LOCUS       NM_022391                713 bp    mRNA    linear   ROD 09-APR-2024
DEFINITION  Rattus norvegicus PTTG1 regulator of sister chromatid separation,
            securin (Pttg1), mRNA.
ACCESSION   NM_022391 XM_008767643
VERSION     NM_022391.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 713)
  AUTHORS   Dun,Y., Hu,H., Liu,F., Shao,Y., He,D., Zhang,L. and Shen,J.
  TITLE     PTTG1 promotes CD34+CD45+ cells to repair the pulmonary vascular
            barrier via activating the VEGF-bFGF/PI3K/AKT/eNOS signaling
            pathway in rats with phosgene-induced acute lung injury
  JOURNAL   Biomed Pharmacother 162, 114654 (2023)
   PUBMED   37018988
  REMARK    GeneRIF: PTTG1 promotes CD34[+]CD45[+] cells to repair the
            pulmonary vascular barrier via activating the
            VEGF-bFGF/PI3K/AKT/eNOS signaling pathway in rats with
            phosgene-induced acute lung injury.
REFERENCE   2  (bases 1 to 713)
  AUTHORS   Perramon,M., Carvajal,S., Reichenbach,V., Fernandez-Varo,G.,
            Boix,L., Macias-Munoz,L., Melgar-Lesmes,P., Bruix,J., Melmed,S.,
            Lamas,S. and Jimenez,W.
  TITLE     The pituitary tumour-transforming gene 1/delta-like homologue 1
            pathway plays a key role in liver fibrogenesis
  JOURNAL   Liver Int 42 (3), 651-662 (2022)
   PUBMED   35050550
  REMARK    GeneRIF: The pituitary tumour-transforming gene 1/delta-like
            homologue 1 pathway plays a key role in liver fibrogenesis.
REFERENCE   3  (bases 1 to 713)
  AUTHORS   Xu,J. and Li,P.
  TITLE     Expression of EAP1 and CUX1 in the hypothalamus of female rats and
            relationship with KISS1 and GnRH
  JOURNAL   Endocr J 63 (8), 681-690 (2016)
   PUBMED   27250217
  REMARK    GeneRIF: EAP1 (Pttg1) gene may be involved in the neuroendocrine
            control of female puberty in correlation with the kisspeptin
            signaling.
REFERENCE   4  (bases 1 to 713)
  AUTHORS   Wang,H., Zhang,Y., Zhou,A., Zhang,R. and Meng,Q.
  TITLE     Effects of silencing connexin43 on expression of pituitary
            tumor-transforming gene in prolactinomas
  JOURNAL   Neurol Res 37 (2), 153-158 (2015)
   PUBMED   25023895
  REMARK    GeneRIF: Altered Cx43 expression modulates Pituitary tumor
            transforming gene expression, which correlates with prolactinoma
            development.
REFERENCE   5  (bases 1 to 713)
  AUTHORS   Yun,J.W., Kim,C.W., Bae,I.H., Park,Y.H., Chung,J.H., Lim,K.M. and
            Kang,K.S.
  TITLE     Expression levels of pituitary tumor transforming 1 and
            glutathione-S-transferase theta 3 are associated with the
            individual susceptibility to D-galactosamine-induced hepatotoxicity
  JOURNAL   Toxicol Appl Pharmacol 242 (1), 91-99 (2010)
   PUBMED   19800905
  REMARK    GeneRIF: pttg1 could predict inter-individual susceptibility to
            D-galactosamine induced hepatotoxicity
REFERENCE   6  (bases 1 to 713)
  AUTHORS   Heaney,A.P., Fernando,M. and Melmed,S.
  TITLE     Functional role of estrogen in pituitary tumor pathogenesis
  JOURNAL   J Clin Invest 109 (2), 277-283 (2002)
   PUBMED   11805140
REFERENCE   7  (bases 1 to 713)
  AUTHORS   Pei,L.
  TITLE     Pituitary tumor-transforming gene protein associates with ribosomal
            protein S10 and a novel human homologue of DnaJ in testicular cells
  JOURNAL   J Biol Chem 274 (5), 3151-3158 (1999)
   PUBMED   9915854
REFERENCE   8  (bases 1 to 713)
  AUTHORS   Dominguez,A., Ramos-Morales,F., Romero,F., Rios,R.M., Dreyfus,F.,
            Tortolero,M. and Pintor-Toro,J.A.
  TITLE     hpttg, a human homologue of rat pttg, is overexpressed in
            hematopoietic neoplasms. Evidence for a transcriptional activation
            function of hPTTG
  JOURNAL   Oncogene 17 (17), 2187-2193 (1998)
   PUBMED   9811450
REFERENCE   9  (bases 1 to 713)
  AUTHORS   Pei,L.
  TITLE     Genomic organization and identification of an enhancer element
            containing binding sites for multiple proteins in rat pituitary
            tumor-transforming gene
  JOURNAL   J Biol Chem 273 (9), 5219-5225 (1998)
   PUBMED   9478977
REFERENCE   10 (bases 1 to 713)
  AUTHORS   Pei,L. and Melmed,S.
  TITLE     Isolation and characterization of a pituitary tumor-transforming
            gene (PTTG)
  JOURNAL   Mol Endocrinol 11 (4), 433-441 (1997)
   PUBMED   9092795
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On or before Nov 30, 2016 this sequence version replaced
            XM_008767643.2, NM_022391.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BF550073.1, SRR26360181.273102.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-13                JAXUCZ010000010.1  28406314-28406326   c
            14-124              JAXUCZ010000010.1  28405699-28405809   c
            125-303             JAXUCZ010000010.1  28404694-28404872   c
            304-397             JAXUCZ010000010.1  28402720-28402813   c
            398-556             JAXUCZ010000010.1  28401490-28401648   c
            557-713             JAXUCZ010000010.1  28400644-28400800   c
FEATURES             Location/Qualifiers
     source          1..713
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q21"
     gene            1..713
                     /gene="Pttg1"
                     /gene_synonym="Pttg"
                     /note="PTTG1 regulator of sister chromatid separation,
                     securin"
                     /db_xref="GeneID:64193"
                     /db_xref="RGD:68359"
     exon            1..13
                     /gene="Pttg1"
                     /gene_synonym="Pttg"
                     /inference="alignment:Splign:2.1.0"
     exon            14..124
                     /gene="Pttg1"
                     /gene_synonym="Pttg"
                     /inference="alignment:Splign:2.1.0"
     CDS             37..636
                     /gene="Pttg1"
                     /gene_synonym="Pttg"
                     /note="pituitary tumor-transforming gene 1 protein;
                     Pituitary tumor transforming; pituitary tumor-transforming
                     1"
                     /codon_start=1
                     /product="securin"
                     /protein_id="NP_071786.1"
                     /db_xref="GeneID:64193"
                     /db_xref="RGD:68359"
                     /translation="MATLIFVDKDNEEPGSRLASKDGLKLGSGVKALDGKLQVSTPRV
                     GKVFGAPGLPKASRKALGTVNRVTEKPVKSSKPLQSKQPTLSVKKITEKSTKTQGSAP
                     APDDAYPEIEKFFPFDPLDFESFDLPEEHQISLLPLNGVPLMILNEERGLEKLLHLDP
                     PSPLQKPFLPWESDPLPSPPSALSALDVELPPVCYDADI"
     exon            125..303
                     /gene="Pttg1"
                     /gene_synonym="Pttg"
                     /inference="alignment:Splign:2.1.0"
     exon            304..397
                     /gene="Pttg1"
                     /gene_synonym="Pttg"
                     /inference="alignment:Splign:2.1.0"
     exon            398..556
                     /gene="Pttg1"
                     /gene_synonym="Pttg"
                     /inference="alignment:Splign:2.1.0"
     exon            557..713
                     /gene="Pttg1"
                     /gene_synonym="Pttg"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcgtagtct tgggtctctc ccctcagtaa tccaggatgg ctactctgat ctttgttgat
       61 aaggataacg aagagccagg cagccgtttg gcatctaagg atggattgaa gctgggctct
      121 ggtgtcaaag ccttagatgg gaaattgcag gtttcaacgc cacgagtcgg caaagtgttc
      181 ggtgccccag gcttgcctaa agccagcagg aaggctctgg gaactgtcaa cagagttact
      241 gaaaagccag tgaagagtag taaacccctg caatcgaaac agccgactct gagtgtgaaa
      301 aagatcaccg agaagtctac taagacacaa ggctctgctc ctgctcctga tgatgcctac
      361 ccagaaatag aaaagttctt ccccttcgat cctctagatt ttgagagttt tgacctgcct
      421 gaagagcacc agatctcact tctccccttg aatggagtgc ctctcatgat cctgaatgaa
      481 gagagggggc ttgagaagct gctgcacctg gacccccctt cccctctgca gaagcccttc
      541 ctaccgtggg aatctgatcc gttgccgtct cctcccagcg ccctctccgc tctggatgtt
      601 gaattgccgc ctgtttgtta cgatgcagat atttaaacgt cttactcctt tatagtttat
      661 gtaagttgta ttaataaagc atttgtgtgt atgctctgac tacctaaccc aaa
//
