LOCUS       NM_017336               4941 bp    mRNA    linear   ROD 12-JUN-2024
DEFINITION  Rattus norvegicus protein tyrosine phosphatase, receptor type, O
            (Ptpro), mRNA.
ACCESSION   NM_017336
VERSION     NM_017336.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4941)
  AUTHORS   Zhang,H., Xiang,L., Yuan,H. and Yu,H.
  TITLE     PTPRO inhibition ameliorates spinal cord injury through shifting
            microglial M1/M2 polarization via the NF-kappaB/STAT6 signaling
            pathway
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1870 (5), 167141 (2024)
   PUBMED   38565385
  REMARK    GeneRIF: PTPRO inhibition ameliorates spinal cord injury through
            shifting microglial M1/M2 polarization via the NF-kappaB/STAT6
            signaling pathway.
REFERENCE   2  (bases 1 to 4941)
  AUTHORS   Huan,Z., Tang,Y., Xu,C., Cai,J., Yao,H., Wang,Y., Bu,F. and Ge,X.
  TITLE     PTPRO knockdown protects against inflammation in hemorrhage
            shock-induced lung injury involving the NF-kappaB signaling pathway
  JOURNAL   Respir Res 23 (1), 195 (2022)
   PUBMED   35906634
  REMARK    GeneRIF: PTPRO knockdown protects against inflammation in
            hemorrhage shock-induced lung injury involving the NF-kappaB
            signaling pathway.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4941)
  AUTHORS   Jiang,W., Wei,M., Liu,M., Pan,Y., Cao,D., Yang,X. and Zhang,C.
  TITLE     Identification of Protein Tyrosine Phosphatase Receptor Type O
            (PTPRO) as a Synaptic Adhesion Molecule that Promotes Synapse
            Formation
  JOURNAL   J Neurosci 37 (41), 9828-9843 (2017)
   PUBMED   28871037
REFERENCE   4  (bases 1 to 4941)
  AUTHORS   Dorofejeva,O. and Barr,A.J.
  TITLE     Defining the molecular basis of interaction between R3
            receptor-type protein tyrosine phosphatases and VE-cadherin
  JOURNAL   PLoS One 12 (9), e0184574 (2017)
   PUBMED   28926625
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4941)
  AUTHORS   Shintani,T., Higashi,S., Takeuchi,Y., Gaudio,E., Trapasso,F.,
            Fusco,A. and Noda,M.
  TITLE     The R3 receptor-like protein tyrosine phosphatase subfamily
            inhibits insulin signalling by dephosphorylating the insulin
            receptor at specific sites
  JOURNAL   J Biochem 158 (3), 235-243 (2015)
   PUBMED   26063811
REFERENCE   6  (bases 1 to 4941)
  AUTHORS   Chen,B. and Bixby,J.L.
  TITLE     A novel substrate of receptor tyrosine phosphatase PTPRO is
            required for nerve growth factor-induced process outgrowth
  JOURNAL   J Neurosci 25 (4), 880-888 (2005)
   PUBMED   15673668
REFERENCE   7  (bases 1 to 4941)
  AUTHORS   Kim,Y.H., Goyal,M., Wharram,B., Wiggins,J., Kershaw,D. and
            Wiggins,R.
  TITLE     GLEPP1 receptor tyrosine phosphatase (Ptpro) in rat PAN nephrosis.
            A marker of acute podocyte injury
  JOURNAL   Nephron 90 (4), 471-476 (2002)
   PUBMED   11961407
  REMARK    GeneRIF: Results suggest that GLEPP1 (Ptrpo) expression reflects
            podocyte injury induced by puromycin aminonucleoside.
REFERENCE   8  (bases 1 to 4941)
  AUTHORS   Wharram,B.L., Goyal,M., Gillespie,P.J., Wiggins,J.E., Kershaw,D.B.,
            Holzman,L.B., Dysko,R.C., Saunders,T.L., Samuelson,L.C. and
            Wiggins,R.C.
  TITLE     Altered podocyte structure in GLEPP1 (Ptpro)-deficient mice
            associated with hypertension and low glomerular filtration rate
  JOURNAL   J Clin Invest 106 (10), 1281-1290 (2000)
   PUBMED   11086029
REFERENCE   9  (bases 1 to 4941)
  AUTHORS   Tagawa,M., Shirasawa,T., Yahagi,Y., Tomoda,T., Kuroyanagi,H.,
            Fujimura,S., Sakiyama,S. and Maruyama,N.
  TITLE     Identification of a receptor-type protein tyrosine phosphatase
            expressed in postmitotic maturing neurons: its structure and
            expression in the central nervous system
  JOURNAL   Biochem J 321 (Pt 3) (Pt 3), 865-871 (1997)
   PUBMED   9032477
REFERENCE   10 (bases 1 to 4941)
  AUTHORS   Tagawa,M., Shirasawa,T., Fujimura,S. and Sakiyama,S.
  TITLE     Identification of a rat protein tyrosine phosphatase gene
            preferentially expressed in the embryonal brain
  JOURNAL   Cell Mol Biol Res 40 (7-8), 627-631 (1994)
   PUBMED   7787880
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On Nov 30, 2020 this sequence version replaced NM_017336.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U28938.1, SRR26643287.12233.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-195               JAXUCZ010000004.1  171895511-171895705
            196-469             JAXUCZ010000004.1  172008096-172008369
            470-628             JAXUCZ010000004.1  172018549-172018707
            629-781             JAXUCZ010000004.1  172019684-172019836
            782-1225            JAXUCZ010000004.1  172022005-172022448
            1226-1387           JAXUCZ010000004.1  172024389-172024550
            1388-1584           JAXUCZ010000004.1  172029316-172029512
            1585-1705           JAXUCZ010000004.1  172036354-172036474
            1706-1899           JAXUCZ010000004.1  172038063-172038256
            1900-2011           JAXUCZ010000004.1  172039339-172039450
            2012-2163           JAXUCZ010000004.1  172045177-172045328
            2164-2284           JAXUCZ010000004.1  172046347-172046467
            2285-2424           JAXUCZ010000004.1  172054151-172054290
            2425-2557           JAXUCZ010000004.1  172059852-172059984
            2558-2678           JAXUCZ010000004.1  172062299-172062419
            2679-2747           JAXUCZ010000004.1  172063735-172063803
            2748-2831           JAXUCZ010000004.1  172065961-172066044
            2832-2867           JAXUCZ010000004.1  172072683-172072718
            2868-2949           JAXUCZ010000004.1  172075940-172076021
            2950-3040           JAXUCZ010000004.1  172086823-172086913
            3041-3117           JAXUCZ010000004.1  172088411-172088487
            3118-3252           JAXUCZ010000004.1  172089304-172089438
            3253-3375           JAXUCZ010000004.1  172089682-172089804
            3376-3530           JAXUCZ010000004.1  172094540-172094694
            3531-3666           JAXUCZ010000004.1  172097472-172097607
            3667-3787           JAXUCZ010000004.1  172103748-172103868
            3788-4941           JAXUCZ010000004.1  172104758-172105911
FEATURES             Location/Qualifiers
     source          1..4941
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q43-q44"
     gene            1..4941
                     /gene="Ptpro"
                     /gene_synonym="GLEPP1; RPTP-BK"
                     /note="protein tyrosine phosphatase, receptor type, O"
                     /db_xref="GeneID:50677"
                     /db_xref="RGD:62068"
     exon            1..195
                     /gene="Ptpro"
                     /gene_synonym="GLEPP1; RPTP-BK"
                     /inference="alignment:Splign:2.1.0"
     CDS             121..3771
                     /gene="Ptpro"
                     /gene_synonym="GLEPP1; RPTP-BK"
                     /EC_number="3.1.3.48"
                     /note="receptor-type protein tyrosine phosphatase D30;
                     Glomerular epithelial protein 1; receptor-type
                     tyrosine-protein phosphatase O"
                     /codon_start=1
                     /product="receptor-type tyrosine-protein phosphatase O
                     precursor"
                     /protein_id="NP_059032.1"
                     /db_xref="GeneID:50677"
                     /db_xref="RGD:62068"
                     /translation="MGHLPRERRGGRRLLPLLGLFVLLKIVSTFHVTVRDDNNIVVSL
                     EASDVVSPTSVYVVRVAGESKNYFFEFEESNGTLPPPVVFKATYHGLYYIISLVVVSG
                     NVVTKPSRSITVLTKPLPVTSVSIYDYKPSPETGVLFEIHYPEKYNVFSRVNISYWEG
                     KDFRTMLYKDFLKGKTVFNHWLPGICYSNITFQLVSEATFNKSTLVECSGVSHEPKQH
                     RTAPYPPRNISVRFVNLNKNNWEEPSGSFPEDSFIKPQDAIGRDRPFHFPEETPETPA
                     SNASSGWPDPNGTEYESTSQPYWWDSASAAPENEEDFVSVLPADYDTEATLGRTEKPT
                     ADPFSAFPVQMTLSWLPPKPPTAFDGFNILIEREGNFTDYLTVDEEAHEFVAELKEPG
                     KYRLSVTTFSSSGACETRKSQSAKSLSFYISPTGEWIEELTEKPQHVSVHVLSSTTAL
                     LSWTSSQENYNSTIVSVVSLTCQKQKESQRLEKQYCTQVNSSKPVIENLVPGAQYQVV
                     MYLRKGPLIGPPSDPVTFAIVPTGIKDLMLYPLGPTAVVLSWTRPYLGVFRKYVVEMF
                     YFNPTTMTSEWTTYYEIAATVSLTSSVRIANLLPAWYYNFRVTMVTWGDPELSCCDSS
                     TISFITAPVAPEITSVEYFNSLLYISWTYGDATTDLSHSRMLHWMVVAEGRRKIKKSV
                     TRNVMTAILSLPPGDIYNLSVTACTERGSNTSMLRLVKLEPAPPKSLFAVNKTQTSVT
                     LLWVEEGVADFFEVLCQKLGSGHDGKLQEPVAVSSHVVTISSLLPATAYNCSVTSFSH
                     DSPSVPTFIAVSTMVTEVNPNVVVISVLAILSILLIGLLLVTLVILRKKHLQMARECG
                     AGTFVNFASLEREGKLPYSWRRSVFTFLTLLPSCLWTDYLLAFYINPWSKNGLKKRKL
                     TNPVQLDDFDSYIKDMAKDSDYKFSLQFEELKLIGLDIPHFAADLPLNRCKNRYTNIL
                     PYDFSRVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLPETRNDFWKMVLQQKS
                     RIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGDITVEMVSEEEQEDWASRHFRINYADE
                     AQDVMHFNYTAWPDHGVPPANAAESILQFVYTVRQQATKSKGPMIIHCSAGVGRTGTF
                     IALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQLMWLKKKQQFC
                     ISDVIYENVSKS"
     exon            196..469
                     /gene="Ptpro"
                     /gene_synonym="GLEPP1; RPTP-BK"
                     /inference="alignment:Splign:2.1.0"
     exon            470..628
                     /gene="Ptpro"
                     /gene_synonym="GLEPP1; RPTP-BK"
                     /inference="alignment:Splign:2.1.0"
     exon            629..781
                     /gene="Ptpro"
                     /gene_synonym="GLEPP1; RPTP-BK"
                     /inference="alignment:Splign:2.1.0"
     exon            782..1225
                     /gene="Ptpro"
                     /gene_synonym="GLEPP1; RPTP-BK"
                     /inference="alignment:Splign:2.1.0"
     exon            1226..1387
                     /gene="Ptpro"
                     /gene_synonym="GLEPP1; RPTP-BK"
                     /inference="alignment:Splign:2.1.0"
     exon            1388..1584
                     /gene="Ptpro"
                     /gene_synonym="GLEPP1; RPTP-BK"
                     /inference="alignment:Splign:2.1.0"
     exon            1585..1705
                     /gene="Ptpro"
                     /gene_synonym="GLEPP1; RPTP-BK"
                     /inference="alignment:Splign:2.1.0"
     exon            1706..1899
                     /gene="Ptpro"
                     /gene_synonym="GLEPP1; RPTP-BK"
                     /inference="alignment:Splign:2.1.0"
     exon            1900..2011
                     /gene="Ptpro"
                     /gene_synonym="GLEPP1; RPTP-BK"
                     /inference="alignment:Splign:2.1.0"
     exon            2012..2163
                     /gene="Ptpro"
                     /gene_synonym="GLEPP1; RPTP-BK"
                     /inference="alignment:Splign:2.1.0"
     exon            2164..2284
                     /gene="Ptpro"
                     /gene_synonym="GLEPP1; RPTP-BK"
                     /inference="alignment:Splign:2.1.0"
     exon            2285..2424
                     /gene="Ptpro"
                     /gene_synonym="GLEPP1; RPTP-BK"
                     /inference="alignment:Splign:2.1.0"
     exon            2425..2557
                     /gene="Ptpro"
                     /gene_synonym="GLEPP1; RPTP-BK"
                     /inference="alignment:Splign:2.1.0"
     exon            2558..2678
                     /gene="Ptpro"
                     /gene_synonym="GLEPP1; RPTP-BK"
                     /inference="alignment:Splign:2.1.0"
     exon            2679..2747
                     /gene="Ptpro"
                     /gene_synonym="GLEPP1; RPTP-BK"
                     /inference="alignment:Splign:2.1.0"
     exon            2748..2831
                     /gene="Ptpro"
                     /gene_synonym="GLEPP1; RPTP-BK"
                     /inference="alignment:Splign:2.1.0"
     exon            2832..2867
                     /gene="Ptpro"
                     /gene_synonym="GLEPP1; RPTP-BK"
                     /inference="alignment:Splign:2.1.0"
     exon            2868..2949
                     /gene="Ptpro"
                     /gene_synonym="GLEPP1; RPTP-BK"
                     /inference="alignment:Splign:2.1.0"
     exon            2950..3040
                     /gene="Ptpro"
                     /gene_synonym="GLEPP1; RPTP-BK"
                     /inference="alignment:Splign:2.1.0"
     exon            3041..3117
                     /gene="Ptpro"
                     /gene_synonym="GLEPP1; RPTP-BK"
                     /inference="alignment:Splign:2.1.0"
     exon            3118..3252
                     /gene="Ptpro"
                     /gene_synonym="GLEPP1; RPTP-BK"
                     /inference="alignment:Splign:2.1.0"
     exon            3253..3375
                     /gene="Ptpro"
                     /gene_synonym="GLEPP1; RPTP-BK"
                     /inference="alignment:Splign:2.1.0"
     exon            3376..3530
                     /gene="Ptpro"
                     /gene_synonym="GLEPP1; RPTP-BK"
                     /inference="alignment:Splign:2.1.0"
     exon            3531..3666
                     /gene="Ptpro"
                     /gene_synonym="GLEPP1; RPTP-BK"
                     /inference="alignment:Splign:2.1.0"
     exon            3667..3787
                     /gene="Ptpro"
                     /gene_synonym="GLEPP1; RPTP-BK"
                     /inference="alignment:Splign:2.1.0"
     exon            3788..4941
                     /gene="Ptpro"
                     /gene_synonym="GLEPP1; RPTP-BK"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggccgcctg gagccgcccg ggcgcccgag gtctaaggct gccagccggg actggtcatt
       61 ttaagcgcca cggggacccg ctggcgctgc catccctccc gggttcctgg tcgcgccacg
      121 atggggcacc tgcctaggga aaggcgcggg ggccgccgcc tgctacctct gctcgggctc
      181 tttgtgctgc tcaagattgt ttcaacgttc cacgtgactg tccgagacga caacaacatc
      241 gttgtgtctt tagaagcttc tgatgtagtc agcccaacct ccgtgtatgt tgtgagggta
      301 gctggcgaat ccaaaaacta tttcttcgaa tttgaggaat ccaatggcac actgcctcct
      361 cctgtggtct ttaaggccac gtatcatggt ctttattaca tcatcagtct ggtggtagtc
      421 agtgggaatg tggtcaccaa accatcccga tcaatcaccg tgctgacaaa acccttgccc
      481 gtaaccagtg tgtctatata tgactataag ccttctcctg agacaggagt actgtttgaa
      541 attcactatc cggaaaaata caacgtgttc agcagagtga acatcagcta ctgggagggg
      601 aaggatttca ggacgatgct gtacaaagac ttcctgaagg ggaaaaccgt gtttaatcac
      661 tggctcccgg ggatctgcta cagtaacatc actttccagc tggtttctga ggcgaccttt
      721 aacaaaagca ccctggtgga gtgcagtggt gtgagtcacg aacccaaaca acacagaaca
      781 gcgccgtatc cccctcgaaa catctctgtt cgctttgtca acttgaacaa gaacaactgg
      841 gaagaaccaa gcgggagctt ccccgaggac tcgttcatca aaccgcaaga cgcgatagga
      901 agagacagac ccttccattt ccccgaggaa acccctgaga cgcccgccag caatgcgtct
      961 tccggctggc ctgacccgaa cggcactgag tatgagagca catctcagcc ctactggtgg
     1021 gacagtgcat ccgcggcccc tgaaaacgag gaggacttcg tcagcgtgct gccagcggac
     1081 tatgacactg aggccacgct cggcaggaca gagaaaccca cagctgaccc tttctctgcc
     1141 ttccccgtgc agatgactct gagctggtta ccaccaaaac cgcctacagc cttcgatggc
     1201 ttcaatatcc tcatagagag ggaagggaac tttaccgact atttgacagt ggatgaagaa
     1261 gcccacgagt ttgttgccga actgaaggag cctggaaagt acagactctc agtgacaacc
     1321 ttcagctcct cgggagcctg tgagactcgg aaaagccagt cagcaaaatc gctcagcttc
     1381 tacatcagcc ccacaggaga gtggattgaa gaactgactg agaaaccgca gcacgtgagt
     1441 gtccacgtct taagctcaac cactgccttg ttgtcgtgga catcttccca ggagaactac
     1501 aacagcacca ttgtgtctgt ggtgtccctg acatgccaga aacagaaaga gagccagcgg
     1561 ctggagaagc agtattgtac ccaggtgaac tcaagcaaac ctgtaattga gaacctggtt
     1621 cccggtgccc agtaccaggt tgtgatgtac ctaagaaaag gccctttgat tgggccacct
     1681 tctgatcctg tgacatttgc cattgttccc acggggataa aggatttaat gctctatcca
     1741 ttgggtccca cggcagtagt gctgagctgg acccgacctt acttgggagt gttcagaaaa
     1801 tacgtggttg aaatgtttta tttcaacccc accaccatga cctccgagtg gacgacctac
     1861 tacgaaatag cagcgaccgt ctccttaaca tcgtccgtga gaatagcaaa tctattgccg
     1921 gcgtggtact acaactttcg cgtaaccatg gtgacgtggg gagatccaga actgagctgc
     1981 tgtgacagtt ccaccatcag cttcataacg gcccccgtcg ctccagaaat cacgtctgtg
     2041 gagtacttca acagcctgct gtacatcagc tggacctacg gggacgccac cactgacctg
     2101 tcccattcga gaatgctaca ctggatggtc gtggcagaag ggaggaggaa aattaaaaag
     2161 agtgtgacac gcaatgtcat gacggccatc cttagcctgc ctccaggaga tatctacaac
     2221 ctgtctgtca cagcctgcac tgagaggggg agtaacacct ccatgctccg ccttgtcaag
     2281 ctagaaccag ctcctccaaa atcactcttc gcagtgaaca aaacgcagac atcggtcacc
     2341 ctgctttggg ttgaggaggg cgtagctgat ttctttgaag tcctctgtca gaagctcggg
     2401 tctggccacg atggcaaact ccaggaaccg gtagctgttt cctcccacgt ggtgaccatc
     2461 tccagcctcc tcccagccac tgcctacaac tgcagtgtca ccagcttcag ccacgacagt
     2521 cccagtgtcc ctacgttcat agctgtctcc acaatggtta cagaggtgaa ccctaatgtg
     2581 gtggtgatct cggtgctggc catcctcagc atacttttaa ttggactgct gttagtgacc
     2641 cttgtcattc tgagaaagaa gcacctgcag atggccaggg agtgtggggc tggcacgttt
     2701 gtcaattttg catccttgga gagggaaggg aaactcccct acagttggcg taggagtgtc
     2761 tttactttct taaccctgct gccctcatgt ctgtggactg actatctgtt ggcattttat
     2821 attaaccctt ggagtaaaaa tggcttaaag aagaggaaac tgacgaaccc tgttcagctg
     2881 gacgattttg attcttacat caaggacatg gccaaggact ctgactataa attctctctt
     2941 cagtttgagg agttgaagtt gattggactg gatattccac actttgctgc agatcttccg
     3001 ctgaaccgat gtaaaaaccg ctatacaaac atcctgccgt acgacttcag cagagtgagg
     3061 ctggtctcca tgaatgaaga agaaggagca gactacatta atgccaatta tattcctggc
     3121 tacaactcac ctcaggagta cattgccacc cagggaccac tgccggaaac cagaaatgat
     3181 ttctggaaga tggtcctgca gcagaagtct cgcatcattg tcatgctcac tcagtgcaat
     3241 gagaaaagaa gggtaaaatg cgaccactac tggccattca cggaagaacc cattgcttat
     3301 ggagacatca ccgtggagat ggtctctgag gaagaacagg aggactgggc cagcagacac
     3361 ttccggatca attatgctga cgaggcccag gatgtgatgc actttaacta cacggcctgg
     3421 ccagaccatg gcgtgcctcc agcaaatgct gccgagagca tcctgcagtt cgtgtacact
     3481 gtccggcagc aagccaccaa gagcaaagga cccatgatca tccactgcag cgcgggcgtg
     3541 ggacggacag gcaccttcat agcccttgac aggctcttgc aacacatccg agatcacgaa
     3601 tttgtggaca tcttggggct ggtgtcagaa atgcgctcat accgaatgtc gatggtacag
     3661 acagaggagc agtacatctt catccatcag tgcgtgcagc tgatgtggct gaagaagaag
     3721 caacagttct gcatcagtga cgtcatctac gagaacgtca gcaagtccta gttcagactc
     3781 gggagcggtg aggccatgat gtctacccat cctcccttgc ttccagaggt tttatagggg
     3841 cctttagtca ctttgtcaaa tcgcgtcccc gctgcgcagt ttgtggacaa ggaggtgatt
     3901 taacctccta gaaccgagaa gacttagcct taaggagcct acaataccgt ttggagtctt
     3961 ttcacttcta gacgtttgat ggaccaaatt cactaggatt tccagaaatg ctcctcctcg
     4021 aagggcggga agtgcccttc ctgatggttc agtcggctct ttgctgcttg ggctgggttt
     4081 ggttttttct tttttttaag tgcaataatt tctgtataat cgtgattttt ttttttacat
     4141 tcgcaattca gaatgttgaa ttgttatccg cccacatcac tgatcagtgc cacagccttg
     4201 ggaaggacct tatcgcagag ttttatctca ccactgaaga ggcatggcta cacacaggaa
     4261 gactcggtga caaatcctca aaggaaatga gcgcgtgtgt ccctccctcc aacctctcga
     4321 agctatgggt caggagtagg tgggcagaga gagaagagag gggttctact cacacgtcag
     4381 ccggtttatc tcttcctatt tcgaatatga gaacctgtgt ttcgaagtag agtaggaaaa
     4441 acattacttg tctgacttgt cgtagtgggt ttcttccttg ttgacagttg ggagtttctt
     4501 ccgtggctct tttgaactag tgtcactgtc atggtccttt tcaaacagcc agagctgact
     4561 caacagtttt gagtctgact ctgaactctg agaaatcttg gtgcctagcc ttctttattt
     4621 ttctgtccac ccgtgtacac aagaacagtt tctccaagag ctataggctg taaaaatgca
     4681 ctttctttcc ccacccagag gagctgggaa ttcagaagtc aggacaacga actcagcatg
     4741 ctaggacagt cactggacac cgtcccttaa gaataccgtt gagcgtctcc gtggattccg
     4801 acaggatatt ctctgggttt ctttgcattt ctgttgtcag actcatttta acccgtgtag
     4861 ctagtggcat tttattcttt ggattttgta tgattaaagt acatgattat gtgttgtgac
     4921 cataaaagtt gtcaaaatga g
//
