LOCUS       NM_053594               3578 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus protein tyrosine phosphatase, receptor type, R
            (Ptprr), transcript variant 1, mRNA.
ACCESSION   NM_053594
VERSION     NM_053594.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3578)
  AUTHORS   Bohm,D., Keller,K., Pieter,J., Boehm,N., Wolters,D., Siggelkow,W.,
            Lebrecht,A., Schmidt,M., Kolbl,H., Pfeiffer,N. and Grus,F.H.
  TITLE     Comparison of tear protein levels in breast cancer patients and
            healthy controls using a de novo proteomic approach
  JOURNAL   Oncol Rep 28 (2), 429-438 (2012)
   PUBMED   22664934
REFERENCE   2  (bases 1 to 3578)
  AUTHORS   Lin,G., Aranda,V., Muthuswamy,S.K. and Tonks,N.K.
  TITLE     Identification of PTPN23 as a novel regulator of cell invasion in
            mammary epithelial cells from a loss-of-function screen of the
            'PTP-ome'
  JOURNAL   Genes Dev 25 (13), 1412-1425 (2011)
   PUBMED   21724833
REFERENCE   3  (bases 1 to 3578)
  AUTHORS   Jung,E.J. and Kim,C.W.
  TITLE     Interaction between chicken protein tyrosine phosphatase 1
            (CPTP1)-like rat protein phosphatase 1 (PTP1) and p60(v-src) in
            v-src-transformed Rat-1 fibroblasts
  JOURNAL   Exp Mol Med 34 (6), 476-480 (2002)
   PUBMED   12526090
REFERENCE   4  (bases 1 to 3578)
  AUTHORS   Blanco-Aparicio,C., Torres,J. and Pulido,R.
  TITLE     A novel regulatory mechanism of MAP kinases activation and nuclear
            translocation mediated by PKA and the PTP-SL tyrosine phosphatase
  JOURNAL   J Cell Biol 147 (6), 1129-1136 (1999)
   PUBMED   10601328
REFERENCE   5  (bases 1 to 3578)
  AUTHORS   Shiozuka,K., Watanabe,Y., Ikeda,T., Hashimoto,S. and Kawashima,H.
  TITLE     Cloning and expression of PCPTP1 encoding protein tyrosine
            phosphatase
  JOURNAL   Gene 162 (2), 279-284 (1995)
   PUBMED   7557444
REFERENCE   6  (bases 1 to 3578)
  AUTHORS   Hendriks,W., Schepens,J., Brugman,C., Zeeuwen,P. and Wieringa,B.
  TITLE     A novel receptor-type protein tyrosine phosphatase with a single
            catalytic domain is specifically expressed in mouse brain
  JOURNAL   Biochem J 305 (Pt 2) (Pt 2), 499-504 (1995)
   PUBMED   7832766
REFERENCE   7  (bases 1 to 3578)
  AUTHORS   Sharma,E. and Lombroso,P.J.
  TITLE     A neuronal protein tyrosine phosphatase induced by nerve growth
            factor
  JOURNAL   J Biol Chem 270 (1), 49-53 (1995)
   PUBMED   7814416
  REMARK    Erratum:[J Biol Chem 1995 Sep 29;270(39):23234]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            D38292.1, D64050.1 and BC089186.1.
            
            On Jan 11, 2008 this sequence version replaced NM_053594.1.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: D38292.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132268
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1087              D38292.1           4-1090
            1088-3378           D64050.1           407-2697
            3379-3578           BC089186.1         2161-2360
FEATURES             Location/Qualifiers
     source          1..3578
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="W"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q22"
     gene            1..3578
                     /gene="Ptprr"
                     /gene_synonym="PC12-PTP1; Pcptp1; R-PTP-R"
                     /note="protein tyrosine phosphatase, receptor type, R"
                     /db_xref="GeneID:94202"
                     /db_xref="RGD:620780"
     exon            1..541
                     /gene="Ptprr"
                     /gene_synonym="PC12-PTP1; Pcptp1; R-PTP-R"
                     /inference="alignment:Splign:2.1.0"
     CDS             484..2454
                     /gene="Ptprr"
                     /gene_synonym="PC12-PTP1; Pcptp1; R-PTP-R"
                     /EC_number="3.1.3.48"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; receptor-type tyrosine-protein phosphatase R;
                     tyrosine phosphatase CBPTP; protein-tyrosine phosphatase
                     PCPTP1"
                     /codon_start=1
                     /product="receptor-type tyrosine-protein phosphatase R
                     isoform 1 precursor"
                     /protein_id="NP_446046.2"
                     /db_xref="GeneID:94202"
                     /db_xref="RGD:620780"
                     /translation="MRRAVGFPALCLLLNLHAAGCFSRNNDHFLAIRQKKSWKPMFIY
                     DHSQDIKKSLDIAQEAYKHNYPAPSEVQISKRHQIVDSAFPRPAYDPSLNLLAASGQD
                     LEIENLPIPAANVIVVTLQMDIDKLNITLLRIFRQGVAAALGLLPQQVHINRLIEKKS
                     QIELFVSPGNRKPGEPQALQAEEVLRSLNVDVLRQSLPQFGIIDVSPEKNVLQGQHEA
                     DKIWSKEGFYAVVIFLSIFIIIVTCLMIIYRLKERLQLSLRQDKEKNQEIHLSPIALQ
                     QAQSEAKAAHSMVQPDQAPKVLNVVVDPQGQCTPEIRNTASTSVCPSPFRMKPIGLQE
                     RRGSNVSLTLDMSSLGNVEPFVAVSTPREKVAMEYLQSASRVLTRPQLRDVVASSHLL
                     QSEFMEIPMNFVDPKEIDIPRHGTKNRYKTILPNPLSRVCLRPKNITDPLSTYINANY
                     IRGYSGKEKAFIATQGPMINTVNDFWQMVWQEDSPVIVMITKLKEKNEKCVLYWPEKR
                     GIYGKVEVLVIGVNECDNYTIRNLVLKRGSHTQHVKHYWYTSWPDHKTPDSAQPLLQL
                     MLDVEEDRLASEGRGPVVVHCSAGIGRTGCFIATSIGCQQLKEEGVVDALSIVCQLRV
                     DRGGMVQTSEQYEFVHHALCLFESRLSPETVQ"
     exon            542..837
                     /gene="Ptprr"
                     /gene_synonym="PC12-PTP1; Pcptp1; R-PTP-R"
                     /inference="alignment:Splign:2.1.0"
     exon            838..951
                     /gene="Ptprr"
                     /gene_synonym="PC12-PTP1; Pcptp1; R-PTP-R"
                     /inference="alignment:Splign:2.1.0"
     exon            952..1107
                     /gene="Ptprr"
                     /gene_synonym="PC12-PTP1; Pcptp1; R-PTP-R"
                     /inference="alignment:Splign:2.1.0"
     exon            1108..1218
                     /gene="Ptprr"
                     /gene_synonym="PC12-PTP1; Pcptp1; R-PTP-R"
                     /inference="alignment:Splign:2.1.0"
     exon            1219..1487
                     /gene="Ptprr"
                     /gene_synonym="PC12-PTP1; Pcptp1; R-PTP-R"
                     /inference="alignment:Splign:2.1.0"
     exon            1488..1674
                     /gene="Ptprr"
                     /gene_synonym="PC12-PTP1; Pcptp1; R-PTP-R"
                     /inference="alignment:Splign:2.1.0"
     exon            1675..1759
                     /gene="Ptprr"
                     /gene_synonym="PC12-PTP1; Pcptp1; R-PTP-R"
                     /inference="alignment:Splign:2.1.0"
     exon            1760..1839
                     /gene="Ptprr"
                     /gene_synonym="PC12-PTP1; Pcptp1; R-PTP-R"
                     /inference="alignment:Splign:2.1.0"
     exon            1840..1977
                     /gene="Ptprr"
                     /gene_synonym="PC12-PTP1; Pcptp1; R-PTP-R"
                     /inference="alignment:Splign:2.1.0"
     exon            1978..2088
                     /gene="Ptprr"
                     /gene_synonym="PC12-PTP1; Pcptp1; R-PTP-R"
                     /inference="alignment:Splign:2.1.0"
     exon            2089..2246
                     /gene="Ptprr"
                     /gene_synonym="PC12-PTP1; Pcptp1; R-PTP-R"
                     /inference="alignment:Splign:2.1.0"
     exon            2247..2360
                     /gene="Ptprr"
                     /gene_synonym="PC12-PTP1; Pcptp1; R-PTP-R"
                     /inference="alignment:Splign:2.1.0"
     exon            2361..3564
                     /gene="Ptprr"
                     /gene_synonym="PC12-PTP1; Pcptp1; R-PTP-R"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagctcgttc ccctcgcagc ctcagctaag acccggagag gtggaatttc gatttgaaac
       61 tccctagcca gggccggggc tgggcatgct cagtgcctcg gtgtatcggg ctgctgctag
      121 ctgcacaggc agcagaggcg ctgcctggct tggaagctgg cacaagagtc caccccactg
      181 tcaccaccga ctgcgggctt caggaaggcc aaacactcac ctcctctgag cgctttacac
      241 ccaccaacct cgagtcccca tctcccgcag catcctactc tcccgtctcc ccatccctta
      301 gggagacgaa gccagtgctc ggttctgtag gcacgccaca gactgctctg tgaaccccag
      361 cggaggaccc tgtcatcgga tgcctcggga tcaaaggact cttggcagtg tttctctcaa
      421 atagcacttt gcctggagtg ggattgcggt ggagtttctc ccccgcccct caatgcacac
      481 actatgagga gagcggtcgg tttccctgca ctgtgcctgc ttcttaatct tcacgctgca
      541 gggtgttttt ccaggaacaa tgaccacttt ttggctattc gtcaaaagaa gagttggaaa
      601 cccatgttca tttatgacca ttcccaagac attaagaaga gcctggatat cgctcaagag
      661 gcatataaac acaactaccc cgccccctca gaagttcaaa taagcaaacg tcaccagatc
      721 gttgattcag catttcctag acctgcatat gacccatctc ttaatctgtt ggctgcatct
      781 ggtcaagacc tcgaaataga aaatctccca attccagcag caaatgtgat tgtggtgaca
      841 ctgcaaatgg atatagacaa gctgaacata accttgcttc ggatcttccg ccaaggagta
      901 gctgcagccc tgggactctt acctcagcaa gtacacatca accgcctcat tgaaaagaag
      961 agccagattg agttgtttgt gtctcccgga aaccggaaac caggagagcc gcaggccctg
     1021 caggctgagg aagtactgcg ttcccttaat gtggatgttt tgcgtcagag tttaccacag
     1081 tttggaatta tagacgtctc ccctgagaaa aatgttttac aagggcagca tgaagcggac
     1141 aagatctgga gcaaagaagg cttttacgcc gtcgtcatct tcctcagcat ctttatcatt
     1201 atagtaacct gtttgatgat catttatagg ttaaaagaaa ggcttcagct ttccttacga
     1261 caagataaag agaaaaacca ggagatccac ctatcgccca ttgcactcca gcaagcacaa
     1321 tcggaggcca aggcagccca cagcatggtc cagcccgacc aggcgccaaa ggtgctgaat
     1381 gttgttgtgg accctcaagg ccaatgcact cctgagattc gaaacaccgc ctccacttct
     1441 gtctgccctt ctcccttcag gatgaagccc ataggactcc aggagcgacg aggttccaat
     1501 gtatctctta cactggacat gagtagcctg ggcaacgtgg aaccctttgt ggccgtctcc
     1561 accccccggg agaaggtagc catggagtac ctgcagtcag ccagccgagt tctcacaagg
     1621 ccacagctga gggacgtcgt ggcaagttcc cacctgcttc aaagtgaatt catggaaata
     1681 ccaatgaact ttgtggatcc caaagaaatt gatattccac gtcatggaac taaaaatcgt
     1741 tataagacca ttttgccaaa tcccctcagc agggtgtgct taagaccaaa aaatataact
     1801 gacccattga gtacttacat caatgctaat tacattcggg gctacagtgg caaggagaaa
     1861 gccttcattg ccacacaggg ccccatgatc aacactgtga atgacttctg gcagatggtt
     1921 tggcaagaag acagtcctgt gattgttatg atcacgaaac tcaaagagaa aaatgagaaa
     1981 tgtgtgctct actggccaga aaagagaggg atttacggca aggttgaggt tctggtcatc
     2041 ggtgtcaatg aatgtgataa ctacaccatc cgcaacctcg tcttgaagcg aggaagtcac
     2101 acccaacatg tgaagcatta ctggtacact tcatggcccg atcacaagac tccagacagt
     2161 gcccagcccc ttctgcagct catgctggac gtagaggaag acagactggc ctctgaaggc
     2221 cgagggcctg tggttgtcca ctgcagtgca gggattggga gaaccggatg tttcatcgct
     2281 acatccattg gctgtcaaca gttgaaagaa gaaggagtcg tagatgcact aagtatcgtc
     2341 tgccagcttc gtgtagacag gggtggaatg gtccaaacca gtgagcagta tgaatttgtg
     2401 caccacgctc tgtgcctgtt cgagagcaga ctttcgccag aaacggtcca gtgactctga
     2461 agatctacca gagcgtcaat ctatcacggg tgattcgtca agttacctac tgagggctcc
     2521 gagaaggagc tccccacgat ggatgaggag gctctaaagc cagcctgagg cgtggattgt
     2581 ggaagctatg gtaacttgaa agattgccac ctttgtgtat aggactgtgt tctaggcatc
     2641 cccctagtta ctccgaagga cctgtgctga tggaggtgtg acagtcctca tgcagcctga
     2701 ggaggattct gttttgtctg tgtcgactct cacacagaac ctgtatgtgt aatattcaga
     2761 gtctgtgctt atggtgactg gaggagctgc ggaagatatc gttatcctgt gttagatgct
     2821 ttaatgttca caaagcctgt cttgtgactg gactgtcagc tgttcaactg ttcctgtatt
     2881 aagtgctatt acctatctca gttaccagag tcttgctgct aaagttgcaa gtgaccgaca
     2941 atggattttt aaccatgacg ttttttgttt ttgaaaaaaa aaaatcaaag gcagtaacta
     3001 ttttatatgg agatgtgtct tgattatctc taataagtgt gtatttatag tatctcctat
     3061 ggatcaatta cagagcacaa tgattgtcac tggatatata tgtatatgta cattacaggt
     3121 atatgtacgc atatatattc tattattaag catagaggta gctcctgttt tacaactcta
     3181 actactatat ttctacattg tgacttgttt tactttaaaa ggggataaac aaatttatag
     3241 taactataaa gtatcaataa ttttaaatac tcatctctct tttactaaga agggattttt
     3301 gaatatagtg tctacttggt ttctctctcc cagtaagaag caggtgcctt tggggatgct
     3361 ccaacctgtt tcatccccaa aagtttttct gaggacaccg tcatgcacgc atgaccttaa
     3421 atttctaaaa ggttttcttc ctcaagagac caatgaaggc aagataaccg cactcagcaa
     3481 acatgagatg ttctgctcag atgtgaattt tcaatgcagc aaagttgact ttcgtactcc
     3541 caataaatga ctcttaacag caaaaaaaaa aaaaaaaa
//
