LOCUS       NM_013080               7871 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus protein tyrosine phosphatase, receptor type Z1
            (Ptprz1), transcript variant 1, mRNA.
ACCESSION   NM_013080 XM_346695
VERSION     NM_013080.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 7871)
  AUTHORS   Tanga,N., Kuboyama,K., Kishimoto,A., Kiyonari,H., Shiraishi,A.,
            Suzuki,R., Watanabe,T., Fujikawa,A. and Noda,M.
  TITLE     The PTN-PTPRZ signal activates the AFAP1L2-dependent PI3K-AKT
            pathway for oligodendrocyte differentiation: Targeted inactivation
            of PTPRZ activity in mice
  JOURNAL   Glia 67 (5), 967-984 (2019)
   PUBMED   30667096
REFERENCE   2  (bases 1 to 7871)
  AUTHORS   Fujikawa,A., Sugawara,H., Tanaka,T., Matsumoto,M., Kuboyama,K.,
            Suzuki,R., Tanga,N., Ogata,A., Masumura,M. and Noda,M.
  TITLE     Targeting PTPRZ inhibits stem cell-like properties and
            tumorigenicity in glioblastoma cells
  JOURNAL   Sci Rep 7 (1), 5609 (2017)
   PUBMED   28717188
  REMARK    GeneRIF: High PTPRZ1 expression is associated with glioblastoma.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7871)
  AUTHORS   Reinehr,S., Reinhard,J., Wiemann,S., Stute,G., Kuehn,S.,
            Woestmann,J., Dick,H.B., Faissner,A. and Joachim,S.C.
  TITLE     Early remodelling of the extracellular matrix proteins tenascin-C
            and phosphacan in retina and optic nerve of an experimental
            autoimmune glaucoma model
  JOURNAL   J Cell Mol Med 20 (11), 2122-2137 (2016)
   PUBMED   27374750
  REMARK    GeneRIF: tenascin-C and phosphacan represent early indicators of
            neurodegeneration.
REFERENCE   4  (bases 1 to 7871)
  AUTHORS   Kuboyama,K., Fujikawa,A., Suzuki,R., Tanga,N. and Noda,M.
  TITLE     Role of Chondroitin Sulfate (CS) Modification in the Regulation of
            Protein-tyrosine Phosphatase Receptor Type Z (PTPRZ) Activity:
            PLEIOTROPHIN-PTPRZ-A SIGNALING IS INVOLVED IN OLIGODENDROCYTE
            DIFFERENTIATION
  JOURNAL   J Biol Chem 291 (35), 18117-18128 (2016)
   PUBMED   27445335
REFERENCE   5  (bases 1 to 7871)
  AUTHORS   Fujikawa,A., Nagahira,A., Sugawara,H., Ishii,K., Imajo,S.,
            Matsumoto,M., Kuboyama,K., Suzuki,R., Tanga,N., Noda,M.,
            Uchiyama,S., Tomoo,T., Ogata,A., Masumura,M. and Noda,M.
  TITLE     Small-molecule inhibition of PTPRZ reduces tumor growth in a rat
            model of glioblastoma
  JOURNAL   Sci Rep 6, 20473 (2016)
   PUBMED   26857455
  REMARK    GeneRIF: The intracellular delivery of SCB4380 by liposome carriers
            inhibited PTPRZ activity in C6 glioblastoma cells, and thereby
            suppressed their migration and proliferation in vitro and tumor
            growth in a rat allograft model.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 7871)
  AUTHORS   Milev,P., Meyer-Puttlitz,B., Margolis,R.K. and Margolis,R.U.
  TITLE     Complex-type asparagine-linked oligosaccharides on phosphacan and
            protein-tyrosine phosphatase-zeta/beta mediate their binding to
            neural cell adhesion molecules and tenascin
  JOURNAL   J Biol Chem 270 (42), 24650-24653 (1995)
   PUBMED   7559574
REFERENCE   7  (bases 1 to 7871)
  AUTHORS   Maurel,P., Meyer-Puttlitz,B., Flad,M., Margolis,R.U. and
            Margolis,R.K.
  TITLE     Nucleotide sequence and molecular variants of rat receptor-type
            protein tyrosine phosphatase-zeta/beta
  JOURNAL   DNA Seq 5 (5), 323-328 (1995)
   PUBMED   7579589
REFERENCE   8  (bases 1 to 7871)
  AUTHORS   Milev,P., Friedlander,D.R., Sakurai,T., Karthikeyan,L., Flad,M.,
            Margolis,R.K., Grumet,M. and Margolis,R.U.
  TITLE     Interactions of the chondroitin sulfate proteoglycan phosphacan,
            the extracellular domain of a receptor-type protein tyrosine
            phosphatase, with neurons, glia, and neural cell adhesion molecules
  JOURNAL   J Cell Biol 127 (6 Pt 1), 1703-1715 (1994)
   PUBMED   7528221
REFERENCE   9  (bases 1 to 7871)
  AUTHORS   Grumet,M., Milev,P., Sakurai,T., Karthikeyan,L., Bourdon,M.,
            Margolis,R.K. and Margolis,R.U.
  TITLE     Interactions with tenascin and differential effects on cell
            adhesion of neurocan and phosphacan, two major chondroitin sulfate
            proteoglycans of nervous tissue
  JOURNAL   J Biol Chem 269 (16), 12142-12146 (1994)
   PUBMED   7512960
REFERENCE   10 (bases 1 to 7871)
  AUTHORS   Maurel,P., Rauch,U., Flad,M., Margolis,R.K. and Margolis,R.U.
  TITLE     Phosphacan, a chondroitin sulfate proteoglycan of brain that
            interacts with neurons and neural cell-adhesion molecules, is an
            extracellular variant of a receptor-type protein tyrosine
            phosphatase
  JOURNAL   Proc Natl Acad Sci U S A 91 (7), 2512-2516 (1994)
   PUBMED   7511813
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            U09357.1, JAXUCZ010000004.1 and BE104455.1.
            
            On Jan 5, 2010 this sequence version replaced NM_013080.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U09357.1, SRR26360194.1381186.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1398              U09357.1           1-1398
            1399-4112           JAXUCZ010000004.1  52505809-52508522
            4113-7851           U09357.1           4113-7851
            7852-7871           BE104455.1         1-20                c
FEATURES             Location/Qualifiers
     source          1..7871
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q22"
     gene            1..7871
                     /gene="Ptprz1"
                     /gene_synonym="Ptpz; PTPzeta-A; PTPzeta-B; PTPzeta-S;
                     RPTPbeta"
                     /note="protein tyrosine phosphatase, receptor type Z1"
                     /db_xref="GeneID:25613"
                     /db_xref="RGD:3455"
     exon            1..163
                     /gene="Ptprz1"
                     /gene_synonym="Ptpz; PTPzeta-A; PTPzeta-B; PTPzeta-S;
                     RPTPbeta"
                     /inference="alignment:Splign:2.1.0"
     CDS             106..7056
                     /gene="Ptprz1"
                     /gene_synonym="Ptpz; PTPzeta-A; PTPzeta-B; PTPzeta-S;
                     RPTPbeta"
                     /EC_number="3.1.3.48"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; receptor-type tyrosine-protein phosphatase
                     zeta; 3H1 keratan sulfate proteoglycan; 3F8 chondroitin
                     sulfate proteoglycan; PTP zeta; R-PTP-zeta; 6B4
                     proteoglycan; protein tyrosine phosphatase, receptor-type,
                     Z polypeptide 1"
                     /codon_start=1
                     /product="receptor-type tyrosine-protein phosphatase zeta
                     isoform 1 precursor"
                     /protein_id="NP_037212.2"
                     /db_xref="GeneID:25613"
                     /db_xref="RGD:3455"
                     /translation="MRILQSFLACVQLLCVCRLDWAYGYYRQQRKLVEEIGWSYTGAL
                     NQKNWGKKYPICNSPKQSPINIDEDLTQVNVNLKKLKFQGWEKPSLENTFIHNTGKTV
                     EINLTNDYYLSGGLSEKVFKASKMTFHWGKCNVSSEGSEHSLEGQKFPLEMQIYCFDA
                     DRFSSFEETVKGKGRLRALSILFEIGVEENLDYKAIIDGTESVSRFGKQAALDPFILQ
                     NLLPNSTDKYYIYNGSLTSPPCTDTVEWIVFKDTVSISESQLAVFCEVLTMQQSGYVM
                     LMDYLQNNFREQQYKFSRQVFSSYTGKEEIHEAVCSSEPENVQADPENYTSLLITWER
                     PRVVYDTMIEKFAVLYQPLEGNDQTKHEFLTDGYQDLGAILNNLIPNMSYVLQIVAIC
                     SNGLYGKYSDQLIVDMPTEDAELDLFPELIGTEEIIKEEDYGKGNEEDTGLNPGRDSA
                     TNQIRKKEPQVSTTTHYNHMGTKYNEAKTNRSPTKGSEFSGKSDVLNTSLNPTSQQVA
                     EFNPEREMSLPSQIGTNLPPHSVEGTSASLNSGSKTLLVFPQMNLSGTAESLNMVSIT
                     EYKEVSADLSEEENLLTDFKLDSGADDSSGSSPASSTVPFSTDNLSHGYTSSSDTPEA
                     VTYDVLRPESTRNALEDSAPSGSEESLKDPSLEGSVWFPGSTDLTTQSETGSGREGFL
                     QVNSTDFQVDESRETTETFSPDATASRGPSVTDMEMPHYSTFAYPPTEVTPHAFTPSS
                     RPLDLAPTSNILHSQTTQPVYNGETPLQPSYSSEVFPLVTPLLLDNQTLNTTPAASSS
                     DSALHATPVFPSVGVSFDSILSSYDDAPLLPFSSASFSSDLFHHLHTVSQTLPQVTSA
                     AERDELSLHASLLVAGGDLLLEPSLVQYSDVMSHQVTIHAASDTLEFGSESAVLYKTS
                     MVSQIESPSSDVVMHAYSSGPETSYAIEGSHHVLTVSSSSAIPVHDSIGVADQGSLLI
                     NPSHISLPESSFITPTASLLQLPPALSGDGEWSGASSDSELLLPDTDGLRTLNMSSPV
                     SVADFTYTTSVSGDDIKPLSKGEMMYGNETELKMSSFSDMAYPSKSTVVPKMSDIVNK
                     WSESLKETSVSVSSINSVFTESLVYPITKVFDQEISRVPEIIFPVKPTHTASQASGDT
                     WLKPGLSTNSEPALSDTASSEVLHPSTQPLLYEAASPFNTEALLQPSFPASDVDTLLK
                     TALPSGPRDPVLTETPMVEQSSSSMSLPLASESASSKSTLHFTSVPVLNMSPSDVHPT
                     SLQRLTVPHSREEYFEQGLLKSKSPQQVLPSLHSHDEFFQTAHLDISQAYPPKGRHAF
                     ATPILSIDEPQNTLISRLVYSEDIFMHPEISITDKALTGLPTTVSDVLIATDHSVPLG
                     SGPISMTTVSPNRDDSVTTTKLLLPSKATSKPTHSARSDADLVGGGEDGDDYDDDDYD
                     DIDSDRFPVNKCMSCSPYRESQEKVMNDSDTQESSLVDQSDPISHLLSENTEEENGGT
                     GVTRVDKSPDKSPPPSMLPQKHNDGREDRDIQMGSAVLPHTPGSKAWAVLTSDEESGS
                     GQGTSDSLNDNETSTDFSFPDVNEKDADGVLEADDTGIAPGSPRSSTPSVTSGHSGVS
                     NSSEAEASNSSHESRIGLAEGLESEKKAVIPLVIVSALTFICLVVLVGILIYWRKCFQ
                     TAHFYLEDNTSPRVISTPPTPIFPISDDIGAIPIKHFPKHVADLHASNGFTEEFETLK
                     EFYQEVQSCTVDLGITADSSNHPDNKHKNRYVNIVAYDHSRVKLTQLAEKDGKLTDYI
                     NANYVDGYNRPKAYIAAQGPLKSTAEDFWRMIWEHNVEVIVMITNLVEKGRRKCDQYW
                     PTDGSEEYGSFLVNQKNVQVLAYYTVRNFTLRNTKIKKGSQKGRSSGRLVTQYHYTQW
                     PDMGVPEYSLPVLAFVRKTAQAKRHAVGPVVVHCSAGVGRTGTYIVLDSMLQQIQHEG
                     TVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAILSKETEVPDSHIHSYVNTLLIP
                     GPSGKTKLEKQFQLLSQSNILQSDYSTALKQCNREKNRTSSIIPVERSRVGISSLSGE
                     GTDYINASYIMGYYQSNEFIITQHPLLHTIKDFWRMIWDHNAQLVVMIPDGQNMAEDE
                     FVYWPNKDEPINCESFKVTLMSEEHKCLSNEEKLIVQDFILEATQDDYVLEVRHFQCP
                     KWPNPDSPISKTFELISIIKEEAANRDGPMIVHDEHGGVTAGTFCALTTLMHQLEKEN
                     SMDVYQVAKMINLMRPGVFTDIEQYQFLYKVVLSLVSTRQEENPSTSLDSNGAALPDG
                     NIAESLESLV"
     exon            164..229
                     /gene="Ptprz1"
                     /gene_synonym="Ptpz; PTPzeta-A; PTPzeta-B; PTPzeta-S;
                     RPTPbeta"
                     /inference="alignment:Splign:2.1.0"
     exon            230..409
                     /gene="Ptprz1"
                     /gene_synonym="Ptpz; PTPzeta-A; PTPzeta-B; PTPzeta-S;
                     RPTPbeta"
                     /inference="alignment:Splign:2.1.0"
     exon            410..561
                     /gene="Ptprz1"
                     /gene_synonym="Ptpz; PTPzeta-A; PTPzeta-B; PTPzeta-S;
                     RPTPbeta"
                     /inference="alignment:Splign:2.1.0"
     exon            562..657
                     /gene="Ptprz1"
                     /gene_synonym="Ptpz; PTPzeta-A; PTPzeta-B; PTPzeta-S;
                     RPTPbeta"
                     /inference="alignment:Splign:2.1.0"
     exon            658..724
                     /gene="Ptprz1"
                     /gene_synonym="Ptpz; PTPzeta-A; PTPzeta-B; PTPzeta-S;
                     RPTPbeta"
                     /inference="alignment:Splign:2.1.0"
     exon            725..882
                     /gene="Ptprz1"
                     /gene_synonym="Ptpz; PTPzeta-A; PTPzeta-B; PTPzeta-S;
                     RPTPbeta"
                     /inference="alignment:Splign:2.1.0"
     exon            883..1033
                     /gene="Ptprz1"
                     /gene_synonym="Ptpz; PTPzeta-A; PTPzeta-B; PTPzeta-S;
                     RPTPbeta"
                     /inference="alignment:Splign:2.1.0"
     exon            1034..1218
                     /gene="Ptprz1"
                     /gene_synonym="Ptpz; PTPzeta-A; PTPzeta-B; PTPzeta-S;
                     RPTPbeta"
                     /inference="alignment:Splign:2.1.0"
     exon            1219..1345
                     /gene="Ptprz1"
                     /gene_synonym="Ptpz; PTPzeta-A; PTPzeta-B; PTPzeta-S;
                     RPTPbeta"
                     /inference="alignment:Splign:2.1.0"
     exon            1346..1392
                     /gene="Ptprz1"
                     /gene_synonym="Ptpz; PTPzeta-A; PTPzeta-B; PTPzeta-S;
                     RPTPbeta"
                     /inference="alignment:Splign:2.1.0"
     exon            1393..4951
                     /gene="Ptprz1"
                     /gene_synonym="Ptpz; PTPzeta-A; PTPzeta-B; PTPzeta-S;
                     RPTPbeta"
                     /inference="alignment:Splign:2.1.0"
     exon            4952..5096
                     /gene="Ptprz1"
                     /gene_synonym="Ptpz; PTPzeta-A; PTPzeta-B; PTPzeta-S;
                     RPTPbeta"
                     /inference="alignment:Splign:2.1.0"
     exon            5097..5188
                     /gene="Ptprz1"
                     /gene_synonym="Ptpz; PTPzeta-A; PTPzeta-B; PTPzeta-S;
                     RPTPbeta"
                     /inference="alignment:Splign:2.1.0"
     exon            5189..5274
                     /gene="Ptprz1"
                     /gene_synonym="Ptpz; PTPzeta-A; PTPzeta-B; PTPzeta-S;
                     RPTPbeta"
                     /inference="alignment:Splign:2.1.0"
     exon            5275..5295
                     /gene="Ptprz1"
                     /gene_synonym="Ptpz; PTPzeta-A; PTPzeta-B; PTPzeta-S;
                     RPTPbeta"
                     /inference="alignment:Splign:2.1.0"
     exon            5296..5392
                     /gene="Ptprz1"
                     /gene_synonym="Ptpz; PTPzeta-A; PTPzeta-B; PTPzeta-S;
                     RPTPbeta"
                     /inference="alignment:Splign:2.1.0"
     exon            5393..5475
                     /gene="Ptprz1"
                     /gene_synonym="Ptpz; PTPzeta-A; PTPzeta-B; PTPzeta-S;
                     RPTPbeta"
                     /inference="alignment:Splign:2.1.0"
     exon            5476..5610
                     /gene="Ptprz1"
                     /gene_synonym="Ptpz; PTPzeta-A; PTPzeta-B; PTPzeta-S;
                     RPTPbeta"
                     /inference="alignment:Splign:2.1.0"
     exon            5611..5745
                     /gene="Ptprz1"
                     /gene_synonym="Ptpz; PTPzeta-A; PTPzeta-B; PTPzeta-S;
                     RPTPbeta"
                     /inference="alignment:Splign:2.1.0"
     exon            5746..5909
                     /gene="Ptprz1"
                     /gene_synonym="Ptpz; PTPzeta-A; PTPzeta-B; PTPzeta-S;
                     RPTPbeta"
                     /inference="alignment:Splign:2.1.0"
     exon            5910..6045
                     /gene="Ptprz1"
                     /gene_synonym="Ptpz; PTPzeta-A; PTPzeta-B; PTPzeta-S;
                     RPTPbeta"
                     /inference="alignment:Splign:2.1.0"
     exon            6046..6192
                     /gene="Ptprz1"
                     /gene_synonym="Ptpz; PTPzeta-A; PTPzeta-B; PTPzeta-S;
                     RPTPbeta"
                     /inference="alignment:Splign:2.1.0"
     exon            6193..6286
                     /gene="Ptprz1"
                     /gene_synonym="Ptpz; PTPzeta-A; PTPzeta-B; PTPzeta-S;
                     RPTPbeta"
                     /inference="alignment:Splign:2.1.0"
     exon            6287..6360
                     /gene="Ptprz1"
                     /gene_synonym="Ptpz; PTPzeta-A; PTPzeta-B; PTPzeta-S;
                     RPTPbeta"
                     /inference="alignment:Splign:2.1.0"
     exon            6361..6489
                     /gene="Ptprz1"
                     /gene_synonym="Ptpz; PTPzeta-A; PTPzeta-B; PTPzeta-S;
                     RPTPbeta"
                     /inference="alignment:Splign:2.1.0"
     exon            6490..6636
                     /gene="Ptprz1"
                     /gene_synonym="Ptpz; PTPzeta-A; PTPzeta-B; PTPzeta-S;
                     RPTPbeta"
                     /inference="alignment:Splign:2.1.0"
     exon            6637..6779
                     /gene="Ptprz1"
                     /gene_synonym="Ptpz; PTPzeta-A; PTPzeta-B; PTPzeta-S;
                     RPTPbeta"
                     /inference="alignment:Splign:2.1.0"
     exon            6780..6915
                     /gene="Ptprz1"
                     /gene_synonym="Ptpz; PTPzeta-A; PTPzeta-B; PTPzeta-S;
                     RPTPbeta"
                     /inference="alignment:Splign:2.1.0"
     exon            6916..7856
                     /gene="Ptprz1"
                     /gene_synonym="Ptpz; PTPzeta-A; PTPzeta-B; PTPzeta-S;
                     RPTPbeta"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cctagaccct ggccagtcac cggcgtcccc tgtctcggtg ttcccactct ctgcacccta
       61 agctgtaccc ctgcggctgg cgaggggccg cggacccggc tggagatgcg aatcctgcag
      121 agcttcctcg cgtgcgttca gctactgtgc gtgtgtcgcc tggactgggc ttatggatac
      181 tacagacaac agagaaaact tgttgaagag attggctggt cctatacagg agcactaaat
      241 caaaaaaatt ggggaaagaa atatccaata tgtaatagcc caaagcagtc tcctattaat
      301 attgatgaag atcttacaca agtaaatgtg aatcttaaga aactgaaatt tcagggttgg
      361 gaaaaaccat ccttggaaaa cacgtttatt cacaacactg ggaaaacagt ggaaataaat
      421 ctcaccaatg actactatct cagtggagga ctttcagaaa aggtcttcaa ggcaagcaaa
      481 atgacttttc actgggggaa atgcaatgtg tcatcggaag gatcggaaca cagcttagaa
      541 gggcagaagt ttccactcga gatgcaaatc tactgcttcg atgcggaccg attttcaagt
      601 tttgaggaaa cagttaaagg aaaaggaagg ttaagggctc tatccatttt atttgagatt
      661 ggagttgaag aaaatttgga ttacaaagcc attattgatg ggactgaaag tgttagtcgt
      721 tttggaaagc aggctgcctt agatccgttc atcttgcaga acctcctgcc aaactccact
      781 gacaagtact acatttacaa cggatcactg acatcccctc cctgcacaga caccgtcgaa
      841 tggattgttt ttaaggatac agttagcatc tctgaaagcc agctggctgt attttgtgaa
      901 gttctcacaa tgcaacagtc cgggtatgtc atgttgatgg attacttaca aaacaatttc
      961 cgagaacaac agtacaagtt ttccaggcag gtgttttctt cgtacactgg gaaggaagag
     1021 attcatgaag cagtgtgcag ttcagaacca gaaaatgtgc aagctgaccc tgagaattac
     1081 accagccttc tgatcacatg ggaaaggcct cgggttgttt atgacacaat gattgagaag
     1141 tttgcggttc tgtaccagcc actggaggga aacgaccaaa ccaagcatga gtttttaaca
     1201 gatggctatc aggacttggg tgccattctc aataacttaa tacctaacat gagttatgtg
     1261 ctccaaatag tggccatatg ctctaatggc ctttatggaa agtacagtga ccaattgata
     1321 gtcgacatgc ctactgagga tgctgaactt gacctctttc ctgaattaat tggaactgaa
     1381 gaaataatca aggaggaaga ctatggaaaa ggcaatgaag aagacactgg cttgaatccc
     1441 ggtagagaca gtgccacaaa ccaaataagg aaaaaggaac cccaggtttc taccacaact
     1501 cactataatc acatggggac taaatataat gaagccaaga ctaaccgatc tccaacgaaa
     1561 ggatctgaat tctctggaaa gagtgatgtt ctcaacacat ccctgaatcc tacttcccaa
     1621 caggttgctg aattcaatcc agaaagagaa atgtccttgc cttctcagat tggaactaac
     1681 ctgccaccac acagtgtgga aggcacctca gcctccttaa acagtggctc taaaactctc
     1741 cttgtcttcc cacagatgaa cttgtctggg actgcagaat ccttaaatat ggtttccata
     1801 acagagtaca aagaggtgtc tgctgacctc agtgaggaag aaaacttact gactgatttc
     1861 aagctcgata gtggagcaga tgattcgtca ggctctagcc ctgcgtcctc cactgtcccc
     1921 ttttccacag ataatctatc ccatggatat acatcttctt cagatacgcc cgaggcggtc
     1981 acgtatgatg tccttaggcc agaatctacg agaaatgctc tagaggattc ggctccatca
     2041 ggttcagaag aatcactaaa ggatccctct cttgaaggga gtgtgtggtt ccctggatcc
     2101 acagacctaa caacacagtc tgagactgga tctgggagag agggctttct ccaagttaac
     2161 tccacggact tccaagttga tgaatcgagg gagacaactg agacattttc tccagatgct
     2221 accgcgtccc ggggtccttc ggtcacagat atggaaatgc cacattattc tacctttgcc
     2281 taccccccga ctgaagtaac accacatgct ttcactccat cctccagacc acttgatttg
     2341 gctcccacta gcaacatcct ccattcgcag acaactcaac cagtatacaa tggtgagaca
     2401 cctcttcaac cttcctacag tagtgaagtc tttcctctag tcaccccttt gttgcttgac
     2461 aatcagaccc tcaacactac ccctgctgct tcaagtagtg attcggcctt gcatgctacg
     2521 cctgtattcc ccagtgttgg tgtgtcattt gactccatcc tgtcttccta tgatgatgca
     2581 cctctgctcc cattttcctc tgcttccttc agtagtgact tgtttcacca tctgcatacg
     2641 gtttctcaaa cccttccgca agttacttca gctgctgaga gggatgagct gtctttgcat
     2701 gcttctctgc tggtggctgg gggtgatttg ctgttagagc ccagccttgt tcagtattct
     2761 gatgtgatgt cacatcaggt cactattcat gctgcttcgg acacattgga atttggtagt
     2821 gagtctgctg tcctttataa aacgtctatg gtttctcaaa tcgaatcacc cagcagtgat
     2881 gtcgttatgc atgcatattc gtcagggcct gaaacttctt atgccattga gggctcccac
     2941 cacgtgctca ctgtttcttc cagttctgca atacctgtgc atgattctat tggtgtagct
     3001 gatcaggggt ccttacttat caatcctagc catatatcac tgcctgagtc ctcatttatt
     3061 actccaactg catcattact gcagcttcct cctgccctct ctggtgatgg ggagtggtct
     3121 ggagcctcct ctgatagtga attgctttta cctgacacag atgggctgag aactcttaac
     3181 atgtcttcac ctgtttctgt agctgatttt acatacacga catctgtgtc tggcgatgat
     3241 attaagccgc tttctaaagg tgaaatgatg tatggaaatg agactgaact gaaaatgtct
     3301 tctttcagtg acatggcata cccttctaaa agcacagtcg tgccaaagat gtctgatatt
     3361 gtaaataagt ggagtgaatc tttaaaagaa acctctgttt ccgtatctag cataaacagc
     3421 gtgtttacag agtctctggt ttatcccata actaaggttt ttgatcagga gattagtcga
     3481 gttccagaga ttatcttccc agttaaacct acacacacag catctcaagc atctggtgac
     3541 acttggctta aacccgggct tagcacaaac tcagagcctg cgctctctga cactgcttct
     3601 agtgaagtat tacacccttc aacacagccc ttgctctatg aggccgcatc tccttttaat
     3661 acggaagcat tgctgcaacc ttcctttccg gcttctgatg ttgacacctt gcttaaaact
     3721 gcccttccct ctgggcctcg tgatccagtg ctgactgaaa cccccatggt tgagcaaagt
     3781 agctcttcca tgtctcttcc cctggcatca gagtctgctt caagcaaaag cacgctgcac
     3841 tttacatctg taccagttct caatatgtca ccttctgatg tgcaccccac ttcacttcaa
     3901 cgcttaacag ttcctcactc gagggaggaa tattttgaac aaggtttgct taagagcaaa
     3961 agtccccagc aagtcctgcc gtccttgcac agccatgacg agtttttcca aactgcacat
     4021 ctggacatta gccaggccta ccctccaaaa ggaaggcatg catttgctac tcctatttta
     4081 tcaatcgatg aaccacaaaa tacacttata agcaggcttg tgtattctga ggacattttc
     4141 atgcaccctg aaatttctat tactgataag gcacttactg gtctaccaac gaccgtttct
     4201 gatgtactta tagctactga ccattctgtt ccattaggaa gtgggcccat ttccatgaca
     4261 actgtttctc ccaacagaga tgattctgtg accacaacca agttgcttct tccttctaaa
     4321 gctacttcta agccgactca tagtgccaga tctgatgccg atttagtagg aggtggtgaa
     4381 gatggtgatg actatgatga tgatgattat gatgacatag atagtgatcg ctttcccgta
     4441 aataagtgta tgtcatgttc accctataga gaatcacagg aaaaggtaat gaatgactcg
     4501 gacacccaag aaagcagtct tgtggatcag agtgacccaa tttcacattt gctctctgag
     4561 aataccgaag aagaaaatgg aggcacgggt gtaactaggg tggataaaag tcctgataag
     4621 tcaccaccac caagtatgct accccagaag cacaatgatg gaagagagga ccgtgacatt
     4681 cagatgggta gtgctgtcct tcctcacacc ccaggatcta aagcatgggc agttttgaca
     4741 agtgatgaag agagtgggtc agggcaaggc acctcagata gccttaatga taatgagact
     4801 tccacagatt tcagtttccc agatgttaat gaaaaggatg ctgatggtgt cctggaagca
     4861 gatgacacag gcatagctcc gggatctcca cggtcctcca caccatctgt tactagtggg
     4921 cattcaggag tatccaacag ttcagaggca gaggccagta atagtagcca tgagtctcgt
     4981 attggtctag ctgaggggtt ggagtctgag aagaaggcgg ttatacccct tgtgatcgtg
     5041 tctgccctga cttttatctg tctagtggtt cttgttggta ttctcatcta ctggagaaaa
     5101 tgcttccaga cggctcactt ttatttagaa gacaatacat cccctcgagt aatatctaca
     5161 ccaccaacac ccatctttcc aatttcagat gatattggag caattccaat aaagcatttt
     5221 ccaaagcacg tagcagactt acatgcaagt aatgggttca ctgaagaatt tgagacactg
     5281 aaagagtttt accaggaagt gcagagctgc actgttgact taggtattac agcagacagc
     5341 tccaatcacc cagacaacaa gcacaagaac agatatgtca acatcgtagc ctatgatcat
     5401 agcagggtta agctcacaca acttgctgaa aaagatggaa aactgactga ttacatcaat
     5461 gccaattatg ttgatggtta caacaggcca aaggcttaca ttgctgccca gggtccactg
     5521 aagtccacag cagaagattt ctggagaatg atatgggagc ataatgtgga agtcatcgtt
     5581 atgataacaa acctcgtgga gaaaggaaga agaaaatgtg accagtactg gcctactgat
     5641 ggcagtgaag aatacgggag cttcctggtc aaccagaaga atgttcaggt gcttgcttat
     5701 tatactgtga ggaatttcac cctaagaaac acaaagataa aaaagggctc tcagaaagga
     5761 agatccagtg gacgcctagt cactcagtat cattacaccc agtggcctga tatgggtgtt
     5821 cccgagtact ccctacccgt gctggccttt gtgaggaaga ctgctcaggc caagcgacat
     5881 gcagtcgggc cagttgttgt ccactgcagc gctggcgtgg ggagaacggg cacatacatt
     5941 gtactagaca gtatgctaca gcagattcaa cacgaaggaa ccgtcaacat atttggtttc
     6001 ttaaaacaca ttcgttctca aaggaattat ttggtgcaaa cagaggagca atacgtcttc
     6061 attcacgaca cactggttga ggccatactc agcaaagaga cagaggtgcc tgacagccac
     6121 atccattcct atgttaatac actcctcata cccggaccat caggcaagac aaaactagag
     6181 aaacaattcc agcttctgag tcagtcaaat attcttcaga gtgactactc cacggccctg
     6241 aagcagtgta acagggagaa gaacagaaca tcctccatca tccccgtgga aagatcgagg
     6301 gtgggcattt catccctgag tggggaaggc acagactaca tcaatgcatc ctatattatg
     6361 ggttattacc agagcaatga attcatcatc acccagcacc cccttctaca caccatcaag
     6421 gacttctgga gaatgatatg ggatcataat gcccagctgg tggttatgat tccagatggt
     6481 caaaacatgg cagaggatga atttgtttac tggccaaata aagatgagcc cataaattgc
     6541 gagagcttca aagtcacgct tatgtctgaa gaacacaaat gtctttcgaa tgaggaaaaa
     6601 ctgatagttc aagacttcat cttggaagcg acacaggatg attatgtgct ggaagtaagg
     6661 cattttcagt gcccgaaatg gccaaatcca gatagtccca ttagtaaaac atttgaactt
     6721 ataagtatta tcaaagaaga agctgctaac agagatgggc ccatgattgt tcacgatgag
     6781 catggaggag taacagcagg gacattttgt gctctcacaa cccttatgca ccaactagaa
     6841 aaagaaaact ccatggatgt ttaccaagta gccaagatga tcaatttgat gaggccggga
     6901 gtcttcactg acattgagca gtaccagttt ctctacaaag tggtcctcag cctggtcagc
     6961 acaaggcagg aagagaatcc atccacctcc ctggatagta atggtgcagc tttgcctgat
     7021 ggaaatatag ctgaaagcct ggagtcttta gtctgacgca gaaagggtgt aggaccaccc
     7081 tcatccaagc agtgtctctt tctaaactta gaaaaatgag tccagttctg ttatctgttt
     7141 acttcccatg acctgacggt aactcattct gctgccaaat tgacaccatt aacaacgtgt
     7201 gcctttttga aagacttctt gtaatccact tattatgttt gaactaaaat gattgaattt
     7261 tacaatgttt ctaagaattg aattgtggca tttttttcca tattgatttt aacaacaaca
     7321 acaaaaaaaa tttgtagata ataggaaaca ccaaccttgg gagatatttg ttcttaagtg
     7381 tcaaattttt agctgtattt gtagcaatca tcaggtttgc tagaaatata acttttaata
     7441 tagtagattg taagtaaacc actttatccc cgatgatatt caacatttta caactgcagt
     7501 attcacctga agtaggagtg acagtaactt atgtaaatac tgccctggtg tctccatgga
     7561 ccaaatttat atttataatt gtagattttt atattttact actgtgtgag ttttctagtg
     7621 gtgtacttga gtttaattag cttactctct ggtcttaact tactctaaat gtcttctaaa
     7681 actgtactgt gttatccaag aaactaacct tctttctgca tgtcatttta acttttgtga
     7741 aaataggaaa ccacttgttt taaaagatgt ttttatgaga ataacacctt accaaacatt
     7801 ccttaaatgg tttttatctg agaagttgca aaaataaata taaatattgc cattaaaaaa
     7861 aaaaaaaaaa a
//
