LOCUS       NM_001017503            2484 bp    mRNA    linear   ROD 14-APR-2024
DEFINITION  Rattus norvegicus purine rich element binding protein B (Purb),
            mRNA.
ACCESSION   NM_001017503 XM_573651
VERSION     NM_001017503.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2484)
  AUTHORS   Maamar,H., Cabili,M.N., Rinn,J. and Raj,A.
  TITLE     linc-HOXA1 is a noncoding RNA that represses Hoxa1 transcription in
            cis
  JOURNAL   Genes Dev 27 (11), 1260-1271 (2013)
   PUBMED   23723417
REFERENCE   2  (bases 1 to 2484)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   3  (bases 1 to 2484)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   4  (bases 1 to 2484)
  AUTHORS   Li,F., Kato,I., Kawaguchi,H., Takasawa,K., Hibino,Y. and Hiraga,K.
  TITLE     The galectin-3 gene promoter binding proteins in the liver of rats
            48-h post-treatment with CCl4
  JOURNAL   Gene 367, 46-55 (2006)
   PUBMED   16309856
REFERENCE   5  (bases 1 to 2484)
  AUTHORS   Shimotai,Y., Minami,H., Saitoh,Y., Onodera,Y., Mishima,Y.,
            Kelm,R.J. Jr. and Tsutsumi,K.
  TITLE     A binding site for Pur alpha and Pur beta is structurally unstable
            and is required for replication in vivo from the rat aldolase B
            origin
  JOURNAL   Biochem Biophys Res Commun 340 (2), 517-525 (2006)
   PUBMED   16376299
  REMARK    GeneRIF: Purb may have role in DNA replication initiation.  [purine
            rich element binding protein B; Purb]
REFERENCE   6  (bases 1 to 2484)
  AUTHORS   Subramanian,S.V., Polikandriotis,J.A., Kelm,R.J. Jr., David,J.J.,
            Orosz,C.G. and Strauch,A.R.
  TITLE     Induction of vascular smooth muscle alpha-actin gene transcription
            in transforming growth factor beta1-activated myofibroblasts
            mediated by dynamic interplay between the Pur repressor proteins
            and Sp1/Smad coactivators
  JOURNAL   Mol Biol Cell 15 (10), 4532-4543 (2004)
   PUBMED   15282343
REFERENCE   7  (bases 1 to 2484)
  AUTHORS   Gupta,M., Sueblinvong,V., Raman,J., Jeevanandam,V. and Gupta,M.P.
  TITLE     Single-stranded DNA-binding proteins PURalpha and PURbeta bind to a
            purine-rich negative regulatory element of the alpha-myosin heavy
            chain gene and control transcriptional and translational regulation
            of the gene expression. Implications in the repression of
            alpha-myosin heavy chain during heart failure
  JOURNAL   J Biol Chem 278 (45), 44935-44948 (2003)
   PUBMED   12933792
REFERENCE   8  (bases 1 to 2484)
  AUTHORS   Ohashi,S., Kobayashi,S., Omori,A., Ohara,S., Omae,A., Muramatsu,T.,
            Li,Y. and Anzai,K.
  TITLE     The single-stranded DNA- and RNA-binding proteins pur alpha and pur
            beta link BC1 RNA to microtubules through binding to the
            dendrite-targeting RNA motifs
  JOURNAL   J Neurochem 75 (5), 1781-1790 (2000)
   PUBMED   11032866
REFERENCE   9  (bases 1 to 2484)
  AUTHORS   Kelm,R.J. Jr., Cogan,J.G., Elder,P.K., Strauch,A.R. and Getz,M.J.
  TITLE     Molecular interactions between single-stranded DNA-binding proteins
            associated with an essential MCAT element in the mouse smooth
            muscle alpha-actin promoter
  JOURNAL   J Biol Chem 274 (20), 14238-14245 (1999)
   PUBMED   10318844
REFERENCE   10 (bases 1 to 2484)
  AUTHORS   Kelm,R.J. Jr., Elder,P.K., Strauch,A.R. and Getz,M.J.
  TITLE     Sequence of cDNAs encoding components of vascular actin
            single-stranded DNA-binding factor 2 establish identity to Puralpha
            and Purbeta
  JOURNAL   J Biol Chem 272 (42), 26727-26733 (1997)
   PUBMED   9334258
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000014.1.
            
            On Dec 5, 2020 this sequence version replaced NM_001017503.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AB182574.1, SRR21887622.252168.1
                                        [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2484              JAXUCZ010000014.1  85556296-85558779   c
FEATURES             Location/Qualifiers
     source          1..2484
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14q21"
     gene            1..2484
                     /gene="Purb"
                     /gene_synonym="pur-beta"
                     /note="purine rich element binding protein B"
                     /db_xref="GeneID:498407"
                     /db_xref="RGD:1559465"
     exon            1..2484
                     /gene="Purb"
                     /gene_synonym="pur-beta"
                     /inference="alignment:Splign:2.1.0"
     CDS             28..981
                     /gene="Purb"
                     /gene_synonym="pur-beta"
                     /note="transcriptional activator protein Pur-beta;
                     transcription factor Pur-beta"
                     /codon_start=1
                     /product="transcriptional regulator protein Pur-beta"
                     /protein_id="NP_001017503.2"
                     /db_xref="GeneID:498407"
                     /db_xref="RGD:1559465"
                     /translation="MADGDSGSERGGGGGGPGSFQPAPRGGGGPGGEQETQELASKRL
                     DIQNKRFYLDVKQNAKGRFLKIAEVGAGGSKSRLTLSMAVAAEFRDSLGDFIEHYAQL
                     GPSSPEQLAAGAEEGGGPRRALKSEFLVRENRKYYLDLKENQRGRFLRIRQTVNRGGG
                     GFGGGPGPGGLQSGQTIALPAQGLIEFRDALAKLIDDYGGEDDELAGGPGGGAGGPGG
                     GLYGELPEGTSITVDSKRFFFDVGCNKYGVFLRVSEVKPSYRNAITVPFKAWGKFGGA
                     FCRYADEMKEIQERQRDKLYERRGGGSGGGDESEGEEVDED"
ORIGIN      
        1 ggcggcggcg aggcggcggc cgagaagatg gcggacggcg acagcggcag cgagcgcggt
       61 ggcggcggcg gcgggcccgg cagcttccag cccgcgcccc gcggcggcgg agggcctggc
      121 ggcgagcagg agacgcagga gctggcctcg aagcggctgg acatccagaa caagcgcttc
      181 tacctggacg tgaagcagaa cgccaagggc cgcttcctca agatcgccga ggtgggcgcg
      241 ggcggctcca agagccgcct cacgctctcg atggcggtgg ccgccgagtt ccgcgactcg
      301 ctgggcgact tcatcgagca ctacgcgcag ctgggtccca gcagcccgga gcagctggcg
      361 gcgggcgccg aggagggcgg cgggccgcgc cgcgcgctta agagcgagtt cctggtgcgc
      421 gagaaccgca agtactacct ggacctcaag gagaaccagc gcggccgctt cctgcgcatc
      481 cgtcagacgg taaaccgcgg cggtggaggc ttcggcgggg gacccgggcc cggcggcctg
      541 cagagcggcc agaccatcgc gctgcccgcg cagggcctca tcgagttccg cgacgcgctc
      601 gccaagctca tcgacgacta cgggggcgag gatgacgagc tggccggtgg cccgggaggc
      661 ggcgccggcg gccctggggg cggcctgtac ggagagctcc cggagggcac ctccatcacg
      721 gtggactcca agcgcttctt cttcgacgtc ggctgcaaca agtacggggt gttcctgcga
      781 gtgagcgagg tgaagccatc ctaccgcaat gccatcaccg tgcccttcaa ggcctggggc
      841 aagtttggag gcgccttctg tcggtatgca gatgaaatga aagaaatcca ggagcgacag
      901 agggataagc tttacgagcg acgcggtggg ggcagcggcg gtggcgacga gtccgagggt
      961 gaggaagtgg atgaggattg aagcggcagc ttcccgtact ggcctccccc accccaccac
     1021 catccccttg gctagagagt tccctttcct actcgtcccc agtgagctag tggagaggga
     1081 tcaggggagg ccgcagacga agaaaacaaa aaataaaata atatagttaa gagaaataac
     1141 cataagaaaa cagtcacaga caattagaga aaagcagtta agttccaagg aactgccagc
     1201 aacctgcaaa gaggacagca gcatctcctc acctgcgcaa gagtctcagc ttctgttgtt
     1261 taaaaccgag gttcgtaaat tcatcaggaa aacattggag gggatagatc ttcgaacgtc
     1321 tgggaccaaa accacatctg ggttacccag actcatccat tggtgatagt tgaatttgtg
     1381 ttgtagctgg gtaatctggt cttaggagcc ctccaggcct cactactgca gcatctatcc
     1441 cttcacctcc atcggcattt tggatctagg tcttaatgga atctttgaga agaaagaggc
     1501 ctttgcagtt acccggttct gagggtacaa gtttatgaaa aggaatgcaa ctttacacaa
     1561 tcatggacag ggcaagagaa gaatgcaaga agccattgga gaattcaaag gttggatcca
     1621 ttttaaaaaa tggttttgca tggaacctgg accaaggccc ctgtcttttc tttgcagaat
     1681 tgttttccgg gatgcaaatg aattcagata tcaaagcttg aactagaatc catttctaaa
     1741 atagtttaaa agttggcaaa aaaaaatttt tttccaaaac aaaagcaatt tttacaatgg
     1801 ggattgctga ggtaggcaca agaagtcagg cataaagcac aaggtggact gtttgagtgg
     1861 attggttgct gctcactaaa gttcttccct tgatctctta agtatggagg tcattaccaa
     1921 gaaatggctt agcgtgagtg agagctggat cccaatggct ccacggtaag agctagtgaa
     1981 ttatggctaa ttcggctgtt acagccactg gctggctgca ttttaaacct taaaacttga
     2041 ctatctgcaa aaaggaactg tggccacaac tgagctttaa tgagatacac atcctcgcag
     2101 agaagttgga aataaccaga actgaagtct cagttcacct tcagtttcat ctctggattt
     2161 actgaatact gacgatcgat cctcaggtcc agaattccag catcatttat tcttttaaaa
     2221 taaattttta agaacttgat ccatcatatt cagtacctca caatcaaagt tggcaaatgg
     2281 tggatgaatg attcaagcat tgcacccggt ggaagctgaa tccatctgtg aatggaactg
     2341 aagtgaacac gaatgctgac tctatcctgg aagcattttt ataccatctt gaaatttcaa
     2401 caaactggca tttgccagtt tatccagctg tctttcaaga ataaaagttg gggttttcaa
     2461 ggatcgcctc ttctatattt taaa
//
