LOCUS       NP_001017503             317 aa            linear   ROD 30-APR-2025
DEFINITION  transcriptional regulator protein Pur-beta [Rattus norvegicus].
ACCESSION   NP_001017503 XP_573651
VERSION     NP_001017503.2
DBSOURCE    REFSEQ: accession NM_001017503.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 317)
  AUTHORS   Maamar,H., Cabili,M.N., Rinn,J. and Raj,A.
  TITLE     linc-HOXA1 is a noncoding RNA that represses Hoxa1 transcription in
            cis
  JOURNAL   Genes Dev 27 (11), 1260-1271 (2013)
   PUBMED   23723417
REFERENCE   2  (residues 1 to 317)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   3  (residues 1 to 317)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   4  (residues 1 to 317)
  AUTHORS   Li,F., Kato,I., Kawaguchi,H., Takasawa,K., Hibino,Y. and Hiraga,K.
  TITLE     The galectin-3 gene promoter binding proteins in the liver of rats
            48-h post-treatment with CCl4
  JOURNAL   Gene 367, 46-55 (2006)
   PUBMED   16309856
REFERENCE   5  (residues 1 to 317)
  AUTHORS   Shimotai,Y., Minami,H., Saitoh,Y., Onodera,Y., Mishima,Y.,
            Kelm,R.J. Jr. and Tsutsumi,K.
  TITLE     A binding site for Pur alpha and Pur beta is structurally unstable
            and is required for replication in vivo from the rat aldolase B
            origin
  JOURNAL   Biochem Biophys Res Commun 340 (2), 517-525 (2006)
   PUBMED   16376299
  REMARK    GeneRIF: Purb may have role in DNA replication initiation.  [purine
            rich element binding protein B; Purb]
REFERENCE   6  (residues 1 to 317)
  AUTHORS   Subramanian,S.V., Polikandriotis,J.A., Kelm,R.J. Jr., David,J.J.,
            Orosz,C.G. and Strauch,A.R.
  TITLE     Induction of vascular smooth muscle alpha-actin gene transcription
            in transforming growth factor beta1-activated myofibroblasts
            mediated by dynamic interplay between the Pur repressor proteins
            and Sp1/Smad coactivators
  JOURNAL   Mol Biol Cell 15 (10), 4532-4543 (2004)
   PUBMED   15282343
REFERENCE   7  (residues 1 to 317)
  AUTHORS   Gupta,M., Sueblinvong,V., Raman,J., Jeevanandam,V. and Gupta,M.P.
  TITLE     Single-stranded DNA-binding proteins PURalpha and PURbeta bind to a
            purine-rich negative regulatory element of the alpha-myosin heavy
            chain gene and control transcriptional and translational regulation
            of the gene expression. Implications in the repression of
            alpha-myosin heavy chain during heart failure
  JOURNAL   J Biol Chem 278 (45), 44935-44948 (2003)
   PUBMED   12933792
REFERENCE   8  (residues 1 to 317)
  AUTHORS   Ohashi,S., Kobayashi,S., Omori,A., Ohara,S., Omae,A., Muramatsu,T.,
            Li,Y. and Anzai,K.
  TITLE     The single-stranded DNA- and RNA-binding proteins pur alpha and pur
            beta link BC1 RNA to microtubules through binding to the
            dendrite-targeting RNA motifs
  JOURNAL   J Neurochem 75 (5), 1781-1790 (2000)
   PUBMED   11032866
REFERENCE   9  (residues 1 to 317)
  AUTHORS   Kelm,R.J. Jr., Cogan,J.G., Elder,P.K., Strauch,A.R. and Getz,M.J.
  TITLE     Molecular interactions between single-stranded DNA-binding proteins
            associated with an essential MCAT element in the mouse smooth
            muscle alpha-actin promoter
  JOURNAL   J Biol Chem 274 (20), 14238-14245 (1999)
   PUBMED   10318844
REFERENCE   10 (residues 1 to 317)
  AUTHORS   Kelm,R.J. Jr., Elder,P.K., Strauch,A.R. and Getz,M.J.
  TITLE     Sequence of cDNAs encoding components of vascular actin
            single-stranded DNA-binding factor 2 establish identity to Puralpha
            and Purbeta
  JOURNAL   J Biol Chem 272 (42), 26727-26733 (1997)
   PUBMED   9334258
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000014.1.
            
            On Dec 5, 2020 this sequence version replaced NP_001017503.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AB182574.1, SRR21887622.252168.1
                                        [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..317
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14q21"
     Protein         1..317
                     /product="transcriptional regulator protein Pur-beta"
                     /note="transcriptional activator protein Pur-beta;
                     transcription factor Pur-beta"
                     /calculated_mol_wt=33401
     Site            2
                     /site_type="acetylation"
                     /note="N-acetylalanine.
                     /evidence=ECO:0000250|UniProtKB:Q96QR8; propagated from
                     UniProtKB/Swiss-Prot (Q68A21.3)"
     Site            6
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q96QR8; propagated from
                     UniProtKB/Swiss-Prot (Q68A21.3)"
     Site            8
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q96QR8; propagated from
                     UniProtKB/Swiss-Prot (Q68A21.3)"
     Site            25
                     /site_type="methylation"
                     /note="Omega-N-methylarginine.
                     /evidence=ECO:0000250|UniProtKB:O35295; propagated from
                     UniProtKB/Swiss-Prot (Q68A21.3)"
     Region          30..256
                     /region_name="DNA-binding.
                     /evidence=ECO:0000250|UniProtKB:O35295"
                     /note="propagated from UniProtKB/Swiss-Prot (Q68A21.3)"
     Region          36..284
                     /region_name="PurA"
                     /note="PurA ssDNA and RNA-binding protein; pfam04845"
                     /db_xref="CDD:282672"
     Site            36
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:O35295; propagated from
                     UniProtKB/Swiss-Prot (Q68A21.3)"
     Site            106
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q68A21.3)"
     Site            157
                     /site_type="methylation"
                     /note="Omega-N-methylarginine.
                     /evidence=ECO:0000250|UniProtKB:O35295; propagated from
                     UniProtKB/Swiss-Prot (Q68A21.3)"
     Region          202..222
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q68A21.3)"
     Site            272
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:O35295; propagated from
                     UniProtKB/Swiss-Prot (Q68A21.3)"
     Region          290..317
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q68A21.3)"
     Site            299
                     /site_type="methylation"
                     /note="Omega-N-methylarginine.
                     /evidence=ECO:0000250|UniProtKB:O35295; propagated from
                     UniProtKB/Swiss-Prot (Q68A21.3)"
     Site            303
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q68A21.3)"
     Site            309
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q68A21.3)"
     CDS             1..317
                     /gene="Purb"
                     /gene_synonym="pur-beta"
                     /coded_by="NM_001017503.2:28..981"
                     /db_xref="GeneID:498407"
                     /db_xref="RGD:1559465"
ORIGIN      
        1 madgdsgser ggggggpgsf qpaprggggp ggeqetqela skrldiqnkr fyldvkqnak
       61 grflkiaevg aggsksrltl smavaaefrd slgdfiehya qlgpsspeql aagaeegggp
      121 rralkseflv renrkyyldl kenqrgrflr irqtvnrggg gfgggpgpgg lqsgqtialp
      181 aqgliefrda lakliddygg eddelaggpg ggaggpgggl ygelpegtsi tvdskrfffd
      241 vgcnkygvfl rvsevkpsyr naitvpfkaw gkfggafcry ademkeiqer qrdklyerrg
      301 ggsgggdese geevded
//
