LOCUS       NM_001191945            3407 bp    mRNA    linear   ROD 28-MAR-2020
DEFINITION  Rattus norvegicus protein tyrosine phosphatase, receptor type, H
            (Ptprh), mRNA.
ACCESSION   NM_001191945 XM_574357
VERSION     NM_001191945.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3407)
  AUTHORS   Dorofejeva O and Barr AJ.
  TITLE     Defining the molecular basis of interaction between R3
            receptor-type protein tyrosine phosphatases and VE-cadherin
  JOURNAL   PLoS ONE 12 (9), e0184574 (2017)
   PUBMED   28926625
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3407)
  AUTHORS   Shintani T, Higashi S, Takeuchi Y, Gaudio E, Trapasso F, Fusco A
            and Noda M.
  TITLE     The R3 receptor-like protein tyrosine phosphatase subfamily
            inhibits insulin signalling by dephosphorylating the insulin
            receptor at specific sites
  JOURNAL   J. Biochem. 158 (3), 235-243 (2015)
   PUBMED   26063811
REFERENCE   3  (bases 1 to 3407)
  AUTHORS   Murata Y, Kotani T, Supriatna Y, Kitamura Y, Imada S, Kawahara K,
            Nishio M, Daniwijaya EW, Sadakata H, Kusakari S, Mori M, Kanazawa
            Y, Saito Y, Okawa K, Takeda-Morishita M, Okazawa H, Ohnishi H,
            Azuma T, Suzuki A and Matozaki T.
  TITLE     Protein tyrosine phosphatase SAP-1 protects against colitis through
            regulation of CEACAM20 in the intestinal epithelium
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 112 (31), E4264-E4271 (2015)
   PUBMED   26195794
REFERENCE   4  (bases 1 to 3407)
  AUTHORS   Sadakata H, Okazawa H, Sato T, Supriatna Y, Ohnishi H, Kusakari S,
            Murata Y, Ito T, Nishiyama U, Minegishi T, Harada A and Matozaki T.
  TITLE     SAP-1 is a microvillus-specific protein tyrosine phosphatase that
            modulates intestinal tumorigenesis
  JOURNAL   Genes Cells 14 (3), 295-308 (2009)
   PUBMED   19170756
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC097997.7.
            
            [WARNING] On Mar 31, 2024 this sequence was replaced by
            NM_001191945.2.
            
            On Jul 17, 2010 this sequence version replaced XM_574357.3.
            
            Summary: may act as a protein tyrosine phosphatase [RGD, Feb 2006].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed/partial sample support SAMEA2689601,
                              SAMN02642676 [ECO:0000350]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-51                AC097997.7         165788-165838
            52-85               AC097997.7         166747-166780
            86-196              AC097997.7         167159-167269
            197-463             AC097997.7         177949-178215
            464-730             AC097997.7         181135-181401
            731-997             AC097997.7         188004-188270
            998-1264            AC097997.7         193088-193354
            1265-1543           AC097997.7         196644-196922
            1544-1810           AC097997.7         200999-201265
            1811-1889           AC097997.7         204702-204780
            1890-1937           AC097997.7         204893-204940
            1938-2028           AC097997.7         208379-208469
            2029-2119           AC097997.7         209256-209346
            2120-2196           AC097997.7         210693-210769
            2197-2331           AC097997.7         210878-211012
            2332-2454           AC097997.7         212306-212428
            2455-2615           AC097997.7         212561-212721
            2616-2751           AC097997.7         213526-213661
            2752-3407           AC097997.7         213749-214404
FEATURES             Location/Qualifiers
     source          1..3407
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="mixed"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q12"
     gene            1..3407
                     /gene="Ptprh"
                     /gene_synonym="Bem2"
                     /note="protein tyrosine phosphatase, receptor type, H"
                     /db_xref="GeneID:171125"
                     /db_xref="RGD:620553"
     CDS             1..2916
                     /gene="Ptprh"
                     /gene_synonym="Bem2"
                     /EC_number="3.1.3.48"
                     /note="receptor-type tyrosine-protein phosphatase H;
                     brain-enriched membrane-associated protein tyrosine BEM-2"
                     /codon_start=1
                     /product="receptor-type tyrosine-protein phosphatase H
                     precursor"
                     /protein_id="NP_001178874.1"
                     /db_xref="GeneID:171125"
                     /db_xref="RGD:620553"
                     /translation="MARAGGNCGVWGSLVLLGLCGCSVVRTAGTRVTVDRLAPASSYE
                     FSVWAEKDGVSGSPQTLIATTAPNPVRNLRVEGQNTTSISLSWDPPENSSSQDLTYWA
                     QCIRYDGQNETRHTKDTRVTVDGLDPGTSYECSVRVEKDGVYSTWETKNTTTAPNPVR
                     NLRVEGQNTTSISLSWDPPENSSSQDLTYWAQCIRYDGQNETRHTKDTRVSVDGLDPG
                     TSYECSVRVEKDGVYSTWETKNTTTAPNPVRNLRVEGQNTTAISLSWDPPENSSSQDL
                     TYWAQCIGYDGKNETRHTKDTRVTVDGLDPGTSYECSVRVEKDGVYSTWETKNTTTAP
                     NPVRNLRVEGQNTTAISLSWDPPENSSSQDLTYWAQCIGYDGKNETRHTKDTRVTVDG
                     LDPGTSYECSVRVEKDGVYSTWETKNTTTVPISAPNPVRNLRVEGQNTTSISLSWDPP
                     ENSSSQDLTYWAQCIRYDGQNETRHTKDTRVSVDGLDPGTSYECSVRVEKDGVYSTWE
                     TKNTTTVPAAVNITSCISTSGGYGIILTWSCPSGSYETFEVEVGRKWSSQNGSLCGKG
                     MTVLDLEPAQSYTATVTTVSNSLKVQSAPATCRTESTAVIAGAIVGILLLFILVGLLI
                     VFLKRRRKKQQPKEVPKDLVFRFPGDILAKDFADHVRENEKDSNCGFAEEYQQLALEG
                     QGQSQMTALALENVSKNRYRNVLPYDWSRVPLQPLHEEPGSDYINASFMPGLWSPKEF
                     IATQGPLPHTVSDFWRMVWEQQSHTLVMLANCMESGQVKCEHYWPLDAQPCTHGQLQV
                     TLVSEEVTENWTVRHLQLFHMKEQQTLSVRQFHYVAWPDHGVPYSPDPLLAFQKLLRQ
                     WLDQTMDGGPPIVHCSAGVGRTGTLIALDVLLRQLECEGLVDPFSFVKKMRESRPLMV
                     QTEAQYVFLHQCILRSLQKPDPALPAKEATYENVASLVYENASAIRAHESEVSASGC"
     exon            1..51
                     /gene="Ptprh"
                     /gene_synonym="Bem2"
                     /inference="alignment:Splign:2.0.8"
     exon            52..85
                     /gene="Ptprh"
                     /gene_synonym="Bem2"
                     /inference="alignment:Splign:2.0.8"
     exon            86..196
                     /gene="Ptprh"
                     /gene_synonym="Bem2"
                     /inference="alignment:Splign:2.0.8"
     exon            197..463
                     /gene="Ptprh"
                     /gene_synonym="Bem2"
                     /inference="alignment:Splign:2.0.8"
     exon            464..730
                     /gene="Ptprh"
                     /gene_synonym="Bem2"
                     /inference="alignment:Splign:2.0.8"
     exon            731..997
                     /gene="Ptprh"
                     /gene_synonym="Bem2"
                     /inference="alignment:Splign:2.0.8"
     exon            998..1264
                     /gene="Ptprh"
                     /gene_synonym="Bem2"
                     /inference="alignment:Splign:2.0.8"
     exon            1265..1543
                     /gene="Ptprh"
                     /gene_synonym="Bem2"
                     /inference="alignment:Splign:2.0.8"
     exon            1544..1810
                     /gene="Ptprh"
                     /gene_synonym="Bem2"
                     /inference="alignment:Splign:2.0.8"
     exon            1811..1889
                     /gene="Ptprh"
                     /gene_synonym="Bem2"
                     /inference="alignment:Splign:2.0.8"
     exon            1890..1937
                     /gene="Ptprh"
                     /gene_synonym="Bem2"
                     /inference="alignment:Splign:2.0.8"
     exon            1938..2028
                     /gene="Ptprh"
                     /gene_synonym="Bem2"
                     /inference="alignment:Splign:2.0.8"
     exon            2029..2119
                     /gene="Ptprh"
                     /gene_synonym="Bem2"
                     /inference="alignment:Splign:2.0.8"
     exon            2120..2196
                     /gene="Ptprh"
                     /gene_synonym="Bem2"
                     /inference="alignment:Splign:2.0.8"
     exon            2197..2331
                     /gene="Ptprh"
                     /gene_synonym="Bem2"
                     /inference="alignment:Splign:2.0.8"
     exon            2332..2454
                     /gene="Ptprh"
                     /gene_synonym="Bem2"
                     /inference="alignment:Splign:2.0.8"
     exon            2455..2615
                     /gene="Ptprh"
                     /gene_synonym="Bem2"
                     /inference="alignment:Splign:2.0.8"
     exon            2616..2751
                     /gene="Ptprh"
                     /gene_synonym="Bem2"
                     /inference="alignment:Splign:2.0.8"
     exon            2752..3407
                     /gene="Ptprh"
                     /gene_synonym="Bem2"
                     /inference="alignment:Splign:2.0.8"
ORIGIN      
        1 atggccagag ctggtgggaa ctgtggggtt tgggggagct tggtgctatt gggtttgtgt
       61 ggttgttctg tggtccggac ggctggcacc agggtcacag tggatagact tgctcctgcc
      121 tcatcctatg aattttccgt gtgggcagag aaagatggag tcagcggctc cccacagacg
      181 ctcatagcca ccacagctcc aaacccagtg agaaacctga gggtcgaagg tcagaacacg
      241 acctccatca gcctgagctg ggaccctcct gagaactcct cctcgcagga cctcacctac
      301 tgggcgcagt gcatcagata tgatggtcaa aatgagaccc ggcatacaaa agacaccaga
      361 gtcactgtgg atggacttga tcctgggact tcatatgaat gctctgtgag agtggagaag
      421 gatggcgtct acagcacttg ggagacaaaa aataccacaa cagctccaaa cccagtgaga
      481 aacctgaggg tcgaaggtca gaacacgacc tccatcagcc tgagctggga ccctcctgag
      541 aactcctcct cgcaggacct cacctactgg gcgcagtgca tcagatatga tggtcaaaat
      601 gagacccggc atacaaaaga caccagagtc tctgtggatg gacttgatcc tgggacttca
      661 tatgaatgct ctgtgagagt ggagaaggat ggcgtctaca gcacttggga gacaaaaaat
      721 accacaacag ctccaaaccc agtgagaaac ctgagggtcg aaggtcagaa caccaccgcc
      781 atcagcctga gctgggaccc tcctgagaac tcctcctcgc aggacctcac ctactgggcg
      841 cagtgcatcg gatatgatgg caaaaatgag acccggcata caaaagacac cagagtcact
      901 gtggatggac ttgatcctgg gacttcatat gaatgctctg tgagagtgga gaaggatggc
      961 gtctacagca cttgggagac aaaaaatacc acaacagctc caaacccagt gagaaacctg
     1021 agggtcgaag gtcagaacac caccgccatc agcctgagct gggaccctcc tgagaactcc
     1081 tcctcgcagg acctcaccta ctgggcgcag tgcatcggat atgatggcaa aaatgagacc
     1141 cggcatacaa aagacaccag agtcacggtg gatggacttg atcctgggac ttcatatgaa
     1201 tgctctgtga gagtggagaa ggatggagtc tacagcactt gggagacaaa aaataccaca
     1261 acagtcccca tttcagctcc aaacccagtg agaaacctga gggtcgaagg tcagaacacg
     1321 acctccatca gcctgagctg ggaccctcct gagaactcct cctcgcagga cctcacctac
     1381 tgggcgcagt gcatcagata tgatggtcaa aatgagaccc ggcatacaaa agacaccaga
     1441 gtctctgtgg atggacttga tcctgggact tcatatgaat gctctgtgag agtggagaag
     1501 gatggcgtct acagcacttg ggagacaaaa aataccacaa cagtaccagc tgctgtcaac
     1561 atcacatcct gcatcagcac ttctgggggt tatgggatca tcctgacctg gtcctgccca
     1621 tctgggagtt atgagacctt tgaggtggaa gtgggcagga agtggagctc ccaaaatgga
     1681 tctttgtgtg ggaagggcat gaccgtgtta gatcttgagc cagctcagtc ctatacagct
     1741 accgtcacga ctgtctctaa tagcctgaag gtccagtctg cccctgcaac ctgccgcaca
     1801 gagagtacag ccgtcattgc tggagccatt gtaggcatcc tcctgctttt catcctggtg
     1861 ggcctgctca ttgtcttcct gaagaggagg agaaagaagc agcagccaaa ggaagtgccc
     1921 aaggatctgg tgttccgctt cccaggggat atcctggcca aagactttgc tgaccatgtc
     1981 agggagaatg aaaaggacag caactgtgga tttgctgagg agtaccagca attggctctg
     2041 gagggccaag gccagtctca gatgacagca ttggctctag agaatgtatc caagaaccgc
     2101 tacaggaatg tgctgcccta tgactggtcc cgggttcccc tgcagcccct ccatgaggaa
     2161 ccaggctcag actacatcaa cgccagtttt atgcctggtc tctggagccc caaggagttc
     2221 attgcaaccc agggtcccct gcctcacact gtgagtgact tctggcgaat ggtgtgggaa
     2281 cagcagagcc acaccctggt catgctggcc aactgcatgg agtctggaca ggtgaagtgt
     2341 gagcattact ggcccctgga tgctcagccc tgcactcatg gccagctgca ggtgacgctg
     2401 gttagtgagg aggtgacaga gaactggaca gtgaggcatc ttcagctctt ccatatgaaa
     2461 gaacagcaga ctctctctgt gcgccaattc cactacgtgg cctggccaga tcacggagtt
     2521 ccttactccc cagacccctt gctggctttc caaaagttgc ttcggcaatg gttggatcag
     2581 accatggatg gaggtccgcc cattgtgcat tgcagtgctg gtgtgggccg gacgggcacc
     2641 ctcattgcac tggatgtcct gctgcggcag ctggagtgtg aggggctggt ggatcccttc
     2701 agctttgtga agaagatgag agagagccgg ccattgatgg tgcagacaga ggcccagtat
     2761 gtgtttctac atcagtgcat cttgagatcc ctccagaagc cagatccagc cctccctgca
     2821 aaggaggcaa cctatgagaa cgtggcaagc ttagtttatg agaatgcatc cgccatcagg
     2881 gcccatgagt ctgaggtctc agcttctggg tgctgaacct agacaaagca atactcaggc
     2941 ctggtctggg cctgtgctgg agcccagata cctggacctc caagtgaact gaggattgga
     3001 gtcctagcct cctcaaccct tgggaggaag cactgaaaac ccatctctgt tgtccaaggg
     3061 caggaaggac tgatgtactt caacttgtga gccctgcctg agagctggaa cctgagaaca
     3121 ggggtgacgg taggtttcct gttctttgag tggaaacagc tacagcctgg gtaggcaggc
     3181 tctcaaagaa acaggctgga acctggattc aaaagaagga atcagggtct tgaattctac
     3241 tacctgaaga gcaaaggcag gcgggtacct gccccttttt acttcagaaa ccaaatcagt
     3301 ctcctttaat ccaaggctga agggagtccc tttgcttgtg gtctccttgt gccccatgtc
     3361 tgtacatttt ttccttctgt ataatttatt aaactcttct ccccgaa
//
