LOCUS       NM_053767               5442 bp    mRNA    linear   ROD 18-FEB-2024
DEFINITION  Rattus norvegicus protein tyrosine phosphatase, receptor type, E
            (Ptpre), mRNA.
ACCESSION   NM_053767 XM_001056164 XM_008759971 XM_341950
VERSION     NM_053767.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5442)
  AUTHORS   Shimizu,H., Nakagawa,Y., Murakami,C., Aoki,N., Kim-Mitsuyama,S. and
            Miyazaki,H.
  TITLE     Protein tyrosine phosphatase PTPepsilonM negatively regulates PDGF
            beta-receptor signaling induced by high glucose and PDGF in
            vascular smooth muscle cells
  JOURNAL   Am J Physiol Cell Physiol 299 (5), C1144-C1152 (2010)
   PUBMED   20686073
  REMARK    GeneRIF: Data show that PTPepsilonM negatively regulates
            PDGFRbeta-mediated signaling pathways that are crucial for the
            pathogenesis of atherosclerosis, and PTPepsilonM may be involved in
            diabetes-accelerated atherosclerosis.
REFERENCE   2  (bases 1 to 5442)
  AUTHORS   Akimoto,M., Mishra,K., Lim,K.T., Tani,N., Hisanaga,S.I.,
            Katagiri,T., Elson,A., Mizuno,K. and Yakura,H.
  TITLE     Protein tyrosine phosphatase epsilon is a negative regulator of
            FcepsilonRI-mediated mast cell responses
  JOURNAL   Scand J Immunol 69 (5), 401-411 (2009)
   PUBMED   19508371
REFERENCE   3  (bases 1 to 5442)
  AUTHORS   Aga-Mizrachi,S., Brutman-Barazani,T., Jacob,A.I., Bak,A., Elson,A.
            and Sampson,S.R.
  TITLE     Cytosolic protein tyrosine phosphatase-epsilon is a negative
            regulator of insulin signaling in skeletal muscle
  JOURNAL   Endocrinology 149 (2), 605-614 (2008)
   PUBMED   18006633
REFERENCE   4  (bases 1 to 5442)
  AUTHORS   Kappert,K., Sparwel,J., Sandin,A., Seiler,A., Siebolts,U.,
            Leppanen,O., Rosenkranz,S. and Ostman,A.
  TITLE     Antioxidants relieve phosphatase inhibition and reduce PDGF
            signaling in cultured VSMCs and in restenosis
  JOURNAL   Arterioscler Thromb Vasc Biol 26 (12), 2644-2651 (2006)
   PUBMED   16990553
  REMARK    GeneRIF: Antioxidants inhibited neointima formation and reduced
            PDGF receptor phosphorylation in the neointima and also increased
            PTP activity.
REFERENCE   5  (bases 1 to 5442)
  AUTHORS   Nakagawa,Y., Aoki,N., Aoyama,K., Shimizu,H., Shimano,H., Yamada,N.
            and Miyazaki,H.
  TITLE     Receptor-type protein tyrosine phosphatase epsilon (PTPepsilonM) is
            a negative regulator of insulin signaling in primary hepatocytes
            and liver
  JOURNAL   Zoolog Sci 22 (2), 169-175 (2005)
   PUBMED   15738637
REFERENCE   6  (bases 1 to 5442)
  AUTHORS   Toledano-Katchalski,H., Tiran,Z., Sines,T., Shani,G.,
            Granot-Attas,S., den Hertog,J. and Elson,A.
  TITLE     Dimerization in vivo and inhibition of the nonreceptor form of
            protein tyrosine phosphatase epsilon
  JOURNAL   Mol Cell Biol 23 (15), 5460-5471 (2003)
   PUBMED   12861030
REFERENCE   7  (bases 1 to 5442)
  AUTHORS   Gil-Henn,H., Volohonsky,G., Toledano-Katchalski,H., Gandre,S. and
            Elson,A.
  TITLE     Generation of novel cytoplasmic forms of protein tyrosine
            phosphatase epsilon by proteolytic processing and translational
            control
  JOURNAL   Oncogene 19 (38), 4375-4384 (2000)
   PUBMED   10980613
REFERENCE   8  (bases 1 to 5442)
  AUTHORS   Tanuma,N., Nakamura,K. and Kikuchi,K.
  TITLE     Distinct promoters control transmembrane and cytosolic protein
            tyrosine phosphatase epsilon expression during macrophage
            differentiation
  JOURNAL   Eur J Biochem 259 (1-2), 46-54 (1999)
   PUBMED   9914474
REFERENCE   9  (bases 1 to 5442)
  AUTHORS   Nakamura,K., Mizuno,Y. and Kikuchi,K.
  TITLE     Molecular cloning of a novel cytoplasmic protein tyrosine
            phosphatase PTP epsilon
  JOURNAL   Biochem Biophys Res Commun 218 (3), 726-732 (1996)
   PUBMED   8579581
REFERENCE   10 (bases 1 to 5442)
  AUTHORS   Elson,A. and Leder,P.
  TITLE     Identification of a cytoplasmic, phorbol ester-inducible isoform of
            protein tyrosine phosphatase epsilon
  JOURNAL   Proc Natl Acad Sci U S A 92 (26), 12235-12239 (1995)
   PUBMED   8618876
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000044.1.
            
            [WARNING] On Apr 3, 2024 this sequence was replaced by NM_053767.3.
            
            On or before Nov 29, 2022 this sequence version replaced
            XM_008759971.3, NM_053767.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: BC166573.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMEA5760383, SAMEA5760384 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-265               JACYVU010000044.1  17273618-17273882
            266-288             JACYVU010000044.1  17336394-17336416
            289-407             JACYVU010000044.1  17379031-17379149
            408-501             JACYVU010000044.1  17386787-17386880
            502-575             JACYVU010000044.1  17387118-17387191
            576-712             JACYVU010000044.1  17389013-17389149
            713-803             JACYVU010000044.1  17394760-17394850
            804-880             JACYVU010000044.1  17398280-17398356
            881-917             JACYVU010000044.1  17399031-17399067
            918-1015            JACYVU010000044.1  17400160-17400257
            1016-1135           JACYVU010000044.1  17402483-17402602
            1136-1299           JACYVU010000044.1  17404224-17404387
            1300-1435           JACYVU010000044.1  17405062-17405197
            1436-1585           JACYVU010000044.1  17406052-17406201
            1586-1679           JACYVU010000044.1  17406466-17406559
            1680-1756           JACYVU010000044.1  17407996-17408072
            1757-1891           JACYVU010000044.1  17409543-17409677
            1892-2017           JACYVU010000044.1  17413301-17413426
            2018-2184           JACYVU010000044.1  17414106-17414272
            2185-2320           JACYVU010000044.1  17416607-17416742
            2321-5442           JACYVU010000044.1  17418543-17421664
FEATURES             Location/Qualifiers
     source          1..5442
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q41"
     gene            1..5442
                     /gene="Ptpre"
                     /gene_synonym="PTPepsilon"
                     /note="protein tyrosine phosphatase, receptor type, E"
                     /db_xref="GeneID:114767"
                     /db_xref="RGD:620771"
     exon            1..265
                     /gene="Ptpre"
                     /gene_synonym="PTPepsilon"
                     /inference="alignment:Splign:2.1.0"
     exon            266..288
                     /gene="Ptpre"
                     /gene_synonym="PTPepsilon"
                     /inference="alignment:Splign:2.1.0"
     exon            289..407
                     /gene="Ptpre"
                     /gene_synonym="PTPepsilon"
                     /inference="alignment:Splign:2.1.0"
     CDS             296..2395
                     /gene="Ptpre"
                     /gene_synonym="PTPepsilon"
                     /EC_number="3.1.3.48"
                     /note="protein tyrosine phosphatase, receptor type,
                     epsilon; receptor-type tyrosine-protein phosphatase
                     epsilon; protein tyrosine phosphatase epsilon-like 2;
                     protein tyrosine phosphatase epsilon-like 1;
                     R-PTP-epsilon"
                     /codon_start=1
                     /product="receptor-type tyrosine-protein phosphatase
                     epsilon precursor"
                     /protein_id="NP_446219.1"
                     /db_xref="GeneID:114767"
                     /db_xref="RGD:620771"
                     /translation="MEPFCPLLLASFSLSLATAGQGNDTTPTESNWTSTTAGPPDPGT
                     SQPLLTWLLLPLLLLLFLLAAYFFRFRKQRKAVVNSNDKKMPNGILEEQEQQRVMLLS
                     RSPSGPKKYFPIPVEHLEEEIRVRSADDCKRFREEFNSLPSGHIQGTFELANKEENRE
                     KNRYPNILPNDHCRVILSQLDGIPCSDYINASYIDGYKEKNKFIAAQGPKQETVNDFW
                     RMVWEQRSATIVMLTNLKERKEEKCYQYWPDQGCWTYGNIRVCVEDCVVLVDYTIRKF
                     CIHPQLPDSCKAPRLVSQLHFTSWPDFGVPFTPIGMLKFLKKVKTLNPSHAGPIVVHC
                     SAGVGRTGTFIVIDAMMDMIHSEQKVDVFEFVSRIRNQRPQMVQTDVQYTFIYQALLE
                     YYLYGDTELDVSSLERHLQTLHGTATHFDKIGLEEEFRKLTNVRIMKENMRTGNLPAN
                     MKKARVIQIIPYDFNRVILSMKRGQEFTDYINASFIDGYRQKDYFMATQGPLAHTVED
                     FWRMVWEWKSHTIVMLTEVQEREQDKCYQYWPTEGSVTHGDITIEIKSDTLSEAISIR
                     DFLVTFKQPLARQEEQVRMVRQFHFHGWPEVGIPTEGKGMIDLIAAVQKQQQQTGNHP
                     ITVHCSAGAGRTGTFIALSNILERVKAEGLLDVFQAVKSLRLQRPHMVQTLEQYEFCY
                     KVVQDFIDIFSDYANFK"
     exon            408..501
                     /gene="Ptpre"
                     /gene_synonym="PTPepsilon"
                     /inference="alignment:Splign:2.1.0"
     exon            502..575
                     /gene="Ptpre"
                     /gene_synonym="PTPepsilon"
                     /inference="alignment:Splign:2.1.0"
     exon            576..712
                     /gene="Ptpre"
                     /gene_synonym="PTPepsilon"
                     /inference="alignment:Splign:2.1.0"
     exon            713..803
                     /gene="Ptpre"
                     /gene_synonym="PTPepsilon"
                     /inference="alignment:Splign:2.1.0"
     exon            804..880
                     /gene="Ptpre"
                     /gene_synonym="PTPepsilon"
                     /inference="alignment:Splign:2.1.0"
     exon            881..917
                     /gene="Ptpre"
                     /gene_synonym="PTPepsilon"
                     /inference="alignment:Splign:2.1.0"
     exon            918..1015
                     /gene="Ptpre"
                     /gene_synonym="PTPepsilon"
                     /inference="alignment:Splign:2.1.0"
     exon            1016..1135
                     /gene="Ptpre"
                     /gene_synonym="PTPepsilon"
                     /inference="alignment:Splign:2.1.0"
     exon            1136..1299
                     /gene="Ptpre"
                     /gene_synonym="PTPepsilon"
                     /inference="alignment:Splign:2.1.0"
     exon            1300..1435
                     /gene="Ptpre"
                     /gene_synonym="PTPepsilon"
                     /inference="alignment:Splign:2.1.0"
     exon            1436..1585
                     /gene="Ptpre"
                     /gene_synonym="PTPepsilon"
                     /inference="alignment:Splign:2.1.0"
     exon            1586..1679
                     /gene="Ptpre"
                     /gene_synonym="PTPepsilon"
                     /inference="alignment:Splign:2.1.0"
     exon            1680..1756
                     /gene="Ptpre"
                     /gene_synonym="PTPepsilon"
                     /inference="alignment:Splign:2.1.0"
     exon            1757..1891
                     /gene="Ptpre"
                     /gene_synonym="PTPepsilon"
                     /inference="alignment:Splign:2.1.0"
     exon            1892..2017
                     /gene="Ptpre"
                     /gene_synonym="PTPepsilon"
                     /inference="alignment:Splign:2.1.0"
     exon            2018..2184
                     /gene="Ptpre"
                     /gene_synonym="PTPepsilon"
                     /inference="alignment:Splign:2.1.0"
     exon            2185..2320
                     /gene="Ptpre"
                     /gene_synonym="PTPepsilon"
                     /inference="alignment:Splign:2.1.0"
     exon            2321..5442
                     /gene="Ptpre"
                     /gene_synonym="PTPepsilon"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtgctggag gcggccggac cgggccggac agatttcctg ctctcctgtg gggctgcggg
       61 ctgcgggctg cgggctacgg gctgcgggct tcggaagaag tcaccggcgg cgtagggacc
      121 tcactgccca cgcgcgtccc cacgaccctc cctcgcgccg gcggggacag cgggcacccc
      181 gaagcagagc ggggcgggca ggcgcccggg agatgcggag tcgccgcggc ggagcgatcg
      241 gagcgacagc accgatccct gggagactat agccctcatt ttcccttggt gtgccatgga
      301 acccttctgt ccactcctgt tggcaagttt tagcttgtcg cttgccacag ctggccaggg
      361 caacgacacc accccaacag agagcaactg gaccagtaca actgcaggtc ctccggaccc
      421 tggcacgtcc cagccgctgc ttacctggct gctgctgcct ctgctcctcc tcctgttcct
      481 ccttgcagcc tacttcttca ggttcaggaa gcagaggaaa gccgtggtca acagcaacga
      541 caagaagatg cctaacggga tcctagaaga acaagagcag cagagagtga tgctactgag
      601 cagatctcca tcgggtccca agaagtactt ccccatccct gtggagcacc tggaggagga
      661 gatccgggtg agatctgcgg atgactgcaa gcggttccga gaggagttca attcattgcc
      721 atccggacac atacaaggaa cctttgaact agcaaataaa gaagaaaaca gagaaaaaaa
      781 cagatacccc aacattctgc ccaatgatca ttgcagagtg attttgagcc aattggatgg
      841 aatcccctgc tctgactaca ttaatgcttc ctacatagat ggctacaaag aaaagaacaa
      901 attcatagca gctcaaggcc ccaagcagga gacagtgaat gacttctgga gaatggtctg
      961 ggagcaaagg tcagccacca ttgtcatgtt gacgaacctg aaggaaagga aggaggagaa
     1021 gtgctaccag tactggccag accagggctg ttggacttat gggaacatcc gggtgtgtgt
     1081 agaggactgc gtggtcctgg tggattacac catccgcaag ttctgcatcc atccgcaact
     1141 ccccgacagc tgcaaagctc cacggctggt ctcacagctg cacttcacca gctggcctga
     1201 ctttggggta ccatttaccc ccatcggaat gctgaagttc ctgaagaaag tgaagacact
     1261 caacccctca catgctgggc ccattgtggt ccactgtagc gcgggcgtgg gtcggactgg
     1321 caccttcatt gtgatcgatg ccatgatgga catgatccac tcggaacaga aggttgacgt
     1381 cttcgagttt gtgtctagaa tccgcaatca gcgccctcag atggtccaga cagatgttca
     1441 gtatacattc atctaccaag ccttactgga atactacctc tatggggaca cggagctgga
     1501 tgtgtcctcc ttggagaggc acctgcagac gctacatggc acagccaccc attttgacaa
     1561 gatcgggctg gaggaagagt tcaggaaact gaccaacgtg cgaatcatga aggagaacat
     1621 gaggacgggc aacctgccgg ccaacatgaa gaaggcccgt gtaatccaga tcatcccata
     1681 tgacttcaat cgggtaatcc tgtccatgaa aagagggcaa gagttcacag actacatcaa
     1741 tgcatccttc atagatggct acaggcagaa ggactacttc atggctacac aggggcctct
     1801 ggcgcacaca gttgaggact tctggaggat ggtctgggag tggaagtcac acacaatcgt
     1861 catgctgact gaggtgcagg agcgggagca ggataaatgc taccagtatt ggccaaccga
     1921 gggctcagtg actcacggag atataactat agaaataaag agtgacaccc tgtctgaagc
     1981 aatcagcata cgagactttc tggttacttt caaacagccc ctggcccgcc aggaagagca
     2041 ggtccggatg gtgagacaat tccatttcca tggctggcct gaggttggaa tccccactga
     2101 gggtaaaggc atgattgacc tgatcgcggc agtgcagaag cagcagcagc agacaggcaa
     2161 ccaccccatc accgtgcact gcagtgcggg agcagggcgg acaggtacat tcatagcact
     2221 cagtaacatt ttggaacgag tgaaagccga gggactccta gatgtgtttc aagctgtgaa
     2281 gagcttaaga cttcagagac cacacatggt gcaaaccctg gagcaatatg aattctgcta
     2341 caaagtggta caagatttta tcgatatatt ttctgattat gctaatttca aatgaagatc
     2401 cctgccttaa aatatttttt aatttaatgg tcagtatatt ttgtaaaaaa aaatcatgtt
     2461 aatttatttc ctagtggata ttaatatccg tcctgattcc tttgtatata ttttgttatg
     2521 ttctaaaggc tacctgctgt aagattatta aatcataaat gtccttttta aaaattggaa
     2581 taacatgtta aggtcaaatg ctatctggga agacatatat ttctcctaat accagtcagt
     2641 atcttagttc tattagattc atgtcatgtg tcatgtggtg tcacacatca tgtatcatgt
     2701 atccacatgc catgtggtgt cacatgtcat gcatctgtaa atgtagttct taacatgtca
     2761 aatgtgtttg tggaaagaca ctaaacctga aaccccttgt ggagaaaacg gttgaagact
     2821 cagagtctga tcacatttat tctccccatg cagggcatca gggtgtggca gacagtggac
     2881 atgggggctt tggtaaagtc ctaggtctca gccatgtggt ccacccttac atatgaaaga
     2941 tcagagcagg aaccaagcac tgcaacgcat agctgaagta cttgaagggg ctgaggcaga
     3001 aggattgtgt tcaggccagg ccagcccagg ctacagtgag actctatcag aaacaaaaac
     3061 aaaaacagaa acataacaaa caaaaaacca gaagattttg taacccaaat ccaggtctca
     3121 gatgtataag ggtagatggt gacttccccg tgagttttaa aaggcatttg tttctgaaag
     3181 gctgtgtaat gccactgtag acttgataag gagatgtgtt ggtaccaggc catctattct
     3241 cacaggcccc cagtgtcctc caaactagcc ctcagagctg tattcctgga actgcttgct
     3301 gtctgtctgc ctgtgtgcct ggctcagaat ccacccaagc tcatttcctg accctaatgg
     3361 ggctcaatgc acagctgctt ccctcccctc tgcattgaaa tgaattggca cgcacgcgca
     3421 cacacaccac taccaccacc accacaccac atacacacac acaaacacac actcatacca
     3481 cagacacaca cacacactca tacacacaca cactcataca cacacacaca cacacacaca
     3541 cacacacaca cacacacaca cacacacaca cacgggcaca gatggtagaa tggccacaag
     3601 caattgcact gtcaatttcc tgacagccat tttggtatgt cagattttct ttgtaaaaag
     3661 ttaacatggt ttgtaagaaa agaattctta aaatctagat ttgtacagtt tttttaaatg
     3721 ccccacctct tggtatttaa tttttaaaga gagagagaga gagagagaga gagagagaga
     3781 gagatcctaa tttgaagtct aacttaccct tggtgcaaat gctgctgagg cctctgagcc
     3841 caggtggcag gcacactgcc tgagacgggt agattagaag gatagagagg ggatggggga
     3901 tgaatgtgga aacattgact tcaataaaaa tgatcgtcct atggcattta gatacctagc
     3961 aaatgagcac attgtaaaaa aaaaaaaaaa agatacctgg tctaagtcat tgaaggcttt
     4021 gaacatgcat agtttgggta cttttttttt tttttagaaa aaaaaacttt ttaaaagaga
     4081 aatgaaaata taaaggcctt atttgcaatt tctatggagg actgatcgcg cctgcctatt
     4141 gtatagtttg tccttgttcg tttatagtgt gtacggggga caaccccagg atctgtcact
     4201 gcttcataca ggtgaacagg tcagaggcac aagctggcag ccagcatgca gggtgaaagc
     4261 aggcagtggc cactgtcatc atcaccagca ggcacagcca gggctggttg cctgtgcttt
     4321 gtgaggcctc cccttctctg agcagcagtg ggagcacagg cagaagacag aagagggagg
     4381 agctttccct ggccagtggt ctcatttgtt tccattttag acgccaagct caatgccttg
     4441 ctttaactga agtgggatag aggggcagta agcccactag aacgaaggtg acctcacacg
     4501 ggtcccaagc caaagttcgg cccaatttag ttactggtcc ttaggatccc cgggcatctc
     4561 ttgtatcaag aaatgcctta gggtagatct tttcaggatg tctagaaaag tattctaatg
     4621 tatgtttttc ctcaccttgg gactgcccca ggttctcctg caggaactct gcgtgtttct
     4681 aaacagcttg tccctttcca gagacagaca aaagccatgc ttttgtgggc acagttgggg
     4741 cagcatttgt actttggaag ggccaatcct tctagtctct tggctgatgt catagccaaa
     4801 ttcagcttcc ctaagtcaca gagcctctgc ctgcaagggg cctcctatgt gggggcctca
     4861 gcatcttctc tgtgtacctg gcatgccctt ttcttcttcc ttcagtctaa gaaggtccgg
     4921 tgtacacccg taaacagcct ggcaccgaca accaccttct cagtcctgtt gcatgcagtc
     4981 ctgttcggtg ccaaacagta gtcagagctg agcgttctga gcaggtgcat ctttggtcac
     5041 tgtgtgactg gctttatgtt tctttctctc tccatgggct agatgaacga ggaacacaca
     5101 cctgtgtttc ccaaggtatt tttatgtgtt tttaaaaact ttttaaaatg agcctgatac
     5161 ccgtgatcca gcatttggcc acgttgttgg tttttgttgt tttgttttgt tttttcatgt
     5221 atactgatac attttcgttt gtaaccaagc catgtttaat ttatgtgcga tctttataat
     5281 acgtgtatgt catggtttca actctcatat attcctggat tccatttact gtttgatctt
     5341 gctctgatta tgccagtgaa tgtcgctgaa ctcttgagac tgaactgcaa gatcaaaaac
     5401 aaacatcctg atgcaagaac aaacctctga ctaccggtct gt
//
