LOCUS       NM_001029902            4464 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus protein tyrosine phosphatase, receptor type, K
            (Ptprk), mRNA.
ACCESSION   NM_001029902 XM_346527
VERSION     NM_001029902.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4464)
  AUTHORS   Iwata,R., Sasaki,N. and Agui,T.
  TITLE     Contiguous gene deletion of Ptprk and Themis causes T-helper
            immunodeficiency (thid) in the LEC rat
  JOURNAL   Biomed Res 31 (1), 83-87 (2010)
   PUBMED   20203423
  REMARK    GeneRIF: Contiguous gene deletion of Ptprk and Themis causes
            T-helper immunodeficiency (thid) in the LEC rat.
REFERENCE   2  (bases 1 to 4464)
  AUTHORS   Novellino,L., De Filippo,A., Deho,P., Perrone,F., Pilotti,S.,
            Parmiani,G. and Castelli,C.
  TITLE     PTPRK negatively regulates transcriptional activity of wild type
            and mutated oncogenic beta-catenin and affects membrane
            distribution of beta-catenin/E-cadherin complexes in cancer cells
  JOURNAL   Cell Signal 20 (5), 872-883 (2008)
   PUBMED   18276111
REFERENCE   3  (bases 1 to 4464)
  AUTHORS   Horvat-Brocker,A., Reinhard,J., Illes,S., Paech,T., Zoidl,G.,
            Harroch,S., Distler,C., Knyazev,P., Ullrich,A. and Faissner,A.
  TITLE     Receptor protein tyrosine phosphatases are expressed by cycling
            retinal progenitor cells and involved in neuronal development of
            mouse retina
  JOURNAL   Neuroscience 152 (3), 618-645 (2008)
   PUBMED   18308476
REFERENCE   4  (bases 1 to 4464)
  AUTHORS   Asano,A., Tsubomatsu,K., Jung,C.G., Sasaki,N. and Agui,T.
  TITLE     A deletion mutation of the protein tyrosine phosphatase kappa
            (Ptprk) gene is responsible for T-helper immunodeficiency (thid) in
            the LEC rat
  JOURNAL   Mamm Genome 18 (11), 779-786 (2007)
   PUBMED   17909891
  REMARK    GeneRIF: The Ptprk gene is responsible for the thid mutation in the
            LEC rat. Results further suggest that RPTPkappa plays a critical
            role in the development of CD4 SP cells in the thymus.
REFERENCE   5  (bases 1 to 4464)
  AUTHORS   Kose,H., Sakai,T., Tsukumo,S., Wei,K., Yamada,T., Yasutomo,K. and
            Matsumoto,K.
  TITLE     Maturational arrest of thymocyte development is caused by a
            deletion in the receptor-like protein tyrosine phosphatase kappa
            gene in LEC rats
  JOURNAL   Genomics 89 (6), 673-677 (2007)
   PUBMED   17434290
  REMARK    GeneRIF: Ptprk appears to function in parallel with or downstream
            of Th-POK/cKrox (also known as ZBTB7B), a master regulator of T
            cell lineage decision.
REFERENCE   6  (bases 1 to 4464)
  AUTHORS   Xu,Y., Tan,L.J., Grachtchouk,V., Voorhees,J.J. and Fisher,G.J.
  TITLE     Receptor-type protein-tyrosine phosphatase-kappa regulates
            epidermal growth factor receptor function
  JOURNAL   J Biol Chem 280 (52), 42694-42700 (2005)
   PUBMED   16263724
REFERENCE   7  (bases 1 to 4464)
  AUTHORS   Wang,S.E., Wu,F.Y., Shin,I., Qu,S. and Arteaga,C.L.
  TITLE     Transforming growth factor {beta} (TGF-{beta})-Smad target gene
            protein tyrosine phosphatase receptor type kappa is required for
            TGF-{beta} function
  JOURNAL   Mol Cell Biol 25 (11), 4703-4715 (2005)
   PUBMED   15899872
REFERENCE   8  (bases 1 to 4464)
  AUTHORS   Drosopoulos,N.E., Walsh,F.S. and Doherty,P.
  TITLE     A soluble version of the receptor-like protein tyrosine phosphatase
            kappa stimulates neurite outgrowth via a Grb2/MEK1-dependent
            signaling cascade
  JOURNAL   Mol Cell Neurosci 13 (6), 441-449 (1999)
   PUBMED   10383829
REFERENCE   9  (bases 1 to 4464)
  AUTHORS   Fuchs,M., Muller,T., Lerch,M.M. and Ullrich,A.
  TITLE     Association of human protein-tyrosine phosphatase kappa with
            members of the armadillo family
  JOURNAL   J Biol Chem 271 (28), 16712-16719 (1996)
   PUBMED   8663237
REFERENCE   10 (bases 1 to 4464)
  AUTHORS   Jiang,Y.P., Wang,H., D'Eustachio,P., Musacchio,J.M.,
            Schlessinger,J. and Sap,J.
  TITLE     Cloning and characterization of R-PTP-kappa, a new member of the
            receptor protein tyrosine phosphatase family with a proteolytically
            cleaved cellular adhesion molecule-like extracellular region
  JOURNAL   Mol Cell Biol 13 (5), 2942-2951 (1993)
   PUBMED   8474452
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AB297790.1.
            
            On Oct 24, 2007 this sequence version replaced NM_001029902.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB297790.1, BR000415.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..4464
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1p12"
     gene            1..4464
                     /gene="Ptprk"
                     /gene_synonym="Rptpk"
                     /note="protein tyrosine phosphatase, receptor type, K"
                     /db_xref="GeneID:360302"
                     /db_xref="RGD:619706"
     exon            1..172
                     /gene="Ptprk"
                     /gene_synonym="Rptpk"
                     /inference="alignment:Splign:2.1.0"
     CDS             76..4395
                     /gene="Ptprk"
                     /gene_synonym="Rptpk"
                     /EC_number="3.1.3.48"
                     /note="receptor-like protein tyrosine phosphatase kappa
                     extracellular region (RPTPK); protein tyrosine
                     phosphatase, receptor type, K, extracellular region;
                     receptor-type tyrosine-protein phosphatase kappa"
                     /codon_start=1
                     /product="receptor-type tyrosine-protein phosphatase kappa
                     precursor"
                     /protein_id="NP_001025073.2"
                     /db_xref="GeneID:360302"
                     /db_xref="RGD:619706"
                     /translation="MDVAAAALPAFVALWLLSPWPLLGSVQGQFSAGGCTFDDGPGAC
                     DYHQDLYDDFEWVHVSAQEPHYLPPEMPQGSYMVVDSSNHDPGEKARLQLPTMKENDT
                     HCIDFSYLLYSQKGLNPGTLNILVRVNKGPLANPIWNVTGFTGRDWLRAELAVSTFWP
                     NEYQVIFEAEVSGGRSGYIAIDDIQVLSYPCDKSPHFLRLGDVEVNAGQNATFQCIAT
                     GRDAVHNKLWLQRRNGEDIPVAQTKNINHRRFAASFRLQEVTKTDQDLYRCVTQSERG
                     SGVSNFAQLIVREPPRPIAPPQLLGVGPTYLLIQLNANSIIGDGPIILKEVEYRMTSG
                     SWTETHAVNAPTYKLWHLDPDTEYEIRVLLTRPGEGGTGLPGPPLITRTKCAEPMRTP
                     KTLKIAEIQARRIAVDWESLGYNITRCHTFNVTICYHYFRGHNESRADCLDMDPKAPQ
                     HVVNHLPPYTNVSLKMILTNPEGRKESEETIIQTDEDVPGPVPVKSLQGTSFENKIFL
                     NWKEPLEPNGIITQYEVSYSSIRSFDPAVPVAGPPQTVSNLWNSTHHVFMHLHPGTTY
                     QFFIRASTVKGFGPATAINVTTNISAPSLPDYEGVDASLNETATTITVLLRPAQAKGA
                     PISAYQIVVEQLHPHRTKREAGTMECYRVPVTYQNSLSGGAPYYFAAELPPGNLPEPA
                     PFTVGDNRTYKGFWNPPLAPRKGYNIYFQAMSSVEKETKTQCVRIATKAAATEEPEVI
                     PDPAKQTDRVVKIAGISAGVLVFILLLLVVIVIVKKSKLAKKRKDAMGNTRQEMTHMV
                     NAMDRSYADQSTLHAEDPLSLTFMDQHNFSPRYENHSATAESSRLLDVPRYLCEGTES
                     PYQTGQLHPAIRVADLLQHINLMKTSDSYGFKEEYESFFEGQSASWDVAKKDQNRAKN
                     RYGNIIAYDHSRVILQPVEDDPSSDYINANYIDGYQRPSHYIATQGPVHETVYDFWRM
                     VWQEQSACIVMVTNLVEVGRVKCYKYWPDDTEVYGDFKVTCVEMEPLAEYVVRTFTLE
                     RRGYNEIREVKQFHFTGWPDHGVPYHATGLLSFIRRVKLSNPPSAGPIVVHCSAGAGR
                     TGCYIVIDIMLDMAEREGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAILEACLCGE
                     TAIPVCEFKAAYFDMIRIDSQTNSSHLKDEFQTLNSVTPRLQAEDCSIACLPRNHDKN
                     RFMDMLPPDRCLPFLITIDGESSNYINAALMDSYRQPAAFIVTQYPLPNTVKDFWRLV
                     YDYGCTSIVMLNEVDLSQGCPQYWPEEGMLRYGPIQVECMSCSMDCDVINRIFRICNL
                     TRPQEGYLMVQQFQYLGWASHREVPGSKRSFLKLILQVEKWQEECEEGEGRTIIHCLN
                     GGGRSGMFCAIGIVVEMVKRQNVVDVFHAVKTLRNSKPNMVEAPEQYRFCYDVALEYL
                     ESS"
     exon            173..295
                     /gene="Ptprk"
                     /gene_synonym="Rptpk"
                     /inference="alignment:Splign:2.1.0"
     exon            296..567
                     /gene="Ptprk"
                     /gene_synonym="Rptpk"
                     /inference="alignment:Splign:2.1.0"
     exon            568..649
                     /gene="Ptprk"
                     /gene_synonym="Rptpk"
                     /inference="alignment:Splign:2.1.0"
     exon            650..765
                     /gene="Ptprk"
                     /gene_synonym="Rptpk"
                     /inference="alignment:Splign:2.1.0"
     exon            766..940
                     /gene="Ptprk"
                     /gene_synonym="Rptpk"
                     /inference="alignment:Splign:2.1.0"
     exon            941..1234
                     /gene="Ptprk"
                     /gene_synonym="Rptpk"
                     /inference="alignment:Splign:2.1.0"
     exon            1235..1537
                     /gene="Ptprk"
                     /gene_synonym="Rptpk"
                     /inference="alignment:Splign:2.1.0"
     exon            1538..1647
                     /gene="Ptprk"
                     /gene_synonym="Rptpk"
                     /inference="alignment:Splign:2.1.0"
     exon            1648..1849
                     /gene="Ptprk"
                     /gene_synonym="Rptpk"
                     /inference="alignment:Splign:2.1.0"
     exon            1850..1955
                     /gene="Ptprk"
                     /gene_synonym="Rptpk"
                     /inference="alignment:Splign:2.1.0"
     exon            1956..2229
                     /gene="Ptprk"
                     /gene_synonym="Rptpk"
                     /inference="alignment:Splign:2.1.0"
     exon            2230..2266
                     /gene="Ptprk"
                     /gene_synonym="Rptpk"
                     /inference="alignment:Splign:2.1.0"
     exon            2267..2405
                     /gene="Ptprk"
                     /gene_synonym="Rptpk"
                     /inference="alignment:Splign:2.1.0"
     exon            2406..2566
                     /gene="Ptprk"
                     /gene_synonym="Rptpk"
                     /inference="alignment:Splign:2.1.0"
     exon            2567..2751
                     /gene="Ptprk"
                     /gene_synonym="Rptpk"
                     /inference="alignment:Splign:2.1.0"
     exon            2752..2839
                     /gene="Ptprk"
                     /gene_synonym="Rptpk"
                     /inference="alignment:Splign:2.1.0"
     exon            2840..2916
                     /gene="Ptprk"
                     /gene_synonym="Rptpk"
                     /inference="alignment:Splign:2.1.0"
     exon            2917..2953
                     /gene="Ptprk"
                     /gene_synonym="Rptpk"
                     /inference="alignment:Splign:2.1.0"
     exon            2954..3051
                     /gene="Ptprk"
                     /gene_synonym="Rptpk"
                     /inference="alignment:Splign:2.1.0"
     exon            3052..3168
                     /gene="Ptprk"
                     /gene_synonym="Rptpk"
                     /inference="alignment:Splign:2.1.0"
     exon            3169..3323
                     /gene="Ptprk"
                     /gene_synonym="Rptpk"
                     /inference="alignment:Splign:2.1.0"
     exon            3324..3459
                     /gene="Ptprk"
                     /gene_synonym="Rptpk"
                     /inference="alignment:Splign:2.1.0"
     exon            3460..3609
                     /gene="Ptprk"
                     /gene_synonym="Rptpk"
                     /inference="alignment:Splign:2.1.0"
     exon            3610..3783
                     /gene="Ptprk"
                     /gene_synonym="Rptpk"
                     /inference="alignment:Splign:2.1.0"
     exon            3784..3915
                     /gene="Ptprk"
                     /gene_synonym="Rptpk"
                     /inference="alignment:Splign:2.1.0"
     exon            3916..4041
                     /gene="Ptprk"
                     /gene_synonym="Rptpk"
                     /inference="alignment:Splign:2.1.0"
     exon            4042..4205
                     /gene="Ptprk"
                     /gene_synonym="Rptpk"
                     /inference="alignment:Splign:2.1.0"
     exon            4206..4341
                     /gene="Ptprk"
                     /gene_synonym="Rptpk"
                     /inference="alignment:Splign:2.1.0"
     exon            4342..4464
                     /gene="Ptprk"
                     /gene_synonym="Rptpk"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctggctgtc ggatttcgcc gcgattcccc cggaggctct ttgcaaagct gcttgaaact
       61 tctcccaaac tcgccatgga tgtggcggcg gcggcgctgc ctgcttttgt ggcgctctgg
      121 ctcctgtccc cgtggcctct cctggggtcg gtccaaggcc agttctcagc aggtggctgc
      181 acttttgatg atgggccagg ggcctgcgac taccaccagg atttatacga tgactttgag
      241 tgggtccatg tcagtgcgca ggaaccccat tacctgcccc ccgaaatgcc tcaaggttcc
      301 tatatggttg tggactcctc aaatcatgat cctggagaga aagcccgcct gcagctgcct
      361 acaatgaagg agaatgacac tcactgtatt gatttcagct acctgttgta cagccagaag
      421 ggcttgaacc cgggcacttt gaacatcctg gttagggtga ataaaggacc tctcgctaat
      481 ccaatttgga acgtgactgg attcactggt cgtgattggc ttcgggctga gctggctgtg
      541 agcacctttt ggcctaatga ataccaggta atatttgaag ctgaagtctc aggagggaga
      601 agtggttata ttgccatcga cgacatccaa gtcttgagtt atccttgcga taagtctcct
      661 catttcctcc gcctgggtga tgtggaggtc aatgcagggc agaatgctac atttcagtgc
      721 attgctacag ggagagatgc tgtacataat aagttatggc tgcagagacg caatggagaa
      781 gacatacctg tagcccagac caagaacatc aatcacagaa gatttgctgc ctctttcaga
      841 ttgcaagaag tgacaaaaac cgaccaggat ttgtaccgct gcgtaactca gtcagaacga
      901 ggttccgggg tttccaattt tgcccagctt attgtgagag aaccacctag acccatcgct
      961 cctccccagc tgcttggtgt tgggcccact tacttgctga tccaactaaa tgccaactct
     1021 attattggcg atggtcccat catcctgaaa gaagtcgagt atcgaatgac gtcaggatct
     1081 tggacggaaa cccatgccgt caatgctcca acatacaagt tatggcattt agatccagat
     1141 acagaatacg agattcgcgt cctgctcacc agacctggag aagggggaac tggactccca
     1201 ggaccaccac taatcaccag aaccaagtgt gcagaaccca tgcggacgcc aaagactttg
     1261 aagattgctg aaatccaggc aaggcgcatc gctgtggact gggagtcctt gggctacaac
     1321 atcacgcgct gccacacttt caacgtcacc atttgctacc attacttccg aggccacaat
     1381 gagagcaggg ccgactgctt ggacatggac cccaaagccc ctcaacacgt tgtaaaccat
     1441 ctgccacctt acacaaatgt cagcctcaag atgatcctaa ccaacccaga ggggaggaag
     1501 gagagcgaag agacaatcat ccagactgat gaggatgtgc ccgggcctgt gccagtcaaa
     1561 tccctccaag gaacatcctt tgaaaacaag atcttcctga actggaaaga gccattggaa
     1621 ccaaatggaa ttatcactca gtatgaggtg agctatagca gcataaggtc atttgaccct
     1681 gctgtcccag tggctgggcc cccgcagacg gtatccaatc tgtggaacag cacacaccat
     1741 gtgtttatgc atcttcaccc tgggaccacc taccagttct tcataagagc cagcaccgtc
     1801 aaaggcttcg ggccagccac agccatcaac gtgaccacaa atatctcagc cccaagctta
     1861 cctgactatg aaggcgttga tgcctctctg aatgaaactg ccaccaccat cactgtactg
     1921 ctgagacctg cacaagccaa aggtgcccca atcagtgctt atcaaattgt ggtggagcag
     1981 ctacacccac atcggaccaa gcgtgaagcc gggaccatgg aatgctaccg ggtaccggtt
     2041 acgtaccaga actccctgag tgggggcgca ccctattact ttgctgcaga actcccccct
     2101 gggaatcttc ctgagccagc tcccttcacc gtgggcgaca accggaccta taaaggcttc
     2161 tggaaccctc ccctggctcc ccgcaaagga tacaacatct atttccaagc gatgagcagc
     2221 gtggagaagg aaactaaaac ccagtgtgtg cgaattgcta caaaagcagc agcaacagaa
     2281 gaaccggaag tgatcccaga cccggcgaag cagacagaca gggtggtgaa aatcgcgggc
     2341 atcagtgctg gcgtcttagt gttcattctt ctcctcctgg ttgtcatagt gattgtgaaa
     2401 aagagcaagc tagctaagaa gcgcaaagat gcgatgggga acacacgtca ggagatgacc
     2461 cacatggtga atgctatgga ccggagttac gctgatcaga gcaccctgca tgcagaagac
     2521 cccctttccc tcaccttcat ggaccaacat aacttcagtc cgagatatga aaaccacagt
     2581 gccacagcag agtctagtcg tctcctcgat gtccctcgat acctctgtga agggacagag
     2641 tccccttacc agacaggaca gctgcaccca gccatcaggg tggccgactt actacagcac
     2701 atcaacctca tgaagacatc cgacagctat gggttcaaag aggagtatga gagcttcttt
     2761 gaaggccagt cagcctcttg ggacgtggct aaaaaggacc aaaacagagc aaagaaccga
     2821 tacggaaaca ttatcgcata cgatcactcc agagtcatct tgcagcccgt ggaggacgat
     2881 ccttcttcag attacattaa tgccaactac atcgatggct accagagacc aagccactac
     2941 attgcaactc aaggaccagt tcatgaaacc gtgtatgatt tttggagaat ggtatggcag
     3001 gagcagtcag cctgtatcgt gatggtcact aatttagtgg aagttggtcg ggtgaaatgc
     3061 tataaatatt ggcctgatga taccgaggtt tacggtgact tcaaagtcac ctgcgtagaa
     3121 atggaaccac ttgctgaata cgtagttagg acattcacct tggagaggag gggctataac
     3181 gaaatccgtg aagtcaaaca gttccacttc actggctggc ccgaccacgg tgtcccctac
     3241 cacgccacag ggctgctgtc ctttatccga agagtcaagc tgtctaaccc tcccagcgct
     3301 gggcccattg tcgtacactg cagtgcgggt gctgggcgca caggctgtta cattgttatt
     3361 gacatcatgc tggacatggc tgaaagagag ggtgtggtcg acatctacaa ctgtgtgaaa
     3421 gccttacgat ctcgccgcat caatatggtc cagacagagg agcagtacat ttttattcat
     3481 gatgccattt tagaagcctg cttatgtgga gaaactgcca tccctgtgtg cgaatttaaa
     3541 gctgcatatt ttgatatgat tcgaatagac tctcagacta actcctctca tctcaaagac
     3601 gaatttcaga ctctgaattc ggtcacccct cgactacaag ctgaagactg cagcatagca
     3661 tgcctgccaa ggaaccacga caagaaccgt ttcatggaca tgctcccacc tgacagatgt
     3721 ctgcctttct taattacaat tgatggggag agcagtaact acatcaatgc tgctcttatg
     3781 gatagctata ggcaaccggc agctttcatc gtcacacaat acccgctgcc gaacactgtg
     3841 aaagacttct ggagattagt atacgattac ggctgtacct ccattgtgat gttaaatgaa
     3901 gtggacttgt cccagggctg tccacagtac tggccagagg aagggatgct gcgatatggc
     3961 cctatccaag tggaatgcat gtcttgttca atggactgtg acgtgatcaa tcggattttt
     4021 aggatatgca acctaactag accacaagaa ggctatctga tggtacagca gttccagtac
     4081 ctaggctggg cttctcatcg agaagtgcct ggctccaaac gctcgttttt gaaactgata
     4141 ctgcaggtgg aaaaatggca ggaagaatgt gaagaaggag aaggccggac gatcatccac
     4201 tgcttgaatg gcggtgggcg cagtggcatg ttctgtgcaa taggcattgt cgtggagatg
     4261 gtgaagcggc aaaatgtggt ggatgttttc catgcagtaa agaccctgag gaacagcaag
     4321 ccaaacatgg tggaagctcc ggagcagtat cgtttctgct atgacgtggc tttggagtac
     4381 ctggagtcct catagttcgg tgatactttg cagaacatca cgtggagatc cgtctgttga
     4441 gccagcagct gttgcacctg ttcc
//
