LOCUS       NM_001170589            2464 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus pseudouridine synthase 7 (Pus7), mRNA.
ACCESSION   NM_001170589
VERSION     NM_001170589.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2464)
  AUTHORS   Guzzi,N., Ciesla,M., Ngoc,P.C.T., Lang,S., Arora,S., Dimitriou,M.,
            Pimkova,K., Sommarin,M.N.E., Munita,R., Lubas,M., Lim,Y.,
            Okuyama,K., Soneji,S., Karlsson,G., Hansson,J., Jonsson,G.,
            Lund,A.H., Sigvardsson,M., Hellstrom-Lindberg,E., Hsieh,A.C. and
            Bellodi,C.
  TITLE     Pseudouridylation of tRNA-Derived Fragments Steers Translational
            Control in Stem Cells
  JOURNAL   Cell 173 (5), 1204-1216 (2018)
   PUBMED   29628141
REFERENCE   2  (bases 1 to 2464)
  AUTHORS   Safra,M., Nir,R., Farouq,D., Vainberg Slutskin,I. and Schwartz,S.
  TITLE     TRUB1 is the predominant pseudouridine synthase acting on mammalian
            mRNA via a predictable and conserved code
  JOURNAL   Genome Res 27 (3), 393-406 (2017)
   PUBMED   28073919
  REMARK    Erratum:[Genome Res. 2017 Aug;27(8):1460. PMID: 28765290]
REFERENCE   3  (bases 1 to 2464)
  AUTHORS   Armour,S.M., Bennett,E.J., Braun,C.R., Zhang,X.Y., McMahon,S.B.,
            Gygi,S.P., Harper,J.W. and Sinclair,D.A.
  TITLE     A high-confidence interaction map identifies SIRT1 as a mediator of
            acetylation of USP22 and the SAGA coactivator complex
  JOURNAL   Mol Cell Biol 33 (8), 1487-1502 (2013)
   PUBMED   23382074
REFERENCE   4  (bases 1 to 2464)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   5  (bases 1 to 2464)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR22399484.46752.1,
                                           SRR26643295.17010.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-61                JAXUCZ010000004.1  12252683-12252743
            62-489              JAXUCZ010000004.1  12256509-12256936
            490-574             JAXUCZ010000004.1  12259553-12259637
            575-676             JAXUCZ010000004.1  12259739-12259840
            677-821             JAXUCZ010000004.1  12265310-12265454
            822-933             JAXUCZ010000004.1  12270881-12270992
            934-1011            JAXUCZ010000004.1  12273071-12273148
            1012-1140           JAXUCZ010000004.1  12279671-12279799
            1141-1266           JAXUCZ010000004.1  12280825-12280950
            1267-1328           JAXUCZ010000004.1  12283748-12283809
            1329-1489           JAXUCZ010000004.1  12284527-12284687
            1490-1616           JAXUCZ010000004.1  12285432-12285558
            1617-1718           JAXUCZ010000004.1  12286619-12286720
            1719-1848           JAXUCZ010000004.1  12290754-12290883
            1849-1940           JAXUCZ010000004.1  12291911-12292002
            1941-2464           JAXUCZ010000004.1  12292380-12292903
FEATURES             Location/Qualifiers
     source          1..2464
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q11"
     gene            1..2464
                     /gene="Pus7"
                     /gene_synonym="RGD1307054"
                     /note="pseudouridine synthase 7"
                     /db_xref="GeneID:296751"
                     /db_xref="RGD:1307054"
     exon            1..61
                     /gene="Pus7"
                     /gene_synonym="RGD1307054"
                     /inference="alignment:Splign:2.1.0"
     exon            62..489
                     /gene="Pus7"
                     /gene_synonym="RGD1307054"
                     /inference="alignment:Splign:2.1.0"
     CDS             95..2077
                     /gene="Pus7"
                     /gene_synonym="RGD1307054"
                     /EC_number="4.2.1.70"
                     /codon_start=1
                     /product="pseudouridylate synthase 7 homolog"
                     /protein_id="NP_001164060.1"
                     /db_xref="GeneID:296751"
                     /db_xref="RGD:1307054"
                     /translation="MEMTSVSLKRGCLVVEDNDSVTPHEETKKQKVSEGCVTNSPDGV
                     ESDSLHSSETKPGPPEAESTLKDGENSGAQVQEEEEEEEEEDGLSEAGEEEEPESFAD
                     MMKHGLTELDVGITKFVSPHQGFSGILKERYSDFVVHEIGKDGRISHLDDLSVPVDEE
                     DPPEDALTVLTAEDRQQLEELQLFKNKETSVAIEVIEDTKEKRTIIHQAIKSLFPGLE
                     TKTEEREGKRYIVAYHAAGKKALANPRKHSWPKSRGSYCHFVLYKENKDTMDAINVLS
                     KYLRVKPNIFSYMGTKDKRAITVQEIAVLKISAQRLAHLNKCLMNFKLGNFSYQKTPL
                     KLGELQGNHFTVVLRNITGTDEQVQQAMHSLQQTGFINYYGMQRFGTTAVPTYQVGRA
                     ILQNSWTEVMDLILKPRSGAEKGYLVKCREEWAKTKDPASALKKLPVKRCVEGQLLRG
                     LSKYGLKNIVSAFGIIPRNNRLMYIHSYQSYVWNSMVSRRIELYGLKPVPGDLVLKGA
                     TATYIEEDDINNYSIHDVVMPLPGFDVIYPKHKISEAYREMLAADNLDIDNMRHTIRD
                     YSLSGAYRKIIIRPQSVSWEVVAYDDPKIPLFNTDVDNLEGKPPPVFASEGRYRALKM
                     DFSLPPSTYATMAIREVLKMDTSIKNQTQLNTSWLR"
     exon            490..574
                     /gene="Pus7"
                     /gene_synonym="RGD1307054"
                     /inference="alignment:Splign:2.1.0"
     exon            575..676
                     /gene="Pus7"
                     /gene_synonym="RGD1307054"
                     /inference="alignment:Splign:2.1.0"
     exon            677..821
                     /gene="Pus7"
                     /gene_synonym="RGD1307054"
                     /inference="alignment:Splign:2.1.0"
     exon            822..933
                     /gene="Pus7"
                     /gene_synonym="RGD1307054"
                     /inference="alignment:Splign:2.1.0"
     exon            934..1011
                     /gene="Pus7"
                     /gene_synonym="RGD1307054"
                     /inference="alignment:Splign:2.1.0"
     exon            1012..1140
                     /gene="Pus7"
                     /gene_synonym="RGD1307054"
                     /inference="alignment:Splign:2.1.0"
     exon            1141..1266
                     /gene="Pus7"
                     /gene_synonym="RGD1307054"
                     /inference="alignment:Splign:2.1.0"
     exon            1267..1328
                     /gene="Pus7"
                     /gene_synonym="RGD1307054"
                     /inference="alignment:Splign:2.1.0"
     exon            1329..1489
                     /gene="Pus7"
                     /gene_synonym="RGD1307054"
                     /inference="alignment:Splign:2.1.0"
     exon            1490..1616
                     /gene="Pus7"
                     /gene_synonym="RGD1307054"
                     /inference="alignment:Splign:2.1.0"
     exon            1617..1718
                     /gene="Pus7"
                     /gene_synonym="RGD1307054"
                     /inference="alignment:Splign:2.1.0"
     exon            1719..1848
                     /gene="Pus7"
                     /gene_synonym="RGD1307054"
                     /inference="alignment:Splign:2.1.0"
     exon            1849..1940
                     /gene="Pus7"
                     /gene_synonym="RGD1307054"
                     /inference="alignment:Splign:2.1.0"
     exon            1941..2464
                     /gene="Pus7"
                     /gene_synonym="RGD1307054"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tcactcccgc gtccggagcc gagcgccctt ttcgccgctc ggccgcgccc tcagactccg
       61 ggttctctta aatgttctct tggaaacaaa aaagatggag atgacaagtg tgtccctgaa
      121 acgcgggtgc ctcgttgtgg aagataacga cagtgtgacc ccacatgagg agacgaagaa
      181 acagaaggtg tctgagggct gtgtgaccaa cagtccggac ggggtggaga gtgacagtct
      241 tcacagcagt gagaccaagc cggggccccc agaagcggaa agcaccttga aagatggcga
      301 gaactccggt gctcaggtgc aggaggaaga ggaggaggag gaggaagagg acggcctttc
      361 ggaggcaggg gaagaggagg agccagagag ctttgcggac atgatgaagc atgggctcac
      421 cgaacttgat gtgggcatca ccaagttcgt gagtcctcat cagggcttct cggggatctt
      481 aaaagaaaga tactctgact tcgtggttca tgaaatcggg aaggatgggc ggatcagcca
      541 tttggatgac ttatctgttc cagtggacga agaggaccct ccagaagatg ccctcactgt
      601 cttgacagct gaggacaggc agcagttgga ggagctccag cttttcaaaa ataaagaaac
      661 cagtgttgcc atcgaggtca ttgaggacac caaagagaaa cgaaccatca tccatcaagc
      721 cattaaatct ctcttcccag gactagagac aaaaacagag gagagagagg ggaagagata
      781 cattgtagcc taccatgctg ctggcaagaa ggctttggca aatccaagaa aacattcttg
      841 gccaaaatcc cggggaagtt actgccactt tgttctctac aaggaaaaca aagacaccat
      901 ggacgccatc aatgtgttgt ccaagtatct gcgggtaaaa ccaaacatat tctcctatat
      961 gggaaccaaa gacaaaaggg ctatcacagt ccaggagatc gctgttctca aaataagtgc
     1021 acaaaggctt gcccacctga ataagtgcct gatgaacttt aagttaggca atttcagcta
     1081 tcagaaaacc cctctgaagt taggagagct tcaaggaaac cacttcactg tcgttctcag
     1141 gaatataacg ggaacggatg aacaagtgca gcaagccatg cattcgctgc agcagaccgg
     1201 cttcatcaac tactacggca tgcagaggtt tgggaccacg gctgttccta cgtaccaggt
     1261 cggaagagca attctacaga attcctggac agaagtcatg gatttaatac tgaaaccccg
     1321 ctctggagct gagaagggtt acttggtgaa atgcagagaa gagtgggcca agaccaaaga
     1381 cccagcctct gccctcaaaa agctacccgt caaaaggtgt gtggaagggc agctgcttcg
     1441 aggactttca aagtatggac tgaagaatat agtctctgcg tttggcataa taccaagaaa
     1501 caaccgctta atgtacatcc acagctacca gagttatgtg tggaatagca tggtgagcag
     1561 gagaatcgag ctgtatgggc tgaagcctgt gccgggggac ctcgtgctca aaggagccac
     1621 ggccacctat attgaggaag atgacattaa taactactcc attcacgatg tggtgatgcc
     1681 tttgcctggc tttgatgtca tctaccccaa acataaaatt agcgaggcct acagggaaat
     1741 gcttgccgca gacaaccttg atattgacaa catgagacac acgattcgag attactcctt
     1801 atcgggggcc taccgaaaga tcatcatccg acctcagagc gtcagctggg aagtggttgc
     1861 atacgatgat cccaaaattc cacttttcaa cacggatgtg gacaacctcg aggggaaacc
     1921 accaccagtc tttgcttctg aaggcagata cagggctctg aagatggact tctctcttcc
     1981 tccctctact tacgccacca tggccattcg agaagtgctc aaaatggaca ccagcatcaa
     2041 gaaccagacc cagctaaaca cgagctggct gcgatgagca gtgggtctga gtagtgggtc
     2101 gctcagagag cggatggacg gatagacaga tgcagacctg cttccgacct gttctgttct
     2161 ttttatgtgc tgactcatgt ttgggatatg aatcttttat agtaaagaat tatttgtatt
     2221 ttgtaaagtt tgtatcagct taaatacttt gcaatatttg tacacatgta caaatcctga
     2281 ggatcctagt tatagctcag aaaattaaaa ttggtcagaa tatcccttag gtgcttaaat
     2341 tctaggacag tttcagcttt gtggctttat aagaataaag ggggggttgg ggatttagct
     2401 cagtggtaga gcacttgcct agcaagtgca aggccctggg ttcggtcccc agctatgaaa
     2461 aaaa
//
