LOCUS       NM_022499                563 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus parvalbumin (Pvalb), mRNA.
ACCESSION   NM_022499
VERSION     NM_022499.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 563)
  AUTHORS   Fan,Z., Gong,X., Xu,H., Qu,Y., Li,B., Li,L., Yan,Y., Wu,L. and
            Yan,C.
  TITLE     Hippocampal parvalbumin and perineuronal nets: Possible involvement
            in anxiety-like behavior in rats
  JOURNAL   Hippocampus 34 (3), 156-165 (2024)
   PUBMED   38100162
  REMARK    GeneRIF: Hippocampal parvalbumin and perineuronal nets: Possible
            involvement in anxiety-like behavior in rats.
REFERENCE   2  (bases 1 to 563)
  AUTHORS   Binette,A.N., Liu,J., Bayer,H., Crayton,K.L., Melissari,L.,
            Sweck,S.O. and Maren,S.
  TITLE     Parvalbumin-Positive Interneurons in the Medial Prefrontal Cortex
            Regulate Stress-Induced Fear Extinction Impairments in Male and
            Female Rats
  JOURNAL   J Neurosci 43 (22), 4162-4173 (2023)
   PUBMED   37127359
  REMARK    GeneRIF: Parvalbumin-Positive Interneurons in the Medial Prefrontal
            Cortex Regulate Stress-Induced Fear Extinction Impairments in Male
            and Female Rats.
REFERENCE   3  (bases 1 to 563)
  AUTHORS   Elgueta,C. and Bartos,M.
  TITLE     Dendritic inhibition differentially regulates excitability of
            dentate gyrus parvalbumin-expressing interneurons and granule cells
  JOURNAL   Nat Commun 10 (1), 5561 (2019)
   PUBMED   31804491
  REMARK    GeneRIF: Dendritic inhibition differentially controls input-output
            transformations in parvalbumin-expressing interneurons (PVIs) and
            granule cells (GCs) of the dentate gyrus.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 563)
  AUTHORS   Permyakov,S.E., Vologzhannikova,A.A., Khorn,P.A., Shevelyova,M.P.,
            Kazakov,A.S., Emelyanenko,V.I., Denesyuk,A.I., Denessiouk,K.,
            Uversky,V.N. and Permyakov,E.A.
  TITLE     Comprehensive analysis of the roles of 'black' and 'gray' clusters
            in structure and function of rat beta-parvalbumin
  JOURNAL   Cell Calcium 75, 64-78 (2018)
   PUBMED   30176502
  REMARK    GeneRIF: These results demonstrate that amino acids of the cluster
            I of beta parvalbumin provide more essential contribution to the
            maintenance of structural and functional properties of the protein
            in comparison with the residues of the cluster II.
REFERENCE   5  (bases 1 to 563)
  AUTHORS   Rossetti,A.C., Paladini,M.S., Colombo,M., Gruca,P.,
            Lason-Tyburkiewicz,M., Tota-Glowczyk,K., Papp,M., Riva,M.A. and
            Molteni,R.
  TITLE     Chronic Stress Exposure Reduces Parvalbumin Expression in the Rat
            Hippocampus through an Imbalance of Redox Mechanisms: Restorative
            Effect of the Antipsychotic Lurasidone
  JOURNAL   Int J Neuropsychopharmacol 21 (9), 883-893 (2018)
   PUBMED   29788232
  REMARK    GeneRIF: Chronic mild stress induced a specific decrease of
            parvalbumin expression in the dorsal hippocampus, an effect
            normalized by lurasidone treatment. Interestingly, the regulation
            of parvalbumin levels was correlated to the modulation of the
            antioxidant master regulator NRF2 and its chaperon protein KEAP1,
            which were also modulated by pharmacological intervention.
REFERENCE   6  (bases 1 to 563)
  AUTHORS   Berchtold,M.W., Epstein,P., Beaudet,A.L., Payne,M.E., Heizmann,C.W.
            and Means,A.R.
  TITLE     Structural organization and chromosomal assignment of the
            parvalbumin gene
  JOURNAL   J Biol Chem 262 (18), 8696-8701 (1987)
   PUBMED   3036821
REFERENCE   7  (bases 1 to 563)
  AUTHORS   Epstein,P., Means,A.R. and Berchtold,M.W.
  TITLE     Isolation of a rat parvalbumin gene and full length cDNA
  JOURNAL   J Biol Chem 261 (13), 5886-5891 (1986)
   PUBMED   3009434
REFERENCE   8  (bases 1 to 563)
  AUTHORS   Williams,T.C., Corson,D.C., Oikawa,K., McCubbin,W.D., Kay,C.M. and
            Sykes,B.D.
  TITLE     1H NMR spectroscopic studies of calcium-binding proteins. 3.
            Solution conformations of rat apo-alpha-parvalbumin and metal-bound
            rat alpha-parvalbumin
  JOURNAL   Biochemistry 25 (7), 1835-1846 (1986)
   PUBMED   3707914
REFERENCE   9  (bases 1 to 563)
  AUTHORS   Berchtold,M.W. and Means,A.R.
  TITLE     The Ca2+-binding protein parvalbumin: molecular cloning and
            developmental regulation of mRNA abundance
  JOURNAL   Proc Natl Acad Sci U S A 82 (5), 1414-1418 (1985)
   PUBMED   3856270
REFERENCE   10 (bases 1 to 563)
  AUTHORS   Berchtold,M.W., Heizmann,C.W. and Wilson,K.J.
  TITLE     Primary structure of parvalbumin from rat skeletal muscle
  JOURNAL   Eur J Biochem 127 (2), 381-389 (1982)
   PUBMED   6754379
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC126090.1.
            
            On Jun 10, 2007 this sequence version replaced NM_022499.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC126090.1, CF977248.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760384, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..563
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q34"
     gene            1..563
                     /gene="Pvalb"
                     /gene_synonym="PALB1; Pva"
                     /note="parvalbumin"
                     /db_xref="GeneID:25269"
                     /db_xref="RGD:3457"
     exon            1..73
                     /gene="Pvalb"
                     /gene_synonym="PALB1; Pva"
                     /inference="alignment:Splign:2.1.0"
     CDS             13..345
                     /gene="Pvalb"
                     /gene_synonym="PALB1; Pva"
                     /note="Parvalbumin (calcium binding protein)"
                     /codon_start=1
                     /product="parvalbumin alpha"
                     /protein_id="NP_071944.1"
                     /db_xref="GeneID:25269"
                     /db_xref="RGD:3457"
                     /translation="MSMTDLLSAEDIKKAIGAFTAADSFDHKKFFQMVGLKKKSADDV
                     KKVFHILDKDKSGFIEEDELGSILKGFSSDARDLSAKETKTLMAAGDKDGDGKIGVEE
                     FSTLVAES"
     exon            74..206
                     /gene="Pvalb"
                     /gene_synonym="PALB1; Pva"
                     /inference="alignment:Splign:2.1.0"
     exon            207..316
                     /gene="Pvalb"
                     /gene_synonym="PALB1; Pva"
                     /inference="alignment:Splign:2.1.0"
     exon            317..538
                     /gene="Pvalb"
                     /gene_synonym="PALB1; Pva"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aacagttgca ggatgtcgat gacagacttg ctcagcgctg aggacatcaa gaaggcgata
       61 ggagccttta ctgctgcaga ctccttcgac cacaaaaagt tcttccagat ggtgggcctg
      121 aagaaaaaga gtgcggatga tgtgaagaag gtgttccaca ttctggacaa agacaaaagt
      181 ggcttcattg aggaggatga gctggggtcc attctgaagg gcttctcctc agatgccaga
      241 gacttgtctg ctaaggaaac aaagacgctg atggctgctg gagacaagga cggggatggc
      301 aagattgggg ttgaagaatt ctccactctg gtggccgaaa gctaagtggc gctgactgct
      361 tgggtctccc acctctccac cccccatgcc ccatctcagc ccttctcgcg gccctcctgg
      421 gtttctgttc agtttgttta tgttattttt tactccccca tcctttatgg ccctcgaatg
      481 acaccactct tctggaaaat gctggagaaa caataaaggc tgtacccatc ggacaccaaa
      541 aaaaaaaaaa aaaaaaaaaa aaa
//
