LOCUS       NM_001108134            1718 bp    mRNA    linear   ROD 23-MAR-2023
DEFINITION  Rattus norvegicus pseudouridine synthase 3 (Pus3), mRNA.
ACCESSION   NM_001108134 XM_001057876 XM_235995
VERSION     NM_001108134.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1718)
  AUTHORS   Shaheen R, Han L, Faqeih E, Ewida N, Alobeid E, Phizicky EM and
            Alkuraya FS.
  TITLE     A homozygous truncating mutation in PUS3 expands the role of tRNA
            modification in normal cognition
  JOURNAL   Hum Genet 135 (7), 707-713 (2016)
   PUBMED   27055666
REFERENCE   2  (bases 1 to 1718)
  AUTHORS   Chen J and Patton JR.
  TITLE     Pseudouridine synthase 3 from mouse modifies the anticodon loop of
            tRNA
  JOURNAL   Biochemistry 39 (41), 12723-12730 (2000)
   PUBMED   11027153
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC158693.1.
            
            On Jan 27, 2008 this sequence version replaced NM_001108134.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC158693.1, BC127541.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132263, SAMD00132264
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1718
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q21"
     gene            1..1718
                     /gene="Pus3"
                     /gene_synonym="RGD1310757"
                     /note="pseudouridine synthase 3"
                     /db_xref="GeneID:315554"
                     /db_xref="RGD:1310757"
     exon            1..404
                     /gene="Pus3"
                     /gene_synonym="RGD1310757"
                     /inference="alignment:Splign:2.1.0"
     CDS             30..1469
                     /gene="Pus3"
                     /gene_synonym="RGD1310757"
                     /EC_number="5.4.99.45"
                     /note="tRNA pseudouridine synthase 3; pseudouridylate
                     synthase 3"
                     /codon_start=1
                     /product="tRNA pseudouridine(38/39) synthase"
                     /protein_id="NP_001101604.1"
                     /db_xref="GeneID:315554"
                     /db_xref="RGD:1310757"
                     /translation="MAETTDRNQIEKLLSRVKELEQEVERLKKEQANNIKDTSVRENS
                     LGCGKAKRAFDFSAHGRRHVALKIAYLGWGYQGFASQENTSNTIEEKLFEALIKTRLV
                     ESRQTSNYHRCGRTDKGVSAFGQVISLDLRSQFPRSRDSEDSNLKDGADDIAKEIRYA
                     HILNRVLPADIRVLAWAPAEPSFSARFSCLERTYRYFFPCADLDIATMNYAAQKYVGT
                     HDFRNLCKMDVANGVTNFQRTILSAQVQTVAQSPGEEGRQGPFQLCQFEVIGQAFLYH
                     QVRCMMAILFLIGQGMEKPEIIDELLNIEKNPQKPQYSMAVEFPLVLYDCKFENTKWI
                     YDHEVHEFNVTHLQQLWANHAVKTHMLYSMLQGLDSVMVTCAAGTKTGEATEWRNIRP
                     SVIKHTSAFVEGVRMRTYKPLMARPKCQGLESRIQHFVRRGRIEHPHLLHKEEKKAKR
                     DCADKEENIVLENPTKRVCIIDAEINSIV"
     exon            405..970
                     /gene="Pus3"
                     /gene_synonym="RGD1310757"
                     /inference="alignment:Splign:2.1.0"
     exon            971..1691
                     /gene="Pus3"
                     /gene_synonym="RGD1310757"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gacctgcatg atttcttcct ggggatgcca tggctgaaac cacagacaga aatcagattg
       61 agaaacttct aagcagagta aaggaactgg agcaggaagt ggaaagactt aagaaagaac
      121 aagccaacaa tataaaagac acaagtgtca gagaaaattc tttaggctgt ggaaaagcta
      181 agcgtgcttt tgattttagt gctcatggcc gtagacatgt agctctaaaa atagcctatc
      241 taggctgggg ataccagggc tttgccagtc aggaaaacac aagcaatacc attgaagaga
      301 aactgtttga ggctttaata aagacccgac tagtagaaag cagacagact tccaactatc
      361 accggtgtgg tcgaacagac aaaggagtta gcgcctttgg acaggtaatt tctctggacc
      421 tgcgttctca gtttccaagg agcagggatt cagaagattc taatttaaaa gatggagctg
      481 atgatattgc taaagagatc cgttatgctc acattctcaa tcgggtgctt cctgcagaca
      541 tcagggtatt ggcctgggcc cctgcagaac ctagcttcag tgctaggttt agctgtcttg
      601 agcggaccta ccgctacttt ttcccctgtg ctgatttaga tattgcaact atgaattatg
      661 cagctcagaa atacgttggc actcatgatt tcagaaactt gtgtaagatg gacgtggcca
      721 atggcgtgac taattttcag aggactatcc tgtctgcaca agtgcaaaca gtggcccaga
      781 gcccaggtga ggagggaagg caagggccat tccagttatg tcaatttgaa gtgattggcc
      841 aggcattcct gtatcatcaa gttcggtgta tgatggctat cctcttcctg attggccaag
      901 gaatggagaa gccagagatt attgatgaac tgctgaacat agagaaaaat ccccagaaac
      961 cgcaatatag catggctgtt gaatttcctc tagtcttata tgactgtaaa tttgaaaata
     1021 ccaagtggat ttatgatcac gaggttcacg aattcaatgt tactcaccta caacagctat
     1081 gggctaatca tgctgttaaa actcacatgc tatatagtat gctacaagga ctagactctg
     1141 ttatggtaac atgcgcagca ggaacaaaga ctggtgaagc aacagaatgg agaaacattc
     1201 gaccctctgt cataaagcac actagtgcct ttgtagaagg agtgagaatg cgcacatata
     1261 agcccctcat ggctcgcccc aaatgccaag gactggaatc ccggatccag cattttgtac
     1321 gaagaggacg aattgagcac ccacatttac tccataagga agaaaaaaaa gcaaagaggg
     1381 actgtgctga caaagaagaa aatattgttt tagagaatcc aacgaagagg gtttgtataa
     1441 tagatgcaga aattaacagc attgtataat tccaggaagc tagcatctct agcaggatcc
     1501 agggagcaac aacgaattaa aattttaatg actagcaaaa gacctaacaa gttcttaaat
     1561 attaagggtg tattctttaa tccctgtcca aaaatattag gaaatgaaag acgcaaagac
     1621 cacttgtcag ttatatgcac ctggaaatct gtgtttttcg ttcaaatcca ttaaagcctg
     1681 gtctacaaat aaaaaaaaaa aaaaaaaaaa aaaaaaaa
//
