LOCUS       NM_001372134           11816 bp    mRNA    linear   ROD 24-APR-2024
DEFINITION  Rattus norvegicus protein tyrosine phosphatase, receptor type, B
            (Ptprb), transcript variant 1, mRNA.
ACCESSION   NM_001372134 XM_008765425
VERSION     NM_001372134.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 11816)
  AUTHORS   Keil,V.C., Gielen,G.H., Pintea,B., Baumgarten,P., Datsi,A.,
            Hittatiya,K., Simon,M. and Hattingen,E.
  TITLE     DCE-MRI in Glioma, Infiltration Zone and Healthy Brain to Assess
            Angiogenesis: A Biopsy Study
  JOURNAL   Clin Neuroradiol 31 (4), 1049-1058 (2021)
   PUBMED   33900414
REFERENCE   2  (bases 1 to 11816)
  AUTHORS   Sahni,S., Krisp,C., Molloy,M.P., Nahm,C., Maloney,S., Gillson,J.,
            Gill,A.J., Samra,J. and Mittal,A.
  TITLE     PSMD11, PTPRM and PTPRB as novel biomarkers of pancreatic cancer
            progression
  JOURNAL   Biochim Biophys Acta Gen Subj 1864 (11), 129682 (2020)
   PUBMED   32663515
REFERENCE   3  (bases 1 to 11816)
  AUTHORS   Beca,F., Krings,G., Chen,Y.Y., Hosfield,E.M., Vohra,P.,
            Sibley,R.K., Troxell,M.L., West,R.B., Allison,K.H. and Bean,G.R.
  TITLE     Primary mammary angiosarcomas harbor frequent mutations in KDR and
            PIK3CA and show evidence of distinct pathogenesis
  JOURNAL   Mod Pathol 33 (8), 1518-1526 (2020)
   PUBMED   32123305
REFERENCE   4  (bases 1 to 11816)
  AUTHORS   Shuwen,H., Xi,Y., Miao,D., Jiamin,X., Jing,Z. and Weili,G.
  TITLE     Nine Genes Mediate the Therapeutic Effects of Iodine-131
            Radiotherapy in Thyroid Carcinoma Patients
  JOURNAL   Dis Markers 2020, 9369341 (2020)
   PUBMED   32626543
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 11816)
  AUTHORS   Luo,Y., Liu,W., Tang,P., Jiang,D., Gu,C., Huang,Y., Gong,F.,
            Rong,Y., Qian,D., Chen,J., Zhou,Z., Zhao,S., Wang,J., Xu,T.,
            Wei,Y., Yin,G., Fan,J. and Cai,W.
  TITLE     miR-624-5p promoted tumorigenesis and metastasis by suppressing
            hippo signaling through targeting PTPRB in osteosarcoma cells
  JOURNAL   J Exp Clin Cancer Res 38 (1), 488 (2019)
   PUBMED   31829261
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 11816)
  AUTHORS   Ulbricht,U., Brockmann,M.A., Aigner,A., Eckerich,C., Muller,S.,
            Fillbrandt,R., Westphal,M. and Lamszus,K.
  TITLE     Expression and function of the receptor protein tyrosine
            phosphatase zeta and its ligand pleiotrophin in human astrocytomas
  JOURNAL   J Neuropathol Exp Neurol 62 (12), 1265-1275 (2003)
   PUBMED   14692702
REFERENCE   7  (bases 1 to 11816)
  AUTHORS   Adamsky,K., Arnold,K., Sabanay,H. and Peles,E.
  TITLE     Junctional protein MAGI-3 interacts with receptor tyrosine
            phosphatase beta (RPTP beta) and tyrosine-phosphorylated proteins
  JOURNAL   J Cell Sci 116 (Pt 7), 1279-1289 (2003)
   PUBMED   12615970
REFERENCE   8  (bases 1 to 11816)
  AUTHORS   Nawroth,R., Poell,G., Ranft,A., Kloep,S., Samulowitz,U.,
            Fachinger,G., Golding,M., Shima,D.T., Deutsch,U. and Vestweber,D.
  TITLE     VE-PTP and VE-cadherin ectodomains interact to facilitate
            regulation of phosphorylation and cell contacts
  JOURNAL   EMBO J 21 (18), 4885-4895 (2002)
   PUBMED   12234928
  REMARK    Erratum:[EMBO J. 2005 Sep 7;24(17):3158]
REFERENCE   9  (bases 1 to 11816)
  AUTHORS   Fachinger,G., Deutsch,U. and Risau,W.
  TITLE     Functional interaction of vascular endothelial-protein-tyrosine
            phosphatase with the angiopoietin receptor Tie-2
  JOURNAL   Oncogene 18 (43), 5948-5953 (1999)
   PUBMED   10557082
REFERENCE   10 (bases 1 to 11816)
  AUTHORS   Gaits,F., Li,R.Y., Ragab,A., Selves,J., Ragab-Thomas,J.M. and
            Chap,H.
  TITLE     Implication of a protein-tyrosine-phosphatase in human lung cancer
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 40 (5), 677-685 (1994)
   PUBMED   7981622
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Feb 10, 2021 this sequence version replaced NM_001372134.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments. The extent of this transcript is
            supported by orthologous data.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643285.27465.1,
                                           SRR26643429.26729.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-279               JAXUCZ010000007.1  53839402-53839680
            280-553             JAXUCZ010000007.1  53840095-53840368
            554-832             JAXUCZ010000007.1  53851690-53851968
            833-1090            JAXUCZ010000007.1  53852987-53853244
            1091-1354           JAXUCZ010000007.1  53854938-53855201
            1355-1624           JAXUCZ010000007.1  53857212-53857481
            1625-1885           JAXUCZ010000007.1  53859391-53859651
            1886-2152           JAXUCZ010000007.1  53864981-53865247
            2153-2416           JAXUCZ010000007.1  53865863-53866126
            2417-2680           JAXUCZ010000007.1  53870537-53870800
            2681-2944           JAXUCZ010000007.1  53871293-53871556
            2945-3208           JAXUCZ010000007.1  53872404-53872667
            3209-3478           JAXUCZ010000007.1  53873082-53873351
            3479-3742           JAXUCZ010000007.1  53876206-53876469
            3743-4006           JAXUCZ010000007.1  53878598-53878861
            4007-4288           JAXUCZ010000007.1  53879856-53880137
            4289-4567           JAXUCZ010000007.1  53882046-53882324
            4568-4717           JAXUCZ010000007.1  53882873-53883022
            4718-4967           JAXUCZ010000007.1  53885972-53886221
            4968-5074           JAXUCZ010000007.1  53889324-53889430
            5075-5174           JAXUCZ010000007.1  53893468-53893567
            5175-5258           JAXUCZ010000007.1  53894439-53894522
            5259-5276           JAXUCZ010000007.1  53894620-53894637
            5277-5358           JAXUCZ010000007.1  53894757-53894838
            5359-5449           JAXUCZ010000007.1  53895401-53895491
            5450-5526           JAXUCZ010000007.1  53896497-53896573
            5527-5661           JAXUCZ010000007.1  53898316-53898450
            5662-5784           JAXUCZ010000007.1  53899854-53899976
            5785-5948           JAXUCZ010000007.1  53900355-53900518
            5949-6084           JAXUCZ010000007.1  53904662-53904797
            6085-6205           JAXUCZ010000007.1  53912169-53912289
            6206-11816          JAXUCZ010000007.1  53915150-53920760
FEATURES             Location/Qualifiers
     source          1..11816
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q22"
     gene            1..11816
                     /gene="Ptprb"
                     /note="protein tyrosine phosphatase, receptor type, B"
                     /db_xref="GeneID:314843"
                     /db_xref="RGD:1305922"
     exon            1..279
                     /gene="Ptprb"
                     /inference="alignment:Splign:2.1.0"
     CDS             226..6228
                     /gene="Ptprb"
                     /EC_number="3.1.3.48"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; receptor-type tyrosine-protein phosphatase
                     beta; protein tyrosine phosphatase, receptor type, B like
                     1"
                     /codon_start=1
                     /product="receptor-type tyrosine-protein phosphatase beta
                     isoform 1 precursor"
                     /protein_id="NP_001359063.1"
                     /db_xref="GeneID:314843"
                     /db_xref="RGD:1305922"
                     /translation="MLSHGALLALWIALSVLQTGVAEQVKCNFTVLESKVSSLSASIQ
                     WRTFGSPCNFSLIYSSDTSGPLWCHPILIDNFTYGCDPKDLQAGTIYNFRIVSLDGEE
                     RSLVLQTDPLPPARLEVNPERTTSTTLQVRWTPSSGKVTWYEVQLFDQNNQKIQEVQV
                     QESATWSQYTFLNLTAGSSYKIGITAVSGGKRSFPVYTNGSTGPSPVEDIGISPNPNS
                     LLISWSRGPGNVEQFRLMLMDKGAIVQDTNVDKRDTSYAFRGLTPGHLYNVTIVTMAS
                     GLQNSRWKLGRTAPMEVSNLKVTSGGSLTSLNVKWQKPLGVIDSYSITLSHQGTVKES
                     KTLPPRATEIQFKDLVPGRFYQVTIRCVSGELSAEKSAMGRTVPEKVSNLVSYNEIWM
                     KSFAVNWTPPAGDWDHYRILLFNDSLVLLNTTVGKEETHFALEGLELIPGRQYEVEVI
                     VESGNLRNSERCQGRTVPLAVLQLRIKQANETSLGITWRAPLGEWEKYTISLMDRELF
                     VIHKSLSKDAKEYTFTNLMPGRNYKATVTSMSGDLKQSASIQGRTVPAQVTDLEVSNQ
                     GMTSSLFTNWTKALGDVEFYQVLLIHENVVVKNESVSSDSSWYSFRALRSGSLYSVVV
                     TTVSGGIPSRQVVAEGRTVPSSVSGVTVNNSGRNDYLSVSWLPAPGEVHHYVVTLSHD
                     SKVVQSLITAKFVSECSFSSLTPGRLYNVTITTKSGNYESHSFSEERTVPDKVQGISV
                     SNSARSDYLKVSWVHATGDFDHYEVTIKNRDSFIQTKSIPKSENECVFARLVPGRLYS
                     ITVTTKSGQYEASEQGTGRTIPEPVKNLTLLNRSTEDLHVTWSRANGDVDQYEVQLLF
                     NDMKVFPPIYLVNTATEYQFSALTPGRHYKILVLTISGDVQQPAFIEGLTVPSTVKNI
                     HISANGATDRLTVTWSPGGGDVDSYVVSAFRQDEKVESHTLPKHGSEHTFHRLEAGAT
                     YRIAIVSVSGSLRNQIDVLGQTVPASVHGVVADNAYSSNSLTVSWQKALGMAERYDIL
                     LLSENGVLLSNTSEPATVKQHKFEDLTPGKKYKMQILTVSGGLFSKEVETEGRTVPAA
                     VTNLRITENSSRHLSFSWTASEGELSWYNIFLYNPDKTLQERAQVDPLVQSFSFQNLL
                     QGRMYKMVIVTHSGELSNESFIFGRTVPAAVNHLKGSNRNMTDSLWFSWSPASGDFDF
                     YELILYNPNGTKKENWREKDVTEWRFQGLIPGRKYTLYVVTHSGDLSNKVTGEGRTAP
                     SPPSLLSFADVANTSLAITWKGPPDWTDYNDFELQWLPGDALTVFNPYSSKKSEGRIV
                     NGLRPGRSYQFSVKTVSGDSWKTYSKPISGSVRTKPDKIQNLHCRPQNSTAIACSWIP
                     PDSDFDGYSIECRKMDTQEIEFSRKLEKEKSLLNIMMLVPHRRYLVSIKVQSAGVTSE
                     VVEDSTITMIDRPPPPPPHIRVNEKDVLISKSSINFTVNCSWFSDTNGAVKYFAVVVR
                     EADSMDELRPEQQHPLPSYLEYRHNASIRVYQTNYFASKCAESPDPDRSSKSFNIKLG
                     GEMDSLGGKCDPSQQKFCDGPLKPHTAYRISIRAFTQLFDEGLKEFTKPLYSDTFFSM
                     PITTESEPLFGVIEGVSAGLFLIGMLVALVAFFICRQKASHSRERSSARLSIRRDRPL
                     SVHLNLGQKGNRKTSCPIKINQFEGHFMKLQADSNYLLSKEYEDLKDVGRSQSCDIAL
                     LPENRGKNRYNNILPYDASRVKLCNVDDDPCSDYINASYIPGNNFRREYIATQGPLPG
                     TKDDFWKMAWEQNVHNIVMVTQCVEKGRVKCDHYWPADQDPLYYGDLILQMVSESVLP
                     EWTIREFKICSEEQLDAHRLLRHFHYTVWPDHGVPETTQSLIQFVRTVRDYINRSPGA
                     GPTVVHCSAGVGRTGTFVALDRILQQLDSKDSVDIYGAVHDLRLHRVHMVQTECQYVY
                     LHQCVRDVLRARKLRNEQENPLFPIYENVNPEYHRDAMYSRH"
     exon            280..553
                     /gene="Ptprb"
                     /inference="alignment:Splign:2.1.0"
     exon            554..832
                     /gene="Ptprb"
                     /inference="alignment:Splign:2.1.0"
     exon            833..1090
                     /gene="Ptprb"
                     /inference="alignment:Splign:2.1.0"
     exon            1091..1354
                     /gene="Ptprb"
                     /inference="alignment:Splign:2.1.0"
     exon            1355..1624
                     /gene="Ptprb"
                     /inference="alignment:Splign:2.1.0"
     exon            1625..1885
                     /gene="Ptprb"
                     /inference="alignment:Splign:2.1.0"
     exon            1886..2152
                     /gene="Ptprb"
                     /inference="alignment:Splign:2.1.0"
     exon            2153..2416
                     /gene="Ptprb"
                     /inference="alignment:Splign:2.1.0"
     exon            2417..2680
                     /gene="Ptprb"
                     /inference="alignment:Splign:2.1.0"
     exon            2681..2944
                     /gene="Ptprb"
                     /inference="alignment:Splign:2.1.0"
     exon            2945..3208
                     /gene="Ptprb"
                     /inference="alignment:Splign:2.1.0"
     exon            3209..3478
                     /gene="Ptprb"
                     /inference="alignment:Splign:2.1.0"
     exon            3479..3742
                     /gene="Ptprb"
                     /inference="alignment:Splign:2.1.0"
     exon            3743..4006
                     /gene="Ptprb"
                     /inference="alignment:Splign:2.1.0"
     exon            4007..4288
                     /gene="Ptprb"
                     /inference="alignment:Splign:2.1.0"
     exon            4289..4567
                     /gene="Ptprb"
                     /inference="alignment:Splign:2.1.0"
     exon            4568..4717
                     /gene="Ptprb"
                     /inference="alignment:Splign:2.1.0"
     exon            4718..4967
                     /gene="Ptprb"
                     /inference="alignment:Splign:2.1.0"
     exon            4968..5074
                     /gene="Ptprb"
                     /inference="alignment:Splign:2.1.0"
     exon            5075..5174
                     /gene="Ptprb"
                     /inference="alignment:Splign:2.1.0"
     exon            5175..5258
                     /gene="Ptprb"
                     /inference="alignment:Splign:2.1.0"
     exon            5259..5276
                     /gene="Ptprb"
                     /inference="alignment:Splign:2.1.0"
     exon            5277..5358
                     /gene="Ptprb"
                     /inference="alignment:Splign:2.1.0"
     exon            5359..5449
                     /gene="Ptprb"
                     /inference="alignment:Splign:2.1.0"
     exon            5450..5526
                     /gene="Ptprb"
                     /inference="alignment:Splign:2.1.0"
     exon            5527..5661
                     /gene="Ptprb"
                     /inference="alignment:Splign:2.1.0"
     exon            5662..5784
                     /gene="Ptprb"
                     /inference="alignment:Splign:2.1.0"
     exon            5785..5948
                     /gene="Ptprb"
                     /inference="alignment:Splign:2.1.0"
     exon            5949..6084
                     /gene="Ptprb"
                     /inference="alignment:Splign:2.1.0"
     exon            6085..6205
                     /gene="Ptprb"
                     /inference="alignment:Splign:2.1.0"
     exon            6206..11816
                     /gene="Ptprb"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ttgggggcga ggcagctcgg gtcagaatgg cagcgtggga agggctgtgc gtcgcgggtc
       61 cccgccgcct gtcgtgtccg cagcccgccc ggggcggcag cagaagcagc ggcggcctca
      121 gcgcttgagc atcgccagcc ccgagggtag cgcgctgcgc ccgcggggcg cgctgagcgc
      181 gcaacaagtg gtacccgagg tgtccctggc tggcttccca gcgaaatgct gagccatgga
      241 gccctactag ccttgtggat cgcactgagc gtcctgcaga ctggagtggc agagcaagtg
      301 aaatgtaact tcacggtgct ggagtccaag gtctctagct tgtcagcgtc tatccagtgg
      361 aggacgttcg ggtcaccctg taactttagc ctcatctaca gcagtgatac ctcagggccc
      421 ttgtggtgcc atcccattct gatagacaac tttacctacg gatgtgaccc caaggattta
      481 caagcaggga ccatctataa cttcaggatt gtttctctgg atggcgaaga gagaagtctg
      541 gtcttacaga cagatccctt gcccccggcc aggcttgaag tcaaccccga gaggacaaca
      601 tcaaccaccc tgcaggtccg gtggactccc tcttctggaa aagtcacctg gtatgaggtg
      661 caattatttg atcaaaacaa tcagaagata caggaagtcc aagttcaaga aagtgccaca
      721 tggagccagt acacttttct gaacctcaca gcgggtagca gttacaaaat tggcatcaca
      781 gctgtttctg gaggaaagcg ctcctttccg gtgtatacca atggatctac cgggccatct
      841 ccagtggaag atattggcat ttcccccaat cctaattctc tcctgatttc ctggtctcgt
      901 ggtcctggga atgtggaaca attcaggctg atgctaatgg ataaaggggc catcgttcag
      961 gacacaaacg tggacaagcg ggacacttct tatgctttcc gtgggctgac ccctggccac
     1021 ctctacaacg tcactattgt caccatggcc tcgggactac aaaactccag gtggaaactg
     1081 gggaggaccg ctcctatgga agtctcaaat ctgaaggtga caagtggtgg cagtttgacc
     1141 tctctaaacg tgaagtggca aaaacctctt ggggttatag attcctacag catcaccctg
     1201 tctcaccaag ggaccgtcaa ggaatccaaa acactaccac ctcgtgctac tgaaattcaa
     1261 tttaaagact tagtccctgg acggttttac caagttacca tccgctgtgt ctctggtgag
     1321 ctctctgctg agaagtcggc aatgggcaga acagttccag aaaaagtgag caatctggtt
     1381 tcctacaacg agatttggat gaagtccttt gcagtgaact ggacgccccc tgctggagat
     1441 tgggatcact accgtatcct gctcttcaat gactccttgg tcctgctcaa caccactgtg
     1501 ggaaaggaag aaacacactt tgccttggaa ggcttggagc tcataccagg aagacagtat
     1561 gaggtagaag tcatcgttga gagtggaaat ctgaggaatt ccgagcgctg ccaaggcagg
     1621 acagtccccc tggctgtcct ccagcttcgg atcaaacagg ctaacgaaac ctcactgggc
     1681 atcacgtggc gggcccctct cggcgaatgg gagaagtata ccatttcact gatggacaga
     1741 gagctctttg tcatccacaa gtcgctctcc aaagatgcca aagaatacac ttttaccaac
     1801 ctgatgcctg gacgaaatta caaggccacc gtcactagca tgagtggaga tttgaagcag
     1861 tcagcttcaa tccaaggaag aacagttcct gcccaagtga ctgacttgga ggtcagcaac
     1921 caagggatga ccagtagtct gttcactaac tggacaaagg cgttaggaga tgtagaattc
     1981 taccaagttt tactgatcca tgaaaatgtg gtcgtcaaaa acgagagtgt ctccagtgac
     2041 tccagctggt acagcttccg ggctctgaga tccggcagcc tctactccgt ggtggtgacc
     2101 acggtgagcg gagggattcc ttcccggcag gtggtggcgg aaggaagaac ggtcccgtcc
     2161 agcgtgagtg gggtgacagt caacaattct ggccggaatg attacctcag cgtctcctgg
     2221 ctgccagcac ctggagaagt gcatcactac gtggtgaccc tgtcccacga cagcaaggtg
     2281 gttcagtccc tcatcactgc caaatttgtc agcgagtgtt ctttcagctc cctcacccca
     2341 ggccgcctct acaatgtgac cataaccacc aagagcggca attatgaaag tcactccttc
     2401 agtgaagaac ggacggtgcc tgacaaagtc cagggaatca gtgttagcaa ctctgccaga
     2461 agtgactact taaaggtgtc ctgggtccat gccactggag actttgacca ctatgaggtc
     2521 accatcaaaa acagagacag cttcattcaa accaaaagca tccccaagtc agaaaatgag
     2581 tgtgtgtttg ctcggctcgt ccccggacgc ctgtacagca tcaccgtcac tacaaagagt
     2641 ggacaatacg aagccagtga acaagggacg gggagaacaa tcccggagcc tgtgaagaac
     2701 ctcacacttc tcaacaggag tacggaggat ctccacgtga cttggtcaag agccaatggg
     2761 gatgtggacc agtacgaggt ccagctgctc ttcaatgaca tgaaagtctt ccctcctatt
     2821 tacctggtga acacagcaac tgagtatcag ttcagtgcac tcacaccggg gcgccattac
     2881 aaaatcctcg tcctgaccat cagcggcgac gtccagcagc cagccttcat tgaaggcctc
     2941 acggttccca gcacggtcaa aaatattcac atttcggcca acggagccac agataggctg
     3001 acggtaacct ggagccctgg tggtggagat gttgactcgt acgtggtgtc tgcgttcagg
     3061 caggatgaga aggttgagtc tcacactctc cccaagcacg gctcggaaca cactttccac
     3121 aggctagagg ccggcgccac ctacaggatt gccatcgttt ctgtcagtgg atccctgaga
     3181 aaccagatag atgtgcttgg gcagacagtt ccagcgtctg tccatggggt cgttgcagac
     3241 aatgcgtaca gcagtaactc cttaacagtg agctggcaga aagcccttgg tatggcagag
     3301 agatatgata tcctgcttct aagtgagaat ggagttcttc tgagcaacac atcagagcca
     3361 gcgaccgtaa aacagcacaa gtttgaagat ctaacgccag gcaagaaata caagatgcag
     3421 atcctaacag tcagcggagg cctctttagt aaggaagtgg agactgaagg ccgaacagtc
     3481 ccagcagctg tcaccaatct gaggatcaca gagaactcca gtagacacct gtccttcagc
     3541 tggactgcct cggagggtga actcagctgg tacaacatct tcttatacaa cccagacaaa
     3601 actcttcagg aacgagctca agtggacccg ctagttcaga gcttctcttt ccagaacttg
     3661 ctacaaggcc gaatgtacaa gatggtgatt gttactcaca gtggagagct gtccaacgag
     3721 tcctttatat tcggcagaac agtcccagcc gccgtgaacc atctcaaagg atccaatcga
     3781 aacatgacag acagcctttg gttcagctgg agcccggcct ccggggactt tgacttctat
     3841 gagctgattc tctacaatcc taacggcaca aagaaggaga actggagaga gaaggatgtg
     3901 acagagtggc gtttccaagg tctcattcct ggaaggaaat acaccctgta tgtggtgact
     3961 cacagtgggg acctcagcaa taaagtcaca ggggagggca gaacagcccc aagtcctccc
     4021 agtcttttgt cattcgccga cgttgccaac acctccttgg ccatcacctg gaagggaccc
     4081 ccggactgga cagactacaa tgactttgag ctgcagtggc tccctggaga tgcgcttact
     4141 gtcttcaacc cctacagcag caaaaaatca gaaggacgaa ttgtgaatgg gcttcgccca
     4201 gggaggtcct atcagttcag tgtcaagacc gtgagcgggg attcctggaa aacctacagc
     4261 aaaccaattt ctgggtctgt gaggacaaaa ccagacaaga tccaaaacct gcattgccgc
     4321 cctcagaact cgacggccat tgcctgctct tggataccac ctgactccga cttcgatggc
     4381 tacagcattg aatgtcgaaa aatggacacc caagaaattg agttttccag aaagctggag
     4441 aaagaaaaat cactgctcaa catcatgatg ttagtgcctc ataggaggta cctggtgtcc
     4501 atcaaggtgc agtcggccgg tgtgaccagc gaggtggttg aagacagcac catcaccatg
     4561 atagaccgcc ctccgccgcc gcctccacat atccgagtga atgagaagga tgtgctgatc
     4621 agcaaatctt ccatcaactt cactgtcaac tgcagctggt tcagcgacac caacggggct
     4681 gttaaatact tcgccgtggt ggtgagagag gctgacagca tggatgagtt gaggccagaa
     4741 cagcagcatc ctctcccttc ctacctggag tacagacaca atgcctccat ccgcgtctac
     4801 cagaccaatt atttcgccag caaatgtgca gaaagtcccg accctgaccg cagttctaaa
     4861 agttttaaca ttaagcttgg aggagagatg gacagtcttg gtggcaaatg tgatcccagt
     4921 cagcaaaaat tctgcgatgg accactgaag ccacacaccg cctacagaat cagcatccgg
     4981 gcttttacac agctatttga tgagggcttg aaagaattca caaaacctct ctattcggac
     5041 acgttcttct ctatgcccat caccacggag tcagagccct tgtttggagt tattgaaggt
     5101 gtgagtgctg gcctgtttct aattggcatg ctggtggccc ttgtcgcctt cttcatctgc
     5161 agacagaaag ctagccatag cagagaaagg tcatctgccc gtctgagcat ccgtagggat
     5221 cggcctttat ctgtccactt gaatctgggc cagaagggca accggaaaac ttcctgtccc
     5281 ataaagataa accagtttga agggcatttc atgaagctgc aagcagactc caactacctt
     5341 ctctccaagg aatatgagga cttaaaagat gtgggtagaa gccaatcatg tgacattgcc
     5401 ctcttgcctg agaatcgagg gaaaaatcga tacaacaaca tattgcccta tgatgcctcg
     5461 agagtgaagc tttgcaacgt agatgatgac ccatgctctg actatatcaa cgccagttac
     5521 atccccggta acaacttcag aagagaatac atcgccactc agggaccgct tccgggcacc
     5581 aaggatgact tctggaaaat ggcgtgggaa caaaatgttc acaacatcgt catggtgacc
     5641 cagtgtgtgg aaaagggcag agtaaagtgt gaccattact ggcccgcaga ccaggacccc
     5701 ctctattatg gtgatcttat cctgcagatg gtctcggaat ctgtgctccc cgagtggacc
     5761 atccgggagt ttaagatatg cagtgaagaa cagttggatg cacacagact cctccgtcac
     5821 ttccactaca cggtgtggcc agaccatggg gtcccagaga ccacccagtc cctgatccag
     5881 tttgtgagaa cggtcaggga ctatatcaac cgaagcccag gggccgggcc caccgtggtg
     5941 cactgcagcg ctggtgtggg cagaacaggg acatttgttg ccctggaccg gatcctccag
     6001 cagttggact caaaggactc cgtggacatt tatggggcag tgcatgacct aagactccac
     6061 agggttcaca tggtccagac cgagtgtcag tacgtctatc tgcatcagtg tgtgagagac
     6121 gtcctcagag caaggaaact gcggaacgaa caagaaaacc ccctgtttcc gatctatgaa
     6181 aatgtgaatc cagagtatca cagagatgca atgtactcga gacattgaga attcacctgg
     6241 agatcccctg gataaaagtt tttcactgtg tgactttaaa agaaaaaaca aaaacaacaa
     6301 aaacaaaaac aaaccttgct tcatgccctg tgggggtgcc agctgtttct gttgatacta
     6361 tgtataattt attaatctga agaatgttac agaatgtatg taatttaaag gtaacagata
     6421 ttattgtata tacttgtatt ttgtggtttc tcctgtaaat atgtattttt tcatcatgtt
     6481 taagatgaag gtttatatac actgtttttc cacactgaga gtgttcctgg cttgttctac
     6541 ataaacccat tcagcctgtg tgacaggacc actggtaaaa tgtgtgtaga ggaagttgca
     6601 aggacagtcc ctggggctgt ttcttacctg tcctgatagt cactgggaaa gcaaaagtca
     6661 gagctggaca gggcacacca aggctagctt tcttatgttg tgaatgaacc ctgggatata
     6721 aggctttctt aggaatgaac cctgggatct taagagtata accgtcggag aaagggtagg
     6781 gctgtagtag accatatgcc aagaaattaa aaatcaatta atggttaaaa ggaggattca
     6841 acagcaccaa agctgagcta ggtgttatct aaactagaag cttcttgtca gactcctccc
     6901 agggtcccaa gccatgggca ccttgaagcg aatgatgcta acgggtaagg agtgctcttg
     6961 acagaaatgc cagcaacacc tctgactgga acctcctgca taaagcaggg tgccacccgc
     7021 aagggtccca gtttgttttc ctctggaaag agttacagtg gtagattatg ctcctgacca
     7081 gagaaagcat ggtatgccaa catgtccata gagagatcta caacatcata tataatgagt
     7141 taaaaagtaa gtgatggtta aaaaaaatca accccagctc tcctttgtct aaaaatcctt
     7201 caaaagttct ttctaactaa cttgatgcag ttaaaatgtt gtcaagattc acctgaagct
     7261 ccatttaata taagcgacac cacacgccct accaatttca tcattaagat ctgtgtttta
     7321 tttgactata aataattcca cgagacattg accagatcaa ggcccaatgg gtgggtcttt
     7381 cctgaggaag gtctagaaag agccccgtgg ttgcctgagg gagatgtaga gcttccattg
     7441 cagaaacagc acacttctcc cggacatacg cacttttgct acatgtcgta cattcccaca
     7501 ataaaacgga cataattggc ataacaattg gaaacaatta acgataccca ttgtataggc
     7561 atgaatcatt gtaactttag cttgtaaata taatgtgata gtcataattt cccaactaca
     7621 tgcccaggct ggaaatgttt ttatggagtg ttcaaagttt atagaaacag aggaactgtc
     7681 cctaaggatt cctgtgtgca gcgttcagaa ttctcagtgt ccctgagctc tgtacccttg
     7741 tgaaaatgat acagggtggc cctgtgtcca gaaacgtgtc tgaggaagag aggggcaagc
     7801 atatctgtaa ctagggggga agtagaggtc aggcatggtt tcggcgtggt gtctgttagt
     7861 aatcattgtt ttcttagagg aaaaagaaaa ggctaggctg agggaacagc tatgaggtag
     7921 cctgcccgtg tgtctacctc tccctcctcc tgagaagaga aaagaaagag gggggcgggg
     7981 tgggggaact gcaaaccagt gttgcttggc gcaaaacatg ttgataacct gggaagagaa
     8041 gctcattttc attttgagga aagctccagc aagggcctgg gacctgcagg gcacggatcc
     8101 aaaatccatt tctttgtcct caaggagaga agcacggtgg agtgaagtta gcattgttac
     8161 tgttttcatt gggaagtgga agaggtctgg gtgaggggag gagaccaggg tatggccgtt
     8221 cttagggcgc ctactagcaa aggctggagc tgtttctatg gcaagtcact agatgtagag
     8281 gagagagtag tgatttgcac acacagcagc tacaaccaca aggcccctgc atgtctgtaa
     8341 ccgtgactga cacacacctc aaagcatcgc aggtgaagtc ggaattccag aactgagcac
     8401 agccacacag ccaggggatg tcatgcattc ttgttctctg tcccacggaa tactaatccc
     8461 tcccctatac tagttttaaa gcccccttag caacaaacgc ttctctatgc aatctctctc
     8521 gggaagatgt aatacagatc ttgctgatct acccgtccag tttagtagag agccagactg
     8581 gaaatgtagc tgctgatagt aagcttgcca ggcatgtggg aggcctgggc tcagtctcag
     8641 ttaccacaaa ataagcaagg agagaaaaag aaagtctcct tcgcggttcg ttctgttggg
     8701 cgcatccccc cttaattgct tcatgtggct gcgcctcggt aaacactcca cgtcctgcca
     8761 tgccgggcat cctgtctgca cctgagcgtg tctctgtact cattaaagct ttcaagtact
     8821 tcaaggctct cagaccttga gagagtctgt tttgcatctt aataattatt tacccaggtt
     8881 ccttataatt aactcctcta atccttcaca ttaaatcaat ttcacattat cattctgctt
     8941 tgctctggaa aggtgccaag tttcccactc ctgaatcaga ttttttcaga gacgcattgc
     9001 cctgtctggg cttgcaaaca ttcatcctga ggaacttccc gccctttagc acctggcatt
     9061 ccactgtcct gtttgttgct tgctgtttct tctcactgtg ccagtcagat gtgactttat
     9121 tctctgtcca tctcattcat ctcctcccac ccatcgctag cacctcataa cctcaacacc
     9181 atgcaagagc gattaagact tagtttttca acactgaaac ggcagcaaca tagcaatttg
     9241 gggtcagtta tatttaggag ggctctgtaa ttaattttgt tattacctct tggaagaaag
     9301 cccaaaatga tatgagaaaa ttatgtgaaa tgctttaaca gatgtccggc gacaccagaa
     9361 ataggacact catgttacac ttcgcagtgc ttctcttggc tccgtgttaa ggctctaact
     9421 ccttatatta aacactttct gatcccattg caaaaaaata gaaaaagaga gagagaaaag
     9481 gaaggaagga agggaggaag gaaggaagga aggaaggaag gaaggaagga aggaaggaag
     9541 ggagggaggg aggaaggaag gaagggagga agggctgcca tgaactaatt cttgtttagt
     9601 tagtttatgg gcattttgga aggttgagtc ctgaagttac tagatctcta tttttgcctg
     9661 ggagccccag ccatggaaca cagtagaatt ttttgttcac acaagctgcc cggaccaaac
     9721 ctgaccatgc catgctgaac acaggtgata agccatagct gcttgtttgt agaaacagtt
     9781 cggaggtttt ctgagttctg tttcagttgg ggggaaaaat gaatgtgatt gaccagacaa
     9841 gagtggaaag aaggcctggg cagtcccaga gagcaagctc tcattcctga ggagtcgaca
     9901 gaaacgaggc acagccgcct gagtgccccg cttccattcc gaggatcgtg aatccaagct
     9961 tgaggagttc ggcgttcaaa gaatgtttca cagcaaagga agctcggcca cgactgcaga
    10021 gaggaagtga aatgatgaga ggggaactgt tggagaagag agcaccaagg cggacatcag
    10081 gaaggcagaa tggcctgtct tccttcttgg gacagccttc aaacatctca tcatgtattt
    10141 ctgttaggat gtccctaatc ccaaaatctg aagctcaagg tgctccccag ttcaagggtt
    10201 tttgagcact aacttgactc cgtggtaagt tctacagctg gccttgtgtg atccatcagt
    10261 cagaacacag ctccattaaa actaccatgt agacttacca tcagccacgt gtacagggta
    10321 cctgagggac tgaaatgaac tgcatgttta gacttgagat tcatcctcaa gactcatatt
    10381 tattcagata ttccaaattt attttaaaag cagattccga tccagagcct ttcaggtaaa
    10441 gggtctctct gacttgcgtg actgttggta gggttcactg tgaccatgta ggtcaagcta
    10501 tctggctggt tcaacagttg gattggttcc cttggttttt gaattagcta agtccatagt
    10561 gcttgtcact gcagatgaag caacttagag tcttatcctc caggataacc aggtaagaaa
    10621 tagtgtttgg ccatttcggt tgaaacccag ggtgacattc aatgcagctg tgataacagc
    10681 aaaaatctga tctcttctaa aactgtgagt agcactggaa acacttccac ctctggttga
    10741 atgtacttga ccgaaggtgg cttccttgga ataaatacat gcattttatt ttttaaggat
    10801 tgtctatata gatagcattc attaagtatg ggcattgttg gtgaatgctt cccaggatag
    10861 atgtttatat agtggaaata caaaagattt attaaaagat acgccaaaga ttatttttta
    10921 gcctacatgc caatgcacat aatcttatgt aagacaccaa aggaagttgt tcaaatctgt
    10981 aaatagtgtc agacaaatgt aacatgtccc ttctcagaat agtcgcaaga agggttggtc
    11041 tctgcctcaa gtaattttct ttaagaaatg ccttccttgc cccaacagca agatttccca
    11101 ttatgtctgt gatgtgtttt gatacccgtg tgtgtaaata tgcattgcat tgagaagggg
    11161 tccatgtgac tgtggcttta gaaatccaat agcctccatc tgccagctag tggggaaggt
    11221 ctacaccgga gttcagagtc ctctggcctc agccacactg acaagagagg ccacaaggtc
    11281 cccacttaaa gagcgcttca tcttggccat tgttgtgttc aattctccaa gaacaaagag
    11341 caagtctctt ccgcttaact ccctccacac agggaacagt tccgggctca cacgccctgt
    11401 atgcacgggt tagagcggaa gttggttctg gctgtgtgct ttggagtcta aagtccacag
    11461 aggtgcattt agctgctcca tcatctgtgt gaatcataat atatataatg taaataaact
    11521 gagcaactga acctcttatg ttctataata gagcactttc ctggttttga aatcatttac
    11581 gttctccgca aatctagcaa aatggcagta aatgtatttt ttcacactac agcattctac
    11641 ccacgctatt gcactgcaac cagtattgtt tgaacaaaga acctcatcta tctctctatt
    11701 taaataatgt atgtgcttaa tatattttca gatatgtaat tgtggttaaa ggaaacctat
    11761 atggaatctt gcacaaaccc tcactgatgt aagaataaaa ctgctgctca ttgaaa
//
