LOCUS       NM_053881               3487 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus protein tyrosine phosphatase, receptor type, N
            (Ptprn), mRNA.
ACCESSION   NM_053881
VERSION     NM_053881.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3487)
  AUTHORS   Toledo,P.L., Torkko,J.M., Muller,A., Wegbrod,C., Sonmez,A.,
            Solimena,M. and Ermacora,M.R.
  TITLE     ICA512 RESP18 homology domain is a protein-condensing factor and
            insulin fibrillation inhibitor
  JOURNAL   J Biol Chem 294 (21), 8564-8576 (2019)
   PUBMED   30979722
  REMARK    GeneRIF: these findings point to ICA512 RESP18HD being a condensing
            factor for protein sorting and granulogenesis early in the
            secretory pathway and for prevention of amyloidogenesis.
REFERENCE   2  (bases 1 to 3487)
  AUTHORS   Torkko,J.M., Primo,M.E., Dirkx,R., Friedrich,A., Viehrig,A.,
            Vergari,E., Borgonovo,B., Sonmez,A., Wegbrod,C., Lachnit,M.,
            Munster,C., Sica,M.P., Ermacora,M.R. and Solimena,M.
  TITLE     Stability of proICA512/IA-2 and its targeting to insulin secretory
            granules require beta4-sheet-mediated dimerization of its
            ectodomain in the endoplasmic reticulum
  JOURNAL   Mol Cell Biol 35 (6), 914-927 (2015)
   PUBMED   25561468
  REMARK    GeneRIF: The ME ICA512 beta2-strand fosters proICA512 dimerization
            until NTF prevents N506 glycosylation.
REFERENCE   3  (bases 1 to 3487)
  AUTHORS   Gomi,H., Kubota-Murata,C., Yasui,T., Tsukise,A. and Torii,S.
  TITLE     Immunohistochemical analysis of IA-2 family of protein tyrosine
            phosphatases in rat gastrointestinal endocrine cells
  JOURNAL   J Histochem Cytochem 61 (2), 156-168 (2013)
   PUBMED   23087044
  REMARK    GeneRIF: In the stomach, IA-2 and IA-2beta were expressed in
            gastrointestinal endocrine cells that secrete serotonin,
            somatostatin, and cholecystokinin/gastrin-1.
REFERENCE   4  (bases 1 to 3487)
  AUTHORS   Harashima,S., Horiuchi,T., Wang,Y., Notkins,A.L., Seino,Y. and
            Inagaki,N.
  TITLE     Sorting nexin 19 regulates the number of dense core vesicles in
            pancreatic beta-cells
  JOURNAL   J Diabetes Investig 3 (1), 52-61 (2012)
   PUBMED   24843546
REFERENCE   5  (bases 1 to 3487)
  AUTHORS   Cai,T., Hirai,H., Zhang,G., Zhang,M., Takahashi,N., Kasai,H.,
            Satin,L.S., Leapman,R.D. and Notkins,A.L.
  TITLE     Deletion of Ia-2 and/or Ia-2beta in mice decreases insulin
            secretion by reducing the number of dense core vesicles
  JOURNAL   Diabetologia 54 (9), 2347-2357 (2011)
   PUBMED   21732083
REFERENCE   6  (bases 1 to 3487)
  AUTHORS   Magistrelli,G., Toma,S. and Isacchi,A.
  TITLE     Substitution of two variant residues in the protein tyrosine
            phosphatase-like PTP35/IA-2 sequence reconstitutes catalytic
            activity
  JOURNAL   Biochem Biophys Res Commun 227 (2), 581-588 (1996)
   PUBMED   8878556
REFERENCE   7  (bases 1 to 3487)
  AUTHORS   Solimena,M., Dirkx,R. Jr., Hermel,J.M., Pleasic-Williams,S.,
            Shapiro,J.A., Caron,L. and Rabin,D.U.
  TITLE     ICA 512, an autoantigen of type I diabetes, is an intrinsic
            membrane protein of neurosecretory granules
  JOURNAL   EMBO J 15 (9), 2102-2114 (1996)
   PUBMED   8641276
REFERENCE   8  (bases 1 to 3487)
  AUTHORS   Passini,N., Larigan,J.D., Genovese,S., Appella,E., Sinigaglia,F.
            and Rogge,L.
  TITLE     The 37/40-kilodalton autoantigen in insulin-dependent diabetes
            mellitus is the putative tyrosine phosphatase IA-2
  JOURNAL   Proc Natl Acad Sci U S A 92 (20), 9412-9416 (1995)
   PUBMED   7568143
REFERENCE   9  (bases 1 to 3487)
  AUTHORS   Payton,M.A., Hawkes,C.J. and Christie,M.R.
  TITLE     Relationship of the 37,000- and 40,000-M(r) tryptic fragments of
            islet antigens in insulin-dependent diabetes to the protein
            tyrosine phosphatase-like molecule IA-2 (ICA512)
  JOURNAL   J Clin Invest 96 (3), 1506-1511 (1995)
   PUBMED   7657822
REFERENCE   10 (bases 1 to 3487)
  AUTHORS   Kambayashi,Y., Takahashi,K., Bardhan,S. and Inagami,T.
  TITLE     Cloning and expression of protein tyrosine phosphatase-like protein
            derived from a rat pheochromocytoma cell line
  JOURNAL   Biochem J 306 (Pt 2) (Pt 2), 331-335 (1995)
   PUBMED   7887886
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000009.1.
            
            On Oct 12, 2022 this sequence version replaced NM_053881.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ211652.1, U40652.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760393,
                                           SAMN12840105 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-165               JAXUCZ010000009.1  84204659-84204823   c
            166-216             JAXUCZ010000009.1  84203092-84203142   c
            217-330             JAXUCZ010000009.1  84202796-84202909   c
            331-427             JAXUCZ010000009.1  84201349-84201445   c
            428-686             JAXUCZ010000009.1  84199830-84200088   c
            687-1035            JAXUCZ010000009.1  84199399-84199747   c
            1036-1167           JAXUCZ010000009.1  84198696-84198827   c
            1168-1202           JAXUCZ010000009.1  84198281-84198315   c
            1203-1480           JAXUCZ010000009.1  84197381-84197658   c
            1481-1567           JAXUCZ010000009.1  84197049-84197135   c
            1568-1647           JAXUCZ010000009.1  84196680-84196759   c
            1648-1712           JAXUCZ010000009.1  84196480-84196544   c
            1713-1931           JAXUCZ010000009.1  84195863-84196081   c
            1932-2132           JAXUCZ010000009.1  84195210-84195410   c
            2133-2280           JAXUCZ010000009.1  84194962-84195109   c
            2281-2354           JAXUCZ010000009.1  84194746-84194819   c
            2355-2432           JAXUCZ010000009.1  84194451-84194528   c
            2433-2552           JAXUCZ010000009.1  84194230-84194349   c
            2553-2719           JAXUCZ010000009.1  84193816-84193982   c
            2720-2773           JAXUCZ010000009.1  84191322-84191375   c
            2774-2838           JAXUCZ010000009.1  84190724-84190788   c
            2839-2912           JAXUCZ010000009.1  84190485-84190558   c
            2913-3487           JAXUCZ010000009.1  84189676-84190250   c
FEATURES             Location/Qualifiers
     source          1..3487
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q33"
     gene            1..3487
                     /gene="Ptprn"
                     /gene_synonym="BEM-3; Ia-2; ICA105; ICA512; PTPLP;
                     R-PTP-N"
                     /note="protein tyrosine phosphatase, receptor type, N"
                     /db_xref="GeneID:116660"
                     /db_xref="RGD:620777"
     exon            1..165
                     /gene="Ptprn"
                     /gene_synonym="BEM-3; Ia-2; ICA105; ICA512; PTPLP;
                     R-PTP-N"
                     /inference="alignment:Splign:2.1.0"
     CDS             33..2984
                     /gene="Ptprn"
                     /gene_synonym="BEM-3; Ia-2; ICA105; ICA512; PTPLP;
                     R-PTP-N"
                     /EC_number="3.1.3.48"
                     /note="receptor-type tyrosine-protein phosphatase-like N;
                     105 kDa islet cell antigen; brain-enriched
                     membrane-associated protein tyrosine phosphatase"
                     /codon_start=1
                     /product="receptor-type tyrosine-protein phosphatase-like
                     N precursor"
                     /protein_id="NP_446333.2"
                     /db_xref="GeneID:116660"
                     /db_xref="RGD:620777"
                     /translation="MRRPRRPGGPAGCGGSEGSGGLRLLVCLLLLSGRPGGCSAISAH
                     GCLFDRRLCSHLEVCIQDGLFGQCQAGVGQARPLLQVTSPVLQRLQGVLRQLMSQGLS
                     WHDDLTQYVISQEMERIPRLRPPEPHPRDRSGSVPRRAGPAGELLSQGNPTGSSPAVQ
                     GLSRPPGDGNGAGVGSPLSSLQAELLPPLLEHLLMPPQPPHPSLTYEPALLQPYLFQQ
                     FGSRDGSRGSESASGVVGHLAKAEDPVLFSRSLSKAILGTHSGHSFGDLTGPSPAQLF
                     QDSGLLYMAQELPVPGRARAPRLPEEGGSSRAEDSSEGHEEEVLGGHGEKSPPQAVQA
                     DVSLQRLAAVLAGYGVELRQLTPEQLSTLLTLLQLLPKGTGRHLGGAVNGGADVKKTI
                     EEQMQRGDTADARPPTPLLPGHPTASSTSIKVRQVLSPGFPEPPKTSSPLGISAVLLE
                     KKSPLGQSQPTVVGQPSARPSAEEYGYIVTDQKPLSLVAGVKLLEILAEHVHMTSGSF
                     INISVVGPAVTFRIRHNEQNLSLADVTQQAGLVKSELEAQTGLQILQTGVGQREESAA
                     VLPRQAHGISPMRSLLLTLVALAGVAGLLVALAVALCMRHHSKQRDKERLAALGPEGA
                     HGDTTFEYQDLCRQHMATKSLFNRAEGQPEPSRVSSVSSQFSDAAQASPSSHSSTPSW
                     CEEPAQANMDISTGHMILAYMEDHLRNRDRLAKEWQALCAYQAEPNTCATAQGEGNIK
                     KNRHPDFLPYDHARIKLKVESSPSRSDYINASPIIEHDPRMPAYIATQGPLSHTIADF
                     WQMVWESGCTVIVMLTPLVEDGVKQCDRYWPDEGSSLYHVYEVNLVSEHIWCEDFLVR
                     SFYLKNVQTQETRTLTQFHFLSWPAEGTPASTRPLLDFRRKVNKCYRGRSCPIIVHCS
                     DGAGRTGTYILIDMVLNRMAKGVKEIDIAATLEHVRDQRPGLVRSKDQFEFALTAVAE
                     EVNAILKALPQ"
     exon            166..216
                     /gene="Ptprn"
                     /gene_synonym="BEM-3; Ia-2; ICA105; ICA512; PTPLP;
                     R-PTP-N"
                     /inference="alignment:Splign:2.1.0"
     exon            217..330
                     /gene="Ptprn"
                     /gene_synonym="BEM-3; Ia-2; ICA105; ICA512; PTPLP;
                     R-PTP-N"
                     /inference="alignment:Splign:2.1.0"
     exon            331..427
                     /gene="Ptprn"
                     /gene_synonym="BEM-3; Ia-2; ICA105; ICA512; PTPLP;
                     R-PTP-N"
                     /inference="alignment:Splign:2.1.0"
     exon            428..686
                     /gene="Ptprn"
                     /gene_synonym="BEM-3; Ia-2; ICA105; ICA512; PTPLP;
                     R-PTP-N"
                     /inference="alignment:Splign:2.1.0"
     exon            687..1035
                     /gene="Ptprn"
                     /gene_synonym="BEM-3; Ia-2; ICA105; ICA512; PTPLP;
                     R-PTP-N"
                     /inference="alignment:Splign:2.1.0"
     exon            1036..1167
                     /gene="Ptprn"
                     /gene_synonym="BEM-3; Ia-2; ICA105; ICA512; PTPLP;
                     R-PTP-N"
                     /inference="alignment:Splign:2.1.0"
     exon            1168..1202
                     /gene="Ptprn"
                     /gene_synonym="BEM-3; Ia-2; ICA105; ICA512; PTPLP;
                     R-PTP-N"
                     /inference="alignment:Splign:2.1.0"
     exon            1203..1480
                     /gene="Ptprn"
                     /gene_synonym="BEM-3; Ia-2; ICA105; ICA512; PTPLP;
                     R-PTP-N"
                     /inference="alignment:Splign:2.1.0"
     exon            1481..1567
                     /gene="Ptprn"
                     /gene_synonym="BEM-3; Ia-2; ICA105; ICA512; PTPLP;
                     R-PTP-N"
                     /inference="alignment:Splign:2.1.0"
     exon            1568..1647
                     /gene="Ptprn"
                     /gene_synonym="BEM-3; Ia-2; ICA105; ICA512; PTPLP;
                     R-PTP-N"
                     /inference="alignment:Splign:2.1.0"
     exon            1648..1712
                     /gene="Ptprn"
                     /gene_synonym="BEM-3; Ia-2; ICA105; ICA512; PTPLP;
                     R-PTP-N"
                     /inference="alignment:Splign:2.1.0"
     exon            1713..1931
                     /gene="Ptprn"
                     /gene_synonym="BEM-3; Ia-2; ICA105; ICA512; PTPLP;
                     R-PTP-N"
                     /inference="alignment:Splign:2.1.0"
     exon            1932..2132
                     /gene="Ptprn"
                     /gene_synonym="BEM-3; Ia-2; ICA105; ICA512; PTPLP;
                     R-PTP-N"
                     /inference="alignment:Splign:2.1.0"
     exon            2133..2280
                     /gene="Ptprn"
                     /gene_synonym="BEM-3; Ia-2; ICA105; ICA512; PTPLP;
                     R-PTP-N"
                     /inference="alignment:Splign:2.1.0"
     exon            2281..2354
                     /gene="Ptprn"
                     /gene_synonym="BEM-3; Ia-2; ICA105; ICA512; PTPLP;
                     R-PTP-N"
                     /inference="alignment:Splign:2.1.0"
     exon            2355..2432
                     /gene="Ptprn"
                     /gene_synonym="BEM-3; Ia-2; ICA105; ICA512; PTPLP;
                     R-PTP-N"
                     /inference="alignment:Splign:2.1.0"
     exon            2433..2552
                     /gene="Ptprn"
                     /gene_synonym="BEM-3; Ia-2; ICA105; ICA512; PTPLP;
                     R-PTP-N"
                     /inference="alignment:Splign:2.1.0"
     exon            2553..2719
                     /gene="Ptprn"
                     /gene_synonym="BEM-3; Ia-2; ICA105; ICA512; PTPLP;
                     R-PTP-N"
                     /inference="alignment:Splign:2.1.0"
     exon            2720..2773
                     /gene="Ptprn"
                     /gene_synonym="BEM-3; Ia-2; ICA105; ICA512; PTPLP;
                     R-PTP-N"
                     /inference="alignment:Splign:2.1.0"
     exon            2774..2838
                     /gene="Ptprn"
                     /gene_synonym="BEM-3; Ia-2; ICA105; ICA512; PTPLP;
                     R-PTP-N"
                     /inference="alignment:Splign:2.1.0"
     exon            2839..2912
                     /gene="Ptprn"
                     /gene_synonym="BEM-3; Ia-2; ICA105; ICA512; PTPLP;
                     R-PTP-N"
                     /inference="alignment:Splign:2.1.0"
     exon            2913..3487
                     /gene="Ptprn"
                     /gene_synonym="BEM-3; Ia-2; ICA105; ICA512; PTPLP;
                     R-PTP-N"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggccggagag cgagagctca gagccgggaa ggatgaggcg cccgcggcgg cccggaggtc
       61 ccgcgggctg cgggggctcc gagggttccg ggggccttcg gctgctggtc tgcctgctgt
      121 tgttgagcgg ccgccccggg ggctgcagcg ccatcagtgc ccacggctgt ctctttgacc
      181 gcagactttg ttcgcatctg gaagtctgta ttcaggatgg cttgtttgga cagtgccagg
      241 caggagtggg gcaggcacgg cccctcttac aagtcacttc cccagttctc cagcgcttac
      301 aaggtgtgct ccggcaactc atgtcccaag gcttgtcctg gcatgatgac ctcacccagt
      361 atgtgatctc ccaggagatg gaacgaatcc ccaggcttcg tcccccagaa cctcatccaa
      421 gggacagatc tggatcggtg cccaggagag caggcccagc aggggaattg ctttctcagg
      481 gcaatcccac tggctcctct cctgctgtcc aggggctctc tcggcctcca ggggatggga
      541 atggagctgg ggtgggctcc ccactgtcct ctctgcaggc tgagctgtta ccccctctct
      601 tggagcatct gctaatgccc ccgcagcctc cacacccgtc tctgacctat gaacctgcat
      661 tgctacaacc ttacttgttc cagcagtttg gttcccgaga tggctcccgg ggctcagaga
      721 gcgcctctgg ggtagttggc catctggcca aggctgaaga tcctgtactc ttcagcagaa
      781 gcctctccaa ggccattttg gggactcact ctggacactc ctttggtgac cttacaggtc
      841 cctcacctgc tcagcttttc caggattcag ggctgctcta catggcccaa gagttgccag
      901 tgcctggcag agcccgggcg ccaaggttgc cagaggaagg gggcagcagc cgggcagagg
      961 actcttcaga gggccatgag gaggaagtac tagggggtca tggggagaag tcccctcccc
     1021 aagcagtaca agcagatgta agtctgcaga gattggctgc tgtgctggca ggctacggag
     1081 tagagctgcg tcagctgacc ccggaacagc tttctaccct cttaaccctg ctgcagttac
     1141 tgcccaaggg cacaggaaga catcttggag gggctgtgaa cggaggagcc gatgtcaaga
     1201 aaacaataga agaacaaatg cagagagggg acacagcaga cgctcggccc cccacaccct
     1261 tgcttcctgg acaccccact gccagctcca cctccatcaa agttcggcag gtgctgagcc
     1321 ctggtttccc tgaacctccc aagacatcca gtcctctggg catctcggct gtcctgctgg
     1381 agaagaaaag tcccttgggc cagagccagc ccacagtggt gggacagcct tcagctcgac
     1441 cgtccgctga ggagtatggc tatatagtca ctgatcagaa acccctgagt ctggtggctg
     1501 gagtgaagtt gctggagatc ctggctgaac atgtgcacat gacttcaggc agcttcatca
     1561 acatcagtgt ggtaggacca gctgtcacct tccgaatccg gcacaatgag cagaacttgt
     1621 ctttggcaga tgtgacccag caagctgggc tggtgaagtc tgaactggaa gcgcagacag
     1681 ggctccagat tttgcagaca ggggtgggac agagggagga atccgccgca gtccttcccc
     1741 gacaagccca tggcatatct cccatgcgct cattgctgct tactctggtg gccctggcag
     1801 gtgtcgctgg gctactagta gctttggcgg tggccctgtg tatgcgccat cattcgaaac
     1861 aacgggataa ggagcgcctg gccgcgctgg ggccggaggg ggcccacggt gacactactt
     1921 ttgaatacca ggacctgtgt cgccagcaca tggccacaaa gtcgctgttt aaccgggcag
     1981 agggtcagcc agagccttct cgggtgagca gtgtgtcctc ccagttcagt gacgcggccc
     2041 aggccagccc cagttcccac agcagcacac cgtcctggtg cgaggagcct gcccaggcca
     2101 acatggacat ctccacagga cacatgattc tggcatacat ggaggatcac ctccggaacc
     2161 gggaccggtt ggccaaggag tggcaggccc tgtgcgccta ccaagcggag ccaaacacct
     2221 gtgccaccgc acaaggtgaa ggcaacatca agaagaaccg ccatcctgac ttcttaccct
     2281 atgaccatgc ccgaatcaag ctgaaagtgg agagcagccc ctctcggagt gattacatca
     2341 acgccagtcc catcatcgag catgaccctc ggatgccggc ctacatagcc acacagggac
     2401 ccctgtccca caccatcgca gacttctggc agatggtgtg ggagagtggc tgcactgtca
     2461 tcgttatgct gacccctttg gtggaggatg gtgtcaaaca gtgtgaccgc tactggccgg
     2521 atgaagggtc ctccctctac cacgtctatg aggtgaacct ggtgtctgag cacatctggt
     2581 gcgaggactt cctggtgcgg agcttctacc tgaagaacgt gcagacccag gagacgcgca
     2641 cgctcactca gttccacttc ctcagctggc cggcagaggg cactccggcc tccacccggc
     2701 cgctgctgga cttccgcagg aaagtgaaca agtgctacag aggccgctcc tgtcccatca
     2761 tagtgcactg cagtgatggt gcagggagga caggcaccta catccttatt gacatggtac
     2821 tgaatcgcat ggcgaaagga gtgaaggaga ttgatatcgc tgccaccctg gagcatgtcc
     2881 gtgaccagcg acctggcctt gtccgttcta aggaccagtt tgagtttgcg ctgacagccg
     2941 tggcggagga ggtgaatgcc atcctcaagg ccctgcccca gtgagccccc tgggtacctc
     3001 agtgggcatc ctggcctctg ctccttctgc ctgtgtgtga gcatttgtgc acccactctt
     3061 cagcccctac ccatctgcca ccttggtccg tccgacttgg gcatgatagc cctttccaac
     3121 ccagtgtgga aggaagtcgg gagggaaggg gcaggtccac cctgctttat tcacgctaga
     3181 accaagatct cctgtgggaa acagacagca ggcaagggga ggagtggaca ccagcagcaa
     3241 gtgtgcccga gccccatcct tcctgagtct ctgtctccct ctgtgtgtgt acctccccac
     3301 tcccaccagc ctatcgtgta tagacaaagc agaatgagaa ggccccagct ccccccagtc
     3361 ctgctaccac tggcctgcca ccttgaccct gctcaacctt ctccctctag cacaagcaaa
     3421 catttctaga aaaatctact tttgtatcaa tgtgaataaa gttagtgtgt tgtctgtgca
     3481 gctgcaa
//
