W., Kakunaga,S., Itoh,S., Shingai,T., Takekuni,K., Satoh,K.,
            Inoue,Y., Hamaguchi,A., Morimoto,K., Takeuchi,M., Imai,T. and
            Takai,Y.
  TITLE     Tage4/Nectin-like molecule-5 heterophilically trans-interacts with
            cell adhesion molecule Nectin-3 and enhances cell migration
  JOURNAL   J Biol Chem 278 (30), 28167-28172 (2003)
   PUBMED   12740392
REFERENCE   8  (bases 1 to 1938)
  AUTHORS   Mueller,S., Cao,X., Welker,R. and Wimmer,E.
  TITLE     Interaction of the poliovirus receptor CD155 with the dynein light
            chain Tctex-1 and its implication for poliovirus pathogenesis
  JOURNAL   J Biol Chem 277 (10), 7897-7904 (2002)
   PUBMED   11751937
REFERENCE   9  (bases 1 to 1938)
  AUTHORS   Baury,B., Geraghty,R.J., Masson,D., Lustenberger,P., Spear,P.G. and
            Denis,M.G.
  TITLE     Organization of the rat Tage4 gene and herpesvirus entry activity
            of the encoded protein
  JOURNAL   Gene 265 (1-2), 185-194 (2001)
   PUBMED   11255021
REFERENCE   10 (bases 1 to 1938)
  AUTHORS   Chadeneau,C., LeMoullac,B. and Denis,M.G.
  TITLE     A novel member of the immunoglobulin gene superfamily expressed in
            rat carcinoma cell lines
  JOURNAL   J Biol Chem 269 (22), 15601-15605 (1994)
   PUBMED   8195207
  REMARK    Erratum:[J Biol Chem 1995 Sep 1;270(35):20870]
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC085741.1.
            
            On Jun 3, 2007 this sequence version replaced NM_017076.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC085741.1, L12025.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1938
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..1938
                     /gene="Pvr"
                     /gene_synonym="Taa1; Tage4"
                     /note="PVR cell adhesion molecule"
                     /db_xref="GeneID:25066"
                     /db_xref="RGD:3813"
     exon            1..170
                     /gene="Pvr"
                     /gene_synonym="Taa1; Tage4"
                     /inference="alignment:Splign:2.1.0"
     CDS             77..1315
                     /gene="Pvr"
                     /gene_synonym="Taa1; Tage4"
                     /note="tumor-associated glycoprotein pE4; tumor-associated
                     antigen 1; tumor-associated glycoprotein E4; poliovirus
                     receptor"
                     /codon_start=1
                     /product="PVR cell adhesion molecule precursor"
                     /protein_id="NP_058772.2"
                     /db_xref="GeneID:25066"
                     /db_xref="RGD:3813"
                     /translation="MAPLAGASRSRVWSVGLLRLLLLSCFTLQKAGGEIAVQVLSNST
                     GFLGGSTVLHCSLASKDNVTITQLTWMKRDPDGSHPSVAVFHPKKGPSISDPERVKFL
                     VAKVYEDLRNASLAISNLRVEDEGIYECQIATFPTGSKSANVWLKVFARPKNTAEALE
                     PSPTLMPQDVAKCISADGHPPGRITWSSNVNGSYREMKETGSQPGTTTVISYLSMVPS
                     SQADGTNITCTVEHESFQEPDQQPLILSLPYPPEVSISGYEGNWYIGLTNVNLTCEAR
                     SKPPPTNYSWSTATGPLPNSTHFQENGSHLLISTVDDLNNTIFVCKAINALGSGQGQV
                     TILVKEASEILPPKTSLGTGYIIAIVFCVLIIGVVAGIVFWKYRRGCGRQSRTLDREN
                     VRYSAANGVSVPNVETNNLR"
     exon            171..524
                     /gene="Pvr"
                     /gene_synonym="Taa1; Tage4"
                     /inference="alignment:Splign:2.1.0"
     exon            525..821
                     /gene="Pvr"
                     /gene_synonym="Taa1; Tage4"
                     /inference="alignment:Splign:2.1.0"
     exon            822..939
                     /gene="Pvr"
                     /gene_synonym="Taa1; Tage4"
                     /inference="alignment:Splign:2.1.0"
     exon            940..1094
                     /gene="Pvr"
                     /gene_synonym="Taa1; Tage4"
                     /inference="alignment:Splign:2.1.0"
     exon            1095..1214
                     /gene="Pvr"
                     /gene_synonym="Taa1; Tage4"
                     /inference="alignment:Splign:2.1.0"
     exon            1215..1249
                     /gene="Pvr"
                     /gene_synonym="Taa1; Tage4"
                     /inference="alignment:Splign:2.1.0"
     exon            1250..1919
                     /gene="Pvr"
                     /gene_synonym="Taa1; Tage4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagaaaggac gcttgcccgc tcgctgctag cttggatccg cgtggactac agggactgaa
       61 tcggacccgg aaccacatgg ccccactcgc cggtgcctct cgctcccggg tgtggtcagt
      121 ggggctactg aggctgctgc tgctgtcctg ctttacgctc cagaaagcgg gtggggagat
      181 agctgtgcag gtgctctcca attcgaccgg cttcttggga gggtctacag tcttgcactg
      241 tagtctggct tccaaagaca atgtgacaat cactcagcta acatggatga agagggatcc
      301 agatggatcc cacccttccg tggctgtctt ccaccccaag aaggggccca gcatctctga
      361 tccagagagg gtgaagttct tggttgccaa ggtgtacgag gatctgagga acgcatctct
      421 ggccatctcg aacttgcgtg tagaagacga aggcatctat gagtgtcaga ttgccacgtt
      481 ccccacaggc agtaagagcg ccaatgtctg gctgaaggtg ttcgcccgac ctaaaaacac
      541 agcagaggcc ctggagccct ctcccacctt gatgccgcag gacgtggcca aatgcatctc
      601 tgctgatggt caccctcctg gacgaatcac gtggtcctcg aatgtgaatg gaagctaccg
      661 tgaaatgaag gaaacagggt cccagccggg caccaccaca gttatcagct acctctccat
      721 ggtgccttct agccaggcag atggcacgaa catcacctgc acagtggaac atgaaagctt
      781 ccaggagccg gaccagcagc cattgatcct ttccctacct tatccacccg aagtgtccat
      841 ctctggctat gaaggcaact ggtacattgg cctcactaac gtgaacctga cctgtgaagc
      901 tcgcagcaaa ccaccgccca ccaactatag ctggagcacg gccacgggtc cccttcccaa
      961 ctccactcat ttccaggaaa acggcagtca cctgctaatc tccaccgtgg atgacctcaa
     1021 taacacgatc tttgtgtgca aagccatcaa tgccctaggg tctgggcagg gccaagtgac
     1081 catcctagtt aaagaggcat ctgagattct gccgccaaag acaagcttag gcactggcta
     1141 catcattgcc atcgtctttt gtgtcctgat catcggagta gtagcaggca ttgtattctg
     1201 gaaatacagg cgtggttgtg gtcggcagtc caggacctta gacagggaga acgtccgcta
     1261 ttcagcagcg aatggcgtct ctgtcccaaa cgtggagacg aacaacttga ggtgatggtg
     1321 ctggggtaga cagaactaag gaacttgaag acataacaac tggaacccta cttccacaaa
     1381 agaaaaagcc tccagagaga cttgactgtc cagtgtggcg aacatagcaa ggttgggggt
     1441 ctccttggcc gctgccgaat tccgcattgt cgaaaggact catggaaccc ggtgtgctga
     1501 ctcacacttg acatctcagc aagcgagggc cacataaagc aaggttgagt ctagcacggc
     1561 tgtagagaga agccctgtct atacacaggc aagctaaggg gctttgagac agtcagaaac
     1621 tgaagtcttt ctttgggtaa ggtaaatcct ctacctcgtg tatgtgacaa acttgaaaga
     1681 cttctacctc tgagactcaa gtgcggactc tctttataag ctgactcagc tggggctaac
     1741 ccctctctcc tctctggaca aggtctcaga gtgtagccaa agctagaccg aaactcacag
     1801 aggtccgtct gtctctacct cccaagtgct gcagttaaag gtttgtgtgt gccacactcc
     1861 tttgctaggt ctttttaata aagtaaaata tttaataaag taatatattt ataaaaaaaa
     1921 aaaaaaaaaa aaaaaaaa
//
