LOCUS       NM_001108684            5009 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus pumilio RNA-binding family member 1 (Pum1), mRNA.
ACCESSION   NM_001108684 XM_001063603 XM_342928
VERSION     NM_001108684.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5009)
  AUTHORS   Martinez,J.C., Randolph,L.K., Iascone,D.M., Pernice,H.F.,
            Polleux,F. and Hengst,U.
  TITLE     Pum2 Shapes the Transcriptome in Developing Axons through Retention
            of Target mRNAs in the Cell Body
  JOURNAL   Neuron 104 (5), 931-946 (2019)
   PUBMED   31606248
REFERENCE   2  (bases 1 to 5009)
  AUTHORS   Treiber,T., Treiber,N., Plessmann,U., Harlander,S., Daiss,J.L.,
            Eichner,N., Lehmann,G., Schall,K., Urlaub,H. and Meister,G.
  TITLE     A Compendium of RNA-Binding Proteins that Regulate MicroRNA
            Biogenesis
  JOURNAL   Mol Cell 66 (2), 270-284 (2017)
   PUBMED   28431233
REFERENCE   3  (bases 1 to 5009)
  AUTHORS   Lee,S., Kopp,F., Chang,T.C., Sataluri,A., Chen,B., Sivakumar,S.,
            Yu,H., Xie,Y. and Mendell,J.T.
  TITLE     Noncoding RNA NORAD Regulates Genomic Stability by Sequestering
            PUMILIO Proteins
  JOURNAL   Cell 164 (1-2), 69-80 (2016)
   PUBMED   26724866
REFERENCE   4  (bases 1 to 5009)
  AUTHORS   Gennarino,V.A., Singh,R.K., White,J.J., De Maio,A., Han,K.,
            Kim,J.Y., Jafar-Nejad,P., di Ronza,A., Kang,H., Sayegh,L.S.,
            Cooper,T.A., Orr,H.T., Sillitoe,R.V. and Zoghbi,H.Y.
  TITLE     Pumilio1 haploinsufficiency leads to SCA1-like neurodegeneration by
            increasing wild-type Ataxin1 levels
  JOURNAL   Cell 160 (6), 1087-1098 (2015)
   PUBMED   25768905
REFERENCE   5  (bases 1 to 5009)
  AUTHORS   Narita,R., Takahasi,K., Murakami,E., Hirano,E., Yamamoto,S.P.,
            Yoneyama,M., Kato,H. and Fujita,T.
  TITLE     A novel function of human Pumilio proteins in cytoplasmic sensing
            of viral infection
  JOURNAL   PLoS Pathog 10 (10), e1004417 (2014)
   PUBMED   25340845
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5009)
  AUTHORS   Chen,D., Zheng,W., Lin,A., Uyhazi,K., Zhao,H. and Lin,H.
  TITLE     Pumilio 1 suppresses multiple activators of p53 to safeguard
            spermatogenesis
  JOURNAL   Curr Biol 22 (5), 420-425 (2012)
   PUBMED   22342750
REFERENCE   7  (bases 1 to 5009)
  AUTHORS   Miles,W.O., Tschop,K., Herr,A., Ji,J.Y. and Dyson,N.J.
  TITLE     Pumilio facilitates miRNA regulation of the E2F3 oncogene
  JOURNAL   Genes Dev 26 (4), 356-368 (2012)
   PUBMED   22345517
REFERENCE   8  (bases 1 to 5009)
  AUTHORS   Filipovska,A., Razif,M.F., Nygard,K.K. and Rackham,O.
  TITLE     A universal code for RNA recognition by PUF proteins
  JOURNAL   Nat Chem Biol 7 (7), 425-427 (2011)
   PUBMED   21572425
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 5009)
  AUTHORS   Kedde,M., van Kouwenhove,M., Zwart,W., Oude Vrielink,J.A., Elkon,R.
            and Agami,R.
  TITLE     A Pumilio-induced RNA structure switch in p27-3' UTR controls
            miR-221 and miR-222 accessibility
  JOURNAL   Nat Cell Biol 12 (10), 1014-1020 (2010)
   PUBMED   20818387
REFERENCE   10 (bases 1 to 5009)
  AUTHORS   Galgano,A., Forrer,M., Jaskiewicz,L., Kanitz,A., Zavolan,M. and
            Gerber,A.P.
  TITLE     Comparative analysis of mRNA targets for human PUF-family proteins
            suggests extensive interaction with the miRNA regulatory system
  JOURNAL   PLoS One 3 (9), e3164 (2008)
   PUBMED   18776931
  REMARK    Publication Status: Online-Only
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473968.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001063603.1, XM_342928.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132263,
                              SAMD00132265 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..5009
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..5009
                     /gene="Pum1"
                     /note="pumilio RNA-binding family member 1"
                     /db_xref="GeneID:362609"
                     /db_xref="RGD:1307190"
     exon            1..79
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            80..453
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     CDS             91..3660
                     /gene="Pum1"
                     /note="pumilio 1"
                     /codon_start=1
                     /product="pumilio homolog 1"
                     /protein_id="NP_001102154.1"
                     /db_xref="GeneID:362609"
                     /db_xref="RGD:1307190"
                     /translation="MSVACVLKRKAVLWQDSFSPHLKHHPQEPANPNMPVVLTSGTGS
                     QAQPQPAANQALAAGTHSSPVPGSIGVAGRSQDDAMVDYFFQRQHGEQLGGGGSGGGG
                     YNTSKHRWPTGDNIHAEHQVRSMDELNHDFQALALEGRAMGEQLLPGKKFWETDESSK
                     DGPKGIFLGDQWRDSAWGTSDHSVSQPIMVQRRPGQSFHVNSEVNSVLSPRSESGGLG
                     VSMVEYVLSSSPGDSCLRKGGFGPRDADSDENDKGEKKNKGAFDGDKLGDLKEEGDVM
                     DKTNGLPVQNGIDADVKDFSRTPGNCQSSANEVDLLGPNQNGSEGLAQLTSTNGAKPV
                     EDFSNMESQSVPLDPMEHVGMEPLQFDYSGTQVPVDSAAATVGLFDYNSQQQLFQRPN
                     ALAVQQLTAAQQQQYALAAAHQPHIAGLAPAAFVPNPYIISAAPPGTDPYTAGLAAAA
                     TLGPAVVPHQYYGVTPWGVYPASLFQQQAAAAAAATNSATQQSAPQAQQGQQQVLRGG
                     ASQRPLTPNQNQQGQQTDPLVAAAAVNSALAFGQGLAAGMPGYPVLAPAAYYDQTGAL
                     VVNAGARNGLGAPVRLVAPAPVIISSSAAQAAVAAAAASANGAAGGLAGTTNGPFRPL
                     GTQQPQPQPQQQPSNNLASSSFYGNNSLSSNSQSSSLFSQGSAQPANTSLGFGSSSSL
                     GATLGSALGGFGTAVANSNTGSGSRRDSLTGSSDLYKRTSSSLAPIGHSFYNSLSFSS
                     SPGPVGMPLPSQGPGHSQTPPPSLSSHGSSSSLNLGGLTNGSGRYISAAPGAEAKYRS
                     ASSASSLFSPSSTLFSSSRLRYGMSDVMPSGRSRLLEDFRNNRYPNLQLREIAGHIME
                     FSQDQHGSRFIQLKLERATAAERQLVFNEILQAAYQLMVDVFGNYVIQKFFEFGSHEQ
                     KLALAERIRGHVLSLALQMYGCRVIQKALEFIPSDQQVINEMVRELDGHVLKCVKDQN
                     GNHVVQKCIECVQPQSLQFIIDAFKGQVFALSTHPYGCRVIQRILEHCLPDQTLPILE
                     ELHQHTEQLVQDQYGNYVIQHVLEHGRPEDKSKIVAEIRGNVLVLSQHKFASNVVEKC
                     VTHASRTERAVLIDEVCTMNDGPHSALYTMMKDQYANYVVQKMIDVAEPGQRKIVMHK
                     IRPHIATLRKYTYGKHILAKLEKYYMKNGVDLGPICGPPNGII"
     exon            454..522
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            523..631
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            632..810
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            811..977
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            978..1248
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            1249..1342
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            1343..1447
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            1448..1599
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            1600..1738
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            1739..1882
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            1883..2179
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            2180..2416
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            2417..2684
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            2685..2814
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            2815..2949
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            2950..3087
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            3088..3213
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            3214..3335
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            3336..3528
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
     exon            3529..5009
                     /gene="Pum1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgaaaggtaa gggggagcga gagcgccggc gagcgaagat cggggggccg gaatccatct
       61 tcatcctacc gctccgcccg tgttggtgga atgagcgttg catgtgtctt gaagagaaaa
      121 gcagtgcttt ggcaggactc tttcagcccc cacctgaaac atcaccctca agaaccagct
      181 aatcccaaca tgcctgttgt tttgacatct ggaacagggt cgcaagcgca gccacagcca
      241 gctgcaaatc aggctcttgc agctgggaca cactccagcc ctgtcccagg atccatagga
      301 gttgcaggcc gttcccagga cgacgctatg gtggactact tctttcagag gcagcatggt
      361 gagcagcttg ggggaggagg aagtggtgga ggcggctata atactagcaa acatcgatgg
      421 cctacagggg ataacattca tgcagaacac caggtgcgct ctatggatga attaaatcat
      481 gattttcaag cacttgctct ggaagggaga gctatgggcg agcagctctt gccaggtaaa
      541 aagttttggg aaacagatga atccagcaaa gatggaccaa aaggaatatt cctgggtgat
      601 caatggcgag acagtgcctg gggaacatca gatcattcag tttcccagcc aatcatggtg
      661 cagagaagac ctggtcagag tttccatgtg aacagtgagg tcaattctgt actgtcccca
      721 cgatcggaga gtgggggact aggcgttagc atggtggagt atgtgttgag ctcatccccg
      781 ggcgattcct gtctaagaaa aggaggattt ggcccaaggg atgcagacag tgatgaaaac
      841 gacaaaggtg aaaagaagaa caagggtgcg tttgatggag ataagctagg agatttgaag
      901 gaggagggag atgtgatgga caagaccaat ggtttgccag tgcagaatgg gattgatgca
      961 gacgtcaaag attttagccg tacccctggt aattgccaga gctctgctaa tgaagtggat
     1021 cttctgggtc caaaccagaa tggttctgag ggcttagccc agctgaccag caccaatggt
     1081 gccaagcctg tggaggattt ctccaacatg gagtcccaga gtgtcccctt ggaccccatg
     1141 gaacatgtgg gcatggagcc tctgcagttt gattattcag gcacgcaggt acctgtggac
     1201 tcagcagcag caacagtggg actttttgac tacaattctc aacaacagct attccaaaga
     1261 cccaatgcgc ttgctgttca gcagttgaca gctgcccagc agcagcaata tgcacttgca
     1321 gcagcccacc agcctcacat cgcaggttta gctcccgctg cgtttgtccc caacccatac
     1381 atcatcagcg ctgctccccc agggacggac ccctacacag ctggattggc tgcagcagcg
     1441 acactcggcc cagctgtggt ccctcaccaa tattatggag tcacgccatg gggtgtctat
     1501 cctgctagtc ttttccagca acaagctgct gcagctgcag cagcaacaaa ttcagctact
     1561 cagcagagtg ccccacaggc ccagcaggga cagcagcagg ttcttcgtgg aggagctagc
     1621 cagcgtcctt tgaccccaaa tcagaaccag cagggacaac aaacagatcc ccttgtagca
     1681 gctgcagcag tgaactctgc tcttgccttt ggacaaggat tggctgcagg tatgccaggt
     1741 tatccagtct tggcacctgc tgcttactat gaccaaactg gtgcccttgt ggtgaatgca
     1801 ggggcaagaa atggcctcgg agctccagtt cggcttgttg ctccagcccc agtcatcatt
     1861 agctcctcag ctgcacaagc agctgttgca gcggctgcag cttcagcaaa tggagcagcc
     1921 ggtggtcttg caggaactac aaatggacca tttcgacctt taggcaccca gcagccccag
     1981 ccccagcccc agcagcagcc cagtaacaat ctggcttcca gctctttcta tggcaacaac
     2041 tctctgagca gtaactccca gagcagctcc ctcttctctc agggctccgc ccagcctgcc
     2101 aacacgtcct tgggattcgg aagcagcagt tcccttggtg ccaccctagg atcggccctt
     2161 ggagggtttg gaacagcagt tgcaaactcc aacactggca gtggctcccg ccgtgactcc
     2221 ctgactggca gcagtgacct ttataagagg acatcgagca gcttggcccc cattggacac
     2281 agtttttata acagccttag cttttcctcc tctcctggac ccgtgggcat gcctctccct
     2341 agtcagggac caggacattc acagacacca cctccttccc tctcttcaca tggatcctct
     2401 tcaagcttaa acctgggagg actcacgaac ggcagtggaa gatacatctc tgctgctcct
     2461 ggtgccgaag ccaagtaccg cagtgcgagc agtgcctcca gccttttcag ccccagcagc
     2521 accctttttt cttcctctcg tttgagatac ggaatgtctg atgttatgcc ctctggcagg
     2581 agcagacttc tggaagactt tcgaaacaac cggtacccta atttacaact gcgggagatt
     2641 gccgggcata taatggaatt ttcccaagac cagcatggtt ctagattcat tcagctgaaa
     2701 ctagagcgag ccacagcagc tgagcgccag cttgtcttca acgaaatcct gcaggctgcg
     2761 taccaactta tggtggatgt gtttggaaat tacgtcattc agaagttctt tgaatttggc
     2821 agccatgaac agaagctggc tttggctgaa cggattcgag gccacgtcct atcattggca
     2881 ctgcagatgt atggctgccg agtcatccag aaagctttgg aatttattcc ctcagaccag
     2941 caggtaatta acgagatggt gcgggagcta gatggccatg tcctgaagtg tgtgaaagac
     3001 cagaatggca accatgtggt tcagaagtgc attgaatgtg tacagcccca gtctttgcag
     3061 ttcatcatcg atgcattcaa ggggcaggtg tttgctttgt ctacgcaccc atatggctgt
     3121 agggtgatcc agaggatcct ggaacactgt ctccccgacc agaccctccc tatcctggag
     3181 gagcttcacc agcacacgga gcagctcgtg caggatcagt atggaaatta tgtaatccaa
     3241 catgtcctgg agcatggtcg tcctgaggat aaaagcaaaa ttgtagcaga gatccgaggc
     3301 aatgtacttg tattgagtca gcacaaattc gcaagcaatg ttgtggagaa gtgtgtcact
     3361 cacgcctcac gtacagagcg tgctgtgctc attgatgagg tatgcaccat gaatgacggt
     3421 ccccacagtg ccttatacac catgatgaag gatcagtatg ccaattatgt ggtccagaag
     3481 atgatcgatg tggctgagcc ggggcagcgg aagattgtca tgcacaagat ccggccacac
     3541 atcgcgactc ttcggaagta cacctatggc aagcacatcc tggccaagct tgagaagtac
     3601 tacatgaaga atggtgtgga cttggggccc atttgtggtc cccctaatgg gatcatctga
     3661 gcagtgcacc catccctgtc ccgctgacct cactgaccct ggcagatcca accagcaacc
     3721 agagatgccc agctcagagt cgaaagtggg cgatggttgc tccgggattg ctccctcctc
     3781 caaaaatgga atcggatcca cttgtggaaa ggcctttgta aatttcattt tattacacat
     3841 aacatgtact aattattttt tttaattgac taattgccct gctgtttact ggtgtatagg
     3901 aacttgtaca taggtaatca gtgtacatga gaggccacat gctttgttca atgttgtatc
     3961 tatattccac atgtggacac tttcagggtg gttggtttaa caaaaaaagt tttaaaaaaa
     4021 gacaaaaaaa ggtttttaac tcatttgcct tgtggcaagt tttgcaaata gctcttcccc
     4081 accccatttt attaaaaaaa gaaacctgag aaatttgaat tttagttaaa taatctcaaa
     4141 ctggcattta acactgttta taaaatatat atatatatat acatatatac atatgaaatg
     4201 ggaacgtttc cgagttgcta aagcatcagc ctgtgatacg gagtttatga cgctctttgg
     4261 agatgacctc atgctgaggg aggtggtagc tgcagatcca ggaggagcgg gaagcacaga
     4321 gacaggccgg aggccagtgg gcatggccac ttgctctatg ggttgccttc tgtgaacact
     4381 gggaagcaga atctgattat ctagcatgag agaacccagc tctgctcctg gtctggcttc
     4441 tatagataca tagtgtatac ttgtgtagac tttgcatata tacggatttg tagtattttc
     4501 ctgttttgat gtctaatctg tatctataat gtaccctagt agtcggacat acttttgatt
     4561 gtacaattgt acatttgtat acctgtaatg taaatgtgga gaagtttgaa tcaacatgaa
     4621 cacgtttttg gtaagaagag aaccggccag cccgtgcact ctgtatatcc caccttttat
     4681 ggttgtagca gatagtgttg tatattgtaa attgtaattt caaacagaag taaatttttt
     4741 tcttttgaag gaataaatgt tctttataca gcctagttaa tgtttaaaaa gaaaaaatag
     4801 cttggtttat ttgtcagcta gtcaagacgg tagtgagagc ctttctaaat gttacttcag
     4861 atgattcagt tcacactagt gttccttttt ttttttttat cctaagaaaa ggtaatgttt
     4921 cgcttatttt gtgacagtca aaaggatgtg cagaagtttc gcctgcccct tccctgctca
     4981 ccacctcccc ttgtaaagtg actcaccct
//
