LOCUS       NM_031600               5131 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus protein tyrosine phosphatase, receptor type N2
            (Ptprn2), mRNA.
ACCESSION   NM_031600
VERSION     NM_031600.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5131)
  AUTHORS   Kang,T., Ye,J., Qin,P., Li,H., Yao,Z., Liu,Y., Ling,Y., Zhang,Y.,
            Yu,T., Cao,H., Li,Y., Wang,J. and Fang,F.
  TITLE     Knockdown of Ptprn-2 delays the onset of puberty in female rats
  JOURNAL   Theriogenology 176, 137-148 (2021)
   PUBMED   34607132
  REMARK    GeneRIF: Knockdown of Ptprn-2 delays the onset of puberty in female
            rats.
REFERENCE   2  (bases 1 to 5131)
  AUTHORS   Ramirez-Franco,J.J., Munoz-Cuevas,F.J., Lujan,R. and Jurado,S.
  TITLE     Excitatory and Inhibitory Neurons in the Hippocampus Exhibit
            Molecularly Distinct Large Dense Core Vesicles
  JOURNAL   Front Cell Neurosci 10, 202 (2016)
   PUBMED   27630542
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5131)
  AUTHORS   Boyken,J., Gronborg,M., Riedel,D., Urlaub,H., Jahn,R. and Chua,J.J.
  TITLE     Molecular profiling of synaptic vesicle docking sites reveals novel
            proteins but few differences between glutamatergic and GABAergic
            synapses
  JOURNAL   Neuron 78 (2), 285-297 (2013)
   PUBMED   23622064
REFERENCE   4  (bases 1 to 5131)
  AUTHORS   Ghai,R., Bugarcic,A., Liu,H., Norwood,S.J., Skeldal,S.,
            Coulson,E.J., Li,S.S., Teasdale,R.D. and Collins,B.M.
  TITLE     Structural basis for endosomal trafficking of diverse transmembrane
            cargos by PX-FERM proteins
  JOURNAL   Proc Natl Acad Sci U S A 110 (8), E643-E652 (2013)
   PUBMED   23382219
REFERENCE   5  (bases 1 to 5131)
  AUTHORS   Cai,T., Hirai,H., Zhang,G., Zhang,M., Takahashi,N., Kasai,H.,
            Satin,L.S., Leapman,R.D. and Notkins,A.L.
  TITLE     Deletion of Ia-2 and/or Ia-2beta in mice decreases insulin
            secretion by reducing the number of dense core vesicles
  JOURNAL   Diabetologia 54 (9), 2347-2357 (2011)
   PUBMED   21732083
REFERENCE   6  (bases 1 to 5131)
  AUTHORS   Caromile,L.A., Oganesian,A., Coats,S.A., Seifert,R.A. and
            Bowen-Pope,D.F.
  TITLE     The neurosecretory vesicle protein phogrin functions as a
            phosphatidylinositol phosphatase to regulate insulin secretion
  JOURNAL   J Biol Chem 285 (14), 10487-10496 (2010)
   PUBMED   20097759
REFERENCE   7  (bases 1 to 5131)
  AUTHORS   Achenbach,P., Kelemen,K., Wegmann,D.R. and Hutton,J.C.
  TITLE     Spontaneous peripheral T-cell responses to the IA-2beta (phogrin)
            autoantigen in young nonobese diabetic mice
  JOURNAL   J Autoimmun 19 (3), 111-116 (2002)
   PUBMED   12419281
REFERENCE   8  (bases 1 to 5131)
  AUTHORS   Jiang,S., Tulloch,A.G., Kim,T.A., Fu,Y., Rogers,R., Gaskell,A.,
            White,R.A., Avraham,H. and Avraham,S.
  TITLE     Characterization and chromosomal localization of PTP-NP-2, a new
            isoform of protein tyrosine phosphatase-like receptor, expressed on
            synaptic boutons
  JOURNAL   Gene 215 (2), 345-359 (1998)
   PUBMED   9714834
REFERENCE   9  (bases 1 to 5131)
  AUTHORS   Fitzgerald,L.R., Walton,K.M., Dixon,J.E. and Largent,B.L.
  TITLE     PTP NE-6: a brain-enriched receptor-type protein tyrosine
            phosphatase with a divergent catalytic domain
  JOURNAL   J Neurochem 68 (5), 1820-1829 (1997)
   PUBMED   9109506
REFERENCE   10 (bases 1 to 5131)
  AUTHORS   Wasmeier,C. and Hutton,J.C.
  TITLE     Molecular cloning of phogrin, a protein-tyrosine phosphatase
            homologue localized to insulin secretory granule membranes
  JOURNAL   J Biol Chem 271 (30), 18161-18170 (1996)
   PUBMED   8663434
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000006.1.
            
            On Nov 26, 2020 this sequence version replaced NM_031600.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U73458.1, Z50735.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-220               JAXUCZ010000006.1  143582568-143582787
            221-271             JAXUCZ010000006.1  143653518-143653568
            272-385             JAXUCZ010000006.1  143772642-143772755
            386-488             JAXUCZ010000006.1  143867214-143867316
            489-651             JAXUCZ010000006.1  143881774-143881936
            652-1000            JAXUCZ010000006.1  143893828-143894176
            1001-1204           JAXUCZ010000006.1  143909142-143909345
            1205-1248           JAXUCZ010000006.1  143910861-143910904
            1249-1634           JAXUCZ010000006.1  143913107-143913492
            1635-1721           JAXUCZ010000006.1  143928154-143928240
            1722-1801           JAXUCZ010000006.1  143940027-143940106
            1802-1866           JAXUCZ010000006.1  144080517-144080581
            1867-2079           JAXUCZ010000006.1  144212983-144213195
            2080-2274           JAXUCZ010000006.1  144235695-144235889
            2275-2422           JAXUCZ010000006.1  144266623-144266770
            2423-2496           JAXUCZ010000006.1  144282598-144282671
            2497-2574           JAXUCZ010000006.1  144289766-144289843
            2575-2694           JAXUCZ010000006.1  144303460-144303579
            2695-2861           JAXUCZ010000006.1  144304317-144304483
            2862-2915           JAXUCZ010000006.1  144309286-144309339
            2916-2980           JAXUCZ010000006.1  144311205-144311269
            2981-3054           JAXUCZ010000006.1  144325353-144325426
            3055-5131           JAXUCZ010000006.1  144332497-144334573
FEATURES             Location/Qualifiers
     source          1..5131
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q33"
     gene            1..5131
                     /gene="Ptprn2"
                     /gene_synonym="PTPNE6; R-PTP-N2"
                     /note="protein tyrosine phosphatase, receptor type N2"
                     /db_xref="GeneID:29714"
                     /db_xref="RGD:61904"
     exon            1..220
                     /gene="Ptprn2"
                     /gene_synonym="PTPNE6; R-PTP-N2"
                     /inference="alignment:Splign:2.1.0"
     CDS             112..3126
                     /gene="Ptprn2"
                     /gene_synonym="PTPNE6; R-PTP-N2"
                     /EC_number="3.1.3.48"
                     /note="receptor-type tyrosine-protein phosphatase N2;
                     phogrin; PTP NE-6; protein tyrosine phosphatase
                     receptor-type N polypeptide 2"
                     /codon_start=1
                     /product="receptor-type tyrosine-protein phosphatase N2
                     precursor"
                     /protein_id="NP_113788.1"
                     /db_xref="GeneID:29714"
                     /db_xref="RGD:61904"
                     /translation="MGLPLPLLLLLLLPPPLPRALPAPASARGRQLPGRLGCLFEDGL
                     CGSLETCVNDGVFGRCQKVPALDTYRYEVSPGALLHLRIILQKLSRTGFTWQDDYTQR
                     VIAQELSNLPKAYLWHEEASSPARSLQQNADNEKWFSLESEVALAKTLRRYLPYLELL
                     SQAPTANAHPRIDHETRPVKGEDSSPENILTYVAHTSALTYPPATRVKYPDNLLRPLS
                     RLQPDELSPKVDSDIDKQKLIAALGAYTAQRPPGENDPEPRYLVHSPMRAPRPFAAPA
                     LSQRWPLPPGDSKDSLSMGDDTLLRSLLKDLQQQAEVDRLGSLKLEEQADSIAGAIQS
                     DPVEGSQESHGRGAEGQLREQADAPEEMLQDHRLPEVDDPAAYKEVSRLSFKLGDLLK
                     DHGSPLLPEAPLLEKSSRAEMKKSEQPEEVLSSEEETAGVEHVKSRTYSKDLLERKPN
                     SEPQPWRLEDQFQNRAPEVWEDEQNLKLAAQGPPSGGLQLEVQPSEEEQQGYILTGNN
                     PLSPEKGKQLMDEVAHLLRVPSSFFADVKVLGPAVIFKVSANIQNMTTADVTKAAVDN
                     KDELEKATGLTILQSGIRPKGKLKLLPHPEEQEDSTKFIVLTFLSIACILAVLLASSL
                     AYCLRHNSHYKLKEKLSGLGADPSADATEAYQELCRQRMAVRPQDHSEGPHTSRINSV
                     SSQLSDGPMPSPSARSSTSSWSEEPAQSNMDISTGHMILAYMEDHLKNKNRLEKEWEA
                     LCAYQAEPDSSLVAQREENAPKNRSLAVLTYDHSRILLKSENSHSNSDYINASPIMDH
                     DPRNPAYIATQGPLPATVADFWQMVWESGCAVIVMLTPLSENGVRQCHHYWPDEGSNV
                     YHVYEVNLVSEHIWCQDFLVRSFYLKNLQTNETRTVTQFHFLSWYDQGVPSSTRSLLD
                     FRRKVNKCYRGRSCPIIVHCSDGAGRSGTYVLIDMVLNKMAKGAKEIDIAATLEHLRD
                     QRPGMVQTKEQFEFALTAVAEEVNAILKALPQ"
     exon            221..271
                     /gene="Ptprn2"
                     /gene_synonym="PTPNE6; R-PTP-N2"
                     /inference="alignment:Splign:2.1.0"
     exon            272..385
                     /gene="Ptprn2"
                     /gene_synonym="PTPNE6; R-PTP-N2"
                     /inference="alignment:Splign:2.1.0"
     exon            386..488
                     /gene="Ptprn2"
                     /gene_synonym="PTPNE6; R-PTP-N2"
                     /inference="alignment:Splign:2.1.0"
     exon            489..651
                     /gene="Ptprn2"
                     /gene_synonym="PTPNE6; R-PTP-N2"
                     /inference="alignment:Splign:2.1.0"
     exon            652..1000
                     /gene="Ptprn2"
                     /gene_synonym="PTPNE6; R-PTP-N2"
                     /inference="alignment:Splign:2.1.0"
     exon            1001..1204
                     /gene="Ptprn2"
                     /gene_synonym="PTPNE6; R-PTP-N2"
                     /inference="alignment:Splign:2.1.0"
     exon            1205..1248
                     /gene="Ptprn2"
                     /gene_synonym="PTPNE6; R-PTP-N2"
                     /inference="alignment:Splign:2.1.0"
     exon            1249..1634
                     /gene="Ptprn2"
                     /gene_synonym="PTPNE6; R-PTP-N2"
                     /inference="alignment:Splign:2.1.0"
     exon            1635..1721
                     /gene="Ptprn2"
                     /gene_synonym="PTPNE6; R-PTP-N2"
                     /inference="alignment:Splign:2.1.0"
     exon            1722..1801
                     /gene="Ptprn2"
                     /gene_synonym="PTPNE6; R-PTP-N2"
                     /inference="alignment:Splign:2.1.0"
     exon            1802..1866
                     /gene="Ptprn2"
                     /gene_synonym="PTPNE6; R-PTP-N2"
                     /inference="alignment:Splign:2.1.0"
     exon            1867..2079
                     /gene="Ptprn2"
                     /gene_synonym="PTPNE6; R-PTP-N2"
                     /inference="alignment:Splign:2.1.0"
     exon            2080..2274
                     /gene="Ptprn2"
                     /gene_synonym="PTPNE6; R-PTP-N2"
                     /inference="alignment:Splign:2.1.0"
     exon            2275..2422
                     /gene="Ptprn2"
                     /gene_synonym="PTPNE6; R-PTP-N2"
                     /inference="alignment:Splign:2.1.0"
     exon            2423..2496
                     /gene="Ptprn2"
                     /gene_synonym="PTPNE6; R-PTP-N2"
                     /inference="alignment:Splign:2.1.0"
     exon            2497..2574
                     /gene="Ptprn2"
                     /gene_synonym="PTPNE6; R-PTP-N2"
                     /inference="alignment:Splign:2.1.0"
     exon            2575..2694
                     /gene="Ptprn2"
                     /gene_synonym="PTPNE6; R-PTP-N2"
                     /inference="alignment:Splign:2.1.0"
     exon            2695..2861
                     /gene="Ptprn2"
                     /gene_synonym="PTPNE6; R-PTP-N2"
                     /inference="alignment:Splign:2.1.0"
     exon            2862..2915
                     /gene="Ptprn2"
                     /gene_synonym="PTPNE6; R-PTP-N2"
                     /inference="alignment:Splign:2.1.0"
     exon            2916..2980
                     /gene="Ptprn2"
                     /gene_synonym="PTPNE6; R-PTP-N2"
                     /inference="alignment:Splign:2.1.0"
     exon            2981..3054
                     /gene="Ptprn2"
                     /gene_synonym="PTPNE6; R-PTP-N2"
                     /inference="alignment:Splign:2.1.0"
     exon            3055..5131
                     /gene="Ptprn2"
                     /gene_synonym="PTPNE6; R-PTP-N2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccgccgcagg agcgctgaga gcgccgcaaa aggagctggc accgcctcgc taaatcccta
       61 tcagtcctcg ctcccgcgcg gccatggact gagcgccaac cggctgcggg gatggggcta
      121 ccgctcccgc ttttgctgct gctgctgctg ccgccgccac tgcctcgcgc tctgccggcc
      181 cccgcgtctg cccgcggccg gcagctccca gggcgcctgg gctgcttgtt tgaggatggc
      241 ttgtgtggat cattggagac ctgtgtgaac gatggtgtgt ttggaagatg tcaaaaggtt
      301 ccggccttgg acacttaccg atatgaggtg tcaccaggag ccctgctgca cctgaggatc
      361 atcttacaga agctctcccg tacaggtttc acgtggcaag atgactatac ccagcgtgtg
      421 atcgcccagg agctttcaaa ccttcccaaa gcctacctat ggcatgagga agcttccagc
      481 ccagccaggt ccttacaaca gaatgcggat aatgaaaaat ggttcagtct ggagagtgag
      541 gtggccctgg ccaagaccct tcggcgctat ctgccctacc tggagcttct gtcccaggcc
      601 ccgacggcaa atgcacaccc caggatagac cacgagactc gtccagttaa gggtgaggac
      661 tcgtcccctg agaacatcct gacctatgtg gcccacacat ctgcactgac ctatcctcct
      721 gcaacccggg tcaagtatcc cgataacctt ctgcgacccc ttagccggct ccagccagat
      781 gagctcagcc ccaaggtaga cagcgacata gacaaacaga agctgattgc agcactgggt
      841 gcctacactg ctcagaggcc tcctggagaa aatgacccag agccacggta tcttgtgcat
      901 agtcccatgc gagcaccaag gcccttcgca gcacctgctt tgtctcagag atggcctcta
      961 cctcctggag actccaaaga ctccctgagt atgggtgatg acacactcct gcggagtctc
     1021 ctgaaggatc tgcagcagca ggctgaagtg gaccgcctgg gctccctgaa gctggaggag
     1081 caggcagatt caattgctgg agccatacaa agtgatcctg tagagggaag ccaagaaagt
     1141 catgggagag gggccgaggg acagctgaga gagcaggcgg atgccccaga ggaaatgctt
     1201 caagatcaca gactaccaga agtggatgac ccagcagcgt acaaggaggt cagccgtctg
     1261 agtttcaagc ttggggacct cttgaaggac catgggtctc ctctattacc tgaagctccc
     1321 cttctggaaa agtcctccag agcagagatg aagaagtcag agcagcctga ggaggtcttg
     1381 tcttcggaag aggagactgc cggggtggag catgtgaaga gccggactta ctccaaagac
     1441 ctattggaaa ggaagccgaa ctcagaaccc caaccctgga ggcttgagga ccagttccaa
     1501 aatcgagctc cagaggtgtg ggaggatgaa caaaacctca agttggcagc acagggaccc
     1561 cctagtggag gccttcagct ggaagtgcag ccttcagagg aggaacaaca gggatacatc
     1621 ctcacaggaa ataaccctct aagtccagag aaggggaagc agctgatgga tgaagttgcc
     1681 catctcctcc gggtaccttc cagcttcttt gcagatgtca aagttttggg accagcagtg
     1741 atcttcaaag tgagtgccaa catccaaaac atgacaacgg cagatgtcac gaaagctgca
     1801 gttgacaaca aagatgagct ggagaaggca actggactga ccatcctgca gagtggaatc
     1861 aggccgaaag gaaagctcaa gctcctaccc catccagaag agcaagagga ctcaaccaag
     1921 ttcattgtgc ttaccttcct ctccatcgcc tgcatcctgg ccgttctcct ggcttccagc
     1981 ctagcctact gcctccgcca caactcacac tacaagctga aggagaaatt gtctggacta
     2041 ggagctgacc ccagcgcaga tgccaccgaa gcctaccagg agctatgccg ccaacgtatg
     2101 gctgttcggc cgcaggatca ctctgaggga ccacatacat cccgcatcaa cagtgtctca
     2161 tcccagctca gcgatgggcc catgcctagt ccttcagccc ggagcagcac ttcatcctgg
     2221 tctgaggagc ctgcccagtc taacatggac atctctactg gccacatgat cctggcctac
     2281 atggaagacc acttgaagaa caagaaccgg ctggagaagg agtgggaggc actgtgcgcc
     2341 tatcaagcag agcccgacag ctcactggtg gcccagagag aggagaatgc acccaagaac
     2401 cgttccctgg ctgtgctgac ctatgaccat tccaggatcc tgttgaagtc tgagaacagc
     2461 cacagcaatt ctgactacat caatgccagc cccattatgg accatgaccc acgaaacccc
     2521 gcgtacattg ccacccaggg cccacttccc gccaccgtgg ccgacttctg gcagatggtg
     2581 tgggaaagcg gctgtgcagt catcgtcatg ctgacacccc tctctgagaa cggcgtccgg
     2641 cagtgccatc actactggcc tgatgaaggt tccaacgtct accatgtcta tgaggtcaat
     2701 ctagtctctg aacacatatg gtgccaggat ttcctggtga gaagctttta cctgaagaac
     2761 ctgcagacca atgagactcg cacggtgacc cagttccact tcctgagttg gtatgaccag
     2821 ggagtccctt cctccacgag gtcactcctg gatttccgca gaaaagtgaa caaatgctac
     2881 cgaggccgct cttgtccgat aattgtccat tgcagtgacg gcgcgggcag gagtggaacc
     2941 tacgtcctga ttgacatggt tctcaataag atggccaaag gtgctaaaga gattgatatc
     3001 gcagcgaccc tggagcactt gagggaccag agaccaggca tggtccagac aaaggagcag
     3061 tttgagtttg cgctgacagc tgtggccgag gaggtgaatg ccatcctgaa ggcccttccc
     3121 cagtaggcac cgaagctgga gctgacggga ccccaccacg agtacttcca ggaccacaac
     3181 aggatatcat ttctgcatct tctgtgtagt aagggggtcc ttcagactcc atagtcaaca
     3241 caggtggcta gttatgtgta cttctgctta accaaatagc acatgtgtgg aaacacccag
     3301 ttaggaggaa ggaaagattc agcttatttg tatcacagtc ttggcaaaat tccttttccc
     3361 taaagcacac tttgacatgg tcgcatcaat gacacagtaa ttagaaaccc actgtggcct
     3421 cctcgggagg gtggttatgt ctgtaaggtg ctgggggggg ggggagggag aatgcaaatg
     3481 gaccagaaca gacagcggga ctcctttggg aagcaccact atagaatcac atttggtgtt
     3541 tgccagtaag acaatctcat catcagggga aaccttcagg gagaagatca gtgtcctgca
     3601 tccctggggc aaatgacagg ctctcatggg gctctgcctg tccctgctga tgtgcttcca
     3661 gcacaccggc tggctgtgtc caccacacgt ggattccaag gacaggaaaa aaaaaaggat
     3721 ttccccaagg gtagacacct taaccctcca gaagtatggg tgctgtatct gttacagaag
     3781 tgaggaccca agtaatagtt cacctttgca aagttacaga ggaacggccc tttggaacat
     3841 ttttagtatt aggatcctgt tttcctcatt acaagaatgc tgaagtatac aattccagaa
     3901 ccccatagta tgctgaagtt acaattccag aacgagtacg gttatttagc aagttccaag
     3961 ggttgccaat gtgtttccca tccagcatcc ccaggaagca ctccaatggt actgaaaagt
     4021 ctctgatgct cctagtcctg gaaagaagtc tggccctttg cctcttcctc ctgcttcctc
     4081 ccagataact ttagtgaaac acattctcac tggatgctcc agtttgctga aacatttggg
     4141 cgttgggctt accacctgcc cacacatagg aaacccactc cagtatccgc aaggcgctgg
     4201 tgcccagaga ggtagaaggc atggctgtaa gccccagttt gtttgtgggg ttgagtatga
     4261 aaaagcccat ctcccgtgtc ccctttgttc cttcccttta gcctcaacat ttcaagttgc
     4321 ggtgcgtaaa ggaggtggct gccgtgcggg aagcgatgcc gcagtgtgtc atgtctctaa
     4381 ttgtgttgtg tatctgctta acatctgcga cgttcctctt ccatttcccc cttcccggaa
     4441 tctaaatgat aattaataga aatgaattta tctgaatata ggaagcatat acttaattgt
     4501 aacttcttat gtttaaagga aaaaccctcg gtgtgatata cagatatatt taattgtgtc
     4561 ctattaaacc ttctgatttc atatttgatg gtctttactt gggaaagtga gagcagttca
     4621 gtcccacgag ggccttttta tttcccaaag atgtaaatcc aagcacagcc cttctccaga
     4681 gcctgagaag caccactggc ttgtcttccg caccaggctc ataccagggg cttctacatc
     4741 actgggattt cactatttaa aaattaccga gcgatcgttg aaggctgcag aactccacag
     4801 gatgggtgca ctccgccctg ctggaagctg cctccagccc tcatcaaagc tccacctcac
     4861 tgagactcgt cctcctgccc catccacatt gtctatgtca gcctctcatg ccacaggaaa
     4921 atgcttctgc acagctcaag ctctggtgac aggaacggat gtaattggga gcaaggcttc
     4981 ctgggttctt tctttcctaa gaatggtaca tctattttgt tttttttaat taactcattg
     5041 gtttatgtac aaaataataa aataatgaat ttcatcatac acacacacac acacacacac
     5101 acacacacac acacacacac acacacacac c
//
