LOCUS       NM_001013860            2863 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus peptidyl-tRNA hydrolase 2 (Ptrh2), mRNA; nuclear
            gene for mitochondrial product.
ACCESSION   NM_001013860 XM_213411
VERSION     NM_001013860.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2863)
  AUTHORS   Brunquell,C., Biliran,H., Jennings,S., Ireland,S.K., Chen,R. and
            Ruoslahti,E.
  TITLE     TLE1 is an anoikis regulator and is downregulated by Bit1 in breast
            cancer cells
  JOURNAL   Mol Cancer Res 10 (11), 1482-1495 (2012)
   PUBMED   22952044
REFERENCE   2  (bases 1 to 2863)
  AUTHORS   Griffiths,G.S., Grundl,M., Leychenko,A., Reiter,S.,
            Young-Robbins,S.S., Sulzmaier,F.J., Caliva,M.J., Ramos,J.W. and
            Matter,M.L.
  TITLE     Bit-1 mediates integrin-dependent cell survival through activation
            of the NFkappaB pathway
  JOURNAL   J Biol Chem 286 (16), 14713-14723 (2011)
   PUBMED   21383007
REFERENCE   3  (bases 1 to 2863)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   4  (bases 1 to 2863)
  AUTHORS   Jan,Y., Matter,M., Pai,J.T., Chen,Y.L., Pilch,J., Komatsu,M.,
            Ong,E., Fukuda,M. and Ruoslahti,E.
  TITLE     A mitochondrial protein, Bit1, mediates apoptosis regulated by
            integrins and Groucho/TLE corepressors
  JOURNAL   Cell 116 (5), 751-762 (2004)
   PUBMED   15006356
  REMARK    Erratum:[Cell. 2005 Aug 12;122(3):485-6]
REFERENCE   5  (bases 1 to 2863)
  AUTHORS   De Pereda,J.M., Waas,W.F., Jan,Y., Ruoslahti,E., Schimmel,P. and
            Pascual,J.
  TITLE     Crystal structure of a human peptidyl-tRNA hydrolase reveals a new
            fold and suggests basis for a bifunctional activity
  JOURNAL   J Biol Chem 279 (9), 8111-8115 (2004)
   PUBMED   14660562
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Nov 27, 2020 this sequence version replaced NM_001013860.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC083801.1, SRR26643292.42439.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-32                JAXUCZ010000010.1  72002575-72002606
            33-2863             JAXUCZ010000010.1  72009776-72012606
FEATURES             Location/Qualifiers
     source          1..2863
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q26"
     gene            1..2863
                     /gene="Ptrh2"
                     /gene_synonym="RGD1306819"
                     /note="peptidyl-tRNA hydrolase 2"
                     /db_xref="GeneID:287593"
                     /db_xref="RGD:1306819"
     exon            1..32
                     /gene="Ptrh2"
                     /gene_synonym="RGD1306819"
                     /inference="alignment:Splign:2.1.0"
     exon            33..2863
                     /gene="Ptrh2"
                     /gene_synonym="RGD1306819"
                     /inference="alignment:Splign:2.1.0"
     CDS             33..578
                     /gene="Ptrh2"
                     /gene_synonym="RGD1306819"
                     /EC_number="3.1.1.29"
                     /note="Bcl-2 inhibitor of transcription"
                     /codon_start=1
                     /product="peptidyl-tRNA hydrolase 2, mitochondrial"
                     /protein_id="NP_001013882.1"
                     /db_xref="GeneID:287593"
                     /db_xref="RGD:1306819"
                     /translation="MLSKLLTMEYLVHPGTLSLAAGVACGMCLGWGLRSHLGIFPQNS
                     TSETNRDTEMGTEASILGESGEYKMILVVRTDLKMGKGKVAAQCSHAAVSAYKQIQRR
                     NPQVLKEWEYCGQPKVVVKAPDEDSLIQLLTHAKALGLTVSLIQDAGRTQIEPGSRTV
                     LGIGPGPVELIDEVTGHLKLY"
ORIGIN      
        1 tggagaacta cgaggtgagc gagaagcttc agatgctttc caagttgttg acaatggagt
       61 atttggttca tcctggtaca ctcagcttgg ctgctggagt tgcttgtggc atgtgcctgg
      121 gctggggcct ccggagccac cttggaatct tcccccagaa ctcaacaagc gagacaaacc
      181 gagacacaga gatgggaacc gaagcaagca tcttgggaga gagtggggaa tacaaaatga
      241 ttcttgtggt tcgaactgac ttaaagatgg ggaaaggaaa ggtcgctgcc cagtgttccc
      301 atgctgcggt ctctgcctac aagcagattc aaaggagaaa ccctcaggtg ctcaaagagt
      361 gggaatactg tggccagccc aaagtggtgg tcaaagctcc agatgaagat tccctcattc
      421 aattactcac ccatgcaaaa gccttgggat tgactgtaag tttaatccaa gatgccggac
      481 gtactcagat tgaaccaggc tctcgaactg tcctgggaat tgggccagga ccagtagaac
      541 taattgatga agttactggc cacctaaaac tttactagat aagcttttgc ttgatggtga
      601 ttctgtccaa agactatgga gcctctcagt aacaataaat gcgtaattct tatccccact
      661 ttaaaatctg ttcccatgtt tctctgtcat atactggacc attaatatct tgagcttaaa
      721 atactattga aggctggaga gatggctcag tggttaaaag cactgactgc tcttccagag
      781 gtcctgagtt caaatcccag caaccacatg atggcttaaa atcatctata atgggatctg
      841 atgccctctt ctggtgtgtc tgacgccagc tactgtgtac ttatatagat aaatctttat
      901 agataaatag ataaatcttt ataaaaaaat tttagaaaaa aaatactatt gaagtggtag
      961 agaaatgcct cagtgattaa gaacacttgt tcttcttgca aaggatggtg caggttcagt
     1021 ttccagtatc cggatgtcag tttacaacca tccagatcca gttccaggaa atccaaaact
     1081 caatcaccaa gcatacacag catccataga catgcaggca agccctcata aatgcaaaga
     1141 atacaaagta agtctcaaga ctaactatgc attccctaga tgctcctgca gagtgatcgg
     1201 gtctaaaaca gactggaagc gagacagtgt tcatgatgct gctgggtgaa aggaagctac
     1261 acttcccatg tacagttatt gcaatttttt ctgctgcttt tagaatgact gataacctct
     1321 tttgattatt aacagaccat tgcctagacc cactgtgcaa ttctgattgc agctttaact
     1381 agctgggtgt tttttaggtg gcctcatacc aggctaatct tgaacttctg gtatttctcc
     1441 tgccttgacc tcccacctgt tgggattgaa agaatgagcc atcataccca gctactctcg
     1501 aaattcattt ctactgaata gttgaaattt taagatcttg tggcattttg atgcttattt
     1561 cttctgatcc acttggtcca agatacttca cagtgattct aattcataaa ctatgaaaat
     1621 tcctgtactt aaccagtgaa accaatgagt ttgtgaagtg aactttgaga atttagggga
     1681 actaagggac tgaagttgtg tccaatcagt ttctcctggg aattttatta tttaagggca
     1741 ctttttctca ctgtatccct gagcctggaa ctcactatgg agtaggctga tctaaactca
     1801 gaggtgctcc tacctctgcc tcccagtgcc aggattaaaa acgcgcactg gcatgtctgt
     1861 ctacataaag ctttcttgac agtcttgtta gaattcattt ttcttgatag ttctagaagg
     1921 ttgacagtga tttgtaagtt cattatatcc tttataacta taatgatgtt aaggagagta
     1981 agaccgtaag tgggaactag gtagaatgat gaagacagct gtaggcagtc accaagttaa
     2041 atgcttggtg catttttatc atacagaagc atgaatggta caggagcaat cacaacactg
     2101 agtgatgcca cagtagcaac agtttctaga cagaatgttt atacaggagt caagtgatgc
     2161 aaccacaagt aactgaggtg aacttaacct taatacgtga ttaggactca ggttatttat
     2221 gaggcttgct gcagacaaat gctcccacac taaaagacta gattcccagc aggatgccgg
     2281 gggtggctga ttcaaggacc tgtaataagc tcgggcttac ctacaaggac acaataaaaa
     2341 ttgctaattc tggtgacaag tcacggcatt tttctggttc acctattctt gttatatact
     2401 tcgtaggact taccgagtag ctctcaaagc atactcgcta cataacttgt tttcattagc
     2461 ttgaatgaaa ggcattttct ctggtgtgtt cctactggtg atctacatga acaagcgacc
     2521 atcatagcct tcacagcccc acattcacag tcaagtttca cttgtcctga tgaagcaatt
     2581 aaagagagca gtatttttct ttcttagcat atgtagggga ggggctttgg gaactgaaag
     2641 ctgggcagta gaaagttttt ttcagggaag tcctcattgg taggtggccc acactcctgt
     2701 agatggccca acatgctttc acacaatgtc agcattgatt gaactcggtg cactgttatg
     2761 aaaaagtgat taacctgaga gggagatgag ggttggggtg ctagggtcag tacattgtat
     2821 acttgactga aattctcagc aaataaaaaa atgactaaaa aca
//
