LOCUS       NM_017269               7637 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus protein tyrosine phosphatase, receptor type, J
            (Ptprj), transcript variant 1, mRNA.
ACCESSION   NM_017269 XM_346663
VERSION     NM_017269.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 7637)
  AUTHORS   Dorofejeva,O. and Barr,A.J.
  TITLE     Defining the molecular basis of interaction between R3
            receptor-type protein tyrosine phosphatases and VE-cadherin
  JOURNAL   PLoS One 12 (9), e0184574 (2017)
   PUBMED   28926625
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7637)
  AUTHORS   Shintani,T., Higashi,S., Takeuchi,Y., Gaudio,E., Trapasso,F.,
            Fusco,A. and Noda,M.
  TITLE     The R3 receptor-like protein tyrosine phosphatase subfamily
            inhibits insulin signalling by dephosphorylating the insulin
            receptor at specific sites
  JOURNAL   J Biochem 158 (3), 235-243 (2015)
   PUBMED   26063811
REFERENCE   3  (bases 1 to 7637)
  AUTHORS   Petermann,A., Haase,D., Wetzel,A., Balavenkatraman,K.K., Tenev,T.,
            Guhrs,K.H., Friedrich,S., Nakamura,M., Mawrin,C. and Bohmer,F.D.
  TITLE     Loss of the protein-tyrosine phosphatase DEP-1/PTPRJ drives
            meningioma cell motility
  JOURNAL   Brain Pathol 21 (4), 405-418 (2011)
   PUBMED   21091576
REFERENCE   4  (bases 1 to 7637)
  AUTHORS   Omerovic,J., Clague,M.J. and Prior,I.A.
  TITLE     Phosphatome profiling reveals PTPN2, PTPRJ and PTEN as potent
            negative regulators of PKB/Akt activation in Ras-mutated cancer
            cells
  JOURNAL   Biochem J 426 (1), 65-72 (2010)
   PUBMED   19922411
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 7637)
  AUTHORS   Tarcic,G., Boguslavsky,S.K., Wakim,J., Kiuchi,T., Liu,A.,
            Reinitz,F., Nathanson,D., Takahashi,T., Mischel,P.S., Ng,T. and
            Yarden,Y.
  TITLE     An unbiased screen identifies DEP-1 tumor suppressor as a
            phosphatase controlling EGFR endocytosis
  JOURNAL   Curr Biol 19 (21), 1788-1798 (2009)
   PUBMED   19836242
REFERENCE   6  (bases 1 to 7637)
  AUTHORS   Baker,J.E., Majeti,R., Tangye,S.G. and Weiss,A.
  TITLE     Protein tyrosine phosphatase CD148-mediated inhibition of T-cell
            receptor signal transduction is associated with reduced LAT and
            phospholipase Cgamma1 phosphorylation
  JOURNAL   Mol Cell Biol 21 (7), 2393-2403 (2001)
   PUBMED   11259588
REFERENCE   7  (bases 1 to 7637)
  AUTHORS   Kovalenko,M., Denner,K., Sandstrom,J., Persson,C., Gross,S.,
            Jandt,E., Vilella,R., Bohmer,F. and Ostman,A.
  TITLE     Site-selective dephosphorylation of the platelet-derived growth
            factor beta-receptor by the receptor-like protein-tyrosine
            phosphatase DEP-1
  JOURNAL   J Biol Chem 275 (21), 16219-16226 (2000)
   PUBMED   10821867
REFERENCE   8  (bases 1 to 7637)
  AUTHORS   Tangye,S.G., Wu,J., Aversa,G., de Vries,J.E., Lanier,L.L. and
            Phillips,J.H.
  TITLE     Negative regulation of human T cell activation by the receptor-type
            protein tyrosine phosphatase CD148
  JOURNAL   J Immunol 161 (8), 3803-3807 (1998)
   PUBMED   9780142
REFERENCE   9  (bases 1 to 7637)
  AUTHORS   de la Fuente-Garcia,M.A., Nicolas,J.M., Freed,J.H., Palou,E.,
            Thomas,A.P., Vilella,R., Vives,J. and Gaya,A.
  TITLE     CD148 is a membrane protein tyrosine phosphatase present in all
            hematopoietic lineages and is involved in signal transduction on
            lymphocytes
  JOURNAL   Blood 91 (8), 2800-2809 (1998)
   PUBMED   9531590
REFERENCE   10 (bases 1 to 7637)
  AUTHORS   Borges,L.G., Seifert,R.A., Grant,F.J., Hart,C.E., Disteche,C.M.,
            Edelhoff,S., Solca,F.F., Lieberman,M.A., Lindner,V., Fischer,E.H.,
            Lok,S. and Bowen-Pope,D.F.
  TITLE     Cloning and characterization of rat density-enhanced phosphatase-1,
            a protein tyrosine phosphatase expressed by vascular cells
  JOURNAL   Circ Res 79 (3), 570-580 (1996)
   PUBMED   8781490
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Jan 4, 2022 this sequence version replaced NM_017269.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA5760386, SAMEA5760389
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            RefSeq Select criteria           :: based on expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-440               JAXUCZ010000003.1  97017217-97017656   c
            441-459             JAXUCZ010000003.1  96913084-96913102   c
            460-708             JAXUCZ010000003.1  96909140-96909388   c
            709-936             JAXUCZ010000003.1  96906972-96907199   c
            937-1149            JAXUCZ010000003.1  96905826-96906038   c
            1150-1413           JAXUCZ010000003.1  96902199-96902462   c
            1414-1671           JAXUCZ010000003.1  96900784-96901041   c
            1672-1929           JAXUCZ010000003.1  96897899-96898156   c
            1930-2205           JAXUCZ010000003.1  96896855-96897130   c
            2206-2496           JAXUCZ010000003.1  96895176-96895466   c
            2497-2628           JAXUCZ010000003.1  96892548-96892679   c
            2629-2839           JAXUCZ010000003.1  96890665-96890875   c
            2840-2964           JAXUCZ010000003.1  96890430-96890554   c
            2965-3052           JAXUCZ010000003.1  96889367-96889454   c
            3053-3094           JAXUCZ010000003.1  96886870-96886911   c
            3095-3182           JAXUCZ010000003.1  96885629-96885716   c
            3183-3273           JAXUCZ010000003.1  96884290-96884380   c
            3274-3347           JAXUCZ010000003.1  96881499-96881572   c
            3348-3482           JAXUCZ010000003.1  96881273-96881407   c
            3483-3602           JAXUCZ010000003.1  96879666-96879785   c
            3603-3763           JAXUCZ010000003.1  96869147-96869307   c
            3764-3899           JAXUCZ010000003.1  96868378-96868513   c
            3900-7637           JAXUCZ010000003.1  96861795-96865532   c
FEATURES             Location/Qualifiers
     source          1..7637
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q24"
     gene            1..7637
                     /gene="Ptprj"
                     /gene_synonym="DEP-1"
                     /note="protein tyrosine phosphatase, receptor type, J"
                     /db_xref="GeneID:29645"
                     /db_xref="RGD:3454"
     exon            1..440
                     /gene="Ptprj"
                     /gene_synonym="DEP-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             345..4058
                     /gene="Ptprj"
                     /gene_synonym="DEP-1"
                     /EC_number="3.1.3.48"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; density enhanced phosphatase-1; receptor-type
                     tyrosine-protein phosphatase eta"
                     /codon_start=1
                     /product="receptor-type tyrosine-protein phosphatase eta
                     isoform 1 precursor"
                     /protein_id="NP_058965.3"
                     /db_xref="GeneID:29645"
                     /db_xref="RGD:3454"
                     /translation="MKPAARETRTPPRSPGLRWALLPLLLLLRQGQVVCAGAAPSPVF
                     DVEAVTSPTSVVLTWKHNDSATSEYKINEGNTLRYTVKNQTSFNITGLSPATSYKFSI
                     TLGTVNETSGKPTYKNITTEPWPVSDLQVAYIGVTQALLAWSNANGTASYRMQIVELT
                     TNSSGGISDLKPGTHKSLAVQGSNETQHDLWVTEGVSDANGTEGSPVANISQLHKNSL
                     ASADPPSARDPSLTEVLLTELKPDTQYKVTIYSQAADGTEGQPGNKVFKTNPIQVSDI
                     RAVNISDSNMTLTWKSNNNESHASFTYKIYVAGGSDSINETVNETQAVIRGLSSSTLY
                     NITVLPFLGQTAGIPGFLQVYTSPRPVSDFRVTNVSLREIGLAWRSNDSESFEIFITQ
                     EGSEKRWNASTGDLSYIVENLKPGTSYQFEIFPRGPNGTEGPSQTVVGRTDCSAVTDI
                     RVVSVSTTEIQLEWQNTDSASGYTYHLVLESENGSIKTNSSQKWITVGGLTPGTLYNV
                     TIFPEVDQMEGNSSSITQYTRPSNVSYIEVNTNTTVAAIQWKNLDAASASYSYSVLIL
                     KAGDGSNVTSRVRDIPSVTIPGLIPGVSYEVKIFTKIRNTEVGNEVPGQKLFCMEPAQ
                     VDSLHCEVVPKEPALVLKWACPPGMNSGFELGVRSDAWDNMTHLENCTLDNDTECRTE
                     VTYLNFSTSYNISIATLSCGKMALPTQSTCTTGITDPPPPDGSPNITSVSHNSVKVKF
                     SGFEASHGPIKAYAVLLTTGEAGQPSTDVLKYTYEDFKKGASDTYVTYLIRIEEKGQS
                     QGLSEALNYEIDVGNQSTTLGYYNGRLEPLGSYRACVAGFTNITYNLQNDGLINGDES
                     YVSFSPYSEAVSLPQDPGVICGAVFGCIFGALAIVAVGGFIFWRKKRKDAKNNEVSFS
                     QIKSKLIRVENFEAYFKKQQADSNCGFAEEYEDLKLIGISLPKYAAEIAENRGKNRYN
                     NVLPYDISRVKLSVQTHSTDDYINANYMPGYHSKKDFIATQGPLPNTLKDFWRMVWEK
                     NVYAIVMLTKCVEQGRTKCEEYWPSKQAQDYGDITVAMTSEVVLPEWTIRDFVVKNMQ
                     SSESHPLRQFHFTSWPDHGVPDTTDLLINFRYLVRDYMKQIPPESPILVHCSAGVGRT
                     GTFIAIDRLIYQIENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLDIIRAQKD
                     SKVDLIYQNTTAMTIYENLEPVSMFGKTNGYIA"
     exon            441..459
                     /gene="Ptprj"
                     /gene_synonym="DEP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            460..708
                     /gene="Ptprj"
                     /gene_synonym="DEP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            709..936
                     /gene="Ptprj"
                     /gene_synonym="DEP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            937..1149
                     /gene="Ptprj"
                     /gene_synonym="DEP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1150..1413
                     /gene="Ptprj"
                     /gene_synonym="DEP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1414..1671
                     /gene="Ptprj"
                     /gene_synonym="DEP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1672..1929
                     /gene="Ptprj"
                     /gene_synonym="DEP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1930..2205
                     /gene="Ptprj"
                     /gene_synonym="DEP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2206..2496
                     /gene="Ptprj"
                     /gene_synonym="DEP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2497..2628
                     /gene="Ptprj"
                     /gene_synonym="DEP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2629..2839
                     /gene="Ptprj"
                     /gene_synonym="DEP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2840..2964
                     /gene="Ptprj"
                     /gene_synonym="DEP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2965..3052
                     /gene="Ptprj"
                     /gene_synonym="DEP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3053..3094
                     /gene="Ptprj"
                     /gene_synonym="DEP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3095..3182
                     /gene="Ptprj"
                     /gene_synonym="DEP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3183..3273
                     /gene="Ptprj"
                     /gene_synonym="DEP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3274..3347
                     /gene="Ptprj"
                     /gene_synonym="DEP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3348..3482
                     /gene="Ptprj"
                     /gene_synonym="DEP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3483..3602
                     /gene="Ptprj"
                     /gene_synonym="DEP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3603..3763
                     /gene="Ptprj"
                     /gene_synonym="DEP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3764..3899
                     /gene="Ptprj"
                     /gene_synonym="DEP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3900..7637
                     /gene="Ptprj"
                     /gene_synonym="DEP-1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggagccgcat gacgcgcgga ggaggcagag ggagcagccg gggccgcggg agcccggagc
       61 tggacgccac gcgcgggggg tgggcgccgc ttgctccgcc ccgcgaagcc cctgcgtgtc
      121 tagggccgcg gccgctccgc gttaggagcg ctaggctccg ccgtgtggcc gccgccgccg
      181 ccgctgccat gtccccgggg aagcccgggg cgggcggagc ggggactagg cggaccggct
      241 ggcggagaag gaggcggagg cgtcggctgg aggcggagac cagggcgccc ggcttcgggc
      301 acacggcggg gcgcgtcccg ggcacgttcc agggcgcgca gggcatgaag cccgcggcgc
      361 gggagacgcg gacacccccg cgctcgcccg ggctccgctg ggcgctgctg ccgctgctgc
      421 tgttgctacg ccagggccag gttgtgtgcg caggtgcggc gcccagtcct gtatttgacg
      481 ttgaagctgt caccagccct accagtgtgg tattaacgtg gaaacacaat gattcagcca
      541 cttcagaata taagataaat gagggaaaca cgctgcggta tactgttaaa aaccagacat
      601 catttaacat cacaggctta agcccagcta cttcctacaa attctccatc accttgggaa
      661 cagtcaatga gacctcagga aagcccacat acaaaaatat cacaacagag ccctggccag
      721 tgtcggatct ccaagtcgcc tacatcggtg tgacacaggc tcttctcgcc tggagcaatg
      781 caaacggcac cgcttcttac cggatgcaga ttgtagagct gaccacaaat tcatcaggtg
      841 gtatttcaga tctgaagccg gggacccata agagcttggc tgtccaagga tcgaatgaga
      901 cccagcatga cttatgggtc acagaaggcg tctcggatgc caatggcacc gagggaagcc
      961 cagtggccaa catatcccaa ctacataaga attctcttgc ctctgcagac ccaccctctg
     1021 cccgggatcc ctccctcaca gaggtcttgc tcactgagct aaagcctgat actcagtaca
     1081 aagtcaccat ttattctcaa gcagcagatg gcacagaagg acagcctggg aacaaagtgt
     1141 ttaaaacaaa tcccatccaa gtttctgaca tccgagctgt gaacatcagt gactcgaaca
     1201 tgaccctgac ctggaaaagc aacaataatg agtcccatgc ttcatttacc tacaaaatat
     1261 acgtggctgg gggttccgac tccatcaacg aaactgtcaa tgagactcag gccgtcatcc
     1321 gtggactcag ctccagtacc ttgtacaaca tcacagtgct tcctttcctg ggtcagaccg
     1381 cgggtatacc aggcttcctc caagtgtaca cttccccccg tcctgtttct gacttccgag
     1441 tgacaaatgt cagcctgagg gaaatcggtt tggcttggag aagcaatgac tcggagtcat
     1501 tcgagatttt catcacgcag gagggaagtg agaaacgttg gaatgcttcg acgggagacc
     1561 tgagctatat cgttgaaaat ttaaagcctg ggaccagtta ccaatttgaa atattcccac
     1621 gaggaccaaa tgggactgaa gggccatccc agacagttgt tggtagaact gactgcagtg
     1681 ctgtgactga catccgcgtg gtcagcgtta gcaccactga aatacagctg gagtggcaga
     1741 atacagacag tgcttctgga tacacttacc atttagttct agagtctgag aatggctcca
     1801 tcaagaccaa cagttctcag aaatggatca cagtgggggg ccttacccca ggcaccttat
     1861 acaatgttac aatctttcca gaagtggacc agatggaggg caactccagc tctattaccc
     1921 agtacacaag gcccagcaat gtgtcctaca ttgaagtaaa caccaacacc accgtggcag
     1981 ccatccagtg gaagaacctg gacgcagcct ctgcttccta ctcctactcc gttcttatct
     2041 tgaaggctgg agatggcagc aatgtaacca gcagggtcag agacatccct tctgtcacca
     2101 tccctgggct aatccccggc gtctcttacg aagtgaagat ctttacaaag attaggaata
     2161 cagaggttgg gaatgaggta cctggtcaga agctgttctg tatggaacct gcacaagtgg
     2221 attccttaca ctgtgaagtg gtcccgaagg agccagcgct ggttctgaag tgggcctgcc
     2281 cccctggcat gaactcaggc tttgaactgg gggtcaggag tgatgcttgg gacaatatga
     2341 cacacttgga gaactgcact ttggacaatg acacagagtg caggacagaa gtcacctatt
     2401 tgaatttttc tacctcgtac aacatcagca ttgccacctt gtcatgtgga aagatggcat
     2461 tgcccaccca gagcacctgc accactggca tcacagaccc acctcctcca gatggatccc
     2521 ctaatattac atcggtcagt cacaattcag taaaggtgaa gttcagtggt tttgaagcca
     2581 gccatggacc tatcaaagcc tatgctgtcc ttctcaccac aggggaagct ggccaaccct
     2641 ccacagatgt tttgaagtac acatatgaag atttcaaaaa gggagcctcc gatacttatg
     2701 tgacatacct cataaggata gaagagaagg gacagtctca gggcttgtct gaagcattga
     2761 actatgagat tgatgtgggg aaccaatcca ctaccctcgg ctactacaac gggaggctag
     2821 agcctctggg ctcctaccgg gcttgcgttg ctggctttac caatattacc tacaaccttc
     2881 agaacgatgg ccttattaat ggggatgaga gctatgtatc tttcagtccg tattcagagg
     2941 ccgtgtcctt gcctcaagat ccaggtgtca tctgcggagc ggtgttcgga tgtatctttg
     3001 gtgccctggc cattgtggct gtgggaggct tcatcttctg gagaaagaaa aggaaagatg
     3061 ccaagaataa tgaagtgtcc ttttctcaaa ttaaatccaa gttaatccga gtggagaatt
     3121 ttgaggccta ctttaagaaa cagcaagccg actccaactg tgggtttgca gaggaatatg
     3181 aggatctgaa gctgattgga ataagtttac ctaaatatgc agcggaaata gctgaaaaca
     3241 gggggaagaa ccgctacaac aacgtcctgc cctatgatat ttctcgagtc aaactttcag
     3301 tccagaccca ttcgacagac gactacatca atgccaacta tatgcctggc taccattcca
     3361 agaaagattt cattgccaca caaggacctt tacccaacac tttgaaagat ttttggcgta
     3421 tggtttggga gaaaaacgta tatgccattg ttatgctgac caaatgtgtg gagcagggaa
     3481 ggaccaaatg tgaagagtac tggccttcca agcaggctca ggactacggg gacataactg
     3541 tggcaatgac atcagaagtt gttcttccgg aatggaccat cagagatttt gtggtgaaaa
     3601 atatgcagag tagtgagagt catcctctgc ggcagttcca tttcacctcc tggcctgacc
     3661 atggtgttcc tgacaccacc gacctgctca tcaactttcg gtacctggtc cgggattaca
     3721 tgaagcagat cccccctgag tcaccaatcc tggtgcattg cagtgctggg gttggaagga
     3781 cgggcacttt cattgctatt gatcgcctga tctatcagat agagaacgag aacaccgtgg
     3841 atgtgtatgg cattgtctac gatcttcgga tgcacaggcc tctgatggta cagacagagg
     3901 accagtatgt tttcctcaat cagtgtgtgt tggatattat cagagcccag aaagactcaa
     3961 aagttgacct catctatcag aacacaaccg caatgacaat ctatgaaaac ctcgagccag
     4021 tgagcatgtt tggaaagact aatggttaca tcgcctagtt ccaaagcaaa cccttctgaa
     4081 gctaaccaga ccgtcacacc cacagtgaag gagaacgccc tgacggggac atgttttatg
     4141 tgtctcattt ctcaattctt tgttctgttc tgttagaact acttggaggg catggggctg
     4201 tgcatgtaaa acatggcaga taggcagttg gggctctcag gggctgtggg caggtggtgt
     4261 gtaaatcagc tgcattcctg attaccaatg ggatgggttc gctttctgtt tttctttcct
     4321 tgagaattgt ggaaaaccag gaaaagtgag ctatgttttt gttttccaag caggtttgtt
     4381 ctcctctctt tctattcctc ccccttctct ctctccctcc cctgcctctc tctgtttttt
     4441 tttaagactt ttatatgatt cacatgctaa agccaggatt atgttgggtt ggatatattt
     4501 taagtatcag aggtctattt ttacctactg tatctcggaa tctagccgat ggaaaagcat
     4561 ggctgtgggt gtttctcatg cagggagggg cacccggtgc ctcttctgcg tgggtttcta
     4621 tttgaacatg tgccttttct gaattatgct tccacgggca aaactcagta gatatctcta
     4681 tttttatatt gaatctcaga attggaatat acagaatatt taaacagtag cttagtatca
     4741 gaggttcgcc tcctcagtaa cattcctgtc ccatcccatt agaggaggct ttctctgcgg
     4801 cccgcccttg acacacattt gtgctccatg ttccttttcc ttcctttctt tttttttttc
     4861 tcccctccca gttttcgcca aagaacttct gttggtgaga ttttcatccc attggttggg
     4921 tgagaataga agtttaaaat atcaccatga gactctctgt gggtgggagt ggggaggaac
     4981 agaggaatca acataccatg gtgtgtgcac cccttttcat cccatctcct atgttctctc
     5041 atttctgtct ttggtaagaa ggattttttt aaaggtgcaa tatgtgacgt agtggttcac
     5101 gatgctctgg gttcttagta atgttttact caggttgtca tttatgtgtg tatgtgtgtg
     5161 tgtgtgtgtg tgtgtgtgtg tgtgtgtgta tgtatgtatg tatgtgtgtt ttatagcgtg
     5221 gtgatctgtg aacatttcag tgtgaactca gattaacccc tttcccccca aagtccactg
     5281 gctttagtct ctctgcagtg acacacatca gtatctactg tatatataaa tactaaactc
     5341 ttacacacca gtcattccta tgaattgagg tgtacaaagt ttgatttgta tcaaagatgt
     5401 aattattatt tttaaaacct ctttcactac actgctgctg taattacttt gaatttttaa
     5461 agaaaaatgt agattttttt tgttttgttt ttggcttcag gtgtgtattc accaagagtt
     5521 tcagaattta tgtggtttta ttttattggt acataatctg caaacttctc aaggcattaa
     5581 catgacaaga tttgtatctc ttatttttat cttgtggctc aggttatatt tgaagaagtt
     5641 tcaagtttat tttctagtag gcagtgaagt atacataagg tcaatgaagg aatcaccagg
     5701 tccctggagt cctgtggctg ttttccacag ttacacatcc tgctgtatgt ttgggaccat
     5761 gggtattgtg ttgaagatga gggcaggggt cttctccgag gacctggcca ctgtgagccc
     5821 tggggtaacc tgtcctctga tgttctgcac tctgttcctc gagtcaccgg cactttgatg
     5881 gctgactgga cctgatcatg agtgtttgta gggttagaga ggctgaacca tgatgtactg
     5941 aaagccctcg ctgtggttca gcactgtagt gtgcgattct tgctgtgacc cagcgctgct
     6001 gtagcactgt tgctgccgtg gctcggcgct ggggcacaac ccctttccct ttgcggtact
     6061 gaaaggattg aaagaagagg tcatggcgct gtcatgctct gggggagaat tttacttctc
     6121 acatggaaac tgcacttttt gctaaatcct ttgcattttg atgttcactt agtgtccagc
     6181 cctttaggat gggctggcca gggtaggttg gccccctgga ctcaacttca ctggggaact
     6241 tgacgctgca gttgtgaatc agggaagcca tgctgtctcc aggtatgggg tgaagctgaa
     6301 catgggctca ttatttccaa atgccctgtc tggtctgctc actaggatgt gctgactttg
     6361 ggcactatac agaggggcct gttctggcag tagttctgtg caccgcctat acacctcagt
     6421 ctgtcaggaa cggttgtagt gggtggtaag gggtccaatc ccacgcagcg cctatgccct
     6481 gcctctgctg ccatggaaag tgcgaggaaa ggacccgccc ctaaaacagc cctgtagaag
     6541 attagagtcc ctcaaaaaaa aaaaagcaac agaatcatga acacatcata tacaattgca
     6601 aaacacagaa accttctcca ctcctacctg tatgggtcta gaaagtcatt aggcatcagc
     6661 cccagcaagc cattcccagt cccaagagga aggctagtga caggtctgga gttccaaatg
     6721 ggcaggtcac aagaagctca ccatgccatt ctacatccgg aggaggactg cgtggtggag
     6781 tttgcatagc aaagccattg gaaagggaaa attgacaaca gagggtaagg ttgggcagag
     6841 agagggggaa ggtccttctc actgtttgcc ccaagccctc agtggaactg tgaatgaaag
     6901 ttggaggagt ctggtgaaat cggaatgatg gaactccctg ctcagatccg atggcagcac
     6961 cgagaaaagc agccagtgtg gggtgtggtc agtgaaaggg ctacagactg gtggccaact
     7021 gctttgaagg acttaggcca ttgactgatg acttctaagg agaaagattt ttccaccaga
     7081 gctgaatcta gcaacaattg gcaccactgg gtgtctgttc tctgaggcca ttttgccatc
     7141 tccagccaga ctttggcaca atggacctgc tggctttgtg ctttgtgaag ttggaggctc
     7201 tggggggtgg gagtggggag gagtggggga gggtcaacta tgcagttggt tcattcatac
     7261 ttgttttctg ggatggagaa gcctgggttt tttgtttgtt tgtttgtttt tttgcaatgc
     7321 ttgattgcgg cttgttgagc taaacaagcc tggagactga agctgattca cctcaaaaca
     7381 aagttggaat tctgcatttt ccagattgct gtgtagcaac tgtgtattca acacctgtag
     7441 ctttttctcc ctggggcaca gaatagaagt tgatgtggac tctaaactgt acttttcttg
     7501 taactatttt ggaatgatgc acatttctaa tgtctgttgt acttgtacag agtattgatg
     7561 taggttgctt ttttttttaa aggaaaaatg gcctgaaaaa ctttttttaa agacttacaa
     7621 ataccaaata taaaata
//
