LOCUS       NM_019140               6042 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus protein tyrosine phosphatase, receptor type, S
            (Ptprs), mRNA.
ACCESSION   NM_019140
VERSION     NM_019140.3
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6042)
  AUTHORS   Ito,S., Ozaki,T., Morozumi,M., Imagama,S., Kadomatsu,K. and
            Sakamoto,K.
  TITLE     Enoxaparin promotes functional recovery after spinal cord injury by
            antagonizing PTPRsigma
  JOURNAL   Exp Neurol 340, 113679 (2021)
   PUBMED   33662380
  REMARK    GeneRIF: Enoxaparin promotes functional recovery after spinal cord
            injury by antagonizing PTPRsigma.
REFERENCE   2  (bases 1 to 6042)
  AUTHORS   Shijo,T., Warita,H., Suzuki,N., Kitajima,Y., Ikeda,K., Akiyama,T.,
            Ono,H., Mitsuzawa,S., Nishiyama,A., Izumi,R. and Aoki,M.
  TITLE     Aberrant astrocytic expression of chondroitin sulfate proteoglycan
            receptors in a rat model of amyotrophic lateral sclerosis
  JOURNAL   J Neurosci Res 96 (2), 222-233 (2018)
   PUBMED   28752900
  REMARK    GeneRIF: The present study found that astrocytes aberrantly and
            progressively expressed PTPsigma and LAR at the site of motor
            neuron degeneration in Tg ALS model rats with mutant SOD1.
REFERENCE   3  (bases 1 to 6042)
  AUTHORS   Choi,Y., Nam,J., Whitcomb,D.J., Song,Y.S., Kim,D., Jeon,S.,
            Um,J.W., Lee,S.G., Woo,J., Kwon,S.K., Li,Y., Mah,W., Kim,H.M.,
            Ko,J., Cho,K. and Kim,E.
  TITLE     SALM5 trans-synaptically interacts with LAR-RPTPs in a
            splicing-dependent manner to regulate synapse development
  JOURNAL   Sci Rep 6, 26676 (2016)
   PUBMED   27225731
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6042)
  AUTHORS   Li,H., Wong,C., Li,W., Ruven,C., He,L., Wu,X., Lang,B.T., Silver,J.
            and Wu,W.
  TITLE     Enhanced regeneration and functional recovery after spinal root
            avulsion by manipulation of the proteoglycan receptor PTPsigma
  JOURNAL   Sci Rep 5, 14923 (2015)
   PUBMED   26464223
  REMARK    GeneRIF: Our study shows that modulation of PTPsigma is a potential
            therapeutic strategy for root avulsion.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6042)
  AUTHORS   Bunin,A., Sisirak,V., Ghosh,H.S., Grajkowska,L.T., Hou,Z.E.,
            Miron,M., Yang,C., Ceribelli,M., Uetani,N., Chaperot,L., Plumas,J.,
            Hendriks,W., Tremblay,M.L., Hacker,H., Staudt,L.M., Green,P.H.,
            Bhagat,G. and Reizis,B.
  TITLE     Protein Tyrosine Phosphatase PTPRS Is an Inhibitory Receptor on
            Human and Murine Plasmacytoid Dendritic Cells
  JOURNAL   Immunity 43 (2), 277-288 (2015)
   PUBMED   26231120
REFERENCE   6  (bases 1 to 6042)
  AUTHORS   Wagner,J., Boerboom,D. and Tremblay,M.L.
  TITLE     Molecular cloning and tissue-specific RNA processing of a murine
            receptor-type protein tyrosine phosphatase
  JOURNAL   Eur J Biochem 226 (3), 773-782 (1994)
   PUBMED   7529177
REFERENCE   7  (bases 1 to 6042)
  AUTHORS   Zhang,W.R., Hashimoto,N., Ahmad,F., Ding,W. and Goldstein,B.J.
  TITLE     Molecular cloning and expression of a unique receptor-like
            protein-tyrosine-phosphatase in the
            leucocyte-common-antigen-related phosphate family
  JOURNAL   Biochem J 302 (Pt 1) (Pt 1), 39-47 (1994)
   PUBMED   8068021
REFERENCE   8  (bases 1 to 6042)
  AUTHORS   Sahin,M. and Hockfield,S.
  TITLE     Protein tyrosine phosphatases expressed in the developing rat brain
  JOURNAL   J Neurosci 13 (11), 4968-4978 (1993)
   PUBMED   8229209
REFERENCE   9  (bases 1 to 6042)
  AUTHORS   Pan,M.G., Rim,C., Lu,K.P., Florio,T. and Stork,P.J.
  TITLE     Cloning and expression of two structurally distinct receptor-linked
            protein-tyrosine phosphatases generated by RNA processing from a
            single gene
  JOURNAL   J Biol Chem 268 (26), 19284-19291 (1993)
   PUBMED   8396131
REFERENCE   10 (bases 1 to 6042)
  AUTHORS   Walton,K.M., Martell,K.J., Kwak,S.P., Dixon,J.E. and Largent,B.L.
  TITLE     A novel receptor-type protein tyrosine phosphatase is expressed
            during neurogenesis in the olfactory neuroepithelium
  JOURNAL   Neuron 11 (2), 387-400 (1993)
   PUBMED   8352946
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000009.1.
            
            [WARNING] On Jul 22, 2024 this sequence was replaced by
            NM_019140.4.
            
            On Nov 27, 2020 this sequence version replaced NM_019140.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA5760383, SAMEA5760386
                              [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-89                JAXUCZ010000009.1  1394003-1394091     c
            90-275              JAXUCZ010000009.1  1375497-1375682     c
            276-421             JAXUCZ010000009.1  1372410-1372555     c
            422-563             JAXUCZ010000009.1  1371836-1371977     c
            564-752             JAXUCZ010000009.1  1369236-1369424     c
            753-863             JAXUCZ010000009.1  1365801-1365911     c
            864-1133            JAXUCZ010000009.1  1356496-1356765     c
            1134-1715           JAXUCZ010000009.1  1354331-1354912     c
            1716-1849           JAXUCZ010000009.1  1353558-1353691     c
            1850-1994           JAXUCZ010000009.1  1353117-1353261     c
            1995-2053           JAXUCZ010000009.1  1348124-1348182     c
            2054-2168           JAXUCZ010000009.1  1347877-1347991     c
            2169-2362           JAXUCZ010000009.1  1346962-1347155     c
            2363-2480           JAXUCZ010000009.1  1345204-1345321     c
            2481-3080           JAXUCZ010000009.1  1344156-1344755     c
            3081-3178           JAXUCZ010000009.1  1343694-1343791     c
            3179-3432           JAXUCZ010000009.1  1342741-1342994     c
            3433-3526           JAXUCZ010000009.1  1342169-1342262     c
            3527-3742           JAXUCZ010000009.1  1341826-1342041     c
            3743-3900           JAXUCZ010000009.1  1341239-1341396     c
            3901-3912           JAXUCZ010000009.1  1341060-1341071     c
            3913-4025           JAXUCZ010000009.1  1340475-1340587     c
            4026-4123           JAXUCZ010000009.1  1339894-1339991     c
            4124-4247           JAXUCZ010000009.1  1339655-1339778     c
            4248-4423           JAXUCZ010000009.1  1339193-1339368     c
            4424-4543           JAXUCZ010000009.1  1338988-1339107     c
            4544-4698           JAXUCZ010000009.1  1337822-1337976     c
            4699-4984           JAXUCZ010000009.1  1337460-1337745     c
            4985-5163           JAXUCZ010000009.1  1337116-1337294     c
            5164-5290           JAXUCZ010000009.1  1335053-1335179     c
            5291-5416           JAXUCZ010000009.1  1334851-1334976     c
            5417-5571           JAXUCZ010000009.1  1334079-1334233     c
            5572-5707           JAXUCZ010000009.1  1333861-1333996     c
            5708-6042           JAXUCZ010000009.1  1333188-1333522     c
FEATURES             Location/Qualifiers
     source          1..6042
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q11"
     gene            1..6042
                     /gene="Ptprs"
                     /gene_synonym="Larptp2; Ptprd; Ptpsigma; Ptpsigma.; Rptpd"
                     /note="protein tyrosine phosphatase, receptor type, S"
                     /db_xref="GeneID:25529"
                     /db_xref="RGD:3452"
     exon            1..89
                     /gene="Ptprs"
                     /gene_synonym="Larptp2; Ptprd; Ptpsigma; Ptpsigma.; Rptpd"
                     /inference="alignment:Splign:2.1.0"
     exon            90..275
                     /gene="Ptprs"
                     /gene_synonym="Larptp2; Ptprd; Ptpsigma; Ptpsigma.; Rptpd"
                     /inference="alignment:Splign:2.1.0"
     CDS             185..5776
                     /gene="Ptprs"
                     /gene_synonym="Larptp2; Ptprd; Ptpsigma; Ptpsigma.; Rptpd"
                     /EC_number="3.1.3.48"
                     /note="R-PTP-S; receptor-type tyrosine-protein phosphatase
                     S; LAR-PTP2; R-PTP-sigma; receptor-type tyrosine-protein
                     phosphatase sigma; leukocyte common antigen-related
                     proten-tyrosine phosphatase 2; leukocyte common
                     antigen-related protein-tyrosine phosphatase 2; protein
                     tyrosine phosphatase, receptor type, D"
                     /codon_start=1
                     /product="receptor-type tyrosine-protein phosphatase S
                     precursor"
                     /protein_id="NP_062013.2"
                     /db_xref="GeneID:25529"
                     /db_xref="RGD:3452"
                     /translation="MAPTWRPSVVSVVGPVGLFLVLLARGCLAEEPPRFIREPKDQIG
                     VSGGVASFVCQATGDPKPRVTWNKKGKKVNSQRFETIDFDESSGAVLRIQPLRTPRDE
                     NVYECVAQNSVGEITVHAKLTVLREDQLPPGFPNIDMGPQLKVVERTRTATMLCAASG
                     NPDPEITWFKDFLPVDPSASNGRIKQLRSGALQIESSEETDQGKYECVATNSAGVRYS
                     SPANLYVRVRRVAPRFSILPMSHEIMPGGNVNITCVAVGSPMPYVKWMQGAEDLTPED
                     DMPVGRNVLELTDVKDSANYTCVAMSSLGVIEAVAQITVKSLPKAPGTPVVTENTATS
                     ITVTWDSGNPDPVSYYVIEYKSKSQDGPYQIKEDITTTRYSIGGLSPNSEYEIWVSAV
                     NSIGQGPPSESVVTRTGEQAPASAPRNVQARMLSATTMIVQWEEPVEPNGLIRGYRVY
                     YTMEPEHPVGNWQKHNVDDSLLTTVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQ
                     QGVPGQPMNLRAEAKSETSIGLSWSAPRQESVIKYELLFREGDRGREVGRTFDPTTAF
                     VVEDLKPNTEYAFRLAARSPQGLGAFTAVVRQRTLQAKPSAPPQDVKCTSLRSTAILI
                     LLEALEKWTEYRVTAVAYTEVGPGPESSPVVVRTDEDVPSAPPRKVEAEALNATAIRV
                     LWRSPTPGRQHGQIRGYQVHYVRMEGAEARGPPRIKDIMLADAQEMVITNLQPETAYS
                     ITVAAYTMKGDGARSKPKVVVTKGAVLGRPTLSVQQTPEGSLLARWEPPADAAEDPVL
                     GYRLQFGREDAAPATLELAAWERRFAAPAHKGATYVFRLAARGRAGLGEEASAALSIP
                     EDAPRGFPQILGAAGNVSAGSVILRWLPPVPAERNGAIIKYTVSVREAGAPGPATETE
                     LAAAAQPGAETALTLQGLRPETAYELRVRAHTRRGPGPFSPPLRYRLARDPVSPKNFK
                     VKMIMKTSVLLSWEFPDNYNSPTPYKIQYNGLTLDVDGRTTKKLITHLKPHTFYNFVL
                     TNRGSSLGGLQQTVTARTAFNMLSGKPSVAPKPDNDGSIVVYLPDGQSPVTVQNYFIV
                     MVPLRKSRGGQFPILLGSPEDMDLEELIQDLSRLQRRSLRHSRQLEVPRPYIAARFSI
                     LPAVFHPGNQKQYGGFDNRGLEPGHRYVLFVLAVLQKNEPTFAASPFSDPFQLDNPDP
                     QPIVDGEEGLIWVIGPVLAVVFIICIVIAILLYKNKPDSKRKDSEPRTKCLLNNADLA
                     PHHPKDPVEMRRINFQTPGMLSHPPIPITDMAEHMERLKANDSLKLSQEYESIDPGQQ
                     FTWEHSNLEANKPKNRYANVIAYDHSRVILQPLEGIMGSDYINANYVDGYRRQNAYIA
                     TQGPLPETFGDFWRMVWEQRSATVVMMTRLEEKSRVKCDQYWPNRGTETYGFIQVTLL
                     DTMELATFCVRTFSLHKNGSSEKREVRHFQFTAWPDHGVPEYPTPFLAFLRRVKTCNP
                     PDAGPVVVHCSAGVGRTGCFIVIDAMLERIRTEKTVDVYGHVTLMRSQRNYMVQTEDQ
                     YSFIHEALLEAVGCGNTEVPARSLYTYIQKLAQVEPGEHVTGMELEFKRLASSKAHTS
                     RFITASLPCNKFKNRLVNILPYESSRVCLQPIRGVEGSDYINASFIDGYRQQKAYIAT
                     QGPLAETTEDFWRALWENNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMA
                     EYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGAPKSGEGFIDFIGQVHKTKEQ
                     FGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKVLRTQRPAMVQTED
                     EYQFCFQAALEYLGSFDHYAT"
     exon            276..421
                     /gene="Ptprs"
                     /gene_synonym="Larptp2; Ptprd; Ptpsigma; Ptpsigma.; Rptpd"
                     /inference="alignment:Splign:2.1.0"
     exon            422..563
                     /gene="Ptprs"
                     /gene_synonym="Larptp2; Ptprd; Ptpsigma; Ptpsigma.; Rptpd"
                     /inference="alignment:Splign:2.1.0"
     exon            564..752
                     /gene="Ptprs"
                     /gene_synonym="Larptp2; Ptprd; Ptpsigma; Ptpsigma.; Rptpd"
                     /inference="alignment:Splign:2.1.0"
     exon            753..863
                     /gene="Ptprs"
                     /gene_synonym="Larptp2; Ptprd; Ptpsigma; Ptpsigma.; Rptpd"
                     /inference="alignment:Splign:2.1.0"
     exon            864..1133
                     /gene="Ptprs"
                     /gene_synonym="Larptp2; Ptprd; Ptpsigma; Ptpsigma.; Rptpd"
                     /inference="alignment:Splign:2.1.0"
     exon            1134..1715
                     /gene="Ptprs"
                     /gene_synonym="Larptp2; Ptprd; Ptpsigma; Ptpsigma.; Rptpd"
                     /inference="alignment:Splign:2.1.0"
     exon            1716..1849
                     /gene="Ptprs"
                     /gene_synonym="Larptp2; Ptprd; Ptpsigma; Ptpsigma.; Rptpd"
                     /inference="alignment:Splign:2.1.0"
     exon            1850..1994
                     /gene="Ptprs"
                     /gene_synonym="Larptp2; Ptprd; Ptpsigma; Ptpsigma.; Rptpd"
                     /inference="alignment:Splign:2.1.0"
     exon            1995..2053
                     /gene="Ptprs"
                     /gene_synonym="Larptp2; Ptprd; Ptpsigma; Ptpsigma.; Rptpd"
                     /inference="alignment:Splign:2.1.0"
     exon            2054..2168
                     /gene="Ptprs"
                     /gene_synonym="Larptp2; Ptprd; Ptpsigma; Ptpsigma.; Rptpd"
                     /inference="alignment:Splign:2.1.0"
     exon            2169..2362
                     /gene="Ptprs"
                     /gene_synonym="Larptp2; Ptprd; Ptpsigma; Ptpsigma.; Rptpd"
                     /inference="alignment:Splign:2.1.0"
     exon            2363..2480
                     /gene="Ptprs"
                     /gene_synonym="Larptp2; Ptprd; Ptpsigma; Ptpsigma.; Rptpd"
                     /inference="alignment:Splign:2.1.0"
     exon            2481..3080
                     /gene="Ptprs"
                     /gene_synonym="Larptp2; Ptprd; Ptpsigma; Ptpsigma.; Rptpd"
                     /inference="alignment:Splign:2.1.0"
     exon            3081..3178
                     /gene="Ptprs"
                     /gene_synonym="Larptp2; Ptprd; Ptpsigma; Ptpsigma.; Rptpd"
                     /inference="alignment:Splign:2.1.0"
     exon            3179..3432
                     /gene="Ptprs"
                     /gene_synonym="Larptp2; Ptprd; Ptpsigma; Ptpsigma.; Rptpd"
                     /inference="alignment:Splign:2.1.0"
     exon            3433..3526
                     /gene="Ptprs"
                     /gene_synonym="Larptp2; Ptprd; Ptpsigma; Ptpsigma.; Rptpd"
                     /inference="alignment:Splign:2.1.0"
     exon            3527..3742
                     /gene="Ptprs"
                     /gene_synonym="Larptp2; Ptprd; Ptpsigma; Ptpsigma.; Rptpd"
                     /inference="alignment:Splign:2.1.0"
     exon            3743..3900
                     /gene="Ptprs"
                     /gene_synonym="Larptp2; Ptprd; Ptpsigma; Ptpsigma.; Rptpd"
                     /inference="alignment:Splign:2.1.0"
     exon            3901..3912
                     /gene="Ptprs"
                     /gene_synonym="Larptp2; Ptprd; Ptpsigma; Ptpsigma.; Rptpd"
                     /inference="alignment:Splign:2.1.0"
     exon            3913..4025
                     /gene="Ptprs"
                     /gene_synonym="Larptp2; Ptprd; Ptpsigma; Ptpsigma.; Rptpd"
                     /inference="alignment:Splign:2.1.0"
     exon            4026..4123
                     /gene="Ptprs"
                     /gene_synonym="Larptp2; Ptprd; Ptpsigma; Ptpsigma.; Rptpd"
                     /inference="alignment:Splign:2.1.0"
     exon            4124..4247
                     /gene="Ptprs"
                     /gene_synonym="Larptp2; Ptprd; Ptpsigma; Ptpsigma.; Rptpd"
                     /inference="alignment:Splign:2.1.0"
     exon            4248..4423
                     /gene="Ptprs"
                     /gene_synonym="Larptp2; Ptprd; Ptpsigma; Ptpsigma.; Rptpd"
                     /inference="alignment:Splign:2.1.0"
     exon            4424..4543
                     /gene="Ptprs"
                     /gene_synonym="Larptp2; Ptprd; Ptpsigma; Ptpsigma.; Rptpd"
                     /inference="alignment:Splign:2.1.0"
     exon            4544..4698
                     /gene="Ptprs"
                     /gene_synonym="Larptp2; Ptprd; Ptpsigma; Ptpsigma.; Rptpd"
                     /inference="alignment:Splign:2.1.0"
     exon            4699..4984
                     /gene="Ptprs"
                     /gene_synonym="Larptp2; Ptprd; Ptpsigma; Ptpsigma.; Rptpd"
                     /inference="alignment:Splign:2.1.0"
     exon            4985..5163
                     /gene="Ptprs"
                     /gene_synonym="Larptp2; Ptprd; Ptpsigma; Ptpsigma.; Rptpd"
                     /inference="alignment:Splign:2.1.0"
     exon            5164..5290
                     /gene="Ptprs"
                     /gene_synonym="Larptp2; Ptprd; Ptpsigma; Ptpsigma.; Rptpd"
                     /inference="alignment:Splign:2.1.0"
     exon            5291..5416
                     /gene="Ptprs"
                     /gene_synonym="Larptp2; Ptprd; Ptpsigma; Ptpsigma.; Rptpd"
                     /inference="alignment:Splign:2.1.0"
     exon            5417..5571
                     /gene="Ptprs"
                     /gene_synonym="Larptp2; Ptprd; Ptpsigma; Ptpsigma.; Rptpd"
                     /inference="alignment:Splign:2.1.0"
     exon            5572..5707
                     /gene="Ptprs"
                     /gene_synonym="Larptp2; Ptprd; Ptpsigma; Ptpsigma.; Rptpd"
                     /inference="alignment:Splign:2.1.0"
     exon            5708..6042
                     /gene="Ptprs"
                     /gene_synonym="Larptp2; Ptprd; Ptpsigma; Ptpsigma.; Rptpd"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcccgccagg cagctccggc cgtgcgcgca cgccgagccg ccggagcccg ggccgacccg
       61 gtgccgggag cagcatgcgg agcccgcagc cgctgctcct ctggacacct cagcctgagg
      121 cctctccgtg agttacgggg acaccatccc ccaccagggc ggaggctgga ggccactgcc
      181 aagcatggcg cccacctgga gacccagcgt ggtgtctgtg gtgggtcctg tggggctctt
      241 ccttgtactg ctggccagag ggtgcttggc tgaagagcca cccagattta tcagagagcc
      301 caaggatcag attggtgtgt caggaggcgt ggcctccttc gtgtgccagg ccacaggtga
      361 ccctaagcca cgggtgacct ggaacaagaa gggcaagaaa gtgaactcac agcgctttga
      421 gaccattgac tttgacgaga gctcgggggc cgtgctgagg atccagccac ttcggacacc
      481 ccgggatgag aacgtgtacg agtgtgtggc ccagaactcg gtgggggaga tcacagttca
      541 tgcgaagctc accgtcctgc gagaggacca gctgcctcct ggcttcccca acattgacat
      601 gggcccccag ttgaaggttg tagagcgcac acgcacagcc accatgctct gtgctgccag
      661 cggaaaccct gaccctgaga tcacctggtt caaggacttc ctgcctgtgg accccagtgc
      721 cagcaatggg cggatcaagc agcttcggtc aggtgccctg cagattgaga gcagcgagga
      781 gacagaccag ggcaagtacg agtgtgtggc caccaacagc gctggggtgc gctactcatc
      841 acctgccaac ctctacgtgc gagtccgccg tgtggccccc cgcttctcca tcctgcccat
      901 gagccacgag atcatgcccg gtgggaatgt gaatatcact tgtgtggctg tgggctcacc
      961 catgccctac gtgaagtgga tgcagggggc agaggacctg acgcctgagg atgacatgcc
     1021 cgtgggtcgg aatgtcctcg aactcacgga tgtcaaagac tcagccaact atacttgtgt
     1081 ggccatgtcc agcctgggag tgatcgaggc cgttgctcag atcactgtaa aatctctccc
     1141 caaagcccct gggactcccg tggtgacgga gaacactgct accagtatca ctgtcacatg
     1201 ggactcaggc aatcctgacc ctgtgtccta ctacgtaatt gagtataaat ccaaaagcca
     1261 ggatgggccg tatcagatca aagaagacat caccaccacg cgctacagca tcggcggcct
     1321 gagccccaac tctgagtatg agatctgggt gtcagctgtc aactccatcg gccagggccc
     1381 ccccagtgag tcggtggtga cccgcacagg cgagcaggca ccagccagtg ctcccaggaa
     1441 tgttcaggcg cgcatgctca gtgccaccac catgattgtg cagtgggagg agcccgtgga
     1501 gcccaatggc ctgatccgtg gctaccgcgt ctactacacc atggagcccg agcatccggt
     1561 gggcaactgg cagaagcaca atgtggacga cagtcttctg accactgtgg gcagcctgct
     1621 agaggatgag acctacactg tgagagtgct cgccttcaca tcggtgggcg atgggccact
     1681 gtcagacccc atccaggtca agacccagca gggagtgccc ggccagccca tgaacttgcg
     1741 ggctgaggcc aagtcagaga ccagcattgg gctctcgtgg agtgcaccac ggcaggagag
     1801 tgtcattaag tatgaactgc tcttccggga gggcgaccga ggccgagagg tggggcgaac
     1861 cttcgaccca accacagcct ttgtggtgga ggacctcaag cccaatacgg agtacgcgtt
     1921 ccggctggcg gctcgctcgc cgcagggcct gggcgccttc accgcggttg tgcgccagcg
     1981 cacactgcag gccaaaccgt cagccccccc tcaagacgtt aagtgcacca gcttgcgctc
     2041 cacggccata ttgatccttc tggaagcttt ggagaaatgg acggagtacc gtgtcaccgc
     2101 cgtggcttac acagaggtgg gaccagggcc cgagagctcg cccgtggtcg tccgcaccga
     2161 tgaggacgtg cccagcgcgc ccccgcggaa ggtggaggcg gaggcgctca acgccacggc
     2221 tatccgagtg ctgtggcgct cgcccacgcc cggcaggcag cacgggcaga tccgcggcta
     2281 ccaggtccac tatgtgcgca tggagggcgc cgaggcccgc gggccaccgc gcatcaagga
     2341 catcatgctg gcggatgccc aggaaatggt gatcacaaac ctccagcctg agactgctta
     2401 ctctatcaca gtagccgcgt ataccatgaa aggcgatggc gctcgcagca aaccgaaggt
     2461 ggtggtgacc aagggagcag tgctgggccg ccccaccctg tcggtgcagc agacccccga
     2521 gggcagcctg ctggcgcgct gggagccccc cgcggacgcg gctgaggacc cagtgcttgg
     2581 ctaccgcctg cagtttgggc gcgaagacgc ggccccggcc acgttggaac tggcggcgtg
     2641 ggagcggcgg ttcgcggcgc ctgcacacaa gggcgccacc tatgtgtttc ggctggcggc
     2701 gcggggccgc gcggggctgg gcgaggaggc ctcggcggcg ctgagcatcc ctgaggacgc
     2761 tccgcgtggc ttcccgcaga tcctgggcgc cgcgggcaac gtgtccgcgg gctccgtaat
     2821 actgcgctgg ctgccacccg tgcccgccga gcgcaacggc gccatcatca agtacacggt
     2881 gtccgtgcgg gaggccggcg ccccagggcc cgcgacagag accgaactgg cggcggcggc
     2941 ccagccgggg gccgagacag cgctcacact acaggggctg cggccggaga cggcctacga
     3001 gctgcgcgtg cgcgcgcaca cgcgtcgggg ccccggcccc ttctcacccc cgctgcgata
     3061 caggcttgcg cgggacccag tctcccccaa gaacttcaag gtgaagatga tcatgaaaac
     3121 ttcagtgctg ctaagctggg agttccctga caactataac tcacccacgc cctacaagat
     3181 ccagtacaat ggactcacac tggacgtgga tggccgcact accaagaagc tgatcacgca
     3241 cctcaagcca cacaccttct ataacttcgt gctcaccaac cgtggcagca gcctgggagg
     3301 cctgcagcag acggtcaccg ccaggaccgc cttcaacatg ctcagtggca agcctagtgt
     3361 cgccccaaag cctgacaacg atggttccat tgtggtctac ctgcctgatg gccagagtcc
     3421 cgtgacagtg cagaactact tcattgtgat ggtcccactt cggaagtctc gtggtggcca
     3481 gttccctatc ctactaggta gtccagagga catggatctg gaggagctca tccaggacct
     3541 ctcccggctg cagaggcgca gcctgcgcca ctcaagacag ctggaggtgc ctcggcctta
     3601 catcgccgct cggttctcca tcctgccagc tgtcttccat cctgggaacc agaagcaata
     3661 tggtggcttt gacaacaggg gcttggagcc aggccaccgt tatgtcctct ttgtacttgc
     3721 tgtgctgcag aagaatgagc ctacatttgc agccagtccc ttctcagacc ccttccaact
     3781 ggacaaccca gacccgcagc ccattgtgga tggcgaggag ggcctcatct gggtgatcgg
     3841 gcccgtgctg gccgtggtct tcatcatctg catcgtaatt gccatcctgc tgtacaagaa
     3901 caagcctgac agcaaacgca aggactcaga gccccgcacc aaatgcttat tgaacaatgc
     3961 agacctcgcc ccccatcacc ccaaggaccc tgtggaaatg cgacgtatca acttccagac
     4021 gccaggtatg ctcagccacc cgcccattcc catcacagac atggctgaac acatggagag
     4081 actcaaagcc aacgacagcc tcaagctctc ccaggagtat gagtccatcg accctggcca
     4141 gcagttcact tgggaacatt cgaacctgga ggccaacaag ccaaagaacc gatacgccaa
     4201 tgtcatcgcc tatgaccatt cacgagtcat cctgcagcct ttagaaggca tcatgggtag
     4261 tgattacatc aatgccaact atgtggacgg ctatcggcgg cagaacgcat acatcgccac
     4321 gcaggggccc ctgcctgaga cctttgggga cttctggcgg atggtgtggg agcagcggtc
     4381 agccactgtg gtcatgatga cacggctgga ggagaaatca cgggtcaaat gtgaccagta
     4441 ctggcctaac cgaggcaccg agacatacgg cttcatccag gtcaccctac tagatactat
     4501 ggagctggcc accttctgtg tcaggacctt ttctctacac aagaatggct ctagtgagaa
     4561 gcgtgaggta cgacattttc agttcacagc atggcctgac cacggggtac ccgagtaccc
     4621 cacacccttc ctggcgtttc tgcgcagagt caagacctgc aacccgcctg acgctggccc
     4681 agttgtggtc cactgcagcg cgggtgtggg gcgtactggc tgcttcattg taattgatgc
     4741 catgttggag cgcatcagaa cagagaagac ggtggatgtg tacggacacg tgacactcat
     4801 gcggtcacag cgcaactaca tggtgcagac agaggatcag tatagcttca tccacgaggc
     4861 actgctggag gctgtgggct gtggcaatac cgaggtcccc gcgcgcagcc tctacaccta
     4921 tatccagaag ctggcccagg tggagcctgg cgagcatgtc acaggaatgg agcttgagtt
     4981 caagaggctt gccagctcca aggcacacac ttcgagattc atcactgcca gcctgccttg
     5041 caacaagttt aagaaccgcc tggtgaacat cctgccgtac gagagctcgc gtgtctgcct
     5101 gcagcccatt cgtggtgtcg agggctctga ctacatcaat gccagcttca tcgacggcta
     5161 cagacagcag aaagcctaca ttgcaacgca gggtccactg gcagagacca cagaggactt
     5221 ctggcgtgcc ctgtgggaga acaactccac tattgtggta atgctcacca agctccgcga
     5281 gatgggccgg gagaagtgcc accagtactg gccagctgag cgctctgccc gctaccagta
     5341 ctttgtggtt gacccgatgg cagagtataa catgccacag tacattctgc gtgagtttaa
     5401 ggtcacagat gcccgggatg gccagtcccg gaccgtccga cagttccagt tcacggactg
     5461 gccagagcag ggtgcaccca agtcagggga aggcttcatt gacttcatcg gccaagtgca
     5521 taagaccaag gagcagtttg gccaggatgg ccccatctcg gtgcactgta gtgctggagt
     5581 gggcaggacc ggagtattca tcactctgag catcgtgctg gagcgaatgc gctacgaggg
     5641 ggtggtggac attttccaga cagtgaaggt gcttcggacc cagcggcctg ccatggtgca
     5701 gacagaggat gagtaccagt tctgcttcca ggcggcgttg gaatacctgg gcagctttga
     5761 tcattatgca acataagcca tgggccccgc ccaacacctc gacccagctc caagtgccct
     5821 gaatgtgagc ccagccctcg gtgctgggtg ggaggcggcc cagggaggaa acctcctctc
     5881 cctggagaca ggcactgcct tctgaagggc acattcctca ttcccttctg actccaaaac
     5941 gaggttccag ggtggggggt agggtggaga gtagaggagc cactgctccc catagctggg
     6001 gtcacaaggg acagaactct gctcccacac ttccctgcct gc
//
