LOCUS       NM_001402009           11913 bp    mRNA    linear   ROD 23-MAR-2023
DEFINITION  Rattus norvegicus protein tyrosine phosphatase, receptor type, T
            (Ptprt), transcript variant 2, mRNA.
ACCESSION   NM_001402009 XM_039105538
VERSION     NM_001402009.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 11913)
  AUTHORS   Hsu HC, Lapke N, Chen SJ, Lu YJ, Jhou RS, Yeh CY, Tsai WS, Hung HY,
            Hsieh JC, Yang TS, Thiam TK and You JF.
  TITLE     PTPRT and PTPRD Deleterious Mutations and Deletion Predict
            Bevacizumab Resistance in Metastatic Colorectal Cancer Patients
  JOURNAL   Cancers (Basel) 10 (9), 314 (2018)
   PUBMED   30200630
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 11913)
  AUTHORS   Zhao Y, Scott A, Zhang P, Hao Y, Feng X, Somasundaram S, Khalil AM,
            Willis J and Wang Z.
  TITLE     Regulation of paxillin-p130-PI3K-AKT signaling axis by Src and
            PTPRT impacts colon tumorigenesis
  JOURNAL   Oncotarget 8 (30), 48782-48793 (2017)
   PUBMED   27447856
REFERENCE   3  (bases 1 to 11913)
  AUTHORS   Yao Y, Shao J, Wu J, Zhang Q, Wang J, Xiao D and Huang F.
  TITLE     The Functional Variant in the 3'UTR of PTPRT with the Risk of
            Esophageal Squamous Cell Carcinoma in a Chinese Population
  JOURNAL   Cell Physiol Biochem 36 (1), 306-314 (2015)
   PUBMED   25967969
REFERENCE   4  (bases 1 to 11913)
  AUTHORS   Qi J, Li N, Fan K, Yin P, Zhao C, Li Z, Lin Y, Wang L and Zha X.
  TITLE     beta1,6 GlcNAc branches-modified PTPRT attenuates its activity and
            promotes cell migration by STAT3 pathway
  JOURNAL   PLoS One 9 (5), e98052 (2014)
   PUBMED   24846175
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 11913)
  AUTHORS   Lim SH, Moon J, Lee M and Lee JR.
  TITLE     PTPRT regulates the interaction of Syntaxin-binding protein 1 with
            Syntaxin 1 through dephosphorylation of specific tyrosine residue
  JOURNAL   Biochem Biophys Res Commun 439 (1), 40-46 (2013)
   PUBMED   23962429
  REMARK    GeneRIF: PTPRT could regulate the interaction of Syntaxin-binding
            protein 1 with Syntaxin 1, and as a result, the synaptic vesicle
            fusion appears to be controlled through dephosphorylation of
            Syntaxin-binding protein 1
REFERENCE   6  (bases 1 to 11913)
  AUTHORS   Zhao Y, Zhang X, Guda K, Lawrence E, Sun Q, Watanabe T, Iwakura Y,
            Asano M, Wei L, Yang Z, Zheng W, Dawson D, Willis J, Markowitz SD,
            Satake M and Wang Z.
  TITLE     Identification and functional characterization of paxillin as a
            target of protein tyrosine phosphatase receptor T
  JOURNAL   Proc Natl Acad Sci U S A 107 (6), 2592-2597 (2010)
   PUBMED   20133777
REFERENCE   7  (bases 1 to 11913)
  AUTHORS   Lim SH, Kwon SK, Lee MK, Moon J, Jeong DG, Park E, Kim SJ, Park BC,
            Lee SC, Ryu SE, Yu DY, Chung BH, Kim E, Myung PK and Lee JR.
  TITLE     Synapse formation regulated by protein tyrosine phosphatase
            receptor T through interaction with cell adhesion molecules and Fyn
  JOURNAL   EMBO J 28 (22), 3564-3578 (2009)
   PUBMED   19816407
REFERENCE   8  (bases 1 to 11913)
  AUTHORS   Yu J, Becka S, Zhang P, Zhang X, Brady-Kalnay SM and Wang Z.
  TITLE     Tumor-derived extracellular mutations of PTPRT /PTPrho are
            defective in cell adhesion
  JOURNAL   Mol Cancer Res 6 (7), 1106-1113 (2008)
   PUBMED   18644975
REFERENCE   9  (bases 1 to 11913)
  AUTHORS   Zhang X, Guo A, Yu J, Possemato A, Chen Y, Zheng W, Polakiewicz RD,
            Kinzler KW, Vogelstein B, Velculescu VE and Wang ZJ.
  TITLE     Identification of STAT3 as a substrate of receptor protein tyrosine
            phosphatase T
  JOURNAL   Proc Natl Acad Sci U S A 104 (10), 4060-4064 (2007)
   PUBMED   17360477
REFERENCE   10 (bases 1 to 11913)
  AUTHORS   Besco JA, Hooft van Huijsduijnen R, Frostholm A and Rotter A.
  TITLE     Intracellular substrates of brain-enriched receptor protein
            tyrosine phosphatase rho (RPTPrho/PTPRT)
  JOURNAL   Brain Res 1116 (1), 50-57 (2006)
   PUBMED   16973135
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000120.1.
            
            [WARNING] On Apr 3, 2024 this sequence was replaced by
            NM_001402009.2.
            
            On Mar 3, 2022 this sequence version replaced XM_039105538.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA5760383, SAMEA5760384
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-284               JACYVU010000120.1  5860097-5860380     c
            285-410             JACYVU010000120.1  5560771-5560896     c
            411-682             JACYVU010000120.1  5476475-5476746     c
            683-764             JACYVU010000120.1  5465701-5465782     c
            765-880             JACYVU010000120.1  5451830-5451945     c
            881-1055            JACYVU010000120.1  5435384-5435558     c
            1056-1349           JACYVU010000120.1  5349117-5349410     c
            1350-1646           JACYVU010000120.1  5155016-5155312     c
            1647-1756           JACYVU010000120.1  5129495-5129604     c
            1757-1958           JACYVU010000120.1  5036719-5036920     c
            1959-2061           JACYVU010000120.1  5035224-5035326     c
            2062-2335           JACYVU010000120.1  4994452-4994725     c
            2336-2372           JACYVU010000120.1  4969057-4969093     c
            2373-2508           JACYVU010000120.1  4934828-4934963     c
            2509-2538           JACYVU010000120.1  4923740-4923769     c
            2539-2687           JACYVU010000120.1  4895488-4895636     c
            2688-2878           JACYVU010000120.1  4857299-4857489     c
            2879-2966           JACYVU010000120.1  4831475-4831562     c
            2967-3043           JACYVU010000120.1  4819251-4819327     c
            3044-3080           JACYVU010000120.1  4809582-4809618     c
            3081-3178           JACYVU010000120.1  4808100-4808197     c
            3179-3295           JACYVU010000120.1  4803924-4804040     c
            3296-3450           JACYVU010000120.1  4800782-4800936     c
            3451-3586           JACYVU010000120.1  4797261-4797396     c
            3587-3736           JACYVU010000120.1  4793884-4794033     c
            3737-3910           JACYVU010000120.1  4791452-4791625     c
            3911-4042           JACYVU010000120.1  4786850-4786981     c
            4043-4168           JACYVU010000120.1  4774028-4774153     c
            4169-4332           JACYVU010000120.1  4773025-4773188     c
            4333-4468           JACYVU010000120.1  4769890-4770025     c
            4469-11913          JACYVU010000120.1  4761578-4769022     c
FEATURES             Location/Qualifiers
     source          1..11913
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q42"
     gene            1..11913
                     /gene="Ptprt"
                     /note="protein tyrosine phosphatase, receptor type, T"
                     /db_xref="GeneID:362263"
                     /db_xref="RGD:1309653"
     exon            1..284
                     /gene="Ptprt"
                     /inference="alignment:Splign:2.1.0"
     CDS             185..4522
                     /gene="Ptprt"
                     /EC_number="3.1.3.48"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; receptor-type tyrosine-protein phosphatase T"
                     /codon_start=1
                     /product="receptor-type tyrosine-protein phosphatase T
                     isoform 2 precursor"
                     /protein_id="NP_001388938.1"
                     /db_xref="GeneID:362263"
                     /db_xref="RGD:1309653"
                     /translation="MGSLGALALCLLRLLLLGLQRPPLPGAGAQSAAGGCSFDEHYSN
                     CGYSVALGTNGFTWEQINTWEKPMLDPAVPTGSFMMVNSSGRASGQKAHLLLPTLKEN
                     DTHCIDFHYYFSSRDRSSPGALNVYVKVNGGPQGNPVWNVSGVVTEGWVKAELAISTF
                     WPHFYQVIFESVSLKGHPGYIAVDEVRVLAHPCRKAPHFLRLQNVEVNVGQNATFQCI
                     AGGKWSQHDKLWLQQWNGRDTALMVTRVVNHRRFSATVSVADTSQRSVSKYRCVIRSD
                     GGSGVSNYAELIVKEPPTPIAPPELLAVGATYLWIKPNANSIIGDGPIILKEVEYRTT
                     TGTWAETHIVDSPNYKLWHLDPDVEYEIRVLLTRPGEGGTGPPGPPLTTRTKCADPVH
                     GPQNVEIVDIRARQLTLQWEPFGYAVTRCHSYNLTVQYQYVFNQQQYEAEEVIQTSSH
                     YTLRGLRPFMTIRLRLLLSNPEGRMESEELVVQTEEDVPGAVPLESIQGGPFEEKIYI
                     QWKPPNETNGVITLYEINYKAVGSLDPSADLSSQRGKVFKLRNETHHLFVGLYPGTTY
                     SFTIKASTAKGFGPPVTTRIATKISAPSMPEYDADSPLNETDTTITVMLKPAQSRGAP
                     VSVYQLVVKEERLQKSRRAADIIECFSVPVSYRNASNLDSLHYFAAELKPSNLPVTQP
                     FTVGDNKTYNGYWNPPLSPLKSYSIYFQALSKANGETKINCVRLATKGASTQNSNTVE
                     PEKQVDNTVKMAGVIAGLLMFIIILLGVMLTIKRRRNAYSYSYYLKLAKKQKETQSGA
                     QREMGPVASTDKPTTKLSTNRNDEGFSSSSQDVNGFTDGSRGELSQPTLTIQTHPYRT
                     CDPVEMSYPRDQFQPAIRVADLLQHITQMKRGQGYGFKEEYEALPEGQTASWDTAKED
                     ENRNKNRYGNIISYDHSRVRLLVLDGDPHSDYINANYIDGYHRPRHYIATQGPMQETV
                     KDFWRMIWQENSASIVMVTNLVEVGRVKCVRYWPDDTEVYGDIKVTLIETEPLAEYVI
                     RTFTVQKKGYHEIRELRLFHFTSWPDHGVPCYATGLLGFVRQVKFLNPPEAGPIVVHC
                     SAGAGRTGCFIAIDTMLDMAENEGVVDIFNCVRELRAQRVNLVQTEEQYVFVHDAILE
                     ACLCGNTAIPVCEFRSLYYNISRLDPQTNSSQIKDEFQTLNIVTPRVRPEDCSIGLLP
                     RNHDKNRSMDVLPLDRCLPFLISVDGESSNYINAALMDSHKQPAAFVVTQHPLPNTVA
                     DFWRLVFDYNCSSVVMLNEMDTAQLCMQYWPEKTSGCYGPIQVEFVSADIDEDIIHRI
                     FRICNMARPQDGYRIVQHLQYIGWPAYRDTPPSKRSLLKAVRRLEKWQEEYDGREGRT
                     VVHCLNGGGRSGTFCAICSVCEMIQQQNIIDVFHIVKTLRNNKSNMVETLEQYKFVYE
                     VALEYLSSF"
     exon            285..410
                     /gene="Ptprt"
                     /inference="alignment:Splign:2.1.0"
     exon            411..682
                     /gene="Ptprt"
                     /inference="alignment:Splign:2.1.0"
     exon            683..764
                     /gene="Ptprt"
                     /inference="alignment:Splign:2.1.0"
     exon            765..880
                     /gene="Ptprt"
                     /inference="alignment:Splign:2.1.0"
     exon            881..1055
                     /gene="Ptprt"
                     /inference="alignment:Splign:2.1.0"
     exon            1056..1349
                     /gene="Ptprt"
                     /inference="alignment:Splign:2.1.0"
     exon            1350..1646
                     /gene="Ptprt"
                     /inference="alignment:Splign:2.1.0"
     exon            1647..1756
                     /gene="Ptprt"
                     /inference="alignment:Splign:2.1.0"
     exon            1757..1958
                     /gene="Ptprt"
                     /inference="alignment:Splign:2.1.0"
     exon            1959..2061
                     /gene="Ptprt"
                     /inference="alignment:Splign:2.1.0"
     exon            2062..2335
                     /gene="Ptprt"
                     /inference="alignment:Splign:2.1.0"
     exon            2336..2372
                     /gene="Ptprt"
                     /inference="alignment:Splign:2.1.0"
     exon            2373..2508
                     /gene="Ptprt"
                     /inference="alignment:Splign:2.1.0"
     exon            2509..2538
                     /gene="Ptprt"
                     /inference="alignment:Splign:2.1.0"
     exon            2539..2687
                     /gene="Ptprt"
                     /inference="alignment:Splign:2.1.0"
     exon            2688..2878
                     /gene="Ptprt"
                     /inference="alignment:Splign:2.1.0"
     exon            2879..2966
                     /gene="Ptprt"
                     /inference="alignment:Splign:2.1.0"
     exon            2967..3043
                     /gene="Ptprt"
                     /inference="alignment:Splign:2.1.0"
     exon            3044..3080
                     /gene="Ptprt"
                     /inference="alignment:Splign:2.1.0"
     exon            3081..3178
                     /gene="Ptprt"
                     /inference="alignment:Splign:2.1.0"
     exon            3179..3295
                     /gene="Ptprt"
                     /inference="alignment:Splign:2.1.0"
     exon            3296..3450
                     /gene="Ptprt"
                     /inference="alignment:Splign:2.1.0"
     exon            3451..3586
                     /gene="Ptprt"
                     /inference="alignment:Splign:2.1.0"
     exon            3587..3736
                     /gene="Ptprt"
                     /inference="alignment:Splign:2.1.0"
     exon            3737..3910
                     /gene="Ptprt"
                     /inference="alignment:Splign:2.1.0"
     exon            3911..4042
                     /gene="Ptprt"
                     /inference="alignment:Splign:2.1.0"
     exon            4043..4168
                     /gene="Ptprt"
                     /inference="alignment:Splign:2.1.0"
     exon            4169..4332
                     /gene="Ptprt"
                     /inference="alignment:Splign:2.1.0"
     exon            4333..4468
                     /gene="Ptprt"
                     /inference="alignment:Splign:2.1.0"
     exon            4469..11913
                     /gene="Ptprt"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agttcgcgcc gcgcctgggc tcggagcgca gcggcgccgg ctcccgcagc cggagaggag
       61 ccagcccccg gagcccagcg gcgcgcactg cctgcagccg cgttggcgat gcggggccgc
      121 cccgcgcccg cccgagtccc ggccctggcg ccctcggaaa ggggctgagc tgcccgccgt
      181 ccgaatgggg agccttggcg cgctcgccct ctgcctgctc cggctcctgc tcctggggct
      241 gcagcggccg ccgttgcccg gcgccggagc gcagagcgcc gcaggtggct gttcttttga
      301 cgaacattac agcaactgcg ggtatagcgt ggctctggga accaatgggt ttacctggga
      361 gcagattaac acgtgggaga agccaatgct ggacccagct gtgcccacag ggtccttcat
      421 gatggtgaat agctctggaa gagcttcagg ccagaaagcc catcttcttc taccaacctt
      481 gaaggagaat gatacccact gcattgactt ccattactac ttctccagcc gagatcgctc
      541 cagtccggga gccttgaatg tctacgtgaa ggtgaatggt ggtccccaag ggaaccctgt
      601 ctggaacgtg tctggggtcg tcactgaggg ctgggtgaag gcagaacttg ccatcagtac
      661 cttctggcct catttctacc aggtgatatt tgaatccgtc tctttgaaag gtcatcctgg
      721 ttacatcgct gtggacgaag ttcgagtcct tgctcatcca tgcagaaaag cacctcattt
      781 cctgcgactc caaaatgttg aggtgaatgt ggggcagaac gccacgtttc agtgcattgc
      841 cggtgggaag tggtcccagc atgacaaact ttggctccag caatggaatg gcagagacac
      901 ggccctcatg gtcacccggg tggtcaacca caggcgcttc tcagccacag tgagtgtggc
      961 agacacctct caacgcagtg tctccaagta tcgctgtgtg atccgctcag acggtgggtc
     1021 tggcgtatcc aactatgcag agctgatcgt gaaagagcct cccacaccta ttgctccccc
     1081 agaactactg gcagtggggg ccacctacct gtggattaaa ccaaacgcca actctattat
     1141 tggggacggc cccatcattc tgaaggaggt agaataccgc acgaccacag gcacttgggc
     1201 tgagacccac atcgtggact ctcccaacta caagctctgg catctggacc ccgatgtgga
     1261 gtacgagatc cgggtgctgc tcacacgacc aggagagggg ggcacaggac caccaggacc
     1321 tcccctcact accaggacca agtgtgccga tcctgtgcat ggccctcaga atgtggagat
     1381 tgtggacatt cgggctcgac agctgaccct gcagtgggag ccctttggct atgcagtgac
     1441 ccgctgccac agctacaacc tcacagtgca gtaccagtac gtgttcaacc agcagcagta
     1501 tgaggccgaa gaggtgatcc agacctcatc ccactatacc ctgcggggtc tgcggccctt
     1561 catgaccatc agactgaggc tgctactgtc caaccctgag ggccggatgg agagtgagga
     1621 gttggtggtt cagactgagg aggatgttcc aggagctgtt cctctggagt ccatccaagg
     1681 aggacccttt gaggagaaga tctatatcca gtggaaacct cccaatgaga ccaatggggt
     1741 catcacactc tatgagatta attacaaggc tgttggctca ctggatccaa gtgctgacct
     1801 gtccagccag agggggaaag tgttcaaact ccggaatgaa acccatcacc tctttgtggg
     1861 tctgtaccct gggactacct actctttcac catcaaggcc agcacagcca agggctttgg
     1921 acccccagtc accactcgga ttgccaccaa gatttcagct ccatcaatgc ccgaatatga
     1981 tgcagatagc ccactcaatg aaacagatac gaccatcaca gtgatgctca aacctgccca
     2041 gtcccgggga gcccctgtca gcgtttacca gttggttgtc aaggaggagc gacttcagaa
     2101 gtctcggaga gcagctgaca tcatcgagtg tttctcagtg cccgtgagct accggaatgc
     2161 ctccaacctc gattctctac actactttgc tgctgagctg aagccctcca atctgcctgt
     2221 cacccagccc ttcacagtgg gagacaacaa gacctacaat ggctactgga atccacccct
     2281 ctccccatta aagagctaca gcatctactt ccaggctctc agcaaagcaa atggagagac
     2341 aaaaatcaac tgcgtgcgtc tggctacaaa aggtgcttcc acccagaatt ctaacactgt
     2401 ggagcccgag aagcaggtcg acaacacagt gaagatggct ggtgtgattg ctggcctcct
     2461 catgttcatc ataattctac tgggggtgat gctgaccatc aaaaggagaa gaaatgctta
     2521 ttcgtactcc tattacttga agctggctaa gaagcagaag gagacccaga gtggagccca
     2581 gagggagatg gggcctgtgg cctcgactga caaacctacc accaagctca gcaccaaccg
     2641 caacgatgaa ggcttctcct ccagctctca ggatgttaac ggattcacag atggcagccg
     2701 tggagagctg tctcagccca ccctcaccat tcagactcac ccctaccgga cttgcgaccc
     2761 tgtagagatg agctaccccc gagaccagtt ccagcccgcc atccgggtag cagacctgct
     2821 tcaacacatc acccagatga agagaggcca gggctacggg ttcaaggaag aatatgaggc
     2881 cttaccagag ggacagacag cttcgtggga cacagccaag gaagatgaaa accgcaataa
     2941 gaatcgatat gggaacatca tatcttatga ccactcccga gtgaggctgt tggtgctgga
     3001 tggagaccct cactcagact acatcaatgc caactacatt gatgggtacc accgaccccg
     3061 gcactacatc gcaactcaag gtccaatgca agagaccgtg aaggactttt ggagaatgat
     3121 ctggcaggaa aactctgcca gcatcgtcat ggtcacaaac cttgtggaag tgggcagggt
     3181 gaagtgtgtc cgatactggc cagatgacac agaggtctat ggagacatta aagtcaccct
     3241 aatagaaaca gagcccctgg cagaatacgt catccgtacc ttcacagtcc agaagaaagg
     3301 ctaccatgag atccgggagc tccgcctctt ccacttcacc agctggcctg accatggtgt
     3361 tccctgctat gccactggcc ttctgggctt tgtccgccag gtcaagttcc tcaacccccc
     3421 agaagccggg cccatagtgg tccactgcag tgctggagcc gggaggactg gctgcttcat
     3481 tgccattgat accatgctcg acatggctga gaatgaaggg gttgtggaca tcttcaactg
     3541 tgtgcgtgaa ctccgggcac agagggtcaa cctggtgcag acagaggaac agtacgtgtt
     3601 tgtgcatgat gccatcctgg aagcatgcct ctgcggcaac acggccatcc ccgtgtgcga
     3661 gttccgctct ctctactaca acatcagcag gctggacccg cagaccaact ccagccagat
     3721 caaagatgag tttcagacac tcaacatcgt gacacctcgg gtgcggcctg aggactgcag
     3781 cattgggctc ttgccccgga accatgacaa gaaccggagc atggatgtcc tgcctctgga
     3841 ccgctgccta cccttcctca tctcagtaga tggagaatcc agcaactaca tcaatgcagc
     3901 actgatggat agccacaagc agcccgccgc ctttgtggtc acccagcacc ctctacccaa
     3961 cactgtggca gacttctgga ggctggtgtt tgattataat tgttcatctg tggtgatgct
     4021 gaatgagatg gacactgctc agctctgtat gcagtactgg cccgagaaga cctctgggtg
     4081 ttatggtccc atccaggtgg agttcgtctc tgcagacatt gatgaggaca tcatccacag
     4141 aatcttccgt atctgtaaca tggctcggcc acaggacggt taccgtattg tccagcacct
     4201 ccagtacatt ggctggcctg cataccgaga cacaccgccc tccaagcgct ctctgctcaa
     4261 agcggtccga cggctggaga aatggcagga ggaatatgat ggaagagagg gtcgcactgt
     4321 ggtccactgc ctaaacgggg gaggccgcag cggaaccttc tgtgctatct gcagcgtgtg
     4381 cgagatgatc caacagcaga acatcatcga cgtgttccac atcgtgaaga ccctccgcaa
     4441 caacaaatcc aacatggtgg agacgctgga acagtataaa tttgtatatg aggtggcact
     4501 ggaatattta agttcttttt agactgattg gatggggaac ccgccagagt tcagaggtcg
     4561 ctgcagctgc ccctcttttt ctgtgactga caatgactgg tctcaggagc tccaaggtga
     4621 cccacctgcc cagctccagg aagaagactg gttgtgtcat gctcggcaga aggccctgca
     4681 gcttctgggg gggtctgtag ctgtgggact tgccttctac acctgacagc atcaggccca
     4741 cagaatgcta cccacaagca aggccctgga cttccaattc ccagacccct tgcttttgtt
     4801 tgttctgagt ttgttactct catggcaagc tgaccgtgca ggtgctggag tatggggagc
     4861 tggtcagcct ttccttacca tccttaggag cactgggggt ggaagttcct ctccatgcta
     4921 tcttgcaaaa gcatagtttg agggatcact gagttattgg ttcctacagt ctcccactgg
     4981 ggactctggc atgaggcacc tgtcaatctg gatcagtgcg acttctggat gccccctaga
     5041 cccagcagga agccttttca tcttacatct aaccagtgct gagtttgact cacttccgcc
     5101 atccccagcc aggccttgac cttctgtaat cgcccggcca acctgctgtg tctgcatcac
     5161 acttcagcaa aggtttcctt tgcttttcca tagtctgtag ggggaggagg gctcacagga
     5221 aatgttacag tacctcttca atctttgtag aaagggctgc tctcctgggg cagggctctt
     5281 gctgacctgt actagatggc actttctgtg agaaagacaa acaagaaaag ctttgagtat
     5341 tttcccaggt acatgtgaaa agaaactctt ataagagtct aaaagcctgt attctcttat
     5401 gtcaaaaaag aaaacaaaag gaaagaaaag gacaggatgg gagtttgaat tgtggctgta
     5461 agataactct cttggattta tatttcctgg ccataccctt gaacagtccc actgtaggat
     5521 aacacagtca ttgaacaaat gaaatgggac ccctgggatt cggtccctgg tttgggggtg
     5581 gggaaataca gcaacacctt tataatttgt ctctccaaat ttcaactctt tccaaaaaaa
     5641 aaaaaaaaaa tccagcagcc attttgaaat tggttactgg ggccccagct tggtttataa
     5701 tataataagt aggtttaggc ctggggccga gtcttgctca gagcatgaat aaattaaggg
     5761 aagggagaga acatttgtgg agtgtttcct gcaagccaag tgccatgctt accacatgct
     5821 tccctgtgac atctcacata gtcagtagca cccctaggga cccctagaga atgctctcat
     5881 catctccatt tggtaactga agaaacccga gcaccctctt cagtgatgga attctgggtt
     5941 ctgaaggcag gtaatggcag gaaaaccttc ctaccatttt tctcatgctt tcttggccaa
     6001 gcaattattt ttatgaaacc gaaataaggc tagaaacttc agagcagaca gagaagtcca
     6061 tgagtagaaa tttaattctt tctttctgat accagttctt cttggtagcc caaactttca
     6121 gatatatttt attaactcat tcccaggtcc ccaggaaagc tagtcttacc taattttatc
     6181 attgctaaaa acaattctca tgctccctcc ggctacaagg cagccagcct gggaagctct
     6241 gcagcctggg ctgagccaca ttatctgaca gccttaatag ccaggagtct aggaaggtct
     6301 atcttgcaga ctgatccagt cgaggagtat gagggacaca gaatccaata aggtgcacat
     6361 cttggccttc gggcccgctg tattgtaggg aagctgagac accttgtaac agttggaaca
     6421 tacaagcatt cagtaagcat aaatgggaga gtgacttgct ctgcctagag cttcctaggc
     6481 aacatccatt ccagtcgcgt gtcaacagat agaaaagaag gaaaaaggaa attcaagccg
     6541 agggggtcaa catgcacaat ggtgaagaca agtgagaagg tatctgcagg gacagatggt
     6601 ggcaggtcag accagataga aggtagcaag gcagggatgg tagcaggaag gtagccagag
     6661 ccagggagga aatgtaaagg ccacagtcac tgccctgcag caacaggaag ctggcagagt
     6721 tcaatggtta tgcactcagc ttagttttgg agaaggctct ctctggacca tcaggacagc
     6781 ctcttttcct ttcatcagac actgtgaaaa catcccctca gtgtgtgctt ttaatatgtt
     6841 gcgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt atgctcatta
     6901 ttttgttgct ggaacaaaat atggagtgaa tcatgagatg gaactcttgt gtataaccca
     6961 gcatctctgt tctaccatgg agcagggtca acgaccttga cctctaagcc tacaaggaca
     7021 ggatatgaaa ggaaatcagg cagccagctc ccatttgtgt gaacccagga actgcctaga
     7081 agtctaagaa caccagagtt gatcaaggaa ggctgtcact ttggtggttc aaaaggaacg
     7141 tgtcaaagaa aaggcaagca aaggaatccc atgagtaact attctccttt gatgggcctc
     7201 ttcccaggta tatttgagca tagccccagg ccccactggt ccttctgggt tcctatggct
     7261 ctagtctcct atcactgaat ggacttccct gtagccttca ggagtctgta gcatagccat
     7321 agccattcag cctgccgcat gctatttctt cagatcttag ccaattccaa cagagaggga
     7381 gtggagggga gaggataaac tacaaatcct aggattcatt ctgctgagga aggagctgaa
     7441 gagctgacag ataaagatga cagtggtcac tgtccttatg aatagtgaga aattaaagaa
     7501 taattccagg ggaaaggaaa tatatgaaaa ttcaggccat gctgggggaa gtcaccaagg
     7561 gctaattcat accttatttt ctcacaatcc aagtattctt agagaaagtg gtcttaaaac
     7621 agtgcataca agaagaaagt agggaaatga cagtcttcag atccctgtgg aggacatgca
     7681 gaagaccttt gatgacatag gaaatggtcc taaggaattt agatgatatt ttccccaaga
     7741 aatctcccaa gaaaacccac cttccaagcg tcttttctca gccaacctac ttataggatg
     7801 ggctcatttt gacaggagca aatgaaggtt gtcaaagtga atcctcactt aggtactgtc
     7861 ttcctgttgg tctccagtgg aacccaaagg gagaagggag aaggtataaa tgagatactg
     7921 tgaactgccc cacttaggtg tgtttatggc ctagatggct tcaggtcaga tcacagctac
     7981 atctcaacct tgtgttcttt tacccctact gatatgatta ccatagatga ggtatgggcc
     8041 tgtgagcttc tagacagcca cagcaggccc ctcttatagg aatggaagag tctgcttgct
     8101 tcaggtgttt ctcagtggga gcgttagcaa ttaaagacca gccatctgtc acctactcca
     8161 tggaactact gttccagtgc tgtggactct aaaacatgag ctccctcttc cacattcttg
     8221 aaatacttgt gattatggcc agcactattt taatggtgag taaatggatc cagaggaaga
     8281 acgcactcgc ccagttaagc aaacttgacc tggttttctg accacagaga caaaattctc
     8341 ccaccatagt atctgagatt tttttttccc cacaagatta ctcttagcaa cagagaaaag
     8401 agcaaaacta atgactcagt agatatcagt aaagcccagt gcagacaatg ataagtttca
     8461 aattcctctg gagcctcacg ttttacatcc atgatctatt tagattccat tttctaattt
     8521 attcttagta gtttaaatat gtctgcataa atctattttg aaatctgtcc tttatctcat
     8581 gcttctctct gattgatctt agggaatatc tctgaccaag gcataatgtc tagccaagtt
     8641 cctcctcctg aggtcaattc taagctcacg ttcacgttca caccaactta cattcccttg
     8701 ggcacatgtg ttgctatgga ggtatcctga ctgtactgct cctgaggctt agcttaggga
     8761 ggtttccaca atgtacccac taacagacta gaagaataac ttacctggat ggcacggtaa
     8821 aggttgagtc cccaaaaccc taggagcaaa ggagaagaag ccaggtgcag atttactcag
     8881 aagatccacg aatgctgaac aatgtctcta tagatttcta tggcttctga tgtgggaaaa
     8941 tcttaggaca cacgtgatga atcttaaaca cccttccctt cacatggctc gacacaagcc
     9001 ctggcttcct gtagcattca gcactccaga caggtactac taagaagtgc agactactct
     9061 ggcttggtac cccagggtga gtaggataag aacttgccgt ttgtcttgaa ctctgacttt
     9121 accatttctg gaatgtaaaa tgtcaggctg aacacggcac ggaaaaggaa acatacacac
     9181 aacctctttg gccaggttta aaggggttaa tctgaaaggc tagggcaggg aaacaagaat
     9241 tcaaattgaa actcaacgtt tactcagaaa caaggatgct tatggagtga ctgttgatct
     9301 cagtaataaa tgctatgggg aaagtttaaa gaaagccacc cctctttagc ctgtagctgg
     9361 ccacccctgc caaccaaaca ggccttcggg accaagctaa agcatgctca atactgtaga
     9421 agatatgtct agatccaata ctaaacatgc tgatcctata ccacaaggtc aatgaattat
     9481 tctgagccaa gatccctaag aatgagtcgc caacccaaac taaaagacaa gtcaaatgat
     9541 aaaacagaaa tagcagtgtc ctctctaagc cttgatttgc ctttctttgc aattgaccag
     9601 tcaacgtgag ggcctctata gcatcctgcc agttccaact cacagccaaa tagaacagaa
     9661 aaatagggga aattcagcca cagacaaccg ggactcaatc ttgtttgcat actgctctgt
     9721 acaggtttcc tgtgtgaggt tgtccctaga tacctctcaa aaactatgaa acgcagaggc
     9781 ctccctttac tgactgtgga gtcacctttg aaattctacc cttccagaga gagagagaga
     9841 gagagagaga gagagagggg tggacagtag aaagttgggg aggaagagaa tagttctaaa
     9901 tcgtgttttc tctgacatat tttagagtca tggagctgat atcctcggaa acacagcaca
     9961 aatgtctctg acatatttgc atacgaataa gctctttcag tttcttggta accacagata
    10021 gatttttgta tgacagtagc tatgtaaatg tattgtggag accaagaacc atttcttgac
    10081 tatccctgcc aacctctaga tgaggtggaa aagctcttaa aggggccaca ttcacccctg
    10141 aaatccattc atattagtgt ccaacaggtg gagtcagtac ccacattcat accctgcccc
    10201 agacctggca tcactttatc tagcatggat acacctaaaa gcttagtagt ggtgcactgc
    10261 agctggtaca gaggatgggc aagaattggg tggggagaca acctactaga aaggacttcg
    10321 gaaggtgctt aaccatgggg cttccttcta gatctgagag ccactctagg tggtaaaatg
    10381 ctgaccctgg ttctttgttg gaatgtttag agaatgacgt gtaggagtct tagaatactg
    10441 gacagcaaag tgatggactg agacctgggc attcagggga tctaatgtag gttgtgattc
    10501 ttcagtgaga cccatttcta gggcttccat gagcagaatt ggaacagtct agaaaaaact
    10561 taagtctcct agaggcacag gcagaagact ggcatccatc gtcatcttaa gcctgtggat
    10621 gataagacag agtcgagcat agttttgcta ccgtggttac tcctatgagt ggtgctaagg
    10681 tggatgagga aacttagtac ctgtaagaaa gagctgactg ctgggcagga agctgcctgt
    10741 ttgagtagct gcccagcaga catcaggcat ccccatctcc tggcctatgt gaagaagcag
    10801 cacagctgag gtagacttca ggcctctctc acttttagtg gatgagtctt tgaacatgaa
    10861 agtcacattt gaactggtac ctccaaactg caagccaagt cggtaggtcg tgcttggttt
    10921 gtgaggcggt agtcctctgt tttcctaaac aaatcatctc cttatatcaa tcaaaaagca
    10981 gcttcatctg catctcctag ccttatccag gatagttagc accagtcaca ggaagcagct
    11041 ccttgtccat acatgtgatg cttagtgcca taactgacaa gggcagccaa tgcccacact
    11101 cactggccat cagggccctc aatgacagac agaaccaata aacatccagg caggagtcaa
    11161 aacaagcctt cacttcatgt tatctccaaa gtttcattca gccctcactc aaggtctgta
    11221 ggaaaagatt tcaaaagcac agtgattctg ttgacacctg atcacaatcg ttcccagtac
    11281 atatatttta tcaccaactg gttcttgggc tagccgaagt tagcctaggc taactcatat
    11341 ttgtaatcag gctcaaaaat catattctat cttttctcct cactctaact cccggtagtc
    11401 aattaaaggt acagttccca tggctactgg atactgtact ggtacagctc tccaggacct
    11461 ctcatggcat tcccagtcta cactagggaa tctgacattt tcatttccca gtggcatatg
    11521 atgtcacatg agacccaagt atccgcacta cccgaagtct ccacaaattc caatggcctg
    11581 cacttgtaca gtttgggttt ttgatagata aagcacgtat gagaagagaa aacaaaataa
    11641 atcaacttca gcagaaagaa agccagcact gtgctgtcaa tgtttttttt ttccctttcc
    11701 ctttttattt ccagttctag cttcaaaaag cagaaggtaa ataatgtcag gtcaatgaat
    11761 atcagatata ttttttgact gtacattaaa gtgacgtgta atctttttac acctgcaagt
    11821 ccatcttatt tattcttgta aatgttccct gacaatgttt gtaatatggc tgtgtttaaa
    11881 agaaatctat acaataaagc tgtgaccctg aga
//
