LOCUS       NM_019249               6539 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus protein tyrosine phosphatase, receptor type, F
            (Ptprf), mRNA.
ACCESSION   NM_019249 XM_346987
VERSION     NM_019249.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6539)
  AUTHORS   Dyck,S., Kataria,H., Akbari-Kelachayeh,K., Silver,J. and
            Karimi-Abdolrezaee,S.
  TITLE     LAR and PTPsigma receptors are negative regulators of
            oligodendrogenesis and oligodendrocyte integrity in spinal cord
            injury
  JOURNAL   Glia 67 (1), 125-145 (2019)
   PUBMED   30394599
  REMARK    GeneRIF: In a spinal cord injury model, blocking LAR and PTPalpha
            receptors promotes oligodendrogenesis.
REFERENCE   2  (bases 1 to 6539)
  AUTHORS   Shijo,T., Warita,H., Suzuki,N., Kitajima,Y., Ikeda,K., Akiyama,T.,
            Ono,H., Mitsuzawa,S., Nishiyama,A., Izumi,R. and Aoki,M.
  TITLE     Aberrant astrocytic expression of chondroitin sulfate proteoglycan
            receptors in a rat model of amyotrophic lateral sclerosis
  JOURNAL   J Neurosci Res 96 (2), 222-233 (2018)
   PUBMED   28752900
  REMARK    GeneRIF: This study showed that astrocytes aberrantly and
            progressively expressed PTPsigma and LAR at the site of motor
            neuron degeneration in Tg ALS model rats with mutant SOD1.
REFERENCE   3  (bases 1 to 6539)
  AUTHORS   Choi,Y., Nam,J., Whitcomb,D.J., Song,Y.S., Kim,D., Jeon,S.,
            Um,J.W., Lee,S.G., Woo,J., Kwon,S.K., Li,Y., Mah,W., Kim,H.M.,
            Ko,J., Cho,K. and Kim,E.
  TITLE     SALM5 trans-synaptically interacts with LAR-RPTPs in a
            splicing-dependent manner to regulate synapse development
  JOURNAL   Sci Rep 6, 26676 (2016)
   PUBMED   27225731
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6539)
  AUTHORS   Li,Y., Zhang,P., Choi,T.Y., Park,S.K., Park,H., Lee,E.J., Lee,D.,
            Roh,J.D., Mah,W., Kim,R., Kim,Y., Kwon,H., Bae,Y.C., Choi,S.Y.,
            Craig,A.M. and Kim,E.
  TITLE     Splicing-Dependent Trans-synaptic SALM3-LAR-RPTP Interactions
            Regulate Excitatory Synapse Development and Locomotion
  JOURNAL   Cell Rep 12 (10), 1618-1630 (2015)
   PUBMED   26321637
REFERENCE   5  (bases 1 to 6539)
  AUTHORS   Song,Y.S., Lee,H.J., Prosselkov,P., Itohara,S. and Kim,E.
  TITLE     Trans-induced cis interaction in the tripartite NGL-1, netrin-G1
            and LAR adhesion complex promotes development of excitatory
            synapses
  JOURNAL   J Cell Sci 126 (Pt 21), 4926-4938 (2013)
   PUBMED   23986473
REFERENCE   6  (bases 1 to 6539)
  AUTHORS   Ahmad,F. and Goldstein,B.J.
  TITLE     Increased abundance of specific skeletal muscle protein-tyrosine
            phosphatases in a genetic model of insulin-resistant obesity and
            diabetes mellitus
  JOURNAL   Metabolism 44 (9), 1175-1184 (1995)
   PUBMED   7666792
REFERENCE   7  (bases 1 to 6539)
  AUTHORS   Ahmad,F., Considine,R.V. and Goldstein,B.J.
  TITLE     Increased abundance of the receptor-type protein-tyrosine
            phosphatase LAR accounts for the elevated insulin receptor
            dephosphorylating activity in adipose tissue of obese human
            subjects
  JOURNAL   J Clin Invest 95 (6), 2806-2812 (1995)
   PUBMED   7769120
REFERENCE   8  (bases 1 to 6539)
  AUTHORS   Ahmad,F. and Goldstein,B.J.
  TITLE     Purification, identification and subcellular distribution of three
            predominant protein-tyrosine phosphatase enzymes in skeletal muscle
            tissue
  JOURNAL   Biochim Biophys Acta 1248 (1), 57-69 (1995)
   PUBMED   7711057
REFERENCE   9  (bases 1 to 6539)
  AUTHORS   Pot,D.A., Woodford,T.A., Remboutsika,E., Haun,R.S. and Dixon,J.E.
  TITLE     Cloning, bacterial expression, purification, and characterization
            of the cytoplasmic domain of rat LAR, a receptor-like protein
            tyrosine phosphatase
  JOURNAL   J Biol Chem 266 (29), 19688-19696 (1991)
   PUBMED   1918076
REFERENCE   10 (bases 1 to 6539)
  AUTHORS   Streuli,M., Krueger,N.X., Hall,L.R., Schlossman,S.F. and Saito,H.
  TITLE     A new member of the immunoglobulin superfamily that has a
            cytoplasmic region homologous to the leukocyte common antigen
  JOURNAL   J Exp Med 168 (5), 1523-1530 (1988)
   PUBMED   2972792
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Nov 26, 2020 this sequence version replaced NM_019249.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L11586.1, SRR26643299.23920.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-111               JAXUCZ010000005.1  137095316-137095426 c
            112-257             JAXUCZ010000005.1  137087255-137087400 c
            258-399             JAXUCZ010000005.1  137086942-137087083 c
            400-588             JAXUCZ010000005.1  137074901-137075089 c
            589-699             JAXUCZ010000005.1  137066584-137066694 c
            700-969             JAXUCZ010000005.1  137056469-137056738 c
            970-1551            JAXUCZ010000005.1  137054602-137055183 c
            1552-1688           JAXUCZ010000005.1  137054243-137054379 c
            1689-1833           JAXUCZ010000005.1  137053623-137053767 c
            1834-2139           JAXUCZ010000005.1  137049945-137050250 c
            2140-2333           JAXUCZ010000005.1  137049152-137049345 c
            2334-2451           JAXUCZ010000005.1  137045007-137045124 c
            2452-3030           JAXUCZ010000005.1  137044353-137044931 c
            3031-3128           JAXUCZ010000005.1  137043586-137043683 c
            3129-3382           JAXUCZ010000005.1  137043147-137043400 c
            3383-3476           JAXUCZ010000005.1  137042968-137043061 c
            3477-3695           JAXUCZ010000005.1  137042165-137042383 c
            3696-3850           JAXUCZ010000005.1  137041639-137041793 c
            3851-3966           JAXUCZ010000005.1  137039093-137039208 c
            3967-4064           JAXUCZ010000005.1  137035917-137036014 c
            4065-4188           JAXUCZ010000005.1  137032859-137032982 c
            4189-4364           JAXUCZ010000005.1  137032561-137032736 c
            4365-4484           JAXUCZ010000005.1  137031787-137031906 c
            4485-4639           JAXUCZ010000005.1  137031401-137031555 c
            4640-4925           JAXUCZ010000005.1  137031039-137031324 c
            4926-5104           JAXUCZ010000005.1  137030760-137030938 c
            5105-5231           JAXUCZ010000005.1  137030412-137030538 c
            5232-5357           JAXUCZ010000005.1  137030057-137030182 c
            5358-5512           JAXUCZ010000005.1  137029744-137029898 c
            5513-5648           JAXUCZ010000005.1  137029514-137029649 c
            5649-6539           JAXUCZ010000005.1  137028149-137029039 c
FEATURES             Location/Qualifiers
     source          1..6539
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..6539
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /note="protein tyrosine phosphatase, receptor type, F"
                     /db_xref="GeneID:360406"
                     /db_xref="RGD:3453"
     exon            1..111
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /inference="alignment:Splign:2.1.0"
     CDS             21..5717
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /EC_number="3.1.3.48"
                     /note="receptor-type tyrosine-protein phosphatase F;
                     leukocyte antigen-related (LAR) PTP receptor; leukocyte
                     common antigen related"
                     /codon_start=1
                     /product="receptor-type tyrosine-protein phosphatase F
                     precursor"
                     /protein_id="NP_062122.2"
                     /db_xref="GeneID:360406"
                     /db_xref="RGD:3453"
                     /translation="MAPEPAPGRRMVPLVPALVMLGLMAGAHGDSKPVFVKVPEDQIG
                     LSGGVASFVCQATGEPKPRITWMKKGKKVSSQRFEVIEFDDGAGSVLRIQPLRVQRDE
                     AIYECTATNSLGEINTSAKLSVLEEDQLPSGFPTIDMGPQLKVVEKARTATMLCAAGG
                     NPDPEISWFKDFLPVDPASSNGRIKQLRSGALQIESSEESDQGKYECVATNSAGTRYS
                     APANLYVRVRRVAPRFSIPPSSQEVMPGGNVNLTCVAVGAPMPYVKWMMGAEELTKED
                     EMPVGRNVLELSNVMRSANYTCVAISSLGMIEATAQVTVKALPKPPIDLVVTETTATS
                     VTLTWDSGNTEPVSFYGIQYRAAGTDGPFQEVDGVASTRYSIGGLSPFSEYAFRVLAV
                     NSIGRGPPSEAVRARTGEQAPSSPPRRVQARMLSASTMLVQWEPPEEPNGLVRGYRVY
                     YTPDSRRPLSAWHKHNTDAGLLTTVGSLLPGITYSLRVLAFTAVGDGPPSPTIQVKTQ
                     QGVPAQPADFQAKAESDTRIQLSWLLPPQERIIKYELVYWAAEDEGQQHKVTFDPTSS
                     YTLEDLKPDTLYHFQLAARSDLGVGVFTPTVEARTAQSTPSAPPQKVTCVSTGSTTVR
                     VSWVPPPADSRNGIITQYSVAYEAVDGEDRKRHVVDGISREHSSWDLLGLEKWTEYRV
                     WVRAHTDVGPGPESSPVLVRTDEDVPSGPPRKVEVEPLNSTAVHVSWKLPVPNKQHGQ
                     IRGYQVTYVRLENGEPRGQPIIQDVMLAEAQETTISGLTPETTYSITVAAYTTKGDGA
                     RSKPKVVTTTGAVPGRPTMMVSTTAMHTALLQWHPPKELPGELLGYRLQYRRADEARP
                     NTIDFGKDDQHFTVTGLHKGATYIFRLAAKNRAGPGEEFEKEITTPEDAPSGFPQNLR
                     VTGLTTSTTELAWDPPVLAERNGRITNYTVVYRDINSQHELQNVTGDVHLTLLGLKPD
                     TTYDIKVRAHTSKGAGPLSPSIQSQTMPMEQVFAKNFRVAAAMKTSVLLSWEVPDSYK
                     SAVPFKILYNGQSVEVDGHSMRKLIADLQPNTEYSFVLMNRGSSAGGLQHLVSIRTAP
                     DLLPQKPLPASAFIEDGRFSLSMPQVQDPSLVRWFYIVVVPIDRVGGNLLAPRWSTPE
                     ELELDELLEAIEQGEEKQRRRRRQAERLKPYVAAQVDELPETFTLGDKKNYRGFYNRP
                     LSPDLSYQCFVLASLKEPMDQKRYASSPYSDEIVVQVTPAQQQEEPEMLWVTGPVLAV
                     ILIILIVIAILLFKRKRTHSPSSKDEQSIGLKDSLLAHSSDPVEMRRLNYQTPGMRDH
                     PPIPITDLADNIERLKANDGLKFSQEYESIDPGQQFTWENSNSEVNKPKNRYANVIAY
                     DHSRVLLTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLPETMGDFWRMVWEQRTAT
                     VVMMTRLEEKSRVKCDQYWPARGTETYGLIQVTLVDTVELATYTMRTFALHKSGSSEK
                     RELRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPLDAGPMVVHCSAGVGRTGCFIVI
                     DAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAAMCGHTEVLARN
                     LYAHIQKLGQVPPGESVTAMELEFKLLANSKAHTSRFISANLPCNKFKNRLVNIMPYE
                     LTRVCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTII
                     VMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSR
                     TIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEQFGQDGPITVHCSAGVGRTGVFIT
                     LSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYLGSFDHYAT"
     exon            112..257
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /inference="alignment:Splign:2.1.0"
     exon            258..399
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /inference="alignment:Splign:2.1.0"
     exon            400..588
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /inference="alignment:Splign:2.1.0"
     exon            589..699
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /inference="alignment:Splign:2.1.0"
     exon            700..969
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /inference="alignment:Splign:2.1.0"
     exon            970..1551
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /inference="alignment:Splign:2.1.0"
     exon            1552..1688
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /inference="alignment:Splign:2.1.0"
     exon            1689..1833
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /inference="alignment:Splign:2.1.0"
     exon            1834..2139
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /inference="alignment:Splign:2.1.0"
     exon            2140..2333
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /inference="alignment:Splign:2.1.0"
     exon            2334..2451
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /inference="alignment:Splign:2.1.0"
     exon            2452..3030
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /inference="alignment:Splign:2.1.0"
     exon            3031..3128
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /inference="alignment:Splign:2.1.0"
     exon            3129..3382
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /inference="alignment:Splign:2.1.0"
     exon            3383..3476
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /inference="alignment:Splign:2.1.0"
     exon            3477..3695
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /inference="alignment:Splign:2.1.0"
     exon            3696..3850
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /inference="alignment:Splign:2.1.0"
     exon            3851..3966
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /inference="alignment:Splign:2.1.0"
     exon            3967..4064
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /inference="alignment:Splign:2.1.0"
     exon            4065..4188
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /inference="alignment:Splign:2.1.0"
     exon            4189..4364
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /inference="alignment:Splign:2.1.0"
     exon            4365..4484
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /inference="alignment:Splign:2.1.0"
     exon            4485..4639
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /inference="alignment:Splign:2.1.0"
     exon            4640..4925
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /inference="alignment:Splign:2.1.0"
     exon            4926..5104
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /inference="alignment:Splign:2.1.0"
     exon            5105..5231
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /inference="alignment:Splign:2.1.0"
     exon            5232..5357
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /inference="alignment:Splign:2.1.0"
     exon            5358..5512
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /inference="alignment:Splign:2.1.0"
     exon            5513..5648
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /inference="alignment:Splign:2.1.0"
     exon            5649..6539
                     /gene="Ptprf"
                     /gene_synonym="LARFN5C"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctgtggagct agaaccctgg atggcccccg agccagcgcc agggaggagg atggtgcccc
       61 ttgtgcctgc cctcgtgatg ctgggtttga tggcaggtgc tcatggcgac agcaaacctg
      121 tctttgttaa ggtccccgag gaccagatcg ggctgtcggg aggggtggcc tccttcgtgt
      181 gccaagccac aggggaaccc aagcctcgaa tcacatggat gaagaaggga aagaaagtca
      241 gctcccagcg ctttgaggta attgagtttg acgacggagc agggtcagtg ctgcggatcc
      301 agccattacg agtgcagcga gacgaagcca tctatgagtg cacggccacg aacagtctcg
      361 gcgagatcaa cacaagtgcc aagctgtcag tacttgaaga ggaccagctg ccgtctgggt
      421 tcccgactat cgacatggga cctcaactga aggtggtgga gaaggctcgc actgccacca
      481 tgctgtgtgc agctggtgga aatccagacc ctgagatctc ttggttcaaa gacttccttc
      541 ctgtggaccc tgcttcaagc aacggtcgta tcaagcagct gcgttcaggt gcattgcaga
      601 ttgagagcag cgaggagtct gaccaaggca agtacgagtg tgtggcaacc aactcggcag
      661 gcacacgcta ctcggccccc gccaacctgt atgtgcgagt gcgccgcgtg gctcctcgtt
      721 tctccatccc tcccagcagc caagaggtaa tgccgggcgg caacgtgaac ctcacgtgtg
      781 tggcagtggg agcacccatg ccgtatgtga agtggatgat gggcgccgag gaacttacca
      841 aagaggacga gatgccagtt ggccgcaatg tgctggagct cagcaatgtc atgcggtctg
      901 ccaactatac ctgtgtggcc atctcttcac tgggcatgat agaggccaca gcccaggtca
      961 cagtaaaagc tctgccaaag cctccaattg atcttgtggt gacagagaca actgccacca
     1021 gtgttaccct gacatgggac tctggaaata ccgagcctgt gtctttctac ggcatccagt
     1081 accgtgcagc tggcacagat ggccccttcc aggaagtgga tggtgtggcc agcacccgat
     1141 acagcattgg tggcctcagc cctttttcag aatatgcctt ccgtgtgttg gctgttaaca
     1201 gcattgggcg aggaccaccc agtgaggcag tgcgagcgcg cacgggtgag caggcaccct
     1261 ccagccctcc acgccgtgtg caggcccgaa tgctgagcgc cagcaccatg ctggtacagt
     1321 gggaaccccc tgaagagccc aatggcctgg tacggggata tcgagtctac tacaccccag
     1381 actctcgacg ccccttgagc gcctggcaca agcataacac cgacgcagga ctccttacca
     1441 ccgtgggcag cctgctacct ggcatcacct acagcctccg cgtcctggcc tttactgccg
     1501 tgggcgacgg ccctcccagc cccaccatcc aagtcaagac acagcaggga gtgcctgcac
     1561 agcctgcaga cttccaggcc aaagccgagt cggacaccag gatccagcta tcatggctgc
     1621 tgcccccgca ggagcggatc atcaagtatg agctggtgta ctgggcagca gaggatgaag
     1681 gccagcagca caaggtgacc ttcgacccca cctcctccta cactctggag gacctgaagc
     1741 ctgacacact gtaccacttc cagctggctg ctcgctcaga tttgggggtg ggcgtcttca
     1801 ctcccaccgt agaggcccgt acagcacagt ccaccccatc cgcccctccc cagaaggtga
     1861 catgtgtgag cacgggctcc accacggtcc gggtaagttg ggttccaccg ccggctgaca
     1921 gccgcaacgg cattatcacc cagtactccg tggcctatga ggcagtggac ggcgaggacc
     1981 gtaaacggca tgtggtggat ggcatcagcc gtgagcattc cagctgggac ctgttgggcc
     2041 tggagaagtg gacggagtac cgggtgtggg tgcgggcaca cacagatgtg ggccctggcc
     2101 ctgagagcag cccggtgctg gtgcgcaccg acgaggacgt gcctagcggg ccaccacgga
     2161 aggtggaggt tgagcctctg aactccactg ctgtgcatgt ctcctggaag ctgcccgtcc
     2221 ccaacaagca gcacggacag attcgtggct accaggtcac ctatgtgcgg ctggagaatg
     2281 gggagccccg aggccagccc atcatccagg atgtcatgct ggctgaggct caggaaacca
     2341 ccatcagcgg cctcaccccc gagaccacct actccattac tgttgctgcc tacaccacta
     2401 agggggacgg tgcccgaagc aagcccaaag tggttactac cacaggggca gtcccaggac
     2461 ggcccaccat gatggtcagc accacggcca tgcacaccgc gctgctgcag tggcacccac
     2521 ccaaggagct gcctggagag ctgctgggct accggctaca ataccgtcgg gccgacgagg
     2581 cgcggcccaa caccatagat tttggcaagg atgaccagca ttttacagtc accggtctgc
     2641 acaaaggggc cacctacatc ttccggctgg ctgccaagaa ccgggctggc ccaggtgaag
     2701 agtttgagaa agagatcacg acccccgagg atgcgcccag tggctttcct caaaacctcc
     2761 gagtgacagg actgaccacg tctaccacgg aactggcctg ggacccgccg gtgctggcag
     2821 agaggaatgg tcgcatcacc aactataccg tggtctaccg tgacatcaac agccagcatg
     2881 aactccagaa tgtcactggt gatgtacacc ttacactctt gggcctcaaa ccggacacca
     2941 cttatgacat caaggtccgt gcacatacca gcaaaggcgc cggcccactc agccccagca
     3001 tccagtccca gaccatgccc atggagcaag tgtttgccaa gaatttccgt gtggccgctg
     3061 caatgaagac atctgtgctg ctcagttggg aggtccccga ctcttacaag tcagctgtac
     3121 ccttcaagat cctgtacaat gggcagagcg tggaggtgga tgggcactcc atgcggaagc
     3181 tgattgcaga cctgcaaccc aacacggagt actccttcgt cctgatgaac cgcggcagca
     3241 gcgctggggg cctacagcac ctggtgtcca tccgcactgc cccagacctc ctgcctcaga
     3301 agccactgcc tgcctctgcc tttatagagg atggccgctt ctccctctcc atgcctcaag
     3361 tgcaggaccc ctcgctagtc aggtggttct acattgtggt ggtgcccatt gaccgtgtgg
     3421 gcgggaacct gctggcacca agatggagca caccagagga gctggagctg gacgagcttc
     3481 tggaggccat cgagcagggt gaggagaaac agcggaggcg tcggcgccaa gcagagcggc
     3541 tgaagcctta cgtggcagct caagtggacg agctccctga gaccttcacc ctgggggaca
     3601 agaagaacta ccgtggcttc tacaaccggc ccctgtctcc ggatctgagt taccagtgct
     3661 ttgtgctcgc ctccctcaag gaacccatgg accagaagcg ctatgcctcc agcccctact
     3721 cggacgagat cgtagtccag gtgacaccag cccagcagca ggaggagccc gagatgctgt
     3781 gggtgacagg ccctgtcctg gcagtcattc tcatcatact cattgtcatc gctatcctcc
     3841 tattcaagag gaagagaaca cattccccat cgtcaaagga tgagcagtca atcgggctga
     3901 aggactccct gttggcccac tcttctgacc ctgtggaaat gcgaaggctt aactaccaga
     3961 ccccaggtat gcgagaccac ccgcccatcc ccatcactga cctggcagac aatattgaac
     4021 gtctcaaagc caatgatggg ctcaagttct cccaggagta tgagtccatt gaccctggac
     4081 agcagttcac gtgggagaat tccaactcag aggtgaacaa gcccaagaac cgctatgcaa
     4141 acgtcattgc ctatgaccac tctcgagtcc tcctcacctc cattgatggt gttcctggga
     4201 gtgactacat caatgccaac tacattgatg gctaccgaaa gcagaatgcc tacatcgcca
     4261 cacagggtcc gctgcctgag accatgggtg atttctggag gatggtgtgg gaacagcgta
     4321 cagccacagt ggtcatgatg accaggctag aggagaaatc ccgggtgaag tgtgatcagt
     4381 attggccagc ccgtggcact gagacctatg gcctcattca ggtgaccctg gtggacactg
     4441 tggagttggc cacgtacacc atgcgcacct tcgcactcca taagagcggc tccagtgaga
     4501 agcgtgagct gcgtcagttc cagttcatgg cctggccaga ccatggggtt cctgagtacc
     4561 ccactcccat cttggccttc ctgagacggg tcaaggcctg taacccgcta gatgcaggac
     4621 ccatggtggt gcattgcagt gctggtgtgg gccgcacggg ctgcttcatt gtcatcgacg
     4681 caatgctgga gcgtatgaag cacgagaaga cagttgacat ctatggccac gtgacgtgca
     4741 tgcgctcgca aaggaactac atggtgcaga cagaggacca gtatgtgttc atccacgagg
     4801 cactgttaga ggctgccatg tgcggacaca ctgaggtgct tgctcgaaac ctctatgccc
     4861 acatccagaa gctaggccaa gtgcctcccg gggagagtgt cactgccatg gagcttgagt
     4921 tcaagttgct ggccaactcc aaggcccaca cgtctcgctt cattagtgcc aacctgccct
     4981 gcaacaagtt caagaaccgc ctggtgaaca tcatgcccta tgagctgact cgagtgtgcc
     5041 tgcaacccat ccgtggtgtg gagggctctg actacatcaa tgccagcttt ctagatggct
     5101 acagacagca gaaggcctac atagctacac aggggcctct ggccgagagc accgaggact
     5161 tctggcgcat gttatgggag cacaattcca ccatcatcgt catgctgacg aagcttcggg
     5221 agatgggcag ggagaaatgt caccagtact ggccagcaga gcgctctgct cgctatcaat
     5281 actttgtcgt tgacccgatg gctgagtaca acatgcccca gtatatcctg cgtgaattca
     5341 aagtcacaga tgcccgggat gggcagtcaa ggacaatccg acagttccag tttacagact
     5401 ggccagagca aggagtaccc aagacggggg aaggcttcat cgacttcatc gggcaggtgc
     5461 acaagacaaa ggagcagttt ggacaggatg ggcccatcac agtacactgc agtgctggtg
     5521 tgggccgcac aggggtgttt atcaccctga gcattgtcct ggagcgcatg cggtacgagg
     5581 gcgtggttga catgttccag accgtgaaga ccctccgcac acagcgccct gcaatggtgc
     5641 agacagagga ccaataccag ctgtgctacc gtgcggccct ggaatacctc ggcagctttg
     5701 atcactatgc aacgtaacta ctgctcccct ctcctccgcc gctcccctga ggggctccgg
     5761 aggggaccca gctcctctga gccataccga ccatcgtcca gccctcctgc acggatgctg
     5821 ttgccggcag agcacagccc actgggatca cagcatttcg ggaacattgc cacaccagtc
     5881 agagagccca gaacacctgg gcaagtaggc ggactggcag cctggctctg ggccctcgtc
     5941 caccgggccc aagtggagcc ctgcttcaag ctctctgttc agctccgcga ttctcatgct
     6001 tctcatgggg tgggaaaggg ggcagagccc cccacgtttt atacatttag gcggggtaga
     6061 ctgcggggtc ctagcctctt cctccgactt tccttttgca ggtctttcac tacagattgg
     6121 gctgctgtgg gagttgggac ttacttgttt tcctttttga gttcacgttg gatccttgta
     6181 caacttctgc ggaaggacac agtacacgct ttccttcctc gagcagagct agggccctac
     6241 ctgagcaagt cggctgtggc ccgggaggca gctgagactc ctgctgtcct ccagcctttc
     6301 agaggagatc ctattccagc caaatgcagg gaaacacttt attttgtttt aggttttgtt
     6361 tttccttgag agcctttttt taggccccac agacagtggt gggcggggag gcgataggaa
     6421 acacatcccc agtgtgcatt taacattcat agcctacaac cacagacgtg tctgggggga
     6481 gcctggcaag gcgttcctcg tcaccatcgt gtttgcaaag gttcaaaaaa gcaaaaatt
//
