LOCUS       NM_001109536            1924 bp    mRNA    linear   ROD 21-MAR-2023
DEFINITION  Rattus norvegicus pentraxin 3 (Ptx3), mRNA.
ACCESSION   NM_001109536 XM_001068884
VERSION     NM_001109536.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1924)
  AUTHORS   Ozer Balin S, Sagmak Tartar A, Ugur K, Kilinc F, Telo S, Bal A,
            Balin M and Akbulut A.
  TITLE     Pentraxin-3: A new parameter in predicting the severity of diabetic
            foot infection?
  JOURNAL   Int Wound J 16 (3), 659-664 (2019)
   PUBMED   30767386
REFERENCE   2  (bases 1 to 1924)
  AUTHORS   Li H, Liu L, Zhou W, Rui Y, He B, Shi Y and Su X.
  TITLE     Pentraxin 3 in bronchoalveolar lavage fluid and plasma in
            non-neutropenic patients with pulmonary aspergillosis
  JOURNAL   Clin Microbiol Infect 25 (4), 504-510 (2019)
   PUBMED   29964232
REFERENCE   3  (bases 1 to 1924)
  AUTHORS   Albert Vega C, Mommert M, Boccard M, Rimmele T, Venet F, Pachot A,
            Leray V, Monneret G, Delwarde B, Brengel-Pesce K, Mallet F and
            Trouillet-Assant S.
  TITLE     Source of Circulating Pentraxin 3 in Septic Shock Patients
  JOURNAL   Front Immunol 9, 3048 (2019)
   PUBMED   30687307
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1924)
  AUTHORS   Herrero-Sanchez MC, Angomas EB, de Ramon C, Telleria JJ, Corchete
            LA, Alonso S, Ramos MDC, Penarrubia MJ, Marquez S, Fernandez N,
            Garcia Frade LJ and Sanchez Crespo M.
  TITLE     Polymorphisms in Receptors Involved in Opsonic and Nonopsonic
            Phagocytosis, and Correlation with Risk of Infection in
            Oncohematology Patients
  JOURNAL   Infect Immun 86 (12), e00709-18 (2018)
   PUBMED   30275011
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1924)
  AUTHORS   Chen X, Luo J, Wu M, Pan Z, Xie Y, Wang H, Chen B and Zhu H.
  TITLE     Study on Association of Pentraxin 3 and Diabetic Nephropathy in a
            Rat Model
  JOURNAL   J Diabetes Res 2018, 8968573 (2018)
   PUBMED   29725602
  REMARK    GeneRIF: Our data showed that the level of PTX3 in renal tissue is
            closely related to renal injury in diabetic nephropathy.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1924)
  AUTHORS   Scarchilli L, Camaioni A, Bottazzi B, Negri V, Doni A, Deban L,
            Bastone A, Salvatori G, Mantovani A, Siracusa G and Salustri A.
  TITLE     PTX3 interacts with inter-alpha-trypsin inhibitor: implications for
            hyaluronan organization and cumulus oophorus expansion
  JOURNAL   J Biol Chem 282 (41), 30161-30170 (2007)
   PUBMED   17675295
REFERENCE   7  (bases 1 to 1924)
  AUTHORS   Okutani D, Han B, Mura M, Waddell TK, Keshavjee S and Liu M.
  TITLE     High-volume ventilation induces pentraxin 3 expression in multiple
            acute lung injury models in rats
  JOURNAL   Am J Physiol Lung Cell Mol Physiol 292 (1), L144-L153 (2007)
   PUBMED   16936248
  REMARK    GeneRIF: A local expression of PTX3 induced by high-volume
            ventilation, either alone or in combination with other pathological
            conditions, suggests that it may be an important mediator in
            ventilator-induced lung injury.
REFERENCE   8  (bases 1 to 1924)
  AUTHORS   Camozzi M, Zacchigna S, Rusnati M, Coltrini D, Ramirez-Correa G,
            Bottazzi B, Mantovani A, Giacca M and Presta M.
  TITLE     Pentraxin 3 inhibits fibroblast growth factor 2-dependent
            activation of smooth muscle cells in vitro and neointima formation
            in vivo
  JOURNAL   Arterioscler Thromb Vasc Biol 25 (9), 1837-1842 (2005)
   PUBMED   16020751
  REMARK    GeneRIF: Local PTX3 upregulation may modulate vascular smooth
            muscle cell activation after arterial injury
REFERENCE   9  (bases 1 to 1924)
  AUTHORS   Diniz SN, Nomizo R, Cisalpino PS, Teixeira MM, Brown GD, Mantovani
            A, Gordon S, Reis LF and Dias AA.
  TITLE     PTX3 function as an opsonin for the dectin-1-dependent
            internalization of zymosan by macrophages
  JOURNAL   J Leukoc Biol 75 (4), 649-656 (2004)
   PUBMED   14726497
REFERENCE   10 (bases 1 to 1924)
  AUTHORS   Ravizza T, Moneta D, Bottazzi B, Peri G, Garlanda C, Hirsch E,
            Richards GJ, Mantovani A and Vezzani A.
  TITLE     Dynamic induction of the long pentraxin PTX3 in the CNS after
            limbic seizures: evidence for a protective role in seizure-induced
            neurodegeneration
  JOURNAL   Neuroscience 105 (1), 43-53 (2001)
   PUBMED   11483299
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JACYVU010000069.1.
            
            [WARNING] On Apr 1, 2024 this sequence was replaced by
            NM_001109536.3.
            
            On Nov 27, 2020 this sequence version replaced NM_001109536.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760383,
                              SAMEA5760386 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-290               JACYVU010000069.1  16959933-16960222
            291-692             JACYVU010000069.1  16960649-16961050
            693-1924            JACYVU010000069.1  16964512-16965743
FEATURES             Location/Qualifiers
     source          1..1924
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q31"
     gene            1..1924
                     /gene="Ptx3"
                     /note="pentraxin 3"
                     /db_xref="GeneID:689388"
                     /db_xref="RGD:1593476"
     exon            1..290
                     /gene="Ptx3"
                     /inference="alignment:Splign:2.1.0"
     CDS             161..1306
                     /gene="Ptx3"
                     /note="pentraxin related; pentraxin-related protein PTX3;
                     pentraxin 3, long"
                     /codon_start=1
                     /product="pentraxin-related protein PTX3 precursor"
                     /protein_id="NP_001103006.1"
                     /db_xref="GeneID:689388"
                     /db_xref="RGD:1593476"
                     /translation="MHLPVILLCALWSAVLAETSYDYELMHVNLDNEIDNGLHPTEDP
                     TPCDCRQEHSEWDKLFIMLENSQMREAMLLQATDDVLRGELQRLRAELGRLAGGMARP
                     CSASGPADARLAQALEPLLQESRDANRRLARLEDAEARRHEATVPSLGAVLEELQRTR
                     ADLSAMQSWVARHWLPAGCETAIFFPMRSKKIFGSVHPVRPMKLESFSACIWVKATDV
                     LNKTILFSYGTKWNPYEIQLYLSSQSLVFVVGGKENKLAADTVVSLGRWSHLCGTWSS
                     EQGSMSLWANGELVATTLEMAKSHPVPEGGLLQIGQEKNGCCVGGGFDETLAFSGRIT
                     GFNIWDRVLSKEEIRASGGAESCHIRGNIVGWGVTEIQAHGGAQYVS"
     exon            291..692
                     /gene="Ptx3"
                     /inference="alignment:Splign:2.1.0"
     exon            693..1924
                     /gene="Ptx3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgctgtgcca ccgacattac tcattcatcc cgttcaggct ttggagcgtt tattaagggc
       61 ttcgctcctg ccttgctcta tctctcccgg gctctcggat cactagagaa cctcgcttct
      121 ttccctgtgg cggctgcgag caaacttcgc ctctccagca atgcatctcc ctgtgattct
      181 gctttgtgct ctctggtctg cagtgttggc tgagacctcc tatgactatg agctcatgca
      241 tgtgaatttg gacaacgaaa tagacaatgg acttcatccc accgaggacc ccacaccatg
      301 cgactgccgc caggaacact cggagtggga caagctgttc atcatgctgg agaactcgca
      361 gatgcgggag gccatgctgt tacaggccac tgacgacgtc ctccgcgggg agttgcagag
      421 gctgcgggcg gaactggggc ggctggcggg cggtatggcg aggccttgct cagccagtgg
      481 cccggcagac gccaggctgg cacaggcgct ggagccgctg ctgcaggaga gccgcgacgc
      541 gaaccgcagg ctggcacgcc tggaagatgc agaggcgcgg cgacacgagg cgacagtgcc
      601 tagcctagga gcggtgctgg aggaactgca gcggacgcgc gccgacctga gcgccatgca
      661 gagctgggtc gctcgccact ggctacccgc aggctgtgaa acagcgattt tcttcccaat
      721 gcgttctaag aagatttttg gaagcgtgca tcctgtgaga ccaatgaagc ttgaatcttt
      781 tagtgcttgt atttgggtca aagccacaga cgtattaaac aaaaccatcc tgttttccta
      841 tggcaccaag tggaacccct atgagatcca gctgtaccta agttcccagt ccctagtgtt
      901 tgtggtgggt gggaaggaga acaagctggc tgcggatact gtggtctccc tggggaggtg
      961 gtcccacctg tgtggcacgt ggagttcaga gcaggggagc atgtccttgt gggcaaatgg
     1021 ggaactggtg gctaccactc tggagatggc caaaagtcac cctgttcctg agggtggact
     1081 cctacagatt ggccaagaaa agaatggttg ctgtgtaggt gggggctttg acgaaacatt
     1141 ggcattttct ggaagaatca caggcttcaa tatctgggat cgagttctca gcaaggagga
     1201 gataagggca agtgggggag ccgaatcatg ccacatccgg ggaaacatcg tcgggtgggg
     1261 agtcacagag attcaggctc atggaggagc tcagtatgtt tcttaagtgt tgtgaaactc
     1321 tacttgaagc caaaggagac tcacacttta aatatatgcc aattggaaag gtctgaaaaa
     1381 cttcggtgcc taataagaac acttgagagg agtgaaggag agacgagttc gtctttattt
     1441 accttggcaa aatgctgaat aaacagttga agggaaggct tgagagaagg cttggggatg
     1501 ttgttactaa gccttatact gtggtgcttt cagattaatg tctgcctctg tcagataaac
     1561 cctcagataa ctaaacagga ctggactctg aacagagaga cgattgtgtt cctttttttt
     1621 tttttttttt tttttttggt taattttatt ttggccagag acatttttat attggaagaa
     1681 taacaaaaca agctctgtgg cccattgttc attcttcctg gtgtgtattt tgtgacaaaa
     1741 gagatgatga gaaaaccata tttataccac aaagtgactt attaacaaac acaaatgtag
     1801 ctttcgtgtt ataatccagt gttccatttg ggagaaagta gttgtgtaat ttatattgtg
     1861 aaatggattt gtattaattt tatttttgta aaagtctact gtaaataaaa tgttttataa
     1921 agct
//
