LOCUS       NM_022925               9940 bp    mRNA    linear   ROD 16-FEB-2025
DEFINITION  Rattus norvegicus protein tyrosine phosphatase, receptor type, Q
            (Ptprq), mRNA.
ACCESSION   NM_022925
VERSION     NM_022925.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 9940)
  AUTHORS   Nagamachi,A., Matsui,H., Asou,H., Ozaki,Y., Aki,D., Kanai,A.,
            Takubo,K., Suda,T., Nakamura,T., Wolff,L., Honda,H. and Inaba,T.
  TITLE     Haploinsufficiency of SAMD9L, an endosome fusion facilitator,
            causes myeloid malignancies in mice mimicking human diseases with
            monosomy 7
  JOURNAL   Cancer Cell 24 (3), 305-317 (2013)
   PUBMED   24029230
REFERENCE   2  (bases 1 to 9940)
  AUTHORS   Goodyear,R.J., Jones,S.M., Sharifi,L., Forge,A. and Richardson,G.P.
  TITLE     Hair bundle defects and loss of function in the vestibular end
            organs of mice lacking the receptor-like inositol lipid phosphatase
            PTPRQ
  JOURNAL   J Neurosci 32 (8), 2762-2772 (2012)
   PUBMED   22357859
REFERENCE   3  (bases 1 to 9940)
  AUTHORS   Schwander,M., Kachar,B. and Muller,U.
  TITLE     Review series: The cell biology of hearing
  JOURNAL   J Cell Biol 190 (1), 9-20 (2010)
   PUBMED   20624897
  REMARK    Review article
REFERENCE   4  (bases 1 to 9940)
  AUTHORS   Jung,H., Kim,W.K., Kim,D.H., Cho,Y.S., Kim,S.J., Park,S.G.,
            Park,B.C., Lim,H.M., Bae,K.H. and Lee,S.C.
  TITLE     Involvement of PTP-RQ in differentiation during adipogenesis of
            human mesenchymal stem cells
  JOURNAL   Biochem Biophys Res Commun 383 (2), 252-257 (2009)
   PUBMED   19351528
REFERENCE   5  (bases 1 to 9940)
  AUTHORS   Kwitek,A.E., Gullings-Handley,J., Yu,J., Carlos,D.C., Orlebeke,K.,
            Nie,J., Eckert,J., Lemke,A., Andrae,J.W., Bromberg,S., Pasko,D.,
            Chen,D., Scheetz,T.E., Casavant,T.L., Soares,M.B., Sheffield,V.C.,
            Tonellato,P.J. and Jacob,H.J.
  TITLE     High-density rat radiation hybrid maps containing over 24,000
            SSLPs, genes, and ESTs provide a direct link to the rat genome
            sequence
  JOURNAL   Genome Res 14 (4), 750-757 (2004)
   PUBMED   15060019
REFERENCE   6  (bases 1 to 9940)
  AUTHORS   Goodyear,R.J., Legan,P.K., Wright,M.B., Marcotti,W., Oganesian,A.,
            Coats,S.A., Booth,C.J., Kros,C.J., Seifert,R.A., Bowen-Pope,D.F.
            and Richardson,G.P.
  TITLE     A receptor-like inositol lipid phosphatase is required for the
            maturation of developing cochlear hair bundles
  JOURNAL   J Neurosci 23 (27), 9208-9219 (2003)
   PUBMED   14534255
REFERENCE   7  (bases 1 to 9940)
  AUTHORS   Seifert,R.A., Coats,S.A., Oganesian,A., Wright,M.B., Dishmon,M.,
            Booth,C.J., Johnson,R.J., Alpers,C.E. and Bowen-Pope,D.F.
  TITLE     PTPRQ is a novel phosphatidylinositol phosphatase that can be
            expressed as a cytoplasmic protein or as a subcellularly localized
            receptor-like protein
  JOURNAL   Exp Cell Res 287 (2), 374-386 (2003)
   PUBMED   12837292
REFERENCE   8  (bases 1 to 9940)
  AUTHORS   Oganesian,A., Poot,M., Daum,G., Coats,S.A., Wright,M.B.,
            Seifert,R.A. and Bowen-Pope,D.F.
  TITLE     Protein tyrosine phosphatase RQ is a phosphatidylinositol
            phosphatase that can regulate cell survival and proliferation
  JOURNAL   Proc Natl Acad Sci U S A 100 (13), 7563-7568 (2003)
   PUBMED   12802008
  REMARK    GeneRIF: PTPRQ represents a subtype of the PTPases whose biological
            activities result from its PIPase activity rather than its PTPase
            activity
REFERENCE   9  (bases 1 to 9940)
  AUTHORS   Wright,M.B., Hugo,C., Seifert,R., Disteche,C.M. and Bowen-Pope,D.F.
  TITLE     Proliferating and migrating mesangial cells responding to injury
            express a novel receptor protein-tyrosine phosphatase in
            experimental mesangial proliferative glomerulonephritis
  JOURNAL   J Biol Chem 273 (37), 23929-23937 (1998)
   PUBMED   9727007
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Jun 3, 2021 this sequence version replaced NM_022925.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF063249.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-123               JAXUCZ010000007.1  44903169-44903291   c
            124-235             JAXUCZ010000007.1  44902737-44902848   c
            236-462             JAXUCZ010000007.1  44901864-44902090   c
            463-532             JAXUCZ010000007.1  44899556-44899625   c
            533-732             JAXUCZ010000007.1  44895628-44895827   c
            733-982             JAXUCZ010000007.1  44894285-44894534   c
            983-1111            JAXUCZ010000007.1  44892317-44892445   c
            1112-1258           JAXUCZ010000007.1  44889710-44889856   c
            1259-1431           JAXUCZ010000007.1  44883504-44883676   c
            1432-1612           JAXUCZ010000007.1  44872746-44872926   c
            1613-1774           JAXUCZ010000007.1  44871264-44871425   c
            1775-1954           JAXUCZ010000007.1  44870982-44871161   c
            1955-2062           JAXUCZ010000007.1  44870264-44870371   c
            2063-2344           JAXUCZ010000007.1  44869732-44870013   c
            2345-2527           JAXUCZ010000007.1  44859519-44859701   c
            2528-2629           JAXUCZ010000007.1  44858720-44858821   c
            2630-2750           JAXUCZ010000007.1  44854999-44855119   c
            2751-2911           JAXUCZ010000007.1  44842235-44842395   c
            2912-3057           JAXUCZ010000007.1  44841386-44841531   c
            3058-3226           JAXUCZ010000007.1  44835629-44835797   c
            3227-3520           JAXUCZ010000007.1  44833221-44833514   c
            3521-3796           JAXUCZ010000007.1  44832697-44832972   c
            3797-3948           JAXUCZ010000007.1  44832176-44832327   c
            3949-4090           JAXUCZ010000007.1  44828347-44828488   c
            4091-4360           JAXUCZ010000007.1  44825681-44825950   c
            4361-4684           JAXUCZ010000007.1  44802475-44802798   c
            4685-4806           JAXUCZ010000007.1  44786360-44786481   c
            4807-4993           JAXUCZ010000007.1  44782762-44782948   c
            4994-5238           JAXUCZ010000007.1  44778503-44778747   c
            5239-5305           JAXUCZ010000007.1  44776434-44776500   c
            5306-5464           JAXUCZ010000007.1  44772523-44772681   c
            5465-5687           JAXUCZ010000007.1  44771576-44771798   c
            5688-5761           JAXUCZ010000007.1  44769189-44769262   c
            5762-5861           JAXUCZ010000007.1  44761641-44761740   c
            5862-5990           JAXUCZ010000007.1  44758670-44758798   c
            5991-6017           JAXUCZ010000007.1  44748347-44748373   c
            6018-6099           JAXUCZ010000007.1  44747601-44747682   c
            6100-6190           JAXUCZ010000007.1  44744050-44744140   c
            6191-6267           JAXUCZ010000007.1  44739999-44740075   c
            6268-6402           JAXUCZ010000007.1  44732318-44732452   c
            6403-6528           JAXUCZ010000007.1  44732001-44732126   c
            6529-6677           JAXUCZ010000007.1  44730539-44730687   c
            6678-6813           JAXUCZ010000007.1  44729842-44729977   c
            6814-6937           JAXUCZ010000007.1  44724408-44724531   c
            6938-9940           JAXUCZ010000007.1  44720916-44723918   c
FEATURES             Location/Qualifiers
     source          1..9940
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q21"
     gene            1..9940
                     /gene="Ptprq"
                     /gene_synonym="rPTP-GMC1"
                     /note="protein tyrosine phosphatase, receptor type, Q"
                     /db_xref="GeneID:360417"
                     /db_xref="RGD:620779"
     exon            1..123
                     /gene="Ptprq"
                     /gene_synonym="rPTP-GMC1"
                     /inference="alignment:Splign:2.1.0"
     CDS             67..6975
                     /gene="Ptprq"
                     /gene_synonym="rPTP-GMC1"
                     /EC_number="3.1.3.67"
                     /EC_number="3.1.3.36"
                     /EC_number="3.1.3.86"
                     /EC_number="3.1.3.95"
                     /note="glomerular mesangial cell receptor protein-tyrosine
                     phosphatase; phosphotidylinositol phosphatase PTPRQ;
                     PTP-RQ; receptor-type tyrosine-protein phosphatase Q;
                     protein-tyrosine phosphatase receptor-type expressed by
                     glomerular mesangial cells protein 1; R-PTP-Q;
                     phosphatidylinositol phosphatase PTPRQ"
                     /codon_start=1
                     /product="phosphatidylinositol phosphatase PTPRQ
                     precursor"
                     /protein_id="NP_075214.2"
                     /db_xref="GeneID:360417"
                     /db_xref="RGD:620779"
                     /translation="MMDFLFSFLFLLIGTSESQVDVSSSFDGTGYDITLSSVSATTYS
                     SPVSRTLATNVTKPGPPVFLAGERVGSAGILLSWNTPPNPNGRIISYVVKYKEVCPWM
                     QTAYTRARAKPDSLEVLLTNLNPGTTYEIKVAAENSAGIGVFSDPFLFQTAESAPGKV
                     VNLTVEALNYSAVNLIWYLPRQPNGKITSFKISVKHARSGIVVKDVSLRVEDILSGKL
                     PECNENSESFLWSTTSPSPTLGRVTPTVRTTQSSSTAARSKISSVWKEPISFVVTHLR
                     PYTTYLFEVSAVTTEAGYIDSTIVRTPESVPEGPPQNCIMGNVTGKAFSISWDPPTIV
                     TGKFSYRVELYGPSGRILDNSTKDLRFAFTHLTPFTMYDVYVAAETSAGVGPKSNLSV
                     FTPPDVPGAVFDLQIAEVEATEIRITWRKPRQPNGIISQYRVKVSVLETGVVLENTLL
                     TGQDESISNPMSPEIMNLVDPMIGFYEGSGEMSSDLHSLASFIYNSHPHNDFPASTRA
                     EEQSSPVVTTRNQYMTDITAEQLSYVVRRLVPFTEHTISVSAFTIMGEGPPTVLTVRT
                     REQVPSSIQIINYKNISSSSILLYWDPPEYPNGKITHYTIYATELDTNRAFQMTTVDN
                     SFLITGLKKYTRYKMRVAASTHVGESSLSEENDIFVRTPEDEPESSPQDVQVTGVSPS
                     ELRLKWSPPEKPNGIIIAYEVLYQNADTLFVKNTSTTDIIISDLKPYTLYNISIRSYT
                     RLGHGNQSSSLLSVRTSETVPDSAPENITYKNISSGEIEISFLPPRSPNGIIQKYTIY
                     LKRSNSHEARTINTTSLTQTIGGLKKYTHYVIEVSASTLKGEGIRSRPISILTEEDAP
                     DSPPQNFSVKQLSGVTVMLSWQPPLEPNGIILYYTVYVWDKSSLRAINATEASLVLSD
                     LDYNVDYGACVTASTRFGDGNARSSIINFRTPEGEPSDPPNDVHYVNLSSSSIILFWT
                     PPVKPNGIIQYYSVYYQNTSGTFVQNFTLLQVTKESDNVTVSARIYRLAIFSYYTFWL
                     TASTSVGNGNKSSDIIHVYTDQDIPEGPVGNLTFESISSTAIHVSWEPPSQPNGLVFY
                     YLSLNLQQSPPRHMIPPLVTYENSIDFDDLEKYTDYIFKITPSTEKGFSETYTTQLHI
                     KTEEDVPDTPPIINTFKNLSSTSILLSWDPPLKPNGAILGYHLTLQGPHANHTFVTSG
                     NHIVLEELSPFTLYSFFAAARTMKGLGPSSILFFYTDESAPLAPPQNLTLINYTSDFV
                     WLTWSPSPLPGGIVKVYSFKIHEHETDTVFYKNISGLQTDAKLEGLEPVSTYSVSVSA
                     FTKVGNGNQYSNVVEFTTQESVPEAVRNIECVARDWQSVSVRWDPPRKANGIIIHYMI
                     TVGGNSTKVSPRDPTYTFTKLLANTSYVFEVRASTSAGEGNESRCDISTLPETVPSAP
                     TNVAFSNVQSTSATLTWTKPDTIFGYFQNYKITTQLRPQKCREWEPEECIEHQKDQYL
                     YEANQTEETVHGLKKFRWYRFQVAASTNVGYSNASEWISTQTLPGPPDGPPENVHVVA
                     TSPFGINISWSEPAVITGPTFYLIDVKSVDDDDFNISFLKSNEENKTTEINNLEVFTR
                     YSVVITAFVGNVSRAYTDGKSSAEVIITTLESVPKDPPNNMTFQKIPDEVTKFQLTFL
                     PPSQPNGNIRVYQALVYREDDPTAVQIHNLSIIQKTDTSVIAMLEGLKGGHTYNISVY
                     AINSAGAGPKVQMRITMDIKAPARPKSKPIPIRDATGKLLVTSTTITIRMPICYYNDD
                     HGPIRNVQVLVAETGAQQDGNVTKWYDAYFNKARPYFTNEGFPNPPCIEGKTKFSGNE
                     EIYVIGADNACMIPGNEEKICNGPLKPKKQYLFKFRATNVMGQFTDSEYSDPIKTLGE
                     GLSERTVEIILSVTLCILSIILLGTAIFAFARIRQKQKEGGTYSPRDAEIIDTKFKLD
                     QLITVADLELKDERLTRLLSYRKSIKPISKKSFLQHVEELCTNSNLKFQEEFSELPKF
                     LQDLSSTDADLPWNRAKNRFPNIKPYNNNRVKLIADVSLPGSDYINASYVSGYLCPNE
                     FIATQGPLPGTVGDFWRMVWETRTKTLVMLTQCFEKGRIRCHQYWPEDNKPVTVFGDI
                     VITKLMEDIQIDWTIRDLKIERHGDCMTVRQCNFTGWPEHGVPENTTPLIHFVKLVRT
                     SRAHDTTPMVVHCSAGVGRTGVFIALDHLTQHINDHDFVDIYGLVAELRSERMCMVQN
                     LAQYIFLHQCILDLLSNKGGHQPVCFVNYSTLQKMDSLDAMEGDVELEWEETTM"
     exon            124..235
                     /gene="Ptprq"
                     /gene_synonym="rPTP-GMC1"
                     /inference="alignment:Splign:2.1.0"
     exon            236..462
                     /gene="Ptprq"
                     /gene_synonym="rPTP-GMC1"
                     /inference="alignment:Splign:2.1.0"
     exon            463..532
                     /gene="Ptprq"
                     /gene_synonym="rPTP-GMC1"
                     /inference="alignment:Splign:2.1.0"
     exon            533..732
                     /gene="Ptprq"
                     /gene_synonym="rPTP-GMC1"
                     /inference="alignment:Splign:2.1.0"
     exon            733..982
                     /gene="Ptprq"
                     /gene_synonym="rPTP-GMC1"
                     /inference="alignment:Splign:2.1.0"
     exon            983..1111
                     /gene="Ptprq"
                     /gene_synonym="rPTP-GMC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1112..1258
                     /gene="Ptprq"
                     /gene_synonym="rPTP-GMC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1259..1431
                     /gene="Ptprq"
                     /gene_synonym="rPTP-GMC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1432..1612
                     /gene="Ptprq"
                     /gene_synonym="rPTP-GMC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1613..1774
                     /gene="Ptprq"
                     /gene_synonym="rPTP-GMC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1775..1954
                     /gene="Ptprq"
                     /gene_synonym="rPTP-GMC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1955..2062
                     /gene="Ptprq"
                     /gene_synonym="rPTP-GMC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2063..2344
                     /gene="Ptprq"
                     /gene_synonym="rPTP-GMC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2345..2527
                     /gene="Ptprq"
                     /gene_synonym="rPTP-GMC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2528..2629
                     /gene="Ptprq"
                     /gene_synonym="rPTP-GMC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2630..2750
                     /gene="Ptprq"
                     /gene_synonym="rPTP-GMC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2751..2911
                     /gene="Ptprq"
                     /gene_synonym="rPTP-GMC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2912..3057
                     /gene="Ptprq"
                     /gene_synonym="rPTP-GMC1"
                     /inference="alignment:Splign:2.1.0"
     exon            3058..3226
                     /gene="Ptprq"
                     /gene_synonym="rPTP-GMC1"
                     /inference="alignment:Splign:2.1.0"
     exon            3227..3520
                     /gene="Ptprq"
                     /gene_synonym="rPTP-GMC1"
                     /inference="alignment:Splign:2.1.0"
     exon            3521..3796
                     /gene="Ptprq"
                     /gene_synonym="rPTP-GMC1"
                     /inference="alignment:Splign:2.1.0"
     exon            3797..3948
                     /gene="Ptprq"
                     /gene_synonym="rPTP-GMC1"
                     /inference="alignment:Splign:2.1.0"
     exon            3949..4090
                     /gene="Ptprq"
                     /gene_synonym="rPTP-GMC1"
                     /inference="alignment:Splign:2.1.0"
     exon            4091..4360
                     /gene="Ptprq"
                     /gene_synonym="rPTP-GMC1"
                     /inference="alignment:Splign:2.1.0"
     exon            4361..4684
                     /gene="Ptprq"
                     /gene_synonym="rPTP-GMC1"
                     /inference="alignment:Splign:2.1.0"
     exon            4685..4806
                     /gene="Ptprq"
                     /gene_synonym="rPTP-GMC1"
                     /inference="alignment:Splign:2.1.0"
     exon            4807..4993
                     /gene="Ptprq"
                     /gene_synonym="rPTP-GMC1"
                     /inference="alignment:Splign:2.1.0"
     exon            4994..5238
                     /gene="Ptprq"
                     /gene_synonym="rPTP-GMC1"
                     /inference="alignment:Splign:2.1.0"
     exon            5239..5305
                     /gene="Ptprq"
                     /gene_synonym="rPTP-GMC1"
                     /inference="alignment:Splign:2.1.0"
     exon            5306..5464
                     /gene="Ptprq"
                     /gene_synonym="rPTP-GMC1"
                     /inference="alignment:Splign:2.1.0"
     exon            5465..5687
                     /gene="Ptprq"
                     /gene_synonym="rPTP-GMC1"
                     /inference="alignment:Splign:2.1.0"
     exon            5688..5761
                     /gene="Ptprq"
                     /gene_synonym="rPTP-GMC1"
                     /inference="alignment:Splign:2.1.0"
     exon            5762..5861
                     /gene="Ptprq"
                     /gene_synonym="rPTP-GMC1"
                     /inference="alignment:Splign:2.1.0"
     exon            5862..5990
                     /gene="Ptprq"
                     /gene_synonym="rPTP-GMC1"
                     /inference="alignment:Splign:2.1.0"
     exon            5991..6017
                     /gene="Ptprq"
                     /gene_synonym="rPTP-GMC1"
                     /inference="alignment:Splign:2.1.0"
     exon            6018..6099
                     /gene="Ptprq"
                     /gene_synonym="rPTP-GMC1"
                     /inference="alignment:Splign:2.1.0"
     exon            6100..6190
                     /gene="Ptprq"
                     /gene_synonym="rPTP-GMC1"
                     /inference="alignment:Splign:2.1.0"
     exon            6191..6267
                     /gene="Ptprq"
                     /gene_synonym="rPTP-GMC1"
                     /inference="alignment:Splign:2.1.0"
     exon            6268..6402
                     /gene="Ptprq"
                     /gene_synonym="rPTP-GMC1"
                     /inference="alignment:Splign:2.1.0"
     exon            6403..6528
                     /gene="Ptprq"
                     /gene_synonym="rPTP-GMC1"
                     /inference="alignment:Splign:2.1.0"
     exon            6529..6677
                     /gene="Ptprq"
                     /gene_synonym="rPTP-GMC1"
                     /inference="alignment:Splign:2.1.0"
     exon            6678..6813
                     /gene="Ptprq"
                     /gene_synonym="rPTP-GMC1"
                     /inference="alignment:Splign:2.1.0"
     exon            6814..6937
                     /gene="Ptprq"
                     /gene_synonym="rPTP-GMC1"
                     /inference="alignment:Splign:2.1.0"
     exon            6938..9940
                     /gene="Ptprq"
                     /gene_synonym="rPTP-GMC1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 attaatgcag gcaacatttc tctccagagc catcaatgtg attgtgctgc tagaaaaaat
       61 gtaataatga tggattttct tttctctttc cttttccttc tcattggaac ttcagagtca
      121 caggttgatg tttccagttc ttttgatggc actgggtatg atataacgct atcttcagtt
      181 tctgccacga cctacagctc gcctgtgagt agaacactgg caacaaatgt gacaaaaccg
      241 gggcctccag tcttcctagc cggggagaga gttggctctg ctgggatact cctttcgtgg
      301 aatacccctc ctaacccaaa tggaagaatc atatcttatg ttgttaagta caaggaagtc
      361 tgtccatgga tgcagacagc atatacccga gcgagagcga agccagacag tctggaggtt
      421 cttctcacta accttaatcc tggaacaaca tatgagatta aggttgctgc tgaaaacagt
      481 gctggcatcg gagtgtttag tgacccattt ctttttcaaa ctgcagaaag tgctccgggt
      541 aaagtagtta acctcacagt ggaagctctc aactactctg cagtaaactt gatttggtat
      601 ttacctcggc aaccaaatgg caaaatcacc agcttcaaga tcagcgtcaa gcacgccaga
      661 agtggcatag tagtcaagga tgtctccctc agagtagagg acattttgtc tgggaaatta
      721 cctgaatgta atgagaacag cgaatctttc ttgtggagta ccaccagccc ctctccaacc
      781 ctgggtagag tgacacctac agttcgcacc acacagtcat ccagcacggc ggcacggagt
      841 aagatcagct ctgtgtggaa ggagcccatc agttttgtgg tgactcactt gagaccttac
      901 acaacgtatc tctttgaagt ctcagccgtt accacggaag caggatatat tgacagcacc
      961 attgttagga cgccagaatc agtgcctgaa ggaccacccc aaaactgtat aatggggaat
     1021 gtcacaggaa aggccttttc aatttcctgg gacccaccaa ctattgtcac aggaaagttt
     1081 agttacagag ttgaattata tgggccatca gggcggattt tggataatag cacgaaagac
     1141 ctccggtttg cgtttacaca tctcacacca ttcacaatgt acgatgtcta tgttgctgcg
     1201 gaaaccagtg ctggggttgg acccaagtca aatctttcag tatttactcc cccagatgtt
     1261 ccaggagcag tgtttgattt acagatcgca gaggtagaag ccacagaaat aagaattact
     1321 tggaggaaac ctcgacaacc aaacggaatc atcagccagt accgtgtgaa agtgtcagtc
     1381 ctagagacag gagtagtttt ggaaaatact ctgctcacag gacaagatga gtctataagc
     1441 aaccccatgt ctccagaaat aatgaaccta gtagacccca tgataggatt ctatgagggc
     1501 tcaggagaaa tgtcttcgga cctgcactcc ctggcttcat tcatatacaa cagccatcca
     1561 cacaatgact ttcctgccag cactagagct gaagagcaaa gttcaccagt tgtaaccacc
     1621 aggaatcagt atatgaccga catcactgcc gaacagctgt cttacgttgt caggcggctt
     1681 gtaccattca ctgagcacac gattagcgta tctgctttca ccatcatggg cgaaggacca
     1741 ccaacggtcc tcactgttag gacacgtgag caagtgccaa gctccatcca aattataaac
     1801 tataaaaata ttagttcttc atctatttta ctgtattggg atcctccaga atatcccaat
     1861 ggaaagatca ctcattacac aatctacgca acggagctgg acacaaacag agcattccag
     1921 atgaccactg tagataacag ctttctcatc acagggttga agaaatatac aagatacaaa
     1981 atgagggttg ctgcctcaac tcatgttggg gaaagttctt tgtcagaaga aaatgacatc
     2041 tttgtgagaa ctccagaaga tgagccagaa tcatcacctc aagatgtcca agtaactggt
     2101 gtgtctccaa gtgaactgag attgaagtgg tccccgcctg aaaaacctaa cgggatcatt
     2161 attgcctatg aggtgcttta ccaaaatgca gacaccttgt ttgtaaaaaa cacctcaacc
     2221 acagacatca ttataagtga cctgaaacct tacacactct ataatatttc tatccggtcg
     2281 tataccagac ttggccatgg caatcagtca tcctcattgc tgtctgtaag gacttcagag
     2341 actgtgcctg atagtgcacc agaaaatatt acttacaaaa acatttcttc aggagagatt
     2401 gagatatcct tccttccccc aaggagtccc aacggcatca tacaaaaata cacaatttac
     2461 ctcaagagaa gtaatagcca tgaggcaaga actataaata caacctcttt gactcaaacc
     2521 attggaggac tgaaaaagta tacccattat gtaatcgagg tgtctgctag tacactcaaa
     2581 ggtgaaggca ttcggagtag gccaataagc atattgaccg aggaagacgc tcctgattct
     2641 cctcctcaga acttctctgt gaaacagttg tctggtgtca ccgtgatgtt gtcatggcaa
     2701 ccacccttgg agccaaatgg aattatcctc tattacacag tttatgtctg ggataaatca
     2761 tctctaagag ctattaatgc aactgaagca tcactggtgt tgtctgactt agactataat
     2821 gttgactacg gtgcctgtgt aacagctagc accagatttg gcgatgggaa cgcaagaagc
     2881 agcatcatta actttcgaac accagaggga gagcccagtg atcctcccaa cgatgtccac
     2941 tatgtgaatc tcagttcctc atcgataatt ctcttttgga ctcctcctgt aaaacctaat
     3001 ggaatcatac aatattattc tgtttattat caaaatactt caggtacttt tgtgcagaac
     3061 tttacacttc ttcaagtaac caaggagtct gacaatgtga cagtgtctgc aaggatatac
     3121 agactggcaa tattcagcta ctatacattt tggctaacag caagtacttc agtcggaaat
     3181 gggaataaaa gcagtgacat aattcatgta tacacagacc aagacatacc tgaaggtcct
     3241 gttggaaacc tgacttttga gtccatttca tcaactgcaa ttcatgtgag ctgggagcca
     3301 ccatcccaac caaatggcct ggtcttctac tacctttcac tgaatttaca gcaaagtccc
     3361 ccacggcaca tgataccacc tctggttacc tatgaaaaca gcatagactt tgatgatctg
     3421 gaaaaatata ctgactatat atttaaaatc actccgtcaa cagaaaaggg attctctgag
     3481 acctatacta cccaactaca catcaaaacg gaagaagacg ttccagacac tccaccaata
     3541 atcaacactt ttaaaaatct ttcttctacc tccattctct tatcatggga tcccccatta
     3601 aagccaaacg gtgcaatact aggttaccat ttaactttac aaggacccca cgccaaccat
     3661 actttcgtca cttccggtaa ccacatagta ctggaagaac tctcgccatt taccttatat
     3721 agtttttttg ctgctgcaag aacaatgaaa ggactcggtc cttccagtat tcttttcttt
     3781 tacacagatg agtcagcgcc tttagcacct ccccagaatt tgactttaat caactacact
     3841 tcagattttg tatggctgac atggagccca agtcctcttc ctggcggtat tgtaaaagta
     3901 tatagtttta aaattcatga gcatgagact gatactgtat tttataagaa tatttcaggt
     3961 cttcagactg atgccaaact tgagggactg gagcctgtta gcacctactc agtcagtgtg
     4021 tctgcattta ccaaagttgg aaatggcaat cagtatagta atgtggtgga atttacaacc
     4081 caggagtctg ttccagaggc tgtacggaat atagagtgcg tggcacgtga ctggcagtca
     4141 gtatcggtga ggtgggaccc accgagaaaa gcaaatggaa taattattca ctatatgata
     4201 acggttggag ggaattctac caaagtctcc cccagagacc ccacgtacac gttcacaaaa
     4261 cttcttgcca atacgtcata cgtctttgaa gtaagagcgt caacgtcagc cggcgaaggc
     4321 aatgaaagca ggtgtgacat cagcacactc ccggagacag ttcccagtgc tcccacaaat
     4381 gtagcgtttt ctaatgtcca gtcaactagt gcaacactaa catggacaaa acctgatact
     4441 atctttggat acttccaaaa ttacaagata actactcaac ttcgtcctca gaagtgcaga
     4501 gaatgggaac ctgaagaatg tattgaacat cagaaagatc aatacctcta tgaagcaaac
     4561 caaacagaag aaacagtgca tgggttaaag aagtttcgat ggtatagatt ccaagtggct
     4621 gctagcacca atgttgggta cagtaatgcc tcggaatgga tttctacaca aacgctgccc
     4681 ggccctcctg acggtcctcc tgaaaatgtg cacgtggtcg caacatcacc ctttggtatc
     4741 aatatcagct ggagtgaacc tgctgtcata actggaccaa cattctacct gattgatgtc
     4801 aaatcggtag atgatgatga ctttaatatt tccttcctga aatcaaatga agaaaacaaa
     4861 accacagaga ttaacaactt agaagtattt acaaggtatt ctgtggtgat cacagccttt
     4921 gtaggaaatg ttagtcgggc atacacagat gggaagtcaa gtgcagaagt gataattacg
     4981 actttagaat cagtgcccaa ggacccacct aataatatga catttcagaa gataccagat
     5041 gaagtaacaa agtttcaatt gacattcctt ccaccttctc agcccaatgg aaacatccga
     5101 gtgtaccaag cactggttta ccgggaagac gatcctactg ctgtccagat tcataacctc
     5161 agcattatcc agaagacgga cacctccgtc attgcaatgc tagaaggctt gaagggtgga
     5221 catacataca acatcagtgt ttacgctatc aacagtgctg gtgctgggcc aaaggtgcag
     5281 atgcgaataa ctatggatat taaagctcca gcacgaccaa aatccaagcc aattcctatc
     5341 cgtgatgcca caggaaaact gcttgtgacg tcaacaacta tcacaatcag aatgccaata
     5401 tgctactaca atgatgacca cgggccaatc agaaatgtac aagtccttgt ggcagaaaca
     5461 ggagctcagc aagacggaaa tgtgacaaag tggtacgatg catattttaa caaagcaagg
     5521 ccatatttta caaacgaagg attccctaat cccccgtgta tagagggaaa gacaaagttc
     5581 agcggcaatg aagaaatcta tgtgataggt gccgataacg cctgtatgat ccctggaaat
     5641 gaagagaaaa tttgcaatgg acctctgaaa cccaaaaagc agtatttgtt taaatttaga
     5701 gccacaaatg tcatgggaca atttactgac tctgagtact ctgaccctat taaaacttta
     5761 ggtgaaggcc tttcagaaag aactgtggag atcatactgt cagtcacttt gtgtatcctc
     5821 tcaataatcc tccttggaac agctattttt gcatttgcaa gaattagaca gaaacagaag
     5881 gaaggtggta catactctcc ccgggacgca gagattatcg acactaaatt caagctggat
     5941 cagctcatca cggtggcaga cttggaactg aaggatgaga gattaacgcg gttacttagt
     6001 tataggaaat ccatcaagcc aataagcaag aaatccttcc tgcaacacgt tgaagagctt
     6061 tgcacaaaca gcaacctaaa gtttcaagag gaattttcgg aattaccaaa atttcttcaa
     6121 gatctctcct caactgatgc tgatctccct tggaacagag caaagaatcg ctttccgaac
     6181 ataaaaccat acaataataa cagagtgaag ctgatagccg acgtaagcct cccgggatcg
     6241 gattacatta atgccagcta tgtctctgga tacttatgtc caaatgagtt tattgctacc
     6301 caaggcccat tgccagggac agtcggagat ttttggagaa tggtttggga aaccagaacg
     6361 aaaacattag taatgctcac acagtgtttt gagaaaggac ggatcagatg ccatcagtat
     6421 tggccagagg acaacaagcc agtgacagtc tttggagaca tagtaattac aaagcttatg
     6481 gaggacattc agatcgactg gaccatcagg gatctgaaaa ttgaaaggca tggagactgc
     6541 atgactgtcc ggcagtgtaa cttcactggt tggcctgagc atggggttcc tgaaaacacc
     6601 acccctttga ttcactttgt gaagttggtg cgaacaagca gagcacatga caccacccct
     6661 atggttgtgc attgcagcgc tggggttgga agaacaggag ttttcattgc tctggaccac
     6721 ttaacacagc acataaatga ccatgacttt gtggacatat atggactagt agctgaactg
     6781 aggagcgaga gaatgtgcat ggtgcagaac ctggcacagt acatcttctt acaccagtgc
     6841 attctggatc ttttatcaaa taaaggaggt catcagcccg tctgttttgt taactactcc
     6901 acacttcaga agatggactc tttggatgcc atggaaggtg atgttgagct tgaatgggaa
     6961 gaaactacca tgtaaaattt ggaccaaaga ttacaacagg aggatagaat tttcagatcc
     7021 caggagccaa cattatccct cttgcttctg aattggactg ggcaaaggaa atctttatgc
     7081 ttcccggacc atgcctcact gactgggctg actgttttat ggacggatgg ttgtaggaaa
     7141 atgctcatat aagatagtca tttgttttat atagaattaa atattatgta attaaaatgt
     7201 ttaagaaaat acatcataca aattttcgag gtcctcaagt cttcttgaaa taagccaaat
     7261 ataaaattat gattatttca tagcgtactt gtttcagaat acattttccc tacgtattgg
     7321 gtttcacttt gaacaaaagc tgtagatgtt aatttggtag tgttattttg gcctccaggc
     7381 tgctgatgtt tcttatggac gacttccaag actgtcataa tgatctgcac ttccacgcac
     7441 gcccctgggt tttgaatcct ctgttttatg agtgtcgaga tatcatctac tgatcccgaa
     7501 cagctgaaca gtaacctcgt gacactgcag agaccgctcg ccctttattc tgcacacagt
     7561 agctctccga gaaaacttta ggctatttaa atagtactgt gatctcaagt ttgcaaaaag
     7621 aaaaagaaaa tttcaaagta cagcctcaca taggaagtta tgcagtacca ttctagcctg
     7681 cctacactgg cacaccaaca ggcacaggtt gcacccactc ttgttttgga atacagagtc
     7741 gagtgaatca gagtccttgt cagccagatt tacactcaac actaacagtt ttgaagagtt
     7801 tctgagtaga aatgtataaa aaagacagta aagcccttca gtgtgtctgt cgcacgtgtg
     7861 gaagctgatg aatggcatgc ctctgtggtg acaacagaaa cttcctcata gatgacactg
     7921 aataacctga cgtcatatct gaggaagaat acttagtacg acttaaagaa attcacaagg
     7981 ctggagcaaa tcagacattt aaaatataaa atcattttaa ctcccttctc tctgcataat
     8041 aatgtacata atttaactgt acgaaattgt tttgtcaaag agtcaaattc gtaataacta
     8101 aatagtatcc attatcctaa ttctgtgata aaaactatgc cttgtgcttt atttctgccg
     8161 aactatgcat acagacaatg tgagcactaa tagaaatgaa tattgatgag ttgggttacc
     8221 ttgaagcatg attaaaatat taattaaatt ttatatgtat tatgacatca acaattatat
     8281 catattatag atattacata ttaatataaa atcatttcta tattagaaca acataattgc
     8341 aatttatatg ctgcatgtaa ttcacataaa attgcttcca aaggcatctt cagaaattaa
     8401 tattgatata gaattccaag caattaaata ttttattcta aaaagcagta tcgataagtt
     8461 cgaaatttgc atgctgtttt tttttacgaa aagcatagac aaatgaatag caactccaac
     8521 tccaatcagc atgtttatgc aattgaaagt tacagaaagc aatgatgaca atgaggagag
     8581 gtctaagagg ttcgagtctc actaaagtct ctcctggtaa tatatggcag gcaacagggt
     8641 ttttgtgttt atggaagtag ccaatgaaaa gttctgattg ggtttacttt taaatatagt
     8701 aaataataat ggtgatggtg gtaagaataa agaaaaatat ataatttggt tcaaaggcca
     8761 gatcatgttc tatgatatct gaaaaataga ttcatgagaa tagctttcct gggttaccca
     8821 gtgtgctcaa atgtgagtgt tcacaaagca actgagtaat accagctctc ttctataacg
     8881 gctctgactg agctgtaaca tcttagtaag tcacctgcag attattttaa aatggaaagc
     8941 ctcttcgctg aaaataagag agtcatgaga atcacttttg cttatactcc aagtatatca
     9001 ccgtccacct caacccatat tctaaataag agtgaatcta tagaagacag tgtggctaga
     9061 atagtttcag atctcctaca aattagtgaa gatgattttc aaaaggactt gaattcttca
     9121 ccagaaaaca atatgcaagt tgttatatct gcacagctta gtaatacatc aagagatttt
     9181 aaccgggagt agatggatag acaaatggct tcctaattag attgtggaag ggcccatgta
     9241 gatagtagtt ctacaggtgg ctactgagtg tgaattaaaa tgaacacctg tagccttttt
     9301 agatccagtt tgtcaaagtt catcgacaca tttgtacagt aaatgagcaa catgtgtttc
     9361 ataggaggca aatgaaactg gagcctctct gaatggttcg ccagagaccg gagcagctgt
     9421 gggtagtgcc tttcacgctg cacttaaatg caccgttttt tccctgttac tttataggaa
     9481 acgtacataa tcagtctttt gcaaaaatac taattaaact ttgacctctg catgaaagga
     9541 caagccacac tctgcaaact acaccaaaca cttgaatttt aaaatggaat ttctgtccag
     9601 cagagtatct ggtaagctcg tgcagtcatt gggataacca agtctattta caaggtcttt
     9661 caggaaattc aaagtaacgt ttttaagaga attggagtgc aaaatgactt gaactactca
     9721 agtaaatgat actaataatt gaaactttaa cgttgttagg cataaactca acaaaatacc
     9781 tatcttttta aaataaagag tatttgagga taaatgattt gttgaatatg cagtttccag
     9841 ggagtaaagc atctagtgta tctacttctg gagatagtct aatgtttatg attatacaca
     9901 tgaaatgttt tgaaacataa aataaacttt acagagttag
//
